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Journal : Jurnal Medik Veteriner

Long-term preclinical evaluation of a bare-metal stent (INA-Stent) in the iliac arteries of Macaca nemestrina Wijayanti, Agustina Dwi; Arifianto, Dinar; Wijayanto, Hery; Purnomo, Agus; Budi, Setyo; Taufiq, Nahar; Yulianto, Heribertus Dedy Kusuma; Siswomihardjo, Widowati
Jurnal Medik Veteriner Vol. 9 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol9.iss1.2026.234-241

Abstract

This study represents the final phase of a preclinical investigation assessing the outcomes of bare-metal stent (INA-Stent) implantation in the iliac arteries of Macaca nemestrina. The aim of the study was to evaluate the condition of the stent and to determine the presence or absence of restenosis and inflammation in the surrounding tissue. The INA-Stent was implanted in four healthy adult M. nemestrina. The animals were euthanized at 6- and 9-month intervals to enable clinical and histological evaluation of the implanted stents. This study specifically reports the terminal preclinical evaluation of the final M. nemestrina, in which the stent had been implanted for 36 months. The assessment was conducted to identify clinical signs and to determine the condition of the stent following surgical implantation in the iliac artery. The procedures included clinical evaluation, anesthesia, catheterization, intravascular optical coherence tomography (OCT), followed by euthanasia, necropsy, and scanning electron microscopy (SEM). Based on the SEM and OCT findings, the INA-Stent was well integrated into the arterial wall, did not induce chronic inflammation, and showed no evidence of restenosis at 36 months post-implantation.
Co-Authors Achmad Nuruddin Safriandono Achmad Wahid Kurniawan Agustina Dwi Wijayanti Ahmad Alfa Trisnapradika, Gustina Alzami, Farrikh Amboro, Lulut Andi Rahmad Rahim Andini, Rintin Zulfia Andriani Eko Prihatiningrum, Andriani Eko Apriliyanto, Heru Arifianto, Dinar Assyafa, Izza Atto’illah, Mochamad Faiq Ayu Pertiwi Bahari, Nooryan Budi Widjajanto De Rosal Ignatius Moses Setiadi Fitriya, Zumrotus Nur Hagus Tarno Hanny Haryanto Harisa, Ardiawan Bagus Harun Al Azies Herfiani, Kheisya Talitha Heribertus Dedy Kusuma Yulianto Herowati, Wise Herowati, Wise Herowati Hery Wijayanto Hidayah, Devi Nurul Hidayat, Moh. Hamdan Hidayat, Novianto Nur Husain, Mochammad Jamaluddin Ifan Rizqa Ignasius, Darnell Ignatius Moses Setiadi, De Rosal Imam Sucahyo Imas Kania Rahman Indra Gamayanto Joko Susilo Kholis, Achmad Nur L. Budi Handoko Larasati, Kartika Mahardianti, Dinda Sarasatus Megantara, Rama Aria Moch Anjas Aprihartha Muljono Muljono Muslih Muslih Nafisa, Zahrun Nahar Taufiq, Nahar Nisa, Isnaini Maulidatu Noor Ageng Setiyanto, Noor Ageng Nur Lailiyah, Wiharyanti Nur Ramadhan, Ashary Nur Safitri, Aprilyani Nurcahyanti, Desy Nurhindarto, Aris Nurjanah, Indah Nurjannah, Indah Pertiwi, Riska Indah Guritno Gita Prabowo, Wahyu Aji Eko Priyadarshini, Rossyda Putra, Zidane Triananda Rahardiansyah, Wahyu Indra Dwiki Rahmad Jumadi Rahman, Imas Kania Rahmawati, Tutus Ramadhan Rakhmat Sani Redjeki, Endah Sri Rini Anggraeni Rofiani, Rofiani Rohmatin Agustina Safitri, Aprilyani Nur Safitri, Riana Intan Sasono Wibowo Sastra, Akhmad Sendi Novianto Setiawan, Aries Shafira, Natasya Risha Siswahyudianto Soeleman, M Arief Sudiarso Sudiarso Sudibyo, Usman Suhaili, Suhaili Suherlan, Yayan Sukamto, Titien Suhartini Supriadi Rustad Sutrisno Adi Prayitno Suyud Widiono T. Sutojo Talitha, Talitha Anindya Trisnapradika, Gustina Alfa Wahid Kurniawan, Achmad Wahyuingsih, Novita Wati, Deny Dwi Kusuma Wibawa, Tangkas Surya Widowati Siswomihardjo Wiharyanti Nur Lailiyah Yustika, Aninda Zami, Farrikh Al Zumroh, Arofatuz