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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Biologi Tropis Health and Medical Journal An-Nadaa: Jurnal Kesehatan Masyarakat Nusantara Hasana Journal Scientific Journal Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES) Journal of Public Health Science (JoPHS)
Anggraini, Debie
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Health and Medical Journal

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The Role of Interleukin 10 Genetic Variations in Pulmonary Tuberculosis: Perspectives of Genetics, Pathogenesis and Immunology Anggraini, Debie
Health and Medical Journal Vol 6, No 1 (2024): HEME January 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i1.1487

Abstract

Pulmonary tuberculosis remains a significant global public health challenge. In efforts to overcome this disease, a deeper understanding of the role of individual genetics, such as IL-10 genetic variation, in the response to M. tuberculosis infection is critical. Research that has been conducted shows that IL-10, which has an important role in regulating the immune response, can also influence the development of TB. Genetic variations in the IL-10 gene play a role in determining the extent of the immune response to TB infection and an individual's risk of this disease. The interaction between Treg cells, IL-10, and TB is also an important aspect in the pathogenesis and management of TB. Although Treg cells and IL-10 have a role in controlling excessive inflammation, too much of either can dampen the immune response needed to overcome infections. The implication of this research is that the development of more targeted and personalized therapy is an important step in overcoming TB. The use of individual genetic knowledge, such as IL-10 genetic variations, can help design more effective therapies and improve patient prognosis. However, challenges such as drug resistance and the complexity of genetic-immunological interactions remain challenges that need to be overcome in TB management. Overall, this study shows the importance of involving the fields of genetics and immunology in global efforts to address pulmonary tuberculosis. With a deeper understanding of the factors that influence the immune response to TB infection, we can hope to develop more effective strategies in the prevention, diagnosis and treatment of this disease and reduce the burden of TB worldwide.
Co-Authors Ade Putra, Idriyan Adelin, Prima Adilah, Putri Aisyaa Bintang Shafiera Aliefia, Desi Amelia, Rinita Anandikha, Tri Anggraeni, Verindra Anissa, mutiara Annisa, Zahra Dwi Ashan, Haves Ayu Hamama Pitra, Dian Bila, Salsha Bunga Najla Amelia Dafidela, Windi Dewi , Nadia Purnama Djong Hon Tjong Efriza Ekawati, Yessi Evra, Nidya Naysa Faadilah, Afkaar Febliyanti, Dwisha Febrian, Muhammad Reyhan Fenando, Dolvi Brillian Fharel, Muhammad Fitri, Vika Samila Habibullah, Muhammad Nabil Haiga, Yuri Hamama Pitra, Dian Ayu Hamda, Rialta Handayani Gusmira, Yuni Hasni, Dita Helmizar, Roland Hirowati Ali, Hirowati Humaira, Zikra Humairah, Zahrati Ibnu Fikrya, Annisa Ilham, Diko Inkha Prajadina Ivan, Muhamad Jefri, Muhamad Junisa, Diva Efrilia Kumala, Olivitari Lastari, Lastari Lestari, Apriliyana Puji liana, nana Madina Munawaroh Mahatma, Gangga Malik, Rifkind Maulana, Muhammad Hafidz Habib Meiriska, Indri Putri Melly , Ariyanti Melya Susanti Morawati, Soufni Muhamad Ivan Muhammad Fharel Mulyani, Intan Munawaroh, Madina Nabila Jihan Zakiyah Nirmala Nirmala, Nirmala Nurwiyeni Oktora, Meta Zulyati Pendri Hariyani , Insil Pernanda, Muhammad Zikri Pratama Putri, Cindy Munawaroh Pratama, Muhammad Tjico Aidil Putri, Afni Mesna putri, Anindya Firrizqi kaurtania Putri, Berliana Amani Putri, Mesya Andira Putriyuni, Anandia Raditya, Rahmat Rafli, Rhandyka Rahma Triyana Rahmadika Akbar, Resti Ramadhani, Novia Reni Lenggogeni Rhandyka Rafli Rika Amran Roland Helmizar Roza Linda, Melia Salsabilla, Intania Salsabilla, Salsabilla Saputri, Rahmi Agu Sari, Meri Ponda Seres Triola Sjaaf, Fidiariani Supardi, Muhammad Miftah Surya Dana, Teguh Tri Septiana, Vina Vatrisya, Gischa Wanandri, Puja Wettry Sagita, Agnesia Yarni, Sisca Dwi Zakiyah, Nabila Jihan Zulyati Oktora, Meta