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All Journal Jurnal Ilmu Keperawatan Manuju : Malahayati Nursing Journal MONSU'ANI TANO Jurnal Pengabdian Masyarakat Jurnal Keperawatan Priority Jurnal Kesmas Prima Indonesia Jurnal Prima Medika Sains Jurnal Ners Indian Journal of Forensic Medicine & Toxicology Caring : Indonesian Journal of Nursing Science JURNAL MITRA PRIMA JINTAN : Jurnal Ilmu Keperawatan International Archives of Medical Sciences and Public Health Hospital Majapahit : Jurnal Ilmiah Kesehatan Politeknik Kesehatan Mojokerto Nurse and Holistic Care JUMANTIK (Scientific Journal of Health research) Jurnal Kesehatan Kusuma Husada Jurnal Ilmu Psikologi dan Kesehatan Health Research Journal of Indonesia Jurnal Keperawatan Holistik Jurnal Kesehatan Strada Jurnal Ilmiah Kesehatan (SJIK) JURNAL KEPERAWATAN Jurnal Penelitian Perawat Profesional
Elis Anggeria
Universitas Prima Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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TOPICAL MORINGA OLEIFERA GEL AND FIBROBLAST/COLLAGEN CHANGES IN A DIABETIC RAT BURN-WOUND MODEL: A PILOT IN VIVO-IN SILICO STUDY TARGETING TGF-BETAR1 Anggeria, Elis; Yunus, Muhammad; Damanik, Derma Wani
International Archives of Medical Sciences and Public Health Vol. 7 No. 1 (2026): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v7i1.1570

Abstract

Diabetic wounds remain a major clinical challenge, as persistent hyperglycemia disrupts fibroblast function and matrix remodeling, delaying healing. Transforming Growth Factor-beta 1 (TGF-beta1) is a key regulator of fibroblast proliferation and collagen synthesis during repair. This pilot study explored Moringa oleifera gel's wound-healing effects using an integrated in vivo in silico approach, generating hypotheses about its mechanism via the TGF-beta1 pathway. Twenty-five streptozotocin-induced diabetic Wistar rats with partial-thickness (Grade II) burn wounds were randomized to 0.5% Na-CMC (negative control), Bioplacenton (positive control), or M. oleifera gel (5%, 10%, or 15%) once daily for 14 days. Because histomorphometric analysis used only two animals per group (n = 2/group), fibroblast and collagen outcomes are reported descriptively as preliminary, pilot-stage observations. The 15% gel group showed descriptively higher mean fibroblast counts than the negative control (110.0 pm 9.9 vs. 54.5 pm 4.9 cells/3 HPF) and higher collagen coverage (score 3, about 80%) than untreated wounds (score 2, about 20%). Molecular docking showed quercetin, a major M. oleifera constituent, has favorable predicted affinity (-9.6 kcal/mol) toward TGF-betaR1's ATP-binding pocket; this is hypothesis-generating only. These preliminary findings suggest topical M. oleifera gel may warrant further investigation as a candidate adjunctive therapy for diabetic wound management.
Co-Authors Adrianis Telaumbanua, Rina Afeus Halawa Agnes Gulo Agnes Gulo Agus Rahmat Yanto Buaya Agustina Sihombing Ajeng Fatikasari Alfando Tuju Allowda Helena Roselyn Zebua Almina Rospitaria Tarigan Almina Rospitaria Tarigan Angelina, Clarita Anggi Sita Br Manullang Ardin Ndruru Aulia Razi Maulana Berutu, Suryani Betty Maria Manalu Br Ginting, Liani Brahmana, Elkana Pramujaya Brigity Sephanie Cindy Faulina Silaban Daeli, Vesty Aprilian Damanik, Derma Wani Debi Novita Siregar Debora, Trionyta Depari, Srika Julia Trikana Br S. Desi Ratna Sari Sihotang Desman Hosada Halawa Devi Ardila Devi Ernija, Fira Dewi Qurniawati Dhea Amalia Dwi Sinta Larasati Elen Madala Handayani Ndruru Elkana Pramujaya Brahmana Elsa Romaito Sianturi Elysabeth Christina Maranatha Samosir Eny Patonah Erman Syukur Laowa Ermi Girsang Ernita Simamora Eva Latifah Nurhayati Evalatifah Nurhayati Ezra Inawati Barus Fajaruddin Nasution Faridnasra Faridnasra Fatemaluo, Ferianus Ferdiansyah Sitopu, Robin Ferianus Fatemaluo Fika Erfin Rawati Gulo Fira Devi Ernija Fitri Kristianis Zalukhu Gerri Anastasya Simamora Ginting, Chrismis Novalinda Girsang, Ermi Gowasa, Honorius Gulo, Legisnaria Halawa , Lira Virna Halawa, Erniyanti Halawa, Wirna Wati Harpenta Halawa Harpenta Halawa, Mardan Darman Hasrat Ndruru Helena Sanofa Hendrik Berkat Nurmansari Zebua Heru Bambang Triono Hesti Pramudya Wardani Maha Hesti Wulansari Honorius Gowasa Hutabarat, Rini Elvira Hutagaol, Priscillia Margaretta Hutapea, Kimberley Maharani Maulibulung Hutomo, Rizky Aditya Imelda Putri Rahayu Iqbal Maidira Darmansyah Irfan Ramadhan Sagala Jamaluddin Jamaluddin Juniatulo Tafonao Karmila Br. Kaban Karolina Dhuka Kemala Sari Kimberley Maharani Maulibulung Hutapea Krisman Harapan Ziliwu Kristin Mei Sara Zebua Kristina L Silalahi Kristina L Silalahi Laily, Eka Isranil Laoly, Marnesry Rahmat Kristin Lase, Hestin Damaris Laura Adelina Br Sebayang Legisnaria Gulo Lenni Krisdayanti Nababan Leo Nardo Dicaprio Lase Lira Virna Halawa Lisca Elisabeth Sihombing Lombu, Meirini Citrahati Luce Yulpina Silaban Lumbantoruan, Marlina Manggalika, Widya Santi Manullang, Anggi Sita Br Mardan Darman Maria Maria Maria Maria Marnesry Rahmat Kristin Laoly Mawaddah, Putri Meiman Berkat Bawamenewi Mesy Gultom Mhd Luthfi Rifai Muhammad Yunus Muliani, Sulis Mutiara Sari Tarigan, Yolanda Netti Vera Simanjuntak Novita, Elsa Nurhabibi Berutu Otomosi Hulu Parida Hanum Patimah Sari Siregar Priscillia Margaretta Hutagaol Putri Mawaddah Putri Nidar Zega Rahmaini Fitri Harahap Rahmi, Intan Mutia Ramanisah Sahputri Sigalingging Rani Risa O. Siagian Resmi Pangaribuan Restueli Waruwu Rina Adrianis Telaumbanua Riswanto Ronatama Paulina Rostina Rostina Rostina Rotua Lenawati Tindaon Rut Karina Br Sembiring Saharman Gea Samosir, Andros Christopher Saruza, nn Sebayang , Laura Adelina Br Selina Br Giawa Septiana Maryani Enjelita Simangunsong Shayla Octaviana Salsabilla Sianturi, Elsa Romaito Sihombing, Agustina Sihombing, Lisca Elisabeth Sihotang, Desi Ratna Sari Silalahi, Kristina L Silitonga, Martha Sinar Kristina Telaumbanua Siska Br Sitepu Siska Ndruru Sitompul, Mutiara Rolika Putri Sofia A. Simanullang Subki Ramadhan Sunarti Sunarti Supriyadi Supriyadi Susanna Syukria Syukria Tarigan, Almina Rospitaria Tarigan, Putri Karina Theresia Marito Siregar Theresia Megawati. H.G. Putri Tiarnida Nababan Tindaon, Rotua Lenawati Triono, Heru Bambang Venty Putri Kristari Larosa Verawaty Fitrinelda Silaban Vesty Aprilian Daeli Wanda Bagus Pratama Waruwu, Restueli Winarti Yasman Suasono Buulolo Yitro Dakhi Yosni Yohana Sipayung Zega, Putri Nidar Zega, Selvi Sri Ica Purwasih