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All Journal International Journal of Public Health Science (IJPHS) JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Althea Medical Journal Jurnal Keolahragaan Journal of Biomedicine and Translational Research Jurnal Penelitian Pendidikan IPA (JPPIPA) IJEMS (Indonesian Journal of Environmental Management and Sustainability) JOURNAL SPORT AREA Journal of Dedicators Community PREPOTIF : Jurnal Kesehatan Masyarakat Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Eduvest - Journal of Universal Studies Jurnal Keperawatan Indonesian Journal of Biomedicine and Clinical Sciences
Muniroh, Muflihatul
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

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Exploring the effects of ursodeoxycholic acid-probiotic combination on Lactobacillus and liver enzyme levels for cholestasis management: An experimental study Nur, Muhammad Hasbi; Lestari, Endang Sri; Budiono, Bernadus Parish; Prasetyo, Sigit Adi; Muniroh, Muflihatul
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art10

Abstract

Background: Cholestasis arises from compromised bile secretion due to hepatocyte dysfunction, leading to liver impairment. Available treatments show limited efficacy, with ursodeoxycholic acid (UDCA) being a primary option. Cholestatic conditions influence gut microbiota; therefore, probiotic therapy emerges as a potential approach. Objective: This investigation aimed to evaluate the impact of combined administration of probiotics and UDCA on Lactobacillus levels, as well as the levels of the enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in rats with restricted common bile ducts .Methods: A total of 35 male Sprague Dawley rats were randomly assigned to 7 groups, each comprising 5 members: K1 (healthy control), K2 (negative control with cholestasis), K3 (positive control with cholestasis given UDCA), K4 (cholestasis given 36 mg probiotics), K5 (cholestasis given 18 mg probiotics and UDCA), K6 (cholestasis given 36 mg probiotics and UDCA), and K7 (cholestasis given 54 mg probiotics and UDCA). The treatment duration was 21 days, during which blood samples were collected for AST and ALT analysis. Lactobacillus count was determined by quantitative polymerase chain reaction (PCR) analysis of fecal samples.Results: When UDCA and probiotics were given together in three different dosages, the Lactobacillus count significantly increased (p<0.05) compared to the other groups. Furthermore, compared to the other treatment groups, the UDCA-probiotic combination group exhibited noticeably lower AST and ALT values.Conclusion: Combining UDCA and probiotics elevated Lactobacillus count and decreased AST and ALT levels in cases of cholestasis more effectively than single therapy.
Exploring the remarkable effect of ursodeoxycholic acid and Allium sativum combination on MMP-9 and TIMP-1 levels in cholestatic rat’s model Sekartaji, Anindhita Dyah; Prasetyo, Sigit Adi; Muniroh, Muflihatul
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art5

Abstract

Background: Cholestasis is a disturbance in the production or flow of bile that causes excessive accumulation of bile fluid and damage in the liver. Chronic liver damage will lead to liver fibrosis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloprotease-1 (TIMP-1) play a critical role in liver fibrosis formation. Although ursodeoxycholic acid (UDCA) and Allium sativum extracts have long been renowned for improving liver function, their combination in alleviating liver fibrosis through the MMP-9 and TIMP-1 inhibitory pathways has yet to be studied.Objective: This study was conducted to assess the efficacy of UDCA and Allium sativum extract combination in altering MMP-9 and TIMP-1 levels, which are the main factors in the progression of liver fibrosis.Methods: We performed an experimental study with a post-test-only control group on 36 Sprague-Dawley rats, which were randomly grouped into healthy, negative, positive, and three treatment groups with UDCA (13.5 mg) and graded doses of Allium sativum extract (3.6 mg; 7.2 mg; and 14.4 mg). Cholestasis induction was done by a choledochal duct ligation, and treatment was given for 14 days. Levels of MMP-9 and TIMP-1 were analyzed after treatment.Results: Combining UDCA and Allium sativum improved the MMP-9 levels significantly in cholestatic rats, compared to administrating UDCA only (p <0.05). Combining UDCA and Allium sativum increased the TIMP-1 level (p < 0.05). Although the MMP-9 level results were under our existing hypothesis, TIMP-1 results showed surprising results. Matrix metalloproteinase-9 levels were strongly negatively correlated with TIMP-1 levels, with a r-value= 0.981.Conclusion: Combining Allium sativum and UDCA alleviates liver fibrosis progression through lowering levels of MMP-9 and increasing levels of TIMP-1.
Co-Authors - Anggorowati Adriyan Pramono Afriana, Rizky Dyas Ahmad Syauqy Ani Margawati Anjani, Gemala Annastasia Ediati Annisa Pratiwi, Annisa Apoina Kartini Ardyarini, Hikmatunnisa Tri Ariani, Mahayu D. Ariosta Ariosta Awal Prasetyo Besari Adi Pramono Bintang, Francisca Natalia Budiono, Bernadus Parish Diana Nur Afifah, Diana Nur Djuara P Lubis Elsa Naviati Endang Sri Lestari Etika Ratna Noer Fitry, Febriana Ramadhani Hadiprajitno, Peter I. Halleyantoro, Ryan Hardhono Susanto Hermawan Istiadi Julian Dewantiningrum Juniarto, Achmad Z. Karlowee, Vega Kesuma, Erlangga Hadi Kesumayadi, Irfan Kis Djamiatun Mambaya, Helvi Desi Mohammad Sulchan Muhammad Nur Muhammad Sulchan Nani Maharani Natalia Dewi Wardani Nugraha, Eka Djatnika Nur, Muhammad Hasbi Nyoman Suci Widyastiti Partiwi, Rina Perdanawati, Mia Qolby, Qonita Nur Renni Yuniati Retnoningrum, Dwi Sadana, Aqsa Aufa Syauqi Sekartaji, Anindhita Dyah Septiani, Bernadeta Novita Sigit Adi Prasetyo, Sigit Adi Sri Achadi Nugraheni Untung Sujianto Utami, Arini Veni, Rizka Widyastuti, Trioni Yetty Movieta Nency, Yetty Movieta Yora Nindita Yosef Purwoko Zetta, Adelia Paradya