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INDONESIA
ODONTO Dental Journal
Published by Universitas Islam Sultan Agung
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 357 Documents
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Sub-Acute Toxicity and Allergy Studies of Bidara Leaf (Ziziphus Mauritiana) Extract as A Wound Healing Material Ma'ruf, Mochammad Taha; Dewi, Putu Sulistiawati; Poernomo, Hendri
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.194-201

Abstract

Background: In dentistry, the wound healing process is often encountered in tooth extractions, incisions, oral and facial surgery, gingival flaps and biopsies. Post-tooth extraction wound is a medium that allows pathogenic microbes to breed and infect the wound. Wound management must be carried out as soon as possible to restore mucosal integrity so as to prevent bacterial infections penetrates the body. Bidara (Ziziphus mauritiana) is one of the plants used as traditional medicine by the community. Research on this plant as a medicinal raw material is increasing, so further research needs to be carried out to prove the safety of this medicinal plant. This study aims to determine the effects of sub-acute toxicity and allergic reactions caused after administering bidara leaf extract on the liver histopathology of mice. Methods: In vivo laboratory experimental study using a post-test only control group design with 24 mice (Mus musculus). The research sample consisted of 4 groups, namely the control group given 0.3% Na-CMC, the treatment group given bidara leaf extract at a dose of 500 mg/kg BW, 600 mg/kg BW, and 700 mg/kg BW. The treatment extract was given orally for 28 days. Results: The results of the study showed that the dose of bidara leaf extract had an effect on the liver histopathology of mice, namely at doses of 600 mg/kg BW and 700 mg/kg BW it had a toxic effect that was visible from changes in liver cell structure. Allergy tests showed that bidara leaf extract did not cause allergic reactions in mice. Conclusion: It can be concluded that bidara leaf extract (Ziziphus mauritiana) does not cause allergies and at certain doses does not have toxicity in the liver of animals study.
Chitosan From Haruan (Channa Striata) Fish Scale Accelerate Wound Healing By Promoting Angiogenesis And Fibroblast Proliferation Putri, Deby Kania Tri; Fitriyana, Annisa; Raudah, Siti; Wardhana, Agung Satria; Wydiamala, Erida; Sarifah, Norlaila; Budipramana, Melisa
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.%p

Abstract

Background: Damage to the integrity of some body tissues due to trauma commonly referred to as injury can occur intentionally or unintentionally. Angiogenesis and fibroblast proliferation are important stages in the proliferation stage in determining the success of the wound healing process. Chitosan from haruan fish scales has active functional groups in the form of anti-inflammatory and antioxidants that are effective in accelerating wound healing. Method: This study was a pure experimental study with a post-test only design with a control group design which was divided into a treatment group and a control group. The treatment group consisted of chitosan haruan fish scales at concentrations of 1%, 3%, and 5%. The control group consisted of povidone iodine as a positive control and no treatment as a negative control. All rats were injured on the back and then euthanized on days 3, 5, 7, and 14. Result: The chitosan from haruan fish scales affected the formation of new blood vessels and fibroblasts on day-3, increase the number of new blood vessels on day-5, decrease the number of new blood vessels accompanied by increase the number of fibroblasts on day-7, and also decrease the number of fibroblasts on day-14.Conclusion:  3%, and 5% chitosan from haruan fish scale proved to be effective against angiogenesis and fibroblast proliferation in wound healing. 
Antibacterial Effectivity of Nanoemulgel Phaleria macrocarpa’s leaf on the Porphyromonas gingivalis ATCC 33277 Biofilm Thickness Pratiwi, Rosa; Ratnawati, Irma Dewi; Ismail, Ade; Nurhapsari, Arlina; Amelia, Rosalita
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.168-174

Abstract

Porphyromonas gingivalis is an oppoturnistic microorganism in periodontal disease that is formed at the stage maturation of biofilm formation. One of the natural materials biofilm reduction is the Phaleria macrocarpa. Phaleria macrocarpa’s leaf contains chemical compounds such as flavonoids, tannins, alkaloids, saponins that function as antibacterials.The aim of this research is to determine the effectiveness of the nanoemulsion of the gel Phaleria macrocarpa’s leaf  on the thickness of the P. gingivalis bacterial biofilm. The research design was carried out with a post test only with a total of 28 samples, then divided into 4 groups of treatment of Phaleria macrocarpa’s leaf extract nanoemulsion gel preparations with variations in concentrations of 30%, 40%, and 50%, as well as a control group of 25% metronidazole gel. The reading of the anti-biofilm thickness test results was measured by OD (Optical density) using an ELISA-reader. One way Anova parametric test among obtained p<0.000 results showing the effect of Phaleria macrocarpa’ leaf gel nanoemulsion extract on the decrease in the thickness of the Porphyromonas gingivalis bacterial biofilm. It can be concluded that the nanoemulsion gel formulation of Phaleria macrocarpa’s leaf extract concentrations of 30%, 40%, and 50% is effective, with a concentration 50% was most effective against reducing the thickness of the bacterial biofilm Porphyromonas gingivalis.
The effect of incorporating hydroxyapatite into Type II glass ionomer cement on flexural strength and the examination of fractured surfaces using scanning electron microscopy Rahmitasari, Fitria; Cevanti, Twi Agnita; Prabowo, Puguh Bayu; Sularsih, Sularsih; Prananingrum, Widyasri
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.152-161

Abstract

Background: Glass ionomer cement (GIC) is widely recognized as the prevailing direct esthetic restorative material. In order for a restoration material to be considered effective, possess favorable physical and mechanical properties. Incorporating with hydroxyapatite (HA) can provide these properties. This research is to investigate the impact of integrating HA into GIC on the flexural strength and scanning electron microscopy (SEM) of the fractured surfaces. Methods: The study consisted of 28 samples of GIC, which are fabricated in the shape of rectangular prisms (25x2x2mm). The samples were divided into four groups n=7. Group 1 is a control group (GIC), Group 2 GIC+2%HA, group 3 GIC+2%HA, and GIC+4%HA. The flexural strength of the sample was evaluated by a Universal testing machine, followed by an examination of the fracture surface using SEM. Result: The Brown-Forsythe was used as data analysis to examine the flexural strength values across all groups, resulting in a statistically significant p-value of less than 0.05. The addition of HA does not result in a significant increase in the flexural strength value of the glass ionomer cement (GIC). The integration of microstructure based on scanning electron microscopy (SEM) pictures demonstrates improved visual quality following the incorporation of HA. Conclusion: The addition of HA to GIC did not result in a significant change in flexural strength compared to the control group. However, GIC group with 2% HA exhibited the highest average flexural strength value among all the groups
CAMBRA Factors Correlated with Dental Caries in Children A'yun, Quroti; Sulistyani, Herastuti; Risnawati, Dewi; Dilianti, Ika Fitri
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Recent data show that the prevalence of dental caries in children aged 10 to 14 years is almost 41.4%. Several methods for managing caries include Caries Management by Risk Assessment (CAMBRA). The CAMBRA method assists doctors in identifying causes of dental caries by identifying risk factors in each patient. Based on research, the etiology of dental caries was discovered by identifying risk factors in each participant. This study aims to identify what factors influence dental caries in children based on CAMBRA. Method: This research uses observational analysis with cross-sectional data. The respondents are students from Kadipiro I Elementary School, Bantul, Daerah Istimewa Yogyakarta, Indonesia. Purposive sampling was used to create the sample, which included 82 children between the ages of 10 and 12. The study was conducted by discovering dental caries risk factors with the CAMBRA method: 1. new cavity or lesion to dentine, 2. white spot, 3. restorations within the last three years, 4. volume of saliva, 5. plaque/ PHPM index, 6. pH saliva, and 7. frequency of sweet foods consumption. The scale of the data was nominal and analysed using the SPSS version 25.0 program, which included frequency analysis and logistic regression. Result: The results of the logistic regression analysis showed that five variables have a significant (p
The Roles Of Sphingosine-1-Phosphate (S1p) On Arthritis: Review Article HUTAMI, ISLAMY RAHMA
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.115-123

Abstract

Arthritis is a pathological condition that results in degeneration of the joints. RA and OA are the most common types of arthritis. RA is a chronic joint inflammation caused by the immune system's self-attack on tissues. By contrast, OA is chronic joint inflammation caused by cartilage breakdown. Both illnesses cause joint discomfort, stiffness, and edema. One genetic factor in arthritis is sphingosine-1-phosphate (S1P). S1P regulates bone homeostasis and growth using 5 receptors: 1, 2, 3, 4, and 5. Thus, this literature review intends to investigate the impact of S1P on arthritis. Methods: The eligibility criteria comprised cross-sectional studies that were published in English until January 2024 and exclusively addressed the role of S1P in arthritis. Results and discussion: From 396 publications, 17 relevant articles were located, and 6 were chosen for the review. The S1P/S1P2 signaling pathway releases osteoclasts to degrade cartilage in osteoarthritis. S1P also promotes bone growth by differentiating osteoblasts and forming blood vessels in the bone marrow. The miR-25 rs41274221 polymorphism may reduce osteoporosis risk. IL-6 is also produced by osteoblasts with S1P. Osteoarthritis is associated with elevated blood S1P and MMP-3 levels. Cyclic strain and inflammation increase Sphk1 upregulation and S1P release, suggesting a role in osteoarthritis. In conclusion, the expression of S1P by osteoclasts, osteoblasts, chondrocytes, and tenocytes is believed to play a crucial role in regulating cell migration and the production of cytokines or chemokines throughout the process of bone formation. Focusing on the S1P pathway may help treat bone and joint diseases.
Cytotoxicity and mechanical properties of biphasic calcium phosphate scaffold from Tegilarca granosa due to its composition Prananingrum, Widyasri; Caroline, Grace; Rizal, Mohammad Basroni; Prabowo, Puguh Bayu; Pratama, Afif Fahwi; Resaldi, Muhammad Firdan; Annisa, Nindya Yuanita; Fadhilah, Yusti; Sari, Rima Parwati
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.247-256

Abstract

Background: Biphasic calcium phosphate (BCP) is graft material contained HA and TCP. Tegilarca granosa shell is a natural source that may converted into BCP. This study aims to determine the composition and cytotoxicity of BCP synthesized from Tegilarca granosa shell used various hydrothermal hours and to evaluate the mechanical properties of BCP scaffold. Methods: Tegilarca granosa shell was converted into BCP using hydrothermal method at 200˚C for 6h (Group 1); 9h (Group 2); and 12h (Group 3). The composition was determined by XRD and the cell viability were evaluated using MTT Assays. Each group was added with 20% gelatin ratio 50:50 (w/v) and freeze-dried to form scaffold. Scaffolds (Ø6mm x 4mm) were prepared for diametral tensile strength (DTS) test (n=6) and scaffolds (Ø7mm x 11mm) were used for compressive strength (CS) test (n=6). All data were analyzed using Kruskall-Wallis followed by Mann-Whitney test. Results: The composition of BCP (HA/ TCP) at Group 1, Group 2, and Group 3 were 81.80%/14,10%; 87%/6%; and 72%/21%. The cell viabilities were good for all groups. The DTS and CS test showed there was a significant difference between Group 1 and Group 3 scaffold, meanwhile there was no significant differences between Group 2 and Group 3 scaffold. Group 3 scaffold showed the highest DTS and CS, 6.921 MPa and 1,233 MPa. Conclusion: The BCP composition were depent on hydrothermal hours. Although all scaffold groups were non-toxic, but BCP scaffold synthesized from Tegilarca granosa shell using hydrothermal for 12 hours showed the highest mechanical properties.
The Correlation Between Caries Severity and Dental Pain Stress Level in the Community of Sucopangepok Village, Jelbuk Subdistrict, Jember Regency Yani, Ristya Widi Endah; Handayani, Ari Tri Wanadyo; Kiswaluyo, Kiswaluyo
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.72-80

Abstract

Background: The results of the Basic Health Research in 2018 show that the prevalence of caries in Indonesia is high (88.8%), and the prevalence of active caries in East Java is also high (42.4%). One of the consequences of untreated caries is stress dental pain due to toothache which has an impact on the quality of life.Method: Observational analytical research with a cross-sectional approach on people aged 17 years and above was conducted on February 2023 – March 2023. A total of 318 respondents uses simple random sampling. The variable of the research are dental caries severity (using the PUFA index) and dental pain stress (using a modification of the Kessler Psychological Distress Scale questionnaire with Perceived Stress Scale).Result: The data obtained were tabulated and analyzed with descriptive statistics and continued with the Spearman correlation test. 36% of respondents age 26-35 years, 57.23% were female. 41.82% have primary school education and work as housewives and farmers. The average caries severity is 2.6 categorized as high with dental pain stress categorized as medium. Spearman correlation test show significance (p) <0.05 which means there is a correlation between caries severity level and dental pain stress.Conclusion: There is a relationship between caries severity and stress dental pain
Effectiveness of herbal medicine as an alternative therapy for burning mouth syndrome: a systematic review Putri, Nadia Tiara; Nuraeny, Nanan
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.202-213

Abstract

Background: Burning mouth syndrome (BMS) is characterized by a burning sensation or dysesthesia of the oral mucosa without accompanying abnormal clinical or laboratory findings. Management of BMS is very important to reduce pain, support nutrition and improve patients’ quality of life. Various studies on BMS therapy have been carried out, one of which is by using alternative materials derived from nature known as herbal ingredients. The objective of this systematic review is to review the effectiveness of herbal medicine to reduce pain in BMS patients. Methods: This systematic review was conducted using the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines. Article searches were conducted through Pubmed, Scopus, Science Direct, Cochrane, and Springer Link published from 2012 to 2022 with specific keywords. The search for articles was limited to human studies and randomized controlled trial (RCT), papers written in English and availability of full text. The risk assessment of bias uses the Modified Jadad Scale. Results: Seven articles with good eligibility that meet the inclusion criteria were analyzed. The herbal medicine reviewed were capsaicin (two articles), Aloe vera, catuama, capsaicin, virgin olive oil, chamomile and crocin (one article for each herbal medicine). All of the herbal medicine reviewed were proven to reduce pain in BMS patients, but capsaicin and catuama showed significant differences with the comparison group. Minimal side effects were also observed with capsaicin and catuama. Conclusion: Herbal medicinal ingredients have been proven to be effective, useful and safe alternative therapies for BMS patients.
the effect of ozonated olive oil on the number of neutrophil cells in the gingiva of male Wistar rats experiencing periodontitis (in vivo) Anwaristi, Aprilia Yuanita; Cahyani, Cahyani; Faizah, Ariyani; Fauziyah, Nida Faradisa; Arifin, Dani Fajar; Hidayanti, Nur; Lestari, Cindy
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.21-29

Abstract

Background: Periodontal tissue, comprising gingiva, periodontal ligament, cementum, and alveolar bone, supports and surrounds teeth. Periodontitis, an inflammation affecting these tissues, manifests through gingival inflammation, pocket formation, and loss of attachment and bone.Purpose: This research aims to investigate whether ozonated olive oil influences neutrophil cell levels in the gingiva of male Wistar rats with periodontitis.Method: Employing a posttest-only control group design, this laboratory study included 24 male Wistar rats with concentrated periodontitis divided into six groups based on the day of observation. Histological analysis was conducted on days 1, 3, and 5, with three control groups and treatment groups.Result: The hypothesis test revealed a significant difference in neutrophil cell count between the ozonated olive oil treatment group and the control group (p < 0.05). The treatment group exhibited superior outcomes compared to control and other treatment groups, as confirmed by the LSD Post Hoc Test (p < 0.05).Conclusion: Administration of ozonated olive oil can influence neutrophil cell involvement in periodontitis healing among male Wistar rats, suggesting its potential therapeutic efficacy

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