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Kosasih
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Formulation and evaluation of antioxidant activity of lip moisturizing serum containing dragon fruit pulp extract (Selenicereus monacanthus (Lem.) D.R.Hunt) and avocado pulp oil (Persea americana Mill.) Taurhesia, Shelly; Kosasih; Irfan, Ade
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI In Press
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2054

Abstract

This study aimed to formulate and evaluate a lip moisturizing serum containing dragon fruit extract (Selenicereus monacanthus (Lem.) D.R.Hunt) and avocado oil (Persea americana Mill.) with a focus on antioxidant activity, moisturizing efficacy, irritation potential, and physical stability. The combination of both ingredients was optimized at a 2:1 ratio of extract to oil, which exhibited the highest antioxidant activity. Based on this ratio, three serum formulations were developed: F0 (placebo), F1 (100×), and F2 (200×). The formulations were evaluated for their physicochemical properties, antioxidant capacity, moisturizing performance, irritation response, and stability using a cycling test. The results demonstrated that the antioxidant activity decreased after formulation but remained strong for F1 and F2 after formulation. Among all formulations, F2 exhibited optimal characteristics - strong antioxidant effect, high moisturizing ability, stable physicochemical properties, and no signs of irritation. These findings indicate that the 2:1 combination of dragon fruit extract and avocado oil can be successfully developed into a stable, effective, and antioxidant-rich natural lip-moisturizing serum.
Co-Authors Abdul Gani Sidqi Ade Irfan Ahmad Syakur Banafif Ahmad Toni, Ahmad Alnando, Dedi Andityo Wahyu Juniarsyah Ari Tri Utami Aryani Kusuma Mukti Asnar, Etty Sofia Mariati Assoc. Prof. Dr. Dr. H. Sumeidi Kadarisman, S.E., M.M Astri Hindarti Astsania Hikmah Alfath Ayu Laili Rahmiyati Ayu Rindwita Indah Peanasari Bambang Agus W Bambang Widarsono Budyawan Herijanto Byan M Pratama Christina Wijaniputri Dahrul Effendi Dharma Jaya Hartono Dian Kurniasih, Dian Dian Prawibawa Dini Indriani Djogo, Ony dr Agung Family, Joko Agung N Dramora Nepy Asmara Drs., M.M5, Fittiana Etty Sofia Etty Sofia Mariati Asnar Fajarini Farida Yuliati, Farida Farida Yuliaty Farida Yuliatya Fitriana Habeahan, Immanuel Heru Atnioko Hutagaol, Tetty Ince Rosmini Irawan Sugoro Isah Amini Yasmin Istahara Jeanny Kathleen Hartini Kadarisman, Sumeidi Karahmawati , Tri Kurniasih, Aas Leony Martila Liya Megawati M Ahmed Mahqfiroh, Juliatul Malik, Rahadian Mantikaisih Laras, Andi Tenri Masitoh, Imas Siti Melinia Cahaya Fitri mulyani, sri rochani Muranny Nurshyaliha Manurung Murni, Detya Okti Noor, Laili Savitri Nova Karlina Nurfitriani, Astrid Nurmala Ahmar Padma Negara, M. Rizqi Panjaitan, Biller Penty Yuni Priyanda Prima, Dero Prof. Dr. VIP Paramarta Putriana Sitompul Rahadian Malik Ricky Agusiady Ridwan Rini Hastuti Risma Ariyani Rita Sulastini Rulia Sobarna Sobarna Kartamihardja Sonya Helen Maysha Sri Rochani Mulyani Suhono Tatang Sudrajat Taufan Nugroho Taufik Zulfikar Taurhesia, Shelly Tjitrayudha, Marcel Verianto Vip Paramarta Vip Pramarta Wahid, Deden Abdul Widjajanti Utojo Y. Ony Djogo Yusup Erisyadi Yuwono, Ismanto Yuyun Yuniarsih Zaenal Aripin