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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Sains dan Teknologi Pangan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Kesehatan Komunitas Dinamisia: Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) JISIP: Jurnal Ilmu Sosial dan Pendidikan Jurnal Mandala Pharmacon Indonesia Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Jurnal Manajemen Transportasi & Logistik (JMTRANSLOG) Griya Journal of Mathematics Education and Application Mukaddimah: Jurnal Studi Islam Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Jurnal Biofiskim: Pendidikan dan Pembelajaran IPA Datokarama English Education Journal (deejournal) Molekul: Jurnal Ilmiah Kimia Jurnal Pengabdian Masyarakat
Ruslin, Ruslin
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Docking-Based Virtual Screening to Identify the Cysteine Protease Falcipain-2 Inhibitors of Plasmodium falciparum Darmin, Wa Ode Yentri Putia Ningtiyas; Arfan, Arfan; Ruslin, Ruslin; Wu, Chun; Arba, Muhammad
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.7376

Abstract

Malaria is an infectious disease caused by Plasmodium protozoan parasites that transmit via the female Anopheles sp. mosquito. Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi are the five Plasmodium species known to infect humans. P. falciparum is the most virulent species, causing the most deaths worldwide. The decrease in efficacy of most antimalarials suggests drug resistance. Therefore, the development of new effective antimalarials, particularly against novel targets, was still required. Cysteine protease falcipain-2 (CPF-2) plays a role in hemoglobin degradation; therefore, inhibiting the activity of this enzyme could be a viable antimalarial target. This study aimed to identify a potential inhibitor for the CPF-2 with PDB ID 3BPF from the ZINC15 database for treating malaria. This study employs a virtual screening workflow with HTVS, SP, and XP docking methods on the Glide Maestro Schrodinger. Based on the glide XP docking score, 10 hit compounds were identified, and their conformational interactions with CPF-2 were compared to the natural ligand (E-64). The binding energy values of hit compounds vary from -7.131 kcal/mol to -8.074 kcal/mol, which is more negative than the E-64 (-6.011 kcal/mol). The three best compounds identified from the ZINC15 database are ZINC000025691540, ZINC000096436101, and ZINC000097797430. All the hit compounds discovered similar interaction with E-64, specifically on the CPF-2 binding pocket residues with Gln36, Cys42, Gly83, Asn173, and His174. All hit compounds exhibit suitable Lipinski rule profiles and are potentially evaluated experimentally as CPF-2 enzyme inhibitor candidates. Keywords: cysteine protease falcipain-2, malaria, molecular docking, Plasmodium falciparum, virtual screening
Multi Atribut Model Fishbein pada Ojek Online di Kabupaten Lombok Timur Ruslin, Ruslin; Ramli, Chairul Aly; Supiarmo, M Gunawan; Faqihi, Ahmad; Ma'ruf, M; Prayogi, Galih Rio; Hermansyah, Hermansyah; Langit Wahyu Gutama, Detha Sekar
Jurnal Manajemen Transportasi & Logistik (JMTRANSLOG) Vol. 11 No. 3 (2024): NOVEMBER
Publisher : Institut Transportasi dan Logistik Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54324/j.mtl.v11i3.1564

Abstract

The main objective of this research is to analyze customer preferences of online motorcycle services in East Lombok using the Fishbein multi-attribute model. A deep understanding of the attributes most valued by customers is essential for service providers and local government to improve service quality of the community's needs. The research was conducted using purposive sampling with data collected over three months through interviews, questionnaires, observations, and literature reviews. The results indicate that all evaluation importance levels is categorized as important, with the highest score of 4.24 attributed to the safety and comfort attributes. On the other hand, the evaluation of belief levels (bi) falls into the good category, with the highest score of 3.83 attributed to driver experience. Based on the customers’ attitude analysis, several attributes receive positive scores: the safety and comfort attributes receive the highest attitude score of 15.94, followed by the driver’s experience attribute with a score of 15.87, and finally the ease of use of the online motorcycle application with a score of 15.61. In conclusion, deeper understanding of customers’ preferences could assist service providers and local government to improve the quality of online motorcycle services in East Lombok Regency.
Exploring the Anti-Inflammatory Activity of Purified Ficus septica Extracts: Insights from In Vitro and In Silico Studies Arfan, Arfan; Ruslin, Ruslin; Yamin, Yamin; Annisa, Finantha; Basrin, Wa Ode Fitrawati
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.189-196.2024

Abstract

Ficus septica is a plant that has demonstrated significant potential as an anti-inflammatory agent. This study evaluates the anti-inflammatory activity and molecular mechanisms of compounds from Ficus septica, focusing on their interactions with Bovine Serum Albumin (BSA) and Cyclooxygenase-2 (COX-2). The results show that the purified extracts from Kadia and Batalaiworu exhibited better anti-inflammatory activity, with IC50 values of 32.04 µg/mL and 32.06 µg/mL, respectively, compared to the crude extracts, which had IC50 values of 42.07 µg/mL and 42.44 µg/mL. Despite this, Diclofenac Sodium exhibited a significantly lower IC50 value of 7.99 µg/mL. Computational studies revealed that Genistein had the strongest binding affinity to BSA with a binding energy of -7.52 kcal/mol, comparable to Diclofenac Sodium (-7.51 kcal/mol). Furthermore, Ficuseptine B and Septicine demonstrated strong binding to COX-2, with binding energies of -9.51 kcal/mol and -9.45 kcal/mol, respectively, outperforming Diclofenac Sodium (-8.49 kcal/mol). These findings suggest that compounds from Ficus septica, particularly Genistein, Ficuseptine B, and Septicine, may serve as potential anti-inflammatory agents through their ability to bind to BSA and COX-2.
IMPROVING STUDENTS’ SPEAKING SKILL THROUGH ROLE PLAY: AN ACTION RESEARCH FOR THE EIGHT GRADE STUDENTS OF SMP NEGERI 1 PEDONGGA Mariani, Mariani; Ruslin, Ruslin; Afifah, Afifah
Datokarama English Education Journal Vol. 1 No. 1 (2020): August
Publisher : English Tadris Department, Tarbiyah and Teacher Training Faculty, Datokarama State Islamic University Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24239/dee.v1i1.4

Abstract

Speaking is the special moment when the student can be improve their speaking in daily life or their classroom. With speaking the students can practice their knowledge of English and they can get new vocabularies. The objective of the research is to improve speaking skill for the eight grade students of SMP Negeri 1 Pedongga in the academic year of 2019/2020 with the use of role play method. Based on the observation, there were some problems in the teaching and learning of speaking. To solve those problems, the researcher implemented role play as a speaking activity.The research was carried out through action research that consisted of two cycles. Each cycle consisted of two meetings. The results of the research showed that there were some improvements in the students speaking skill. In cycle I, there were some unsuccessful actions. Meanwhile, in cycle II, the implementation of role play techniques was successful in improving the students’ speaking skill. The conclusion of this research were the students low in speaking was caused by lack in vocabulary, self-confident, and they were confused how to pronounced the word. The success in teaching doesn’t depend on the lesson program only, but more important is how to the teacher present the lesson and uses various method to manage the class.
Desain Realistic Mathematics Education Integrasi Tradisi Peresean Masyarakat Lombok pada Materi Kombinasi Supiarmo, M. Gunawan; Primajati, Gilang; Ruslin, Ruslin
Griya Journal of Mathematics Education and Application Vol. 5 No. 2 (2025): Juni 2025
Publisher : Pendidikan Matematika FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/griya.v5i2.663

Abstract

Mathematics learning is often considered abstract and less relevant to real life, making it difficult for students to understand the concept. Realistic Mathematics Education (RME) offers an approach that helps students build understanding through real situations. The Peresean tradition with its competition structure and cultural values ​​has the potential to be a concrete and meaningful combination learning context. This study aims to design a realistic mathematics learning design that integrates the Peresean tradition into a combination of materials at the Senior High School level. The main problem behind this study is the low understanding of students towards the combination concept due to the delivery of material that is too abstract and has minimal relevance to real life. The RME approach offers a solution through the use of the real context of the Peresean Tradition which was chosen because it has a competition structure that has the potential to be mathematically modeled in the combination context, such as selecting opponents or compiling match schemes. This study uses a qualitative approach with the type of design research in the development studies category. The research process is limited to the preliminary design stage, which includes context analysis, literature studies, and the development of learning designs. The research results are in the form of a theoretical and contextual culture-based learning design, which is validated reflectively based on RME principles and suitability to the curriculum.
Evaluasi Kualitas Pelayanan Terhadap Kepuasan Pasien di Puskesmas Lepo-Lepo Kota Kendari dengan Metode SERVQUAL dan Zone of Tolerance (ZoT) Kuncoro, Shienny; Wahyuni, Wahyuni; Sahidin, Sahidin; Irnawati, Irnawati; Arba, Muhammad; Ruslin, Ruslin; Fristiohady, Adryan
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.697

Abstract

Upaya peningkatan mutu pelayanan kesehatan, Puskesmas Lepo-Lepo senantiasa menampung semua saran, keluhan dan pengaduan dari masyarakat yang menyoroti tentang kualitas pelayanan yang telah diterima. Sehingga perlu dilakukan evaluasi kualitas pelayanan. Pengukuran kualitas pelayanani di Puskesmas Lepo-Lepo dapat i diukuri dengani menggunakani metodei servicei qualityi (servqual).i Metodei servquali pertamai kalii dikenalkani olehi Parasuramani meliputii 5i i dimensii yaitui Tangible,ii Reliability,ii Responsiveness,ii Assurance,ii Emphaty.i Metodei inii seringi digunakani untuki melihati sejauhi manai kesenjangani antarai harapani padai suatui layanani dani kenyataani layanani yangi diterima. Tujuan penelitian ini untuk mengevaluasi kualitas pelayanan di Puskesmas Lepo-Lepo apakah sudah  sesuai dengan harapan pasien atau sebaliknya sehingga Puskesmas Lepo-Lepo dapat melakukan perbaikan yang lebih baik. Pada penelitian ini telahi dilakukani wawancarai dengani menggunakani kuisoner kepada 100 responden jumlah pasien Puskesmas Lepo-Lepo tahun 2023.  Hasil dari penelitian ini diperoleh nilai GAP untuk dimensi tangible nilai GAP terkecil -0,57  dan terbesar -0,46, untuk dimensi reliability nilai GAP terkecil -0,49  dan terbesar -0,46, untuk dimensi responsiveness  nilai GAP terkecil -0,51  dan terbesar -0,31, untuk dimensi assurance  nilai GAP terkecil -0,51  dan terbesar -0,32, dan untuk dimensi emphaty  nilai GAP terkecil -0,39  dan terbesar -0,28. Nilai GAP pada tiap dimensi masih negatif menunjukkan bahwa ada beberapa pasien merasa tidak puas terhadap pelayanan Puskesmas Lepo-Lepo. Nilai GAP kemudian dianalisis dengan metode Zone of  Tolerance (ZoT) untuk melihat apakah ketidakpuasan pasien masih bisa diterima atau tidak.  Hasil analisis dengan ZoT  positif  yaitu pada  0,36 – 0,58, dapat disimpulkan bahwa meskipun pasien tidak sepenuhnya puas, kualitas pelayanan yang diberikan masih dalam batas yang dapat diterima.
Pengaruh Display dan Persepsi Harga Terhadap Keputusan Pembelian di Apotek Retail Modern Mirawanti G, Wa Ode; Ruslin, Ruslin; Jabbar, Asriullah; Sahidin, Sahidin; Fristiohady, Adryan; Arba, Muh.; Irnawati, Irnawati; Wahyuni, Wahyuni
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.726

Abstract

Perkembangan apotek retail modern di Kota Kendari semakin cepat, mempengaruhi dinamika pasar produk farmasi dan perilaku konsumen. Penelitian ini bertujuan untuk menganalisis pengaruh tampilan produk dan persepsi harga terhadap keputusan pembelian di apotek retail modern. Menggunakan pendekatan kuantitatif, penelitian ini melibatkan 100 responden yang merupakan pelanggan di salah satu Apotek retail modern. Data dikumpulkan melalui kuesioner berbasis skala Likert dan dianalisis menggunakan metode deskriptif serta SEM PLS 4.0 dengan software Smart PLS 4.0. Hasil penelitian menunjukkan bahwa tampilan produk dan persepsi harga memiliki pengaruh signifikan terhadap keputusan pembelian. Model yang dibangun memiliki nilai R Square sebesar 0,710, yang menunjukkan bahwa 71% variasi dalam keputusan pembelian dapat dijelaskan oleh faktor-faktor yang diteliti. Nilai Q Square sebesar 0,692 mengindikasikan bahwa model ini memiliki relevansi prediktif yang tinggi. Temuan ini memberikan wawasan penting bagi manajer apotek dalam merancang strategi pemasaran yang lebih efektif dan meningkatkan pengalaman pelanggan.
PENGARUH BRAND IMAGE DAN KUALITAS PELAYANAN TERHADAP LOYALITAS KONSUMEN DI APOTEK DENGAN LAYANAN DOKTER KELUARGA Putri, Natalia Christiani; Fristiohady, Adryan; Ruslin, Ruslin; Wahyuni, Wahyuni; Akib, Nur Illiyyin
Jurnal Kesehatan Komunitas Vol 11 No 2 (2025): Jurnal Kesehatan Komunitas
Publisher : LPPM Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/keskom.Vol11.Iss2.2198

Abstract

The continuous growth in the number of pharmacies in Kendari City has intensified competition in this business sector. In such a competitive landscape, brand image and service quality become crucial factors influencing consumer preferences when choosing a pharmacy. Apotek PS, which has been serving the Kendari community for over a decade, is recognized for its strong brand reputation and reliable service standards. This study aims to explore the impact of brand image and service quality on customer loyalty at Apotek PS. Data were collected through a Google Form-based questionnaire completed by 100 customers who had visited at least twice. The collected data were then analyzed using descriptive statistical methods and the Structural Equation Modeling (SEM) approach with the assistance of SmartPLS software. The findings of this study confirm that both brand image and service quality contribute positively and significantly to customer loyalty. Together, these two variables account for 78.4% (indicating a strong influence) of customer loyalty, with a Q-squared value of 0.772, signifying a high level of predictive accuracy. Furthermore, the PLS model evaluation demonstrates an acceptable level of model fit. Based on the Cross-validated Predictive Ability Test, the PLS model exhibits a higher predictive accuracy than the IA and LM models, leading to the conclusion that the PLS model performs better in predicting customer loyalty.
Pengaruh Brand Image dan Kualitas Pelayanan Terhadap Loyalitas Konsumen di Apotek X Putri, Natalia Christiani; Ruslin, Ruslin; Sahidin, Sahidin; Arba, Muhammad; Irnawati, Irnawati; Wahyuni, Wahyuni; Akib, Nur Illiyyin; Fristiohady, Adryan
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.694

Abstract

Perkembangan jumlah apotek di Kota Kendari yang semakin bertambah menyebabkan persaingan bisnis apotek semakin ketat, dengan banyak apotek yang saling berlomba untuk menarik pelanggan. Dalam konteks ini, brand image dan kualitas pelayanan menjadi aspek krusial yang bisa memengaruhi keputusan konsumen ketika memilih apotek. Apotek X sebagai salah satu apotek yang telah lama beroperasi di Kota Kendari tentunya memiliki brand image dan standar kualitas pelayanan. Tujuan penelitian ini berfokus guna memahami pengaruh brand image dan kualitas pelayanan terhadap loyalitas pelanggan di Apotek X Kota Kendari. Sampel penelitian sebanyak 100 partisipan merupakan pelanggan yang sudah membeli produk obat di Apotek X minimal dua kali. Metode pengambilan sampel yakni purposive sampling. Skala yang dimanfaatkan penelitian ini ialah skala likert. Teknik analisis data memanfaatkan analisis deskriptif dan SEM PLS yang disusun dengan bantuan software Smart PLS 4.0. Simpulan penelitian ini menegaskan bahwasanya variabel baik brand image maupun kualitas pelayanan berpengaruh positif dan substansial pada loyalitas pelanggan.
Management of the Tumpasan Bara Spring Water Source for the Clean Water Needs of Lelemer Village: Pengelolaan Sumber Mata Air Tumpasan Bara untuk Kebutuhan Air Bersih Perkampungan Lelemer Ruslin, Ruslin; Riswan Hadi Saputra; Chairul Aly Ramli; Sumiati, Sumiati; Lidia Puspita Sari Sagala; Ahmad Faqihi; Munajap, Munajap; Antori, Antori; M. Gunawan Supiarmo
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 3 (2024): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v8i3.19105

Abstract

Abstract Water is the most important thing that must be available to support human life. For generations, people with habits and cultures have used water sources in their territory to meet their daily needs. However, Lelemer Village experiences a shortage of clean water supply such as drinking, bathing, etc. This problem happened because one of the springs could not maximize distribution to the community. Tumpasan Bara is water runoff from cliff rocks with unstable soil quality, so it is vulnerable to landslides that can pollute and even close water distribution pipes because the spring management infrastructure has not met the standards. Therefore, the purpose of this project is to improve upstream infrastructure so that resources can be spread and support the welfare of the Lelemer village community. Typically done by making strides in the upstream foundation so that clean water can be distributed ideally. Therefore, the benefits of this project expect to anticipate backing the welfare of the Lelemer town community. Abstrak Air merupakan kebutuhan paling utama yang harus tersedia untuk menunjang kehidupan manusia. Secara turun temurun masyarakat melalui kebiasaan, dan budaya memanfaatkan sumber air di wilayahnya untuk memenuhi kebutuhan sehari-hari. Akan tetapi pada perkampungan Lelemer justru mengalami kekurangan debit air baik itu untuk keperluan minum, mandi dan lain-lain. Hal ini disebabkan salah satu sumber mata air, yaitu mata air Tumpasan Bara tidak dapat mereka maksimalkan untuk memenuhi kebutuhan. Tumpasan Bara merupakan limpasan air dari bebatuan tebing dengan kualitas tanah yang labil, sehingga rentan akan longsoran tanah yang dapat mencemari bahkan menutup pipa penyalur air dikarenakan infrastruktur pengelolaan mata air tersebut belum mememenuhi standar. Maka tujuan pengabdian masyarakat ini dilakukan adalah untuk melakukan perbaikan infrastrukur hulu agar air bersih dapat tersalurkan dan mendukung kesejahteraan masyarakat perkampungan Lelemer. Hal ini dilakukan dengan memperbaiki infrastrukur hulu agar air bersih dapat tersalurkan dengan optimal. Sehingga hasil kegiatan pengabdian ini diharapkan dapat mendukung kesejahteraan masyarakat perkampungan Lelemer.
Co-Authors Abda Abda Ahmad Faqihi Ahmad Faqihi, Ahmad Aiyi Asnawi Amran, Mulyaty Annisa, Finantha Antori, Antori Anwar, Irvan Apriani, Rini Arba, Muh. Arba, Muhammad Ari Sartinah, Ari Armadani, Fery Indradewi Aspadiah, Vica Ayu Wandira Bafadal, Mentarry Basrin, Wa Ode Fitrawati Chairul Aly Ramli Darmin, Wa Ode Yentri Putia Ningtiyas Dedu, La Ode Arfan Eka, Bau Mirna Ayu Fadhliyah Malik Fahyuddin Fahyuddin, Fahyuddin Fitri Handayani Fristiohady, Adryan Galih Rio Prayogi Hayati, Siti Hermansyah Hermansyah Irnawati Irnawati Isnawati, Nur Jabbar, Asriullah Jahidin Jahidin Jaya, Muhammad Imin Kasmawati, Henny Kuncoro, Shienny La Aba La Harimu La Ode Aman Langit Wahyu Gutama, Detha Sekar Lidia Puspita Sari Sagala M. Gunawan Supiarmo Ma'ruf Ma'ruf Makrawati, Makrawati Malina, Rachma Mariani Mariani Mawarni Mawarni Mega Fatimah Rosana Mirawanti G, Wa Ode Mistriyani, Mistriyani Mubarak Mubarak Muh Nurtanzis Sutoyo Muhammad Afif Muhammad Ilyas Muhammad Jefriyanto B Muliatin, Muliatin Mulyana, Wa Ode Munajap, Munajap Munasari, Dian Mustikawati, Wa Ode Ifan Nasrudin Nur Illiyyin Akib nuralifa, nuralifa Nurjanah, Mega Nurlansi, Nurlansi Nurramadhani A. Sida Omir, Sri Wahyuli Astian Pasaeno, Nur Afrianingsih Pascayantri, Asniar Permani, Putu Sintya Primajati, Gilang Putri, Anastasyah Putri, Natalia Christiani Rahman, Abraham Ramadhani, Nursavhira Ramli, Chairul Aly Rayani, Nur Ridwan, Harnina Riswan Hadi Saputra Ruben, Sony Sabarudin Sabarudin Sahidin . Sahumena, Muhamad Handoyo Sakti, La Ode Awal Sapuan, Hamdani Sarimu, La Sarmadan Sarmadan Sihani, Nur Aviarahma Sitti Aisyah Sumiati Sumiati Sunandar Ihsan, Sunandar Supiarmo, M Gunawan Supiarmo, M. Gunawan Suria, Yuyun Suryani Suryani Syahbuddin Syahbuddin wahyuni wahyuni Wally, Sumi Wardana, Gede Yogi Prana Wu, Chun Yamin, Yamin Zaid, Sudirman