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Journal : Biomedical Journal of Indonesia

Side Stream Cigarette Smoke and Its Role in Inducing Oxidative Stress in Rat Cerebral Tissue Farindra, Irmawan; Rakhmawati, Annisa; Rusdi, Warda Elmaida; Benge, Wilhemus Dionysius Mario Randy; Farmananda, Irsandi Rizki; Rusdi, Muhammad Salsabeela
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.253

Abstract

Introduction. Smoking behavior can affect not only the individual smoker but also those around them. Individuals exposed to secondhand smoke are at risk of developing similar health problems as those faced by individuals who actively smoke. Secondhand smoke causes an imbalance of systemic oxidants and antioxidants characterized by the presence of a lipid peroxidation product, namely Malondialdehyde (MDA). The main objective of this study was to assess how exposure to sidestream cigarette smoke affects MDA levels in rat cerebral tissue Methods. A true experimental study was conducted using 30 male Wistar rats with a post-test only control group design. All rats were randomly divided into 5 groups, namely 1 control group and 4 treatment groups. A total of 270 cigarettes were used as exposure sources. A spectrophotometer at a wavelength (λmax) of 533 nm was used to measure MDA levels. The MDA level data were then analyzed. ANOVA and Kruskall Wallis tests were performed after evaluating the results of the Normality and Homogeneity tests. A p value <0.05 indicates significant data. Results. The results indicate that the group exposed to cigarette smoke using 4 cigarettes for 30 days (P4) exhibited elevated MDA levels compared to the control group. Statistical analysis showed a significant correlation between secondhand smoke and increased MDA levels (p < 0.05). Conclusion. This study results suggest that exposure to SSCS contributes to increased MDA levels in the brain tissue of Wistar rats, which indicates oxidative stress.
Co-Authors Agus Aan Adriansyah Ain Darojah Siddiq Ramadhana Alam, Regita Shalsabillah Dhita Alfaridzi, Aditya Rizky Algristian, Hafid Alif Nur Hanifa Almah, Bunga An Nur Rahmillah Anggita Lusiana Dewi Annif Munjidah Annisa Rakhmawati, Annisa Aqila, Muhammad Akmal Aqilah, Nahwa Shofiyul Ariefianto, Satrio Eko Artanti, Widyana Beta Artyuga, Ahmad Hero Aulia Fahira Ayrton Putra Maizoniarta Ayu Aisyah Alya Hamida A’Yunin, Atik Quurrota Bambang Edi Suwito Bambang Edi Suwito4 Benge, Wilhemus D.M.R Benge, Wilhemus Dionysius Mario Randy Benge, Wilhemus Dionysius Mario Randy Choirinah Fadhilatul Rohmah Danny Irawan Dera Julia Ghazalah Agatha Dewi Masithah Dwijayanti, ira Farakhin, Noer Farmananda, Irsandi Rizki Farmananda, Irsandi Rizki Fathima Az Zahra Faiq Firlani, Osya Azifa Galih Wicaksono Hafidatut Taufiqoh Hermawati, Nathania Fauziah Hidayat Ira Dwijayanti Irsandi Rizky Farmananda Junaedi, Mohammad Dwinanda Kartika Yuliani Krismawati, Amelia Laila Hanum Lailiyah, Hikmatul M. Shodiq M. Shodiq Maizoniarta, Ayrton Putra Marinda Dwi - Mery Indartiningsih Muhammad Salsabeela Rusdi Muhammad, Akbar Reza Nahwa Shofiul Aqilah Nailuvar, Revani Yuni Nanda Nabilah Putri Ni Made Linawati Noer Farakhin Noora, Gusti Maya Shafira Novia Lailatul Karimah Nuari, Nuzlan Nur Zuwariyah Nuzulul Husnul Khotimah Pramistyowati , Magda Budi Pratiwi, Viera Nuriza Prilistyo, Dwimantoro Iman Putri, Salsabil Nabila Wigayana Putri, Winawati Eka Ramadhany, Rahmat Rizal Rizkina, Marosa Nabila Rully Genadi Abidin Rusdi, Muhammad Salsabeela Rusdi, Warda El Maida Rusmana, Raissa Aydien Saffanah, Vena Saksia Prima Saputra, M. Kevin Bintang Satriya Wijaya Setiawan, Muhammad Devabrata Tengku Riza Zarzani N Tia Maya Affrita Tirthaningsih, Ni Wajan Viskasari P. Kalanjati Warda El Maida Rusdi Warda Elmaida Rusdi Wibowo, Novan Kurnia Wilada, Hajar Yanis Kartini Yasmin Amini Yasmin Amini Yuniati, Dyah Zuwariyah, Nur