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All Journal EKSAKTA: Journal of Sciences and Data Analysis Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences The Journal of Experimental Life Sciences (JELS) Biotropika Indonesian Green Technology Journal The Journal of Pure and Applied Chemistry Research Journal of Mathematical and Fundamental Sciences Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL CITRA KEPERAWATAN Indonesian Journal of Chemistry Indonesian Food Science and TechnologyJournal Berdikari: Jurnal Pengabdian Masyarakat Indonesia International Journal of Community Service Learning JKPK (Jurnal Kimia dan Pendidikan Kimia) JSMARTech : Journal of Smart Bioprospecting and Technology Jurnal Pengabdian kepada Masyarakat Nusantara Journal of Applied Veterinary Science and Technology Berkala Penelitian Hayati Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Makara Journal of Science Pustaka: Jurnal Bahasa dan Pendidikan Bagimu Negeri : Jurnal Pengabdian Kepada Masyarakat Engagement: Jurnal Pengabdian Kepada Masyarakat DIVERSITY: Journal of Multi Science Linearity Journal of Tropical Diversity
Safitri, Anna
Brawijaya University
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Molecular Interaction of Purple Rice Ferulic Acid and Skin Aging-Related Enzymes Wijayanti, Ernanin Dyah; Fatchiyah, Fatchiyah; Safitri, Anna; Siswanto, Dian
Makara Journal of Science Vol. 29, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Purple rice is rich in ferulic acid, a phenolic acid abundant in rice. Ferulic acid (FA) has long been recognized for its anti-oxidant properties, which are linked to its skin anti-aging activity owing to its ability to scavenge free radicals and pro-tect cells from damage. Skin anti-aging activity could be assessed by inhibiting skin aging enzymes. However, there was limited information on the mechanism of FA inhibition of these enzymes. This study focused on the molecular interac-tion between purple rice FA and collagenase or tyrosinase, both with and without their substrates. The interaction be-tween FA (CID 445858), collagenase (2Y6I), tyrosinase (5M8M), collagenase substrate (CID 5486160), and tyrosinase substrate (CID 6057) was docked using Hex 8.0.0 Cuda with the default settings. Discovery Studio 2020 and LigPlot software were used to visualize the docking results. Ascorbic acid (CID 54670067) and kojic acid (CID 3840) were used as positive controls for collagenase and tyrosinase, respectively. Molecular docking revealed that FA formed electro-static, hydrogen, and hydrophobic bonds with all aging enzymes, substrates, and enzyme–substrate complexes. FA could bind to both free enzymes and free substrates, consequently attenuating enzyme–substrate bonding, and preventing the substrate from binding appropriately in its normal position. Molecular dynamics simulations demonstrated that FA formed a stable bond with tyrosinase, similar to kojic acid, although the bond with collagenase was less stable. However, the pattern of each parameter during the simulation was comparable with that of ascorbic acid. The current study indicated that the FA from purple rice had the potential to act as an inhibitor of skin aging en-zymes and could be developed as a skin anti-aging candidate
Genomic Profile of OsCOMT in Indonesian Purple Rice Wijayanti, Ernanin Dyah; Safitri, Anna; Siswanto, Dian; Fatchiyah, Fatchiyah
Biotropika: Journal of Tropical Biology Vol. 10 No. 3 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.03.04

Abstract

The Indonesian purple rice (IPR), a crossbreeding of black and white rice, is a potential source of ferulic acid. Up to this point, the genomic similarity between the crossbreeding and its parentals has not been determined, particularly in genes involved in ferulic acid biosynthesis. In this present work, we analysed the profile of Oryza sativa caffeic acid-O-methyltransferase (OsCOMT) gene in IPR. The genomic DNA was extracted by CTAB method, then amplified with a specific primer of OsCOMT gene. The amplicon was sequenced by Sanger method and confirmed by geneID NC_029259.1. The IPR showed an amplicon of 708 bp sequence of the OsCOMT gene, indicating the gene involved in ferulic acid biosynthesis. The IPR gene profile is similar to the parentals, but there are variations in point mutations that distinguish it from the parentals. Aspartic acid was changed to Glutamine by mutations at positions 52, 69, and 79. We suggest that IPR has a novel OsCOMT gene variant that is unique as it is the crossbreed.
Bioprospeksi: Eksplorasi Senyawa Aktif Penurun Penderita Stroke dari Organisme Laut Putri, Radwa Fathin H; Yufani, Rofika An; Saniyawati, Fang You Dwi Ayu Shalu; Safitri, Anna
Journal of Tropical Diversity Vol 1 No 1 (2025): Februari
Publisher : Penerbit Brainy Bee

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64283/jotdiverse.2025.1(1):1

Abstract

Stroke is a deadly disease in Indonesia. Meanwhile, marine organisms can contribute to providing active compounds for anti-stroke. The purpose of this review is to provide an overview of stroke sufferers in Indonesia and to identify potential active compounds from marine organisms that can treat or prevent stroke. The writing method was carried out by tracing the literature related to stroke and organisms that produce anti-stroke active compounds through Google Scholar. After collecting data from various literature, the next step was to process the data using simple statistics. Marine organisms that potentially contain anti-stroke active compounds are sea cucumbers (DHA, Docosahexaenoic acid), sea urchins (flavonoids), starfish (flavonoids), and jellyfish (amino acids), while marine organism biomarkers are biological responses of all living things in the sea to pollution and environmental pressures. This review is expected to be the beginning of the development of bioprospecting based on omics: metabarcoding and metagenomics, transcriptomics, proteomics, glycomics, lipidomics, and metabolomics.
Antihypertensive Effect of Rice Bran Derived Amino Acids Through Modulation of iNOS Expression and Renal Histopathology in DOCA Salt Induced Hypertensive Rats Muhammad Fikri Nur; Devi Ramadani; Muh Fikry Baharuddin; Almas Dwi Khairana; Saidun Fiddaroini; Akhmad Sabarudin; Anna Safitri; Wibi Riawan; Dyah Kinasih Wuragil; Hilman Nurmahdi; Aulanni'am Aulanni'am
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.13491

Abstract

Hypertension is a major global health concern and a leading risk factor for cardiovascular mortality. Conventional treatment with ACE inhibitors like captopril is effective but often causes adverse effects including cough, dizziness, and renal impairment. This study evaluated the antihypertensive effects of rice bran in DOCA-salt-induced hypertensive rats. In vitro analysis revealed 45.58% soluble fiber and rich amino acid content, including 2.121 mg L-Arginine, a nitric oxide precursor promoting vasodilation. Male Wistar rats were divided into five groups: negative control, positive control, captopril treatment (5 mg/kg BW), and rice bran supplementation at 1% and 2% of 25 g feed. The 2% rice bran group significantly (p < 0.05) reduced renal iNOS expression by 88.32% compared to hypertensive controls, surpassing captopril's 22.96% reduction. Histopathological examination revealed notable renal protection with complete absence of fatty degeneration and minimal glomerular inflammation in the 2% rice bran group. These findings demonstrate potent antihypertensive activity through ACE inhibition, enhanced nitric oxide bioavailability, and mitigation of oxidative and inflammatory stress, establishing rice bran as a promising natural therapeutic alternative for hypertension management
Pemberdayaan Desa Sidorahayu Kabupaten Malang melalui Inovasi Eco Enzim Safitri, Anna; Srihardyastutie, Arie; Sutrisno, Sutrisno; Aulanni'am, Aulanni'am; Sukardi, Ernawati; Yusrina, Nur; Wasino, Wasino
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 7 No. 1 (2026): Edisi Januari - Maret
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v7i1.8457

Abstract

Desa Sidorahayu, Kecamatan Wagir, Kabupaten Malang menghadapi permasalahan pengelolaan sampah organik rumah tangga yang belum optimal, khususnya limbah kulit buah dan sayuran yang berpotensi mencemari lingkungan. Keterbatasan pengetahuan dan keterampilan masyarakat dalam mengolah sampah menjadi produk bernilai guna menjadi permasalahan krusial yang memerlukan solusi aplikatif dan berkelanjutan. Program ini menawarkan penerapan Teknologi Tepat Guna (TTG) berupa inovasi eco enzim sebagai solusi pengelolaan sampah organik sekaligus upaya pemberdayaan masyarakat. Kegiatan dilaksanakan melalui tahapan sosialisasi, pelatihan, demonstrasi, praktik langsung, serta pendampingan produksi dan pemanfaatan eco enzim hingga tingkat dusun. Mahasiswa KKN Tematik berbobot 4 SKS dilibatkan sebagai fasilitator untuk mempercepat transfer pengetahuan dan meningkatkan partisipasi warga. Hasil evaluasi kegiatan semakin menegaskan efektivitas program, dengan 90% peserta menilai proses pembuatan eco enzim sangat mudah dan 88% menyatakan kegiatan ini sangat bermanfaat, hal ini menunjukkan tingkat penerimaan yang sangat baik sekaligus mengindikasikan peluang keberlanjutan program di tingkat komunitas. Selain itu, terbentuk kelompok warga pengelola eco enzim yang mulai memanfaatkan produk untuk kebutuhan rumah tangga dan kebersihan lingkungan. Program ini menunjukkan bahwa inovasi eco enzim efektif sebagai pendekatan pemberdayaan masyarakat dalam pengelolaan sampah organik secara berkelanjutan.
Co-Authors Ainun Sajidah Ajeng Erika Prihastuti Haskito Akhmad Sabarudin Aldila Noviatri Almas Dwi Khairana Almayda, Nabila Anna Roosdiana Anna Roosdiana Anna Roosdiana Anna Roosdiana Anna Roosdiana Annisa, Choirin Arie Srihardyastutie Arief, Miftahudin Ary Mustofa Ahmad Asri Nurul Huda Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Aulanni`am Aulanni`am Avander Alexander Nuban Aviva Levina Aviva Levina Budi Kamulyan Cairns, James Robert Ketudat Chanif Mahdi Chanif Mahdi Citra Sari Devi Ramadani Dewi Ratih Tirto Sari Dian Siswanto Dwi Putri Woro Pamungkas Dyah Kinasih Wuragil Dzakiyyah Salmaa Eko Suyanto Ellya Indahyanti Ellysia Hitdatania Ernanin Dyah Wijayanti Eva Nur Laili Octaviana Fadlila, Safina Samara Nur Fairus Suryani Munir fatchiyah . Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fatimah, Wahyu Dwi Febrianti, Wiwin Dwi Firza Rajasa Gunawan Gatrananda, Sayyid Izzudin Gunawan, Firza Rajasa Handayu Untari Haskito, Ajeng Erika Prihastuti Hilman Nurmahdi Irfan Mustafa Irfan Mustafa James Robert Ketudat Cairns Lay, Peter A. Layta Dinira Levina, Aviva Lidwina Faraline Triprisila Lidwina Faraline Triprisila Masruri Masruri Muh Fikry Baharuddin Muhammad Fikri Nur Muhrimah, Siti Nariswari, Bintari nasrullah wilutono Nia Kurnianingsih Nia Kurniawan Ningsih, Zubaidah Novi Kurnianingsih Noviatri, Aldila Oktarini, Dwi Oktavia Eka Puspita, Oktavia Eka Peter A Lay Peter A Lay Purnamasari, Citra Putri, Radwa Fathin H Rahmaniah, Galuh Rensani Taloin Rista Nikmatu Rohmah Saidun Fiddaroini Saniyawati, Fang You Dwi Ayu Shalu Sari, Dewi Ratih Tirto Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Savira Ayu Damayanti Senge, Yeyen Susana Siti Mariyah Ulfa Sovia Rosalin Sri Wardhani Suci Amaliyah Sukardi, Ernawati Sunarni Sunarni Sutrisno Sutrisno Sutrisno, Sutrisno Tri Wahyu Nugroho Ulfa Andayani Ulfa Andayani Untari, Handayu Wasino Wasino Wibi Riawan Yenny Kornitasari Yoravika Dwiwibangga Yufani, Rofika An Yusrina, Nur Zahara, Izaz Aqeiluz