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Effect of Intermittent Fasting on Decreased Interleukin-6 Genes mRNA Expression in Mice (Mus Musculus) Herman, Sriyana; Muhammad Basir; Mochammad Hatta; Suryani As’ad; Ilhamjaya Patellongi; Ahmad Hadi Modi
Indonesian Andrology and Biomedical Journal Vol. 5 No. 2 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iabj.v5i2.65697

Abstract

Nowadays, the development of various degenerative diseases is very rapid. The rapid development of the disease has encouraged the wider community to understand the impact. Intermittent fasting can help prevent the emergence of cancer (one of the degenerative diseases) because during fasting the body's cells are in protective mode so as to protect the body from disease. Intermittent fasting reduces the body's inflammatory status by inhibiting the expression of proinflammatory cytokines, especially interleukin-6 (IL-6). This study aims to examine the effect of intermittent fasting on IL-6 gene mRNA expression. This study is an experiment with Pretest-Posttest with Control Group design to examine the effect of intermittent fasting on the of IL-6 genes mRNA expression. The subjects of this study were 10 mice divided into 2 groups: the intermittent fasting group and the control group. The research was carried out at the Laboratory of Molecular Biology and Immunology Department, Faculty of Medicine, Universitas Hasanuddin, Makassar, as a place for the maintenance and care of experimental animals as well as examination of IL-6 genes mRNA expression. The study was conducted for 30 days. The results showed a decrease in the average value of IL-6 mRNA expression of subjects before and after intermittent fasting with the value of ρ = 0.003 (ρ <0.05) showed that there is a significant effect between intermittent fasting on the decrease in IL-6 genes mRNA expression. In conclusion, there is a decline in the IL-6 genes mRNA expression after intermittent fasting.
Hubungan Dismenorea dengan Gangguan Aktivitas Belajar Mahasiswa S1 Keperawatan Universitas Megarezky Mongkapu, Graceya; Fitrianingsih, Julia; Herman, Sriyana; Gaffar, Herry Darsim; Mustamin, Mustamin; Rusli, Rusli
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 16 No 1 (2024): MARET
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36089/job.v16i1.2366

Abstract

Pendahuluan: Karakteristik sosiodemografi ibu berperan penting dalam mengidentifikasi risiko persalinan prematur sehingga intervensi dini dapat dilakukan untuk mencegahnya. Dismenorea juga dapat memengaruhi aktivitas sehari-hari, termasuk aktivitas belajar. Tujuan: Penelitian ini bertujuan mengetahui hubungan antara dismenorea dengan aktivitas belajar mahasiswi S1 Keperawatan Universitas Megarezky. Metode: Penelitian ini menggunakan metode kuantitatif dengan desain cross-sectional. Populasi penelitian adalah seluruh mahasiswi S1 Keperawatan angkatan 2016-2018 sebanyak 222 orang. Sampel diambil menggunakan purposive sampling dengan kuesioner sebagai instrumen untuk mengukur hubungan dismenorea dengan aktivitas belajar. Hasil: Dari 143 mahasiswi yang menjadi responden, 43 orang (30,1%) mengalami nyeri ringan, 63 orang (44,1%) nyeri sedang, dan 37 orang (25,9%) nyeri berat. Sebanyak 107 mahasiswi (74,8%) melaporkan aktivitas belajar terganggu akibat dismenorea, sementara 36 mahasiswi (25,2%) tidak terganggu. Uji chi-square menunjukkan nilai p < 0,05 (p=0,004), yang menunjukkan adanya hubungan signifikan antara dismenorea dan aktivitas belajar. Kesimpulan: Terdapat hubungan yang signifikan antara dismenorea dan aktivitas belajar mahasiswi S1 Keperawatan Universitas Megarezky Makassar, dengan hasil uji chi-square yang menunjukkan p < 0,05.
INTERVENSI PERILAKU CARING KELUARGA TERHADAP PERUBAHAN DEPRESI DAN TINGKAT KEMANDIRIAN PASIEN POST STROKE ISKEMIK DI WILAYAH KABUPATEN MOJOKERTO Sulystiono, Dony; Widarti, Luluk; Masyfahani, Muhammad Afif Hilmi; Maemonah, Siti; Herman, Sriyana; Rusli, Rusli
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 16 No 4 (2024): DESEMBER
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36089/job.v16i4.2480

Abstract

Stroke sering menyebabkan kecacatan jangka panjang yang mempengaruhi kualitas hidup pasien, termasuk munculnya depresi dan berkurangnya kemampuan untuk melakukan Aktivitas Kehidupan Sehari-hari (ADL). Depresi pada pasien stroke dapat memperburuk kondisi fisik dan emosional mereka. Penelitian ini bertujuan untuk mengevaluasi pengaruh intervensi medis dan perilaku peduli keluarga terhadap depresi dan ADL pasien pasca-stroke. Desain penelitian ini adalah kuasi-eksperimental dengan pendekatan Nonrandomized Pretest-Posttest Control Group. Sebanyak 30 pasien pasca-stroke dari Kabupaten Mojokerto dibagi menjadi dua kelompok: kelompok perlakuan (15 pasien) yang menerima intervensi medis dan dukungan keluarga, dan kelompok kontrol (15 pasien) yang hanya menerima perawatan medis konvensional selama dua bulan. Hasil penelitian menunjukkan bahwa kelompok perlakuan mengalami penurunan depresi yang signifikan (p = 0,000) dan peningkatan ADL yang signifikan (p = 0,000). Sebaliknya, kelompok kontrol tidak menunjukkan perubahan signifikan pada depresi (p = 0,508) dan ADL (p = 0,091). Kombinasi antara intervensi medis dan perilaku peduli keluarga dapat efektif dalam mengurangi depresi dan meningkatkan ADL pada pasien pasca-stroke di Kabupaten Mojokerto. Temuan ini menunjukkan bahwa dukungan keluarga dan perawatan yang melibatkan keterlibatan keluarga dapat menjadi komponen penting dalam rehabilitasi stroke, selain perawatan medis.
Pengaruh Edukasi Video Terhadap Pengetahuan Dan Sikap Remaja Tentang Pernikahan Usia Dini Di SMP Islam Pagimana, Kabupaten Banggai Tahun 2024 Rismawati, Rismawati; Yulis, Dian Meiliani; Yuliana, Besse; Herman, Sriyana; Rusli, Rusli
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 16 No 4 (2024): DESEMBER
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36089/job.v16i4.2487

Abstract

This study aims to analyze the effect of video-based education about early marriage on the knowledge and attitudes of students at SMP Islam Pagimana, Banggai Regency, Central Sulawesi. The design of this study is a pre-experimental study with a one-group Pretest-Posttest design. In this study, the researcher provided a group intervention that was initially measured through a test (Pretest), then after the intervention was given the group would be measured again using a Posttest. This research was conducted at SMP Islam Pagimana, Banggai Regency, Central Sulawesi in December 2024. The population in this study were all students of SMP Islam Pagimana, Banggai Regency in the 2023/2024 academic year with a total of 248 people. The sample used in this study was 71, but to anticipate dropouts, 10% was added to a total of 78 people. The respondents used in this study were classes VII, VIII, and X. Samples from each class were taken using the spin or random method because the number of students in each class was different. Data collection from the research results used a questionnaire. Data analysis used was univariate and bivariate analysis. The results of the study showed that there was an increase in knowledge before and after counseling by 21.7%. There was an increase in attitudes before and after counseling by 56.4%. It is known that there is a significant difference in the average increase in knowledge about early marriage before and after being given educational videos.
Analisis Pengaruh Dukungan Keluarga Terhadap Edukasi Kesehatan Di Posyandu Lansia Wilayah Kerja UPTD Puskesmas Nambo Kabupaten Banggai Sulawesi Tengah Dj Sanudin, Rindy Antika; Rahayu, Mesra; Herman, Sriyana; Yulis, Dian Meiliani; Rusli, Rusli
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 16 No 4 (2024): DESEMBER
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36089/job.v16i4.2488

Abstract

Integrated Health Service for Elderly (called Elderly Posyandu) is a form of activity to handle the health of the elderly population. Elderly Posyandu offers activities in the form of health education to the elderly. The active role of the elderly's family is a supporting factor to make the elderly interested in participating in health education activities at the Posyandu. This study aims to analyze the influence of family support factors on the activeness of the elderly in participating in health education at the Elderly Posyandu in the working area of UPTD Puskesmas Nambo, Banggai Regency, Central Sulawesi. The type of research used is observational analytic with a cross-sectional research design. Data collection using a questionnaire. The sample in this study was 95 elderly people in the Working Area of UPTD Puskesmas Nambo, Banggai Regency, Central Sulawesi. Data analysis using the chi-square test. The results of this study indicate that there is an influence of emotional support (p = 0.000), appreciation support (p = 0.000), informational support (p = 0.000) and instrumental support (p = 0.000) on the activeness of the elderly in participating in health education at the UPTD Nambo Health Center, Banggai Regency, Central Sulawesi. Most respondents have high family support and are active in participating in health education at the Elderly Posyandu. The results of this study are expected to be a reference for health workers and families to provide support to the elderly, especially to participate in health education at the Posyandu.
Efek Media Slide dan Media Sosial terhadap Pengetahuan HIV/AIDS dan VCT (Voluntary Counseling and Testing) pada Pekerja PT. X di Kabupaten Tabalong Astuti, Henni Widia; Rezeki Sudarmin, Ria; Hairuddin, Hairuddin; Meiliani Yulis, Dian; Herman, Sriyana
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 16 No 4 (2024): DESEMBER
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36089/job.v16i4.2490

Abstract

This study aims to analyze the effectiveness of health promotion media, namely slide media and social media (animated videos), in improving workers' knowledge and interest in HIV/AIDS and Voluntary Counseling and Testing (VCT) at PT. X, Tabalong Regency, South Kalimantan. The study utilized a quasi-experimental design with a two-group pre-posttest method, involving 360 respondents. Group A received counseling using slide media, while Group B was educated through animated videos shared via WhatsApp. The results showed a significant increase in knowledge in both groups, with the slide media group demonstrating higher effectiveness compared to the social media group (p < 0.001). However, interest in VCT did not show a significant relationship with increased knowledge in either group (p > 0.05). Slide media proved to be more effective than social media in enhancing workers' knowledge of HIV/AIDS. These findings highlight the importance of using appropriate health promotion media to educate workers about health issues.
Pengaruh Penyuluhan Tentang Kehamilan Tidak Diinginkan (KTD) dan Bahaya Aborsi pada Remaja SMA GKST 2 Tentena Herman, Sriyana; Mongkapu, Graceya Alisirargi; Ridwan, Eka Sari; Rusli
Proceedings Series on Health & Medical Sciences Vol. 7 (2025): Proceedings of the 1st National Seminar on Global Health and Social Issue (LAGHOSI)
Publisher : UM Purwokerto Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pshms.v7i.1437

Abstract

Latar Belakang: Kehamilan tidak diinginkan (KTD) dan bahaya aborsi merupakan hal yang kompleks dengan berbagai dampak negatif bagi individu, keluarga, dan masyarakat serta kesehatannya. Kehamilan yang tidak diinginkan pada remaja merupakan salah satu dampak dari perilaku seks bebas, sehingga diperlukan pendekatan yang komprehensif dan terpadu. Pencegahannya dapat dilakukan melalui berbagai upaya, antara lain pendidikan seks yang komprehensif, kemudahan akses terhadap layanan kesehatan reproduksi, promosi penggunaan kontrasepsi yang efektif, serta dukungan sosial dan spiritualitas pada generasi muda. Tujuan: Penelitian ini bertujuan untuk mengetahui pengetahuan remaja terhadap kehamilan tidak diinginkan dan bahaya aborsi. Metode: Menggunakan desain penelitian pre-experimental design dengan jenis one group pretest-posttest, dengan jumlah sampel 50 responden pada remaja di SMA GKST 2 Tentena Kabupate Poso Provinsi Sulawesi Tengah. Hasil: responden dijadikan sampel hasil uji hipotesis dengan menggunakan uji Wilcoxon didapatkan sebanyak 47 sampel mengalami peningkatan pengetahuan (positive Ranks) dan 3 sampel dengan tingkat pengetahuan sama (ties) pada pretest dan posttest sedangkan nilai p = 0,000 < a = 0,05, ini berarti H0 ditolak dan Ha diterima. Kesimpulan: Terdapat efektivitas yang signifikan dalam penyuluhan, yaitu mempengaruhi tingkat pengetahuan remaja tentang kehamilan yang tidak diinginkan dan bahaya aborsi. Dengan memberikan informasi yang akurat, dukungan emosional, dan mendorong tanggung jawab seksual, akan membantu remaja membuat keputusan yang lebih cerdas dan bertanggung jawab mengenai kesehatan reproduksinya.
Pre dan Post Pengetahuan Kanker Payudara dan Kanker Serviks pada Ibu yang Berkunjung di Posyandu Kamboja Desa Demangan Jaya Herman, Sriyana; Maharani, Citra; Amri, Fahrial Al; Syarif; Rusli
Proceedings Series on Health & Medical Sciences Vol. 7 (2025): Proceedings of the 1st National Seminar on Global Health and Social Issue (LAGHOSI)
Publisher : UM Purwokerto Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pshms.v7i.1451

Abstract

Latar belakang: Kanker payudara (carcinoma mammae) merupakan tumor ganas yang tumbuh di dalam jaringan payudara dan tumbuh di dalam kelenjar susu, jaringan lemak, maupun jaringan ikat pada payudara, dimana prevalensinya terus menjadi peningkatan terutama di negara sedang berkembang yang sering berakibat fatal karena keterlambatan diagnosis. Tujuan: Untuk meningkatkan pengetahuan tentang kanker payudara dan kanker serviks secara dini sebelum dan sesudah diberikan penyuluhan pada semua ibu yang berkunjung di Posyandu Kamboja Desa Demangan Jaya Kabupaten Banggai Provinsi Sulawesi Tengah. Metode: Jenis penelitian ini adalah cross sectional study dengan menggunakan pendekatan pre post design study. Responden penelitian ini adalah para remaja, ibu hamil dan lansia yang hadir dalam wilayah kerja Puskesmas Bunta, dengan waktu pelaksanaan tanggal 20 Mei 2024 berjumlah 32 responden. Hasil: Bahwa responden terbanyak terdapat pada pengetahuan cukup yaitu sebanyak 15 responden (46,9%), pada pengetahuan tinggi sebanyak 9 responden (28,1%), dan pada pengetahuan rendah adalah sebanyak 8 responden (25,%). Kesimpulan: Pelaksanaan edukasi berbasis booklet tentang kangker payudara dan kangker serviks dapat meningkatkan pemahaman dan pengetahuan para remaja, ibu hamil, dan lansia yang berada di wilayah puskesmas bontan.
Differences of Maternal Sociodemographic Characteristics with Term and Preterm Birth Among 17 Hospitals In South Sulawesi Herman, Sriyana; Syamsuriati; Handayani, Rika; Fitrianingsih, Julia; Alanti; Andriani; Marzila, Mariani; Lestari, Eka; Rusli
Public Health of Indonesia Vol. 11 No. 1 (2025): January - March
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11i1.917

Abstract

Background:Maternal sociodemographic characteristics play a crucial role in identifying preterm labor, enabling early intervention to prevent its occurrence and recurrence. Understanding these characteristics can support the development of preventive strategies and improve maternal and neonatal health outcomes. Objective:This study aims to determine whether there are significant differences in the sociodemographic characteristics of mothers experiencing term and preterm labor across hospitals in Makassar City. Method:This study employed an observational analytical design involving 257 mothers who had undergone term and preterm labor in 17 hospitals. Data were collected using the Health Card for Preterm Pregnant Women (KASIHKU) instrument and analyzed through an independent samples t-test to compare means between the two groups. Results:Significant differences were observed in the sociodemographic characteristics between term and preterm labor groups across 11 variables, with five variables showing a p-value < 0.05: Body Mass Index (BMI) (CI95%: 0.44–0.66, p < 0.000), history of preterm labor (CI95%: 0.08–0.23, p < 0.000), presence of flour albus (CI95%: 0.32–0.54, p < 0.000), HIV/AIDS status (CI95%: 0.07–0.00, p < 0.039), and Edinburgh Postnatal Depression Scale (EPDS) score (CI95%: 0.02–0.18, p < 0.009). Conclusion:Maternal sociodemographic characteristics, specifically BMI, history of preterm labor, presence of flour albus, HIV/AIDS status, and EPDS score, show significant differences between term and preterm labor groups. These findings provide a foundation for future research and the development of targeted interventions to prevent preterm labor based on maternal sociodemographic factors.  Keywords:Preterm labor; Sociodemographic characteristics; Hospital
Analysis of factors related to the incidence of hypertension in the elderly Mbali, Menis; Herman, Sriyana; Rahman, Abdul
Jurnal Ilmiah Kesehatan Sandi Husada Vol 13 No 2 (2024): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v13i2.1213

Abstract

Introduction: Hypertension or high blood pressure is one of the main health problems in the elderly population in various parts of the world. The elderly are more susceptible to hypertension due to the ageing process that affects the elasticity of blood vessels, as well as increased peripheral resistance. In addition, various risk factors, such as an unhealthy lifestyle, poor diet, and certain medical conditions, can worsen the condition of hypertension in the elderly. Objective: This study aims to analyze factors related to the incidence of hypertension in the elderly. Methods: This research uses a cross-sectional design, an analytical study that studies the causes of incidents or incidents. Data collection uses a questionnaire. The sample in this study was 64 elderly hypertensive patients in the working—data analysis using the chi-square test. Result: The results of this study indicate that there is a relationship between physical activity (p=0.000), obesity (p=0.000), diet (p= 0.029), smoking habits (p=0.000) and work (p=0.020) with the incidence of hypertension in the elderly in working. Conclusion: The incidence of hypertension in the elderly with the variables studied shows that there is a relationship, and the most related variable is obesity. So, it is hoped that the elderly, especially those who are obese, should be given intervention to maintain their diet so that complications do not occur and can reduce the risk of hypertension.