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All Journal EKSAKTA: Journal of Sciences and Data Analysis Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences The Journal of Experimental Life Sciences (JELS) Biotropika Indonesian Green Technology Journal The Journal of Pure and Applied Chemistry Research Journal of Mathematical and Fundamental Sciences Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL CITRA KEPERAWATAN Indonesian Journal of Chemistry Indonesian Food Science and TechnologyJournal Berdikari: Jurnal Pengabdian Masyarakat Indonesia International Journal of Community Service Learning JKPK (Jurnal Kimia dan Pendidikan Kimia) JSMARTech : Journal of Smart Bioprospecting and Technology Jurnal Pengabdian kepada Masyarakat Nusantara Journal of Applied Veterinary Science and Technology Berkala Penelitian Hayati Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Makara Journal of Science Pustaka: Jurnal Bahasa dan Pendidikan Bagimu Negeri : Jurnal Pengabdian Kepada Masyarakat Engagement: Jurnal Pengabdian Kepada Masyarakat Journal of Tropical Diversity
Safitri, Anna
Brawijaya University
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Bioprospeksi: Eksplorasi Senyawa Aktif Penurun Penderita Stroke dari Organisme Laut Putri, Radwa Fathin H; Yufani, Rofika An; Saniyawati, Fang You Dwi Ayu Shalu; Safitri, Anna
Journal of Tropical Diversity Vol 1 No 1 (2025): Februari
Publisher : Penerbit Brainy Bee

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64283/jotdiverse.2025.1(1):1

Abstract

Stroke is a deadly disease in Indonesia. Meanwhile, marine organisms can contribute to providing active compounds for anti-stroke. The purpose of this review is to provide an overview of stroke sufferers in Indonesia and to identify potential active compounds from marine organisms that can treat or prevent stroke. The writing method was carried out by tracing the literature related to stroke and organisms that produce anti-stroke active compounds through Google Scholar. After collecting data from various literature, the next step was to process the data using simple statistics. Marine organisms that potentially contain anti-stroke active compounds are sea cucumbers (DHA, Docosahexaenoic acid), sea urchins (flavonoids), starfish (flavonoids), and jellyfish (amino acids), while marine organism biomarkers are biological responses of all living things in the sea to pollution and environmental pressures. This review is expected to be the beginning of the development of bioprospecting based on omics: metabarcoding and metagenomics, transcriptomics, proteomics, glycomics, lipidomics, and metabolomics.
Antihypertensive Effect of Rice Bran Derived Amino Acids Through Modulation of iNOS Expression and Renal Histopathology in DOCA Salt Induced Hypertensive Rats Muhammad Fikri Nur; Devi Ramadani; Muh Fikry Baharuddin; Almas Dwi Khairana; Saidun Fiddaroini; Akhmad Sabarudin; Anna Safitri; Wibi Riawan; Dyah Kinasih Wuragil; Hilman Nurmahdi; Aulanni'am Aulanni'am
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13491

Abstract

Hypertension is a major global health concern and a leading risk factor for cardiovascular mortality. Conventional treatment with ACE inhibitors like captopril is effective but often causes adverse effects including cough, dizziness, and renal impairment. This study evaluated the antihypertensive effects of rice bran in DOCA-salt-induced hypertensive rats. In vitro analysis revealed 45.58% soluble fiber and rich amino acid content, including 2.121 mg L-Arginine, a nitric oxide precursor promoting vasodilation. Male Wistar rats were divided into five groups: negative control, positive control, captopril treatment (5 mg/kg BW), and rice bran supplementation at 1% and 2% of 25 g feed. The 2% rice bran group significantly (p < 0.05) reduced renal iNOS expression by 88.32% compared to hypertensive controls, surpassing captopril's 22.96% reduction. Histopathological examination revealed notable renal protection with complete absence of fatty degeneration and minimal glomerular inflammation in the 2% rice bran group. These findings demonstrate potent antihypertensive activity through ACE inhibition, enhanced nitric oxide bioavailability, and mitigation of oxidative and inflammatory stress, establishing rice bran as a promising natural therapeutic alternative for hypertension management
Pemberdayaan Desa Sidorahayu Kabupaten Malang melalui Inovasi Eco Enzim Safitri, Anna; Srihardyastutie, Arie; Sutrisno, Sutrisno; Aulanni'am, Aulanni'am; Sukardi, Ernawati; Yusrina, Nur; Wasino, Wasino
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 7 No. 1 (2026): Edisi Januari - April
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v7i1.8457

Abstract

Desa Sidorahayu, Kecamatan Wagir, Kabupaten Malang menghadapi permasalahan pengelolaan sampah organik rumah tangga yang belum optimal, khususnya limbah kulit buah dan sayuran yang berpotensi mencemari lingkungan. Keterbatasan pengetahuan dan keterampilan masyarakat dalam mengolah sampah menjadi produk bernilai guna menjadi permasalahan krusial yang memerlukan solusi aplikatif dan berkelanjutan. Program ini menawarkan penerapan Teknologi Tepat Guna (TTG) berupa inovasi eco enzim sebagai solusi pengelolaan sampah organik sekaligus upaya pemberdayaan masyarakat. Kegiatan dilaksanakan melalui tahapan sosialisasi, pelatihan, demonstrasi, praktik langsung, serta pendampingan produksi dan pemanfaatan eco enzim hingga tingkat dusun. Mahasiswa KKN Tematik berbobot 4 SKS dilibatkan sebagai fasilitator untuk mempercepat transfer pengetahuan dan meningkatkan partisipasi warga. Hasil evaluasi kegiatan semakin menegaskan efektivitas program, dengan 90% peserta menilai proses pembuatan eco enzim sangat mudah dan 88% menyatakan kegiatan ini sangat bermanfaat, hal ini menunjukkan tingkat penerimaan yang sangat baik sekaligus mengindikasikan peluang keberlanjutan program di tingkat komunitas. Selain itu, terbentuk kelompok warga pengelola eco enzim yang mulai memanfaatkan produk untuk kebutuhan rumah tangga dan kebersihan lingkungan. Program ini menunjukkan bahwa inovasi eco enzim efektif sebagai pendekatan pemberdayaan masyarakat dalam pengelolaan sampah organik secara berkelanjutan.
Molecular Dynamics Simulation of Heparin 8 and 12 Saccharides With 2S Sulfation Pattern and 1C4 Iduronate Conformation To FGF2-FGFR1 Ternary Complex As Environmentally Friendly Anticancer Drug Candidate Discovery Barroroh, Himmatul; Mazyadi, Muhammad; Hakim, Lukman; Safitri, Anna; Widodo, Widodo
The Journal of Pure and Applied Chemistry Research Vol. 15 No. 1 (2026): Edition January-April 2026
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.015.01.8000

Abstract

Heparin is a linear polysaccharide composed of repeating 1–4 linked units of iduronic acid and glucosamine and is widely used as an anticoagulant drug. This paper reports characteristics of three-dimensional structural changes and stability of the FGF2–FGFR1 ternary complex in the presence of heparin 8- and 12-saccharide fragments with a 2S sulfation pattern and ^1C₄ iduronate conformation using in silico approach. Study was performed using molecular docking followed by 100 ns molecular dynamics (MD) simulations. Heparin 8- and 12-saccharide ligands were docked to the FGF2–FGFR1 ternary complex, then was evaluated by MD using GROMACS to monitor backbone root mean square deviation (RMSD), residue root means square fluctuation (RMSF), and key residue interactions over time. Docking suggested a more favorable initial binding energy for the 8-saccharide ligand, whereas MD revealed that the 12-saccharide ligand more effectively maintained stable interactions between FGF2 and FGFR1, as indicated by lower backbone RMSD at the end of the simulation and more persistent contacts at basic residues in the heparin-binding sites of both proteins. These dynamic stability features provide a mechanistic explanation for previously reported in vitro findings, showing that 12-saccharide 2S heparin fragments exert stronger FGF2-dependent antiangiogenic and anticancer effects than shorter fragments, thereby supporting their potential as environmentally friendly anticancer drug candidates.
Biosorption of Lead (Pb) from Aqueous Solution by Immobilized Aspergillus niger: A Green Technology for Heavy Metals Removal Nuban, Avander Alexander; Safitri, Anna; Andayani, Ulfa
Indonesian Green Technology Journal Vol. 10 No. 1 (2021): Indonesian Green Technology Journal
Publisher : Sekolah Pascasarjana, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lead has very toxic properties and cannot be degraded in waters that leads to health problems, such as disorders of the nervous system, heart, kidneys, digestive tract, and causing memory loss. One of the environmentally friendly methods that can reduce and even eliminate Pb is the biosorption. One of the microorganisms that can be utilized in biosorption technology is Aspergillus niger. In the current study, Pb biosorption was carried out by modifying Aspergillus niger which was immobilized in the Ca-alginate matrix. This study aims to determine the optimum biosorption conditions which include pH, contact time, initial Pb concentration, and amount of adsorbent. Results showed that the optimum conditions for Pb biosorption were pH 6.0, with contact time of 4 h, Pb concentration was 80 ppm, and at adsorbent concentration of 3 g, with the percentage of Pb adsorbed was 98.40%. FTIR spectra results show that the Pb biosorption process causes shifts in certain wavenumbers, from 1296.16 cm-1 to 1307.74 cm-1 which was a characteristic of the amine amide (CN) group, and a shift in wavenumber from 1122.57 cm-1 to 1168.86 cm-1 which was from carboxyl functional group. The interaction between Pb and the adsorbent surface was suggested through a physical adsorption, and hence the adsorption process was reversible.
Mikroenkapsulasi Berbasis Gum Arabik dari Ekstrak Air Pletekan (Ruellia tuberosa L.) dan Aktivitas Inhibisi Terhadap Alpha Amilase Gunawan, Firza Rajasa; Srihardyastutie, Arie; Roosdiana, Anna; Safitri, Anna
Indonesian Green Technology Journal Vol. 11 No. 2 (2022): Indonesian Green Technology Journal
Publisher : Sekolah Pascasarjana, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.igtj.2022.011.02.05

Abstract

Tanaman pletekan (Ruellia tuberosa L.) diketahui memiliki kandungan metabolit sekunder seperti flavonoid, fitosterol, sehingga diusulkan memiliki aktivitas biologis sebagai inhibitor enzim alpha-amilase. Mikroenkapsulasi merupakan metode yang dapat melindungi serta mengontrol pelepasan senyawa aktif. Penelitian ini bertujuan untuk melakukan fabrikasi terhadap ekstrak air pletekan dengan menggunakan bahan penyalut gum Arabik dan menguji aktivitasnya sebagai inhibitor untuk enzim alpha-amilase, serta mengetahui karakter mikrokapsul ekstrak air pletekan yang dihasilkan. Mikroenkapsulasi dilakukan pada variasi pH (3, 4, 5, dan 6) dan waktu pengadukan (30, 60, 90, dan 120 menit). Kondisi optimum mikrokapsul ditentukan berdasarkan penentuan efisiensi mikroenkapsulasi. Hasil penelitian menunjukkan bahwa pH 5 merupakan kondisi optimum dengan nilai efisiensi mikroenkapsulasi sebesar 51,3%. Sedangkan waktu pengadukan 90 menit merupakan kondisi optimum dengan nilai efisiensi mikroenkapsulasi sebesar 52,7%. Uji aktivitas inhibisi enzim alpha-amilase pada mikrokapsul dilakukan pada kondisi optimum menghasilkan nilai IC50 sebesar 71,61 µg/mL.. Karakterisasi menggunakan spektrofotometer FTIR menghasilkan bilangan gelombang 3401,51 cm-1 (O-H), 1608,77 cm-1 (C=C), dan 1081,07 cm-1 (C-O-C) yang menandakan terbentuknya mikrokapsul ekstrak air pletekan. Sedangkan hasil karakterisasi menggunakan SEM menunjukkan bahwa permukaan mikrokapsul yang dihasilkan masih heterogeny, dengan kecenderunagn berbentuk bulat, dan menghasilkan ukuran yang beragam berkisar antara 0,933 – 3,08 µm. Kata kunci: alpha-amilase, flavonoid, mikroenkapsulasi, pH, R. tuberosa L., waktu pengadukan
Co-Authors Ainun Sajidah Ajeng Erika Prihastuti Haskito Akhmad Sabarudin Aldila Noviatri Almas Dwi Khairana Almayda, Nabila Anna Roosdiana Anna Roosdiana Anna Roosdiana Anna Roosdiana Annisa, Choirin Arie Srihardyastutie Arief, Miftahudin Ary Mustofa Ahmad Asri Nurul Huda Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Aulanni`am Aulanni`am Avander Alexander Nuban Aviva Levina Aviva Levina Budi Kamulyan Cairns, James Robert Ketudat Chanif Mahdi Chanif Mahdi Citra Sari Devi Ramadani Dewi Ratih Tirto Sari Dian Siswanto Dwi Putri Woro Pamungkas Dyah Kinasih Wuragil Dzakiyyah Salmaa Eko Suyanto Ellya Indahyanti Ellysia Hitdatania Ernanin Dyah Wijayanti Eva Nur Laili Octaviana Fadlila, Safina Samara Nur Fairus Suryani Munir fatchiyah . Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatimah, Wahyu Dwi Febrianti, Wiwin Dwi Gatrananda, Sayyid Izzudin Gunawan, Firza Rajasa Handayu Untari Haskito, Ajeng Erika Prihastuti Hilman Nurmahdi Himmatul Barroroh Irfan Mustafa Irfan Mustafa James Robert Ketudat Cairns Lay, Peter A. Layta Dinira Levina, Aviva Lidwina Faraline Triprisila Lidwina Faraline Triprisila Lukman Hakim Masruri Masruri Mazyadi, Muhammad Muh Fikry Baharuddin Muhammad Fikri Nur Muhrimah, Siti Nariswari, Bintari nasrullah wilutono Nia Kurnianingsih Nia Kurniawan Ningsih, Zubaidah Novi Kurnianingsih Noviatri, Aldila Nuban, Avander Alexander Oktarini, Dwi Oktavia Eka Puspita, Oktavia Eka Peter A Lay Peter A Lay Purnamasari, Citra Putri, Radwa Fathin H Rahmaniah, Galuh Rensani Taloin Rista Nikmatu Rohmah Saidun Fiddaroini Saniyawati, Fang You Dwi Ayu Shalu Sari, Dewi Ratih Tirto Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Savira Ayu Damayanti Senge, Yeyen Susana Siti Mariyah Ulfa Sovia Rosalin Sri Wardhani Suci Amaliyah Sukardi, Ernawati Sunarni Sunarni Sutrisno Sutrisno Sutrisno, Sutrisno Tri Wahyu Nugroho Ulfa Andayani Ulfa Andayani Ulfa Andayani, Ulfa Untari, Handayu Wasino Wasino Wibi Riawan Widodo Widodo Yenny Kornitasari Yoravika Dwiwibangga Yufani, Rofika An Yusrina, Nur Zahara, Izaz Aqeiluz