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Perbandingan Aktivitas Antibakteri Ekstrak Etanol Dan Aseton Limbah Kulit Bawang Putih (Allium Sativum L.) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus Aprila, Nur Amalia; Ulfa, Ade Maria; Susanti, Dwi
Jurnal Ilmiah Wahana Pendidikan Vol 10 No 1 (2024): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.10469632

Abstract

Skin infections are infections caused by pathogenic bacteria Staphylococcus aureus, such as acne, boils, scabies, versicolor, and wound infections. Treatment of skin infections can be done using natural ingredients, one of which is garlic skin waste (Allium sativum L.). This study aims to compare the antibacterial activity of ethanol and acetone extracts of garlic skin waste (Allium sativum L.) against Staphylococcus aureus. This study used maceration extraction method using 70% ethanol and 80% acetone solvents and antibacterial testing was carried out by disc diffusion method. The concentrations of 70% ethanol extract and 80% acetone of garlic skin waste used were 3%, 25%, 50% and 75%. The results showed 75% ethanol extract concentration with an average inhibition zone diameter of 2.96 mm, while 75% acetone extract with an average inhibition zone diameter of 1.7 mm with a weak category. The higher the concentration of ethanol and acetone extracts of garlic skin waste, the wider the inhibition zone. This study can be concluded that the antibacterial activity of ethanol extract with 75% concentration is better than the activity of acetone extract with the same concentration with p-value <0.05.
Rasionalitas Penggunaan Obat Antihipertensi di Puskesmas Pinang Jaya Kota Bandar Lampung Pratama, Rendiko Agung Candra; Ulfa, Ade Maria; Rudy, Muhammad
Jurnal Ilmiah Wahana Pendidikan Vol 10 No 5 (2024): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.10544723

Abstract

Hypertension is blood pressure above 140/90 mm Hg. Hypertension patients at Pinang Jaya Health Center, Bandar Lampung City, are included in the 10 largest diseases which occupy the second highest number suffered by patients. The hypertension treatment cycle is quite long so it must be diagnosed early and treated appropriately. The purpose of this study was to determine the rational use of antihypertensive drugs in hypertensive patients at Pinang Jaya Health Center, Bandar Lampung City based on the right indication, the right diagnosis, the right drug, the right patient, the right dose, the right method of administration and the right time interval for administration. The method used in this study is retrospective which is non-experimental (observational). Data were taken from patient medical records during January-December 2022 and the sample obtained was 104 patients, most of whom were female as many as 85 (81.73%) and patients aged 56-65 years as many as 29 (27.88%). The groups of drugs prescribed were amlodipin 98 (94.23%), captopril 2 (1.92%) and the use of combination therapy drugs, namely amlodipin with captopril 4 (3.85%). The rational use of antihypertensive drugs that meet the rational category of the right diagnosis, the right drug, the right indication, the right patient, the right dose, the right method of administration and the right time interval for administration is 100%. The use of antihypertensive drugs for outpatients at Pinang Jaya Health Center, Bandar Lampung City is rational.
Uji Aktivitas Kombinasi Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) Dan Kulit Jeruk Nipis (Citrus aurantifolia) Terhadap Penyembuhan Luka Sayat Saputri, Naila; Nofita, Nofita; Ulfa, Ade Maria
Jurnal Ilmiah Wahana Pendidikan Vol 10 No 9 (2024): Jurnal Ilmiah Wahana Pendidikan
Publisher : Peneliti.net

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.11180260

Abstract

Plants that are efficacious as wound healers from natural ingredients, namely binahong leaves and lime peel. This study aims to determine the effectiveness of the combination of binahong leaf extract (Anredera cordifolia (Ten.) Steenis) and lime peel (Citrus aurantifolia) on the healing of cuts in male rats (Rattus noervegicus). In the test animal, an incision was made on the back with a length of 2 cm and a wound depth of 0.2 cm using a scalpel (bisturi). The test animals were divided into six treatment groups: normal control without ointment, negative control given ointment base, positive control given povidone iodine ointment, formulation 1 given extract combination ointment (1:3), formulation 2 given extract combination ointment (1:1). , and formulation 3 was given an extract combination ointment (3:1). Ointment is given twice daily for 14 days. Observation of wound healing was carried out by measuring the decrease in the length of the incision in the test animals. The results showed that the combination ointment of binahong leaf extract and lime peel formulation 1 with concentration (1:3) and formulation 2 with concentration (1:1) experienced healing on the 8th day, formulation 3 with concentration (3:1) experienced recovery on day 9. Statistical results using the Mann Whitney HocPost for the F1, F2, and F3 treatment groups compared to the positive control did not have a significant difference because the value obtained was p> 0.05. It was concluded that the combination ointment of binahong leaf extract and lime peel has healing activity for cuts and can be used as a healer for cuts.
FORMULASI DAN UJI EFEKTIVITAS KELEMBABAN SEDIAAN KRIM M/A EKSTRAK KULIT MANGGIS (Garcinia mangostana L.) Clarista, Helaria Eren; Ulfa, Ade Maria; Nofita, Nofita
JURNAL PENELITIAN TERAPAN KESEHATAN Vol 11 No 2 (2024): JURNAL PENELITIAN TERAPAN KESEHATAN
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jptk.v11i2.877

Abstract

Skin can be said to be moist if it has a water content of 40%. One way to maintain the effectiveness of moisture in the skin is by using moisturizing cosmetics, such as cream. Mangosteen fruit (Garcinia mangostana L.) is a plant that has benefits, especially in its skin. There are compounds that have been proven to provide a moisturizing effect thereby protecting the skin from skin oxidation and free radicals. The purpose of making this cream is to moisturize the skin and utilize mangosteen peel extract. The advantage of cream with the O/W emulsion type is that it does not cause a sticky feeling, is easy to spread on the skin surface, is soft, and is easily washed off with water. Mangosteen peel extract was obtained using the maceration method with 96% ethanol. The cream preparation was made into 4 formulations K0, F1, F2, and F3 based on the amount of mangosteen extract used. Then a Physical Evaluation Test, Irritation Test, Likeability Test and Moisture Test were carried out. Each formulation was tested for moisture using an SK-8 skin analyzer. Evaluation of cream use was carried out by 12 volunteers for 5 days with use during the day. The overall results obtained were that the 3% mangosteen extract F1 formulation met the quality standards for physical cream preparations and had a high increase in water content in the volunteers' skin with a percent water content value of 50.16%. Meanwhile, in the analysis of the Wilcoxon test and Paired T-test data, a significance value of 0.00 (<0.05) was obtained which means that mangosteen peel extract cream can increase moisture in the skin, and variations in extract concentration have an influence on the effectiveness of the cream in moisturizing the skin.
SINTESIS KATALIS CaO DARI CANGKANG TELUR BEBEK UNTUK DEGRADASI TETRASIKLIN DAN ALLURA RED Feronica, Sagita; Ulfa, Ade Maria; Husein, Saddam
JFM (Jurnal Farmasi Malahayati) Vol 8, No 1 (2025)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v8i1.17593

Abstract

Proses fotokatalisis ini limbah tetrasiklin dan katalis CaO akan dicampurkan sehingga diharapkan dari proses fotokatalisis ini dapat mendegradasi limbah tetrasiklin dan membuat kontaminan berkurang atau hilang. Hasil yang diperoleh katalis CaO Cangkang telur bebek memiliki intensitas puncak yang cukup tajam yaitu 2θ= 32,23, 37,39, dan 53,93 serta memiliki serapan pada 3 daerah serapan yaitu 721 cmˉˡ, 875 cmˉˡ, dan 1420 cmˉˡ. Larutan simulasi limbah tetrasiklin dengan konsentrasi 50 ppm setelah dilakukan fotokatalisis berubah warna menjadilebih bening. Larutan simulasi limbah merah allura dengan konsentrasi 50 ppm setelah dilakukan fotokatalisis berubah warna menjadi lebih bening. Degradasi yang terjadi selama proses fotokatalisis menurun seiring dengan lamanya durasi penyinaran lampu UV. Kesimpulan penelitian ini adalah Sintesis katalis CaO dari cangkang telur ayam menghasilkan katalis CaO yang mampu berperan mempercepat reaksi dalam proses fotokatalisis terhadap degradasi limbahtetrasiklin dan limbah merah allura.
PENGARUH EDUKASI DAGUSIBU (DAPATKAN, GUNAKAN, SIMPAN DAN BUANG) SEDIAAN OBAT SIRUP ANAK TERHADAP TINGKAT PENGETAHUAN IBU DI LANGKAPURA BANDAR LAMPUNG Ulfa, Ade Maria; Sunowo, Joko; Muliyanti, Reni; Putri, Restika Ananda; Liani, Reza
Jurnal Pengabdian Farmasi Malahayati (JPFM) Vol 7, No 2 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jpfm.v7i2.18238

Abstract

ABSTRACTDagusibu is an educational program established by the Indonesian Pharmacists Association (IAI) related to obtaining, using, storing, and disposing of medicine correctly. The lack of knowledge regarding information on how to manage drugs from getting the medicine until it is no longer consumed and finally disposed of, so that the impact of misuse of syrup in the community can be prevented. This counseling activity was aimed to determine the increase in mother's knowledge about DAGUSIBU for children's syrup preparation before and after counseling in Langkapura Bandar Lampung. The method used was survey method in the form of discussion, interviews, and observation and statistical analysis using paired T test. The results showed an increase in knowledge of mothers who had babies / toddlers about DAGUSIBU children's syrup medicine correctly seen from the average value obtained before counseling amounted to 36.94% and after counseling, namely amounted to 91.11% so that an increase of an increase of 54.17%. Statistical data showed that there was a relationship between providing education with increased knowledge of mothers who have babies / toddlers where the p-value was 0.00 with a confidence level of 95%. Keywords: DAGUSIBU, education, medicine, counseling, syrup. ABSTRAKDagusibu adalah program edukasi yang dibentuk oleh Ikatan Apoteker Indonesia (IAI) terkait dapatkan, gunakan, simpan, dan buang obat dengan benar. Minimnya pengetahuan masyarakat mengenai informasi tentang tata cara pengelolaan obat dari mendapatkan obat hingga sudah tidak dikonsumsi lagi dan akhirnya dibuang, sehingga dampak dari kesalahan penyalahgunaan obat sirup pada masyarakat dapat dicegah. Kegiatan penyuluhan ini bertujuan mengetahui peningkatan pengetahuan Ibu tentang DAGUSIBU sediaan obat sirup anak sebelum dan sesudah penyuluhan di Kelurahan Langkapura Bandar Lampung. Metode yang digunakan  metode survei berupa diskusi, wawancara, dan observasi dan analisis statistik menggunakan uji paired T test. Hasil edukasi didapatkan peningkatan pengetahuan ibu-ibu yang memiliki bayi/balita tentang DAGUSIBU obat sirup anak dengan benar dilihat dari nilai rata-rata yang diperoleh sebelum penyuluhan sebesar 36,94% dan setelah dilakukan penyuluhan yaitu sebesar 91,11%  sehingga diperoleh peningkatan sebesar 54,17 %. Data statistik menunjukkan  ada hubungan antara pemberian edukasi dengan peningkatan pengetahuan ibu-ibu yang memiliki bayi/balita dimana p-value 0,00 dengan taraf kepercyaan 95%. Kata Kunci: DAGUSIBU, edukasi, obat, penyuluhan, sirup
Pengaruh Bentuk Sediaan Kosmetik Ekstrak Etanol Kulit Buah Pepaya (Carica papaya L.) terhadap Stabilitas Fisika dan Kimia Aprilia, Berlian Nindi; Ulfa, Ade Maria; Amalia, Putri
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.1061

Abstract

Kulit adalah lapisan terluar tubuh yang berperan melindungi terhadap patogen. Paparan sinar matahari berlebih memicu pembentukan radikal bebas yang merusak integritas kulit. Penelitian bertujuan untuk mengevaluasi pengaruh bentuk sediaan kosmetik (gel dan spray) yang mengandung ekstrak etanol kulit buah pepaya terhadap stabilitas fisika dan kimia. Kulit buah pepaya (Carica papaya L.) dikenal kaya senyawa bioaktif dengan potensi antioksidan. Penelitian dilakukan dengan ekstraksi perkolasi menggunakan pelarut etanol 70% diperoleh rendemen 42,2%. Uji stabilitas dilakukan dengan metode cycling test. Parameter stabilitas fisik meliputi evaluasi organoleptis, homogenitas, pengukuran pH, daya sebar, daya lekat, dan viskositas. Kedua sediaan menunjukkan perubahan variatif namun tetap berada dalam batas stabilitas yang ditentukan sepanjang masa penyimpanan. Metode FRAP (Ferric Reducing Antioxidant Power) digunakan untuk menguji aktivitas antioksidan sebelum dan setelah 12 hari penyimpanan, menunjukkan penurunan signifikan pada kedua sediaan. Analisis data menggunakan SPSS 26.0 dengan uji Repeated Measures ANOVA, Friedman dan Wilcoxon. Hasil diperoleh bahwa bentuk sediaan gel dan spray secara signifikan memengaruhi pH, daya sebar, daya lekat, dan viskositas dengan nilai Sig. <0,05.