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Journal : Ovozoa: Journal of Animal Reproduction

Synergistic protective effects of α-tocopherol and zinc sulfate on superoxide dismutase activity and p53 expression in ovarian granulosa cells of lead-exposed female Wistar rats (Rattus norvegicus) iqbal dwi warsito; Suherni Susilowati; Erma Safitri; Ragil Angga Prastiya; Maya Nurwartanti Yunita; Amung Logam Saputro
Ovozoa: Journal of Animal Reproduction Vol. 14 No. 1 (2025): Ovozoa: Journal of Animal Reproduction
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ovz.v14i1.2025.16-24

Abstract

This study aimed to evaluate the protective effects of α-tocopherol and zinc sulfate on oxidative stress parameters in ovarian granulosa cells of female Wistar rats (Rattus norvegicus) exposed to lead acetate (Pb(C₂H₃O₂)₂). A total of 25 rats were randomly divided into five groups: Control (C), lead exposure only (T0), α-tocopherol + lead (T1), zinc sulfate + lead (T2), and α-tocopherol + zinc sulfate + lead (T3). Treatments were administered orally for 21 days. Superoxide dismutase (SOD) levels were measured spectrophotometrically, and p53 expression was analyzed using immunohistochemistry. The results showed that SOD levels significantly decreased in group T0 compared to the control (p <0.05), while treatment with either α-tocopherol (T1), zinc sulfate (T2), or their combination (T3) significantly improved SOD levels compared to T0. Moreover, p53 expression was markedly elevated in T0, indicating enhanced oxidative stress and potential apoptosis, whereas all antioxidant-treated groups showed reduced p53 expression, with T3 demonstrating values comparable to the control group. In conclusion, the combination of α-tocopherol and zinc sulfate provided a synergistic antioxidant effect, effectively enhancing SOD levels and suppressing p53 expression in granulosa cells of lead-exposed rats. This suggested a promising therapeutic potential of these compounds in mitigating lead-induced ovarian toxicity.
Co-Authors Abdul Samik Ade Miftakhul Aziz Agustono, Bodhi Al arif, Mohammad Anam Amaliya, Anny Amung Logam Saputro Ani Wijayanti Ashari, Lukman Ashilla Afandik, Nadya Atikah Madarina Hisyam, Mirza Boedi Setiawan Burhanudin Chozin, Aminullah Alhady Diana Santi Dinul, Ahmad Rajul Erma Safitri ERMA SAFITRI Estoepangestie, Agnes Theresia Soelih Faisal Fikri Firdausyi, Aulia Amatul Haditanojo, Wiyanto Hanafi, Ulfiani Fauzia Hani Plumeriastuti Hanifah, Novi Fitria Hanun Putri Nuraida Hermin Ratnani Hidanah, Sri Hidayatuh Sholihah, Alfi Imam Mustofa IMAM MUSTOFA Imas Hapsari Rahmaningtyas iqbal dwi warsito Iskandari, Novia Nur Iwan Sahrial Hamid Khafsah, Khafsah Kuncorojakti, Suryo Lailiyah, Fahlevi Lestari, Dewi Sri Ma'ruf, Mohammad Arief Mafruchati, Maslichah Milladiya Khuriyah Zahra, Reyza Mirni Lamid Muhammad Gufron Muhammad Thohawi Elziyad Purnama Mumtazi, Fauzan Nurina Naqsmagita, Salsabilla Nusdianto Triakoso Praja, Ratih Novita Prastika, Zeni Prayogo, Danu Pudji Srianto Putri Nurmalia Damayanti Putri, Lusi Rosita Sartono Ratna Damayanti Restiadi, Tjuk Imam Safitri, Ainun Merta Salsabila Putri, Elma Saputro, Amung Logam Sari, Sera Yunita Setyawan, Firman Soeharsono Soeharsono Solikhah, Tridiganita Intan Sri Pantja Madyawati, Sri Pantja Suherni Susilowati Suherni Susilowati Sulistyowati, Deny Sunaryo Hadi Warsito Tatik Hernawati Tito, Muhammad Tri Lestari Tri Wahyu Suprayogi Trilas Sardjito Ulinuha, Meidina Zulva Umama, Ayu Riza Warsito, Sunaryo Hadi Warsito, Sunaryo Hadi Weliyani, Trima Wibawati, Prima Ayu Widayani, Prasita Widya Paramita Lokapirnasari Widya Paramita Lokapirnasari Yeni Dhamayanti Yudhana, Aditya Yunita, Maya Nurwartanti