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Endy Juli Anto
Universitas Methodist Indonesia
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The Impact of a High-Fat Diet on Blood Glucose Levels Atta Celine Nouli Saruksuk; Jekson Martiar Siahaan; Irene Ruminta Tua Damanik; Endy Juli Anto; Jadeny Sinarta
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5374

Abstract

Background: Diabetes mellitus (DM) sufferers in the world and even inIndonesia are expected to continue to increase, especially type 2 DM(DMT2). DMT2 often occurs in people who are obese, the cause of obesityis often consuming foods that contain a lot of fat. Hyperlipidemia plays arole in the pathogenesis of pancreatic β-cell dysfunction.Research method: This study is an experimental laboratory study with apretest-posttest only controlled group design, using male white rats(Rattus norvegicus) with a sample size of 30 divided into 6 groups, namelythe normal group, the negative control group, the positive control group,the group given a high fatty diet (HFD). The independent variable is HFD,while the dependent variable is blood sugar levels. Data were analyzedusing the Anova test.Results: Giving HFD of 4 ml/day for 4 weeks has not been able to increaseKGD to hyperglycemic, this is thought to be because the HFD was notgiven for long enough so that insulin resistance had not occurred in thetest animals.Conclusion: Based on the results of the study, it was concluded that givingHFD for 4 weeks still could not increase KGD in male white mice tobecome hyperglycemic
Centella Asiatica Leaf Extract Increases FGF2 and Improves Paw Histopathology in Acute-Inflammation Rats Ratna Mega Sary; Endy Juli Anto; Jekson Martiar Siahaan
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2548

Abstract

Excessive acute inflammation causes oedema and tissue injury, while conventional anti-inflammatory drugs are limited by adverse effects. Centella asiatica contains bioactive compounds with anti-inflammatory and pro-healing properties; VEGF and FGF2 mediate angiogenesis and tissue repair. To evaluate the effect of C. asiatica leaf ethanol extract on serum VEGF and FGF2 levels and paw histopathology in rats with acute inflammation. Thirty male Wistar rats were randomised into five groups: normal, negative control (carrageenan), positive control (sodium diclofenac), and extract 2 and 4 g/kgBW orally. Acute inflammation was induced by subplantar carrageenan; paw volume, serum VEGF and FGF2 (ELISA), and haematoxylin-eosin histopathology were assessed. Data were analysed by ANOVA and post hoc LSD. FGF2 differed significantly among groups (p<0.001); carrageenan lowered FGF2 whereas the extract increased it (2 g/kgBW 410.76; 4 g/kgBW 335.42 pg/mL). VEGF was unchanged (p=0.713). The 4 g/kgBW dose reduced oedema and neutrophil infiltration comparably to the positive control. C. asiatica leaf ethanol extracts increased FGF2 and improved acute-inflammation histopathology, particularly at 4 g/kgBW.
Ethanol Extract of Gotu Leaves (Centella asiatica (L.) Urban) Increases PDGF Levels but Does Not Change TNF-α and Malondialdehyde in Wistar Rats in a Carrageenin-Induced Acute Inflammatory Model Mira Mustika; Endy Juli Anto; Jekson Martiar Siahaan
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2551

Abstract

Conventional anti-inflammatory therapies with NSAIDs and glucocorticoids are limited by gastrointestinal, renal, and metabolic side effects, thus encouraging the search for plant-based alternatives. Gotu kola leaves (Centella asiatica (L.) Urban) are rich in triterpenoids and flavonoids which are reported to have anti-inflammatory and wound-healing activities. This study aimed to analyze the effect of gotu kola leaf ethanol extract on tumor necrosis factor-alpha (TNF-α), platelet-derived growth factor (PDGF), malondialdehyde (MDA), and leg edema volume in male Wistar rats with carrageenan-induced acute inflammation model. Thirty rats were randomized into five groups (n=6): normal, negative control (carrageenan), positive control (carrageenan + sodium diclofenac), and two extract treatment groups of 2 g/kgBB and 4 g/kgBB orally. Edema was measured with a plethysmometer in the first minute and every hour for 4 hours; Serum TNF-α, PDGF, and MDA levels were measured by ELISA. Data were analyzed with one-way ANOVA and LSD follow-up test (α=0.05). Screening for positive phytochemicals of flavonoids, alkaloids, saponins, tannins, phenols, glycosides, and steroids/triterpenoids. PDGF levels differed significantly between groups (p=0.001), highest in the 4 g/kgBB group (2.14±0.12 ng/mL) and lowest in the negative control (1.66±0.10 ng/mL). The volume of edema was significantly different at the beginning and 1st hour (p=0.001) but not at the 2nd to 4th hour. The levels of TNF-α (p=0.423) and MDA (p=0.072) were not significantly different. Ethanol extract of Centella asiatica leaves, especially at a dose of 4 g/kgBB, increased PDGF and decreased early-phase edema, showing modulation potential towards tissue repair, but had no significant effect on TNF-α and MDA in this acute model.
Co-Authors Agnes Imelda Manurung Alex M. Lumbanraja Alexander P. Marpaung Anjany, Larasaty Ardinata, Dedi - Atta Celine Nouli Saruksuk B. Hutagalung , Sanggam Binarwan Halim Binarwan Halim Caroline Koswara Chalil, M. Jalaluddin A. Dearni Damanik Depari, A. A. Diani Nazma Dina Keumala Sari Dina R. Purba Dwi L. D. S. Siahaan Dwi Lunarta Doderina Siahaan Efbertias Sitorus Eka Samuel P Hutasoit Elizabeth Septianur Girsang Enney Evirosa J. Simanjuntak Fadinie, Wulan Faskanita M. Nadapdap Fauzi, Tengku M. Fauzi, Tengku Muhammad Frengky S. Manullang Frengky S. Manullang Gani, Endang Haryanti Girsang, Elizabeth Girsang, Elizabeth Septianur Grace Stefani Christanto Hadyanto L Hadyanto Lim Hakim, Enggrek Pelita Hamdi, Tasrif Helmida Gultom Hutapea, Kenal P. Hutasoit, Eka Samuel P Hutasoit, Eka Samuel P Hutasoit, Eka Samuel P. Ilyas, Syaffrudin Inda M. Sinaga Irene Ruminta Tua Damanik Irfan Hamdani, Irfan Irina, Sinta Ivonne R. V. O Situmeang Ivonne Ruth Vitamaya Oishi Situmeang Jadeny Sinarta Jadeny Sinatra Jadeny Sinatra Jeffrey Jerry Tobing Jimmy Jimmy Jones Simatupang Juli Jamnasi Juli Jamnasi Juli Jamnasi Juliyanti Juliyanti Kembaren, Alfri Yoganta S. Laura P. S. Tambunan Lubis, Andriamuri P. Maludin Panjaitan Manik, Widya Dayanti Feronika Manullang, Frengky S. Manullang, Frenky Sorimuda Mei Jayanti Siregar Meilinda, Selvia Melissa Angie Mira Mustika Momot, Estela Salomina Nababan, Manaor Bismar Posman Natalie S., Karen Novianti, Wulan Noviyanti, Berliana Noviyanti, Berliana Novrina Situmorang Panataria, Lince Romauli Panjaitan, Bintang Andika Pasaribu, Sumihar Pratiwi, Ade Dwi Putri Chairani Eyanoer Putri Chairani Eyanoer, Putri Chairani Ragnar Octavianus Sitorus Ratih Praseti Yanti Ratna Mega Sary Ria Oktavia Rimbun, Surjadi Ronald T. H. Tambunan Ronald T. H. Tambunan Ronald T. H. Tambunan, Rusli, Kenvin SARAGIH, MEYLIN KRISTINA Sari, Dina Keumala Sembiring, Budi Darmanta Sembiring, Mikael Siahaan, Jekson Martiar Sihaloho, Kerin Repaskatri Sihaloho, Lovian Nauli Sihombing, Parsaoran Sijabat, Kesia Silaen, Ester L. R. Silalahi, Veraci Silangit, Thomas Silitonga, Hendrika A Silitonga, Hendrika A Silitonga, Hendrika Adriana Silitonga, Hendrika Andriana Simanjuntak, Evirosa J. Simanjuntak, Harry C Simanjuntak, Harry C Simanjuntak, Jeremia Simanjuntak, Pantas Simatupang, Aditia Erick Cantona Simbolon, Boyke M. Sinaga, Inda M. Sinatra, Jadeny Sirait, Kilian Sitepu, John Frans Siti Normi Sitompul, Michael Sabatino Situmeang, Ivonne Ruth Vitamaya Oishi Stephanie S., Kezia Steven Tjendra Sucipto Sucipto Sucipto Sucipto Syafruddin Ilyas Syafruddin Ilyas Syafruddin Ilyas Tambunan, Ronald T. H. Tambunan, Ronald Tunggul Hotmarojahan Tampubolon, Benny Tanjung, Qodri F. Tarigan, Juliyanti Tarigan, Menang B Tarigan, Menang Bastanta Tengku M. Fauzi Tengku M. Fauzi Thomas Silangit Tiara Larasati Tiji, Widjaya Taufik Tim Lions Club Medan Angkasa Tim Lions Club Medan Angkasa Tobing, Paul S. M. L. Vivian Vivian Widjaya Taufik Tiji Widjaya Taufik Tiji Wijaya Taufik Tiji Wijaya, Mega YUNAFRI, ANDRI Zainumi, Cut M.