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All Journal Jurnal Penelitian Saintek Jurnal Ilmiah Farmasi JBIO: jurnal biosains (the journal of biosciences) Best Journal (Biology Education, Sains and Technology) GANDRUNG: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Nusantara FORTE JOURNAL Jurnal Farmanesia Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Jurnal ABDIMAS MUTIARA Jurnal Medika STIKes Kesehatan Baru JURNAL TEKNOLOGI, KESEHATAN DAN ILMU SOSIAL
Marbun, Eva Diansari
Universitas Sari Mutiara Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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FORMULASI SEDIAAN KRIM TABIR SURYA EKSTRAK ETANOL DAUN PECUT KUDA (Stachytarpheta jamaicensis L) DAN UJI Surya Protection Factor (SPF) SECARA IN VITRO Marbun, Eva Diansari; Sapitri, Alfi; Sianipar, Artha Yuliana; Asfianti, Vivi
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.10697

Abstract

Tabir surya merupakan suatu bahan topikal yang berfungsi untuk mengurangi dampak radiasi yang di sebabkan oleh sinar UV. Daun pecut kuda (Stachytarpetha jamaicensis L) merupakan tanaman yang banyak di manfaatkan untuk menjaga kesehatan dan sebagai obat tradisisonal. Tujuan dari penelitian ini Untuk mengetahui ekstrak etanol daun pecut kuda (Stachytarpheta jamaicensis L) dapat di formulasikan menjadi sediaan krim tabir surya, dan Untuk mengetahui nilai SPF (Sun Protector Factor) dari ekstrak daun pecut kuda (Stachytarpheta jamaicensis L). Metode peneleitian ini menggunakan metode eksperimental atau percobaan yang di mulai dari pengambilan sampel, sortasi basah, pengeringan, sortasi kering, penimbangan, penghalusan simplisia, perkolasi, dan rotary hingga menjadi ekstrak. Hasil penelitian uji mutu fisik krim tabir surya ekstrak etanol daun pecut kuda dengan konsetrasi 1%,2%,3% berbentuk setengah padat, warna cokelat, dan berbau khas rossae. Homogenitas pada sediaan yaitu homogen, Uji pH pada ketiga konsentrasi yaitu 5,9, 6,3, 6,5. Uji tipe krim menunjukkan ketiga konsentrasi yang termasuk tipe m/a. Uji daya lekat pada ketiga konsentrasi memenuhi syarat uji yaitu lebih dari 1 detik. Uji daya sebar pada ketiga konsentrasi memenuhi syarat uji yaitu 5-7cm. Uji iritasi pada ketiga konsentrasi tidak memberikan efek iritasi pada kulit. Uji Viskositas pada ketiga konsentrasi rata-rata 14300. Uji hiodonik dapat di simpulkan bahwa sedian yang paling di sukai panelis adalah konsentrasi 2%. Dan uji nili SPF di dapat hasil F1:1,97(minimal, F2:3,25(minimal), F3:6,41(Ekstra). Kesimpulan pana penelitian ini adalah formulasi ekstrak etanol daun pecut kuda(Stachytarpetha jamaicenis L) dapat di formulasikan sebagai sediaan tabir surya, dan ekstrak etanol daun pecut kuda (Stachytarpetha jamaicensis L) mempunyai nilai SPF(Surya Protection Factor).
Uji Aktivitas Antibakteri Ekstrak Fermentasi Bawang putih tunggal (Allium sativum L.) Terhadap Bakteri Staphylococcus aureus dan Methicillin-resistant Staphylococcus aureus (MRSA) Sapitri, Alfi; Marbun, Eva Diansari; Arisetya, Dian
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.152

Abstract

The pathogenicity of S. aureus bacteria is often associated with purulent wound infections in both humans and animals, which is the main cause of pyemia cases. Methicillin-Resistant Staphylococcus aureus (MRSA) is a Staphylococcus aureus bacteria that is resistant or immune to methicillin-type antibiotics and its derivatives. This study aims to see the activity of extracts from single garlic fermentation (Allium sativum L) which have antibacterial effects against Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria. This study was conducted at the Pharmacy Laboratory of Sari Mutiara Indonesia University in June-August 2024. This research method was carried out experimentally, the extraction was maceration and the media was tested using MHA to see the bacterial inhibition power. Based on the results of phytochemical screening examinations of single garlic fermentation extracts, it showed the presence of chemical compound groups in the form of Alkaloids, Flavonoids, Tannins, and Saponins. Where the concentration of single garlic fermentation extract is 5%; 10%; 15%. The results of the inhibition test against Staphylococcus aureus bacteria were 9.74 mm; 11.48 mm; 12.19 mm, positive control (chloramphenicol) 12.35 mm. The results of the inhibition test against Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria were 8.49 mm; 10.58 mm, 11.33 mm, positive control (chloramphenicol) 11.42 mm. Ethanol extract from single garlic fermentation has weak antibacterial activity against Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria.
Formulasi dan Evaluasi Sediaan Obat Kumur Dari Ekstrak Fermentasi Bawang Lanang (Allium sativum L.) Marbun, Eva Diansari; Sapitri, Alfi; Arisetya, Dian; Thaib, Cut Masyithah; Haliza, Aipak; Purba, Elizabet Kristina; Helmi, Helmi
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.153

Abstract

Mouthwash is a dilute concentration of antibacterial solution used to fight oral microbes, fight oral infections, cleansers, to eliminate bad breath, fresh and antiseptic. Mouthwash plays an important role in an individual's oral hygiene, mouthwash helps to relieve symptoms of gingivitis, inflamed gums and can also be relied on to destroy pathogenic bacteria. (Banu & Gayathri, 2016). The purpose of this study was to see if the extract from fermented Bawang Lanang (Allium sativum L) can be formulated into a mouthwash. This research method is an experimental laboratory. By including preparation of materials, sample identification, Making fermented Bawang Lanang, making extracts, extract yields, phytochemical screening, then formulated into a mouthwash. After that, an evaluation of the physical preparation of the mouthwash was carried out (organoleptic test, pH test, viscosity test and stability test). The results of the evaluation of the mouthwash preparation starting from the organoleptic test, pH test did not exceed pH 7, viscosity test of the series was stable for 3 months. Conclusion: Mouthwash preparations containing fermented ethanol extract of male shallots can be used as mouthwash, with good stability.
Buah Pisang barangan (Musa acuminata linn) Sebagai Media Alternatif Perkembangbiakan Bakteri Lubis, Retnita Ernayani; Sapitri, Alfi; Arisetya, Dian; Marbun, Eva Diansari
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.155

Abstract

Barangan banana (Musa acuminata linn) has an energy content of 89 calories, 22.84 grams of carbohydrates, 1.09 grams of protein and 0.33 grams of fat. The nutritional content and bioactive substances of barangan bananas have phenolics, anthocyanins and phenols. The purpose of this study was to determine whether barangan bananas can potentially be an alternative medium for bacterial growth. The growth method used in this study was the scratch method, with the calculation of the number of colonies using the TPC (Total Plate Count) method. The results of the study on the scratch method at various concentrations were able to grow optimally on barangan banana-based media at a concentration of 36%. The shorter exponential phase (log) period in the 36% concentration media with a higher cell density than in the 12% concentration media. Conclusion: Barangan banana (Musa acuminata linn) can potentially be an alternative medium for bacterial growth.
MEMBANDINGKAN EFEKTIVITAS PEMBERSIH LANTAI SEBAGAI DESINFEKTAN MENGGUNAKAN UJI KOEFISIEN FENOL TERHADAP Salmonella typhi: Comparison Of The Effectiveness Of Floor Cleaner As A Disinfectant Using The Phenol Coefficient Test Against Salmonella Typhi Napitupulu, Muhammad irianto; Hutasoit , Audi T.A.; Pebriyandi, Fajar; Tampubolon, Manuppak Irianto; Marbun, Eva Diansari
Jurnal Farmanesia Vol 12 No 1 (2025): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v12i1.6024

Abstract

Latar belakang: Salmonella typhi masih menjadi penyebab utama demam tifoid di berbagai wilayah endemis. Permukaan lantai yang terkontaminasi dapat menjadi media penyebaran bakteri ini, terutama di fasilitas umum dan rumah tangga. Oleh karena itu, pemilihan pembersih lantai yang efektif sebagai desinfektan sangat penting untuk upaya pencegahan. Tujuan: Penelitian ini bertujuan untuk mengevaluasi dan membandingkan efektivitas desinfektan dari sepuluh merek pembersih lantai terhadap Salmonella typhi menggunakan metode Koefisien Fenol (KF). Metode: Uji dilakukan dengan menginokulasikan suspensi S. typhi ke dalam larutan pembersih lantai dan fenol 5% pada berbagai pengenceran. Pertumbuhan bakteri diamati setelah inkubasi selama 48 jam pada suhu 30 °C. Nilai KF dihitung berdasarkan rasio efektivitas masing-masing produk terhadap fenol sebagai standar. Hasil: Dari sepuluh merek yang diuji, hanya dua produk menunjukkan nilai KF di atas 1, yang berarti lebih efektif dibandingkan fenol 5%. Sebagian besar produk lainnya memiliki efektivitas lebih rendah atau setara dengan fenol. Simpulan: Hanya sebagian kecil pembersih lantai yang efektif sebagai desinfektan terhadap Salmonella typhi. Hasil ini menunjukkan pentingnya sosialisasi pemilihan produk yang terbukti efektif secara ilmiah dalam rangka mengurangi risiko penyebaran infeksi di lingkungan.
Comparison of Extraction Methods on Medicinal Plants from the Lauraceae, Myristicaceae, Myrtaceace, Piperaceace, Rubiaceace, Solanaceace, and Zingiberaceae Families Susanti, Julia; Fitri, Widya; Thaib, Cut Masyitah; Napitupulu, Muhammad Irianto; Pebriyandi, Fajar; Marbun, Eva Diansari
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.116

Abstract

Indonesia is recognized as the second most biodiverse country in the world after Brazil. The use of medicinal plants in traditional medicine is gaining popularity due to their proven health benefits and fewer side effects compared to synthetic drugs. Several plant families, such as Myrtaceae, Rubiaceae, and Solanaceae, are known to include species widely utilized in traditional therapies. This study aims to compare the extract yields obtained through maceration, percolation, and Soxhlet extraction methods from various medicinal plants. The extraction process used 96% ethanol as a solvent. The results revealed that extract yields varied significantly depending on the extraction method applied. In conclusion, this study demonstrates that the choice of extraction method—maceration, percolation, or Soxhlet—significantly influences the extract yield obtained from different plant families.
Edukasi Pemanfaatan Pisang Kepok sebagai Media Tumbuh Bakteri dan Aplikasi Fisika dalam Proses Pengolahan Tepung Pisang di SMA Negeri 7 Medan Lubis, Retnita Ernayani; Sapitri, Alfi; Diansari Marbun, Eva; Arisetya, Dian
Jurnal Pengabdian Masyarakat Nusantara (JPMN) Vol. 5 No. 1 (2025): Februari - Juli 2025
Publisher : Lembaga Otonom Lembaga Informasi dan Riset Indonesia (KITA INFO dan RISET)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jpmn.v5i1.4746

Abstract

This community service activity aims to improve students' scientific literacy through education on the use of kepok bananas as an alternative medium for bacterial growth and the application of physics concepts in the process of processing banana flour. The program was implemented at SMA Negeri 7 Medan, which has limited science laboratory facilities, so that learning is still predominantly theoretical. The activity was designed through four main stages: initial survey, socialization, training, and mentoring. Students were guided to recognize the starch content in bananas as an energy source for microorganisms and to understand the principle of heat transfer in drying bananas. Implementation was carried out through direct practice of making banana flour and bacterial culture media based on local materials. Evaluation of the results showed a significant increase in student understanding, with more than 80% of students successfully making effective growth media marked by the formation of even bacterial colonies. In addition, 92% of students stated that this activity increased their understanding of science in an applicable and enjoyable way. This activity also opens up opportunities for cross-disciplinary integration (biology and physics) and the potential for entrepreneurship based on banana processing. The entire program proves that science learning based on local materials and direct practice can be an effective strategy to improve students' scientific skills and learning independence in high schools.
IDENTIFIKASI SENYAWA METABOLIT SEKUNDER PADA EKSTRAK DAUN SIRSAK (Annona muricata L.): LITERATUR REVIEW Marpaung, Jon Kenedy; Suharyanisa; Komsary, Pauline; Syahfitri, Novita; Manik, Maria Partiwi; Fitri, Nadiatul; Marbun, Eva Diansari
Jurnal STIKes Kesehatan Baru Vol. 3 No. 1 (2025): Jurnal Medika Kesehatan Baru
Publisher : Sekolaah Tinggi Ilmu Kesehatan (STIKes) Kesehatan Baru Doloksanggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70751/stikeskbdoloksanggul.v3i1.102

Abstract

Daun sirsak (Annona muricata L.) diketahui mengandung berbagai senyawa metabolit sekunder seperti alkaloid, flavonoid, terpenoid, dan saponin yang memiliki potensi aktivitas biologis. Penelitian ini bertujuan untuk mengidentifikasi senyawa metabolit sekunder pada ekstrak daun Annona muricata L berdasarkan data dari berbagai artikel ilmiah. Metode penelitian menggunakan metode systematic literature review (SLR). Hasil tinjauan menunjukkan bahwa daun sirsak mengandung flavonoid, alkaloid, saponin, tanin, terpenoid, steroid, serta senyawa fenolik lainnya. Kandungan dan kadar senyawa tersebut bervariasi tergantung pada jenis pelarut, metode ekstraksi, serta teknik analisis yang dilakukan, seperti KLT, FT-IR, GC-MS, dan spektrofotometri UV-Vis. Flavonoid merupakan senyawa dominan yang berperan sebagai antioksidan, antibakteri, dan antiinflamasi. Dengan demikian, daun sirsak memiliki potensi besar sebagai sumber senyawa bioaktif alami yang dapat dimanfaatkan dalam pengembangan obat herbal dan terapi komplementer.
Aktivitas Antibakteri Ekstrak Etanol Bulbil Porang (Amophophallus muelleri Blume.) Terhadap Bakteri Staphylococcus aureus dan Streptococcus mutans Sapitri, Alfi; Marbun, Eva Diansari; Arisetya, Dian; Lubis, Retnita Ernayani
Herbal Medicine Journal Vol 8 No 2 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i2.161

Abstract

The porang is a fruit produced by the porang plant which is brownish black in color, oval in shape like a stone and the size is approximately the size of small marbles to large marbles, growing between the stems of the porang plant. This study aimed to determine the activity of the ethanol extract of the porang frog (Amorphophallus muelleri Blume) as an antibacterial against Staphylococcus aureus and Streptococcus mutans bacteria and to determine the chemical compounds contained in the porang frog (Amorphophallus muelleri Blume). Porang frog simplicia powder was extracted in 96% ethanol by maceration. Simplicia powder is screened to determine its phytochemical content. The antibacterial activity test was carried out using the Kirby Bauer method using paper discs against Staphylococcus aureus and Streptococcus mutans bacteria to determine the zone of inhibition. The simplicia results showed that the simplicia frog porang had 6.08% water content, 29.11% water soluble extract, 9.70% ethanol soluble extract, 93.51% total ash content, insoluble ash content in ethanol. acid 91.96%. Simplicia said porang contains alkaloids, flavonoids, and tannins.The ethanol extract of the porang frog (Amorphophallus muelleri Blume) has antibacterial activity against Staphylococcus aureus and Streptococcus mutans bacteria.
Isolation of Secondary Metabolites of Zingiberaceae Rhizomes by Spectrofotometry and Chromatography: A Review Supartiningsih, Supartiningsih; Mairani, Fridelly; Putri, Ananda Dwi; Panggabean, Indah Elsayanti; Situmorang, Imelda Stefani Overia; Erni, Erni; Marbun, Eva Diansari
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 02 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i02.133

Abstract

The Zingiberaceae family, known as the ginger family, is rich in secondary metabolites that contribute to its extensive use in traditional and modern medicine. Understanding effective methods for isolating these metabolites is crucial for advancing their pharmaceutical and nutraceutical applications. A literature review of 10 journal articles published between 2015 and 2025 was conducted. The focus was on spectrophotometric (UV-Vis, FTIR) and chromatographic (TLC, HPLC, LC-MS) techniques applied to the rhizomes of Zingiberaceae species. Data on compound identification, quantification, and method performance were analysed. Rhizomes of Curcuma aeruginosa, Alpinia purpurata, Zingiber officinale, and Boesenbergia pandurata were reported to contain flavonoids, alkaloids, phenolics, terpenoids, and curcuminoids. Spectrophotometric methods provided functional group identification and estimation of total metabolite concentrations. Chromatographic approaches enabled separation, purification, and structural elucidation with high specificity. Notably, flavenochromane C from Zingiber cassumunar and piperine from Alpinia purpurata were identified using LC-MS and NMR spectroscopy. In addition, TLC-densitometry for curcuminoids and xanthorrhizol in Curcuma xanthorrhiza demonstrated high accuracy and precision. Spectrophotometric techniques offer rapid and cost-effective screening, while chromatographic methods provide detailed identification and quantification of specific compounds. The complementary use of both approaches enhances the accuracy and reliability of isolating Zingiberaceae metabolites, supporting their further utilisation in medicinal research and product development.
Co-Authors Alfi Safitri Alfi Sapitri Alfi Sapitri Amanda Putri, Amelia Ana, Mauli Andre Prayoga Artha Yuliana Sianipar Artha Yuliana Sianipar Asfianti, Vivi Barus, Darwita Juniwati Bemby, Arman br Ginting, Grace Anastasia Christica Ilsanna Surbakti Darwita Juniwati Barus Denny Satria Dian Arisetya, Dian Erni Erni Fitri, Nadiatul Fitri, Widya Fridelly Mairani Apt Ginting, Mandike Grace Anastasia br Ginting Grace Anastasia Ginitng Haliza, Aipak Harianja, Ester Saripati Helmi Helmi Herlinawati, Eria Nita Hutasoit , Audi T.A. Komsary, Pauline Mainal Furqan Manik, Maria Partiwi Manuppak Tampubolon Marpaung, Jon Kenedy Modesta Tarigan Napitupulu, Muhammad irianto Natanael Prilitius Panggabean, Indah Elsayanti Pebriyandi, Fajar Prayoga, Andre Purba, Elizabet Kristina Purba, Sri Dearmaita Putri, Ananda Dwi Raissa Fitri Realita Lifiani Retnita Ernayani Lubis Rezza Fikrih Utama Rizki Ndraha, Alva Hagaini Rosina Sitohang Santy Simamora Sapitri*, Alfi Sapitri, Alfi Sianipar, Artha Yuliana Silitonga, Evawani M Siti Maimunah Sitinjak, Joan Mervin Situmorang, Imelda Stefani Overia Suharyanisa Supartiningsih - - SURBAKTI, CHRISTICA ILSANNA Susanti, Julia Syahfitri, Novita Syukur Berkat Waruwu Tampubolon, Manuppak Irianto Thaib, Cut Masyitah Thaib, Cut Masyithah Turrahmi, Alvia Ulfayani Mayasari Utama, Rezza Fikrih Vivi Asfianti Zuhairiah Nasution, Zuhairiah