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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian JURNAL FARMASIMED (JFM) Eureka Herba Indonesia Indo-MathEdu Intellectuals Journal International Journal of Science and Society (IJSOC) Pharmacy Reports Jurnal Kesehatan dan Pengelolaan Lingkungan Jurnal Lingkar Mutu Pendidikan Jurnal Sehat Indonesia (JUSINDO) Jurnal Praktik Baik Pembelajaran Sekolah dan Pesantren Jurnal Ilmiah Pengabdian dan Inovasi Journal of Professional Teacher Education Jurnal Kesehatan dr. Soebandi Riemann : Research of Mathematics and Mathematics Education Journal Of Medicine And Health Sciences (Medisci) Murabbi: Pendidikan Guru Madrasah Ibtidaiyah Hexagon: Jurnal Ilmu dan Pendidikan Matematika Hipotenusa: Journal of Mathematical Society Scientific Development Journal Indonesian Journal of Jamu Jurnal Pendidikan dan Inovasi Pembelajaran
Kintoko
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Journal : JURNAL FARMASIMED (JFM)

 1 
Combination of Essential Oils of Ylang-Ylang (Cananga Odorata), Jasmine (Jasminum Sambac), and Mint Leaves (Mentha Piperita) TestingAphrodisiac on Male Mice Formulated in Candle Forms marpaung, Tio Widia A.; Kintoko; Wahyu Widyaningsih; Moch Saiful Bachri; Amelia Regina Arsyad
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7q01y176

Abstract

This study explored the potential of Jasminum sambac (jasmine) and Mentha piperita (peppermint) as natural sexual stimulants (aphrodisiacs) to enhance sexual activity in males and females through the use of essential oils. The main objective was to identify the most effective combination of essential oil formulations, which were evaluated through several biological and physiological parameters, including sexual behavior in mice, sperm quality, testicular histopathology, and wax-based formulations as the delivery medium. Three formulations were tested: P1 (3:1:1), P2 (1:3:1), and P3 (1:1:3), administered to mice using a humidifier via inhalation. Sexual behavior was assessed through mounting latency and mounting frequency as indicators of libido. Sperm quality parameters included morphology, motility, viability, and sperm count. Testicular histopathology was examined to evaluate tissue structure and spermatogenesis activity. The results demonstrated that the P1 formulation was the most effective, showing the highest aphrodisiac activity. In the sexual behavior test, P1 recorded an activity value of 21±6.2, indicating enhanced libido. Sperm quality testing also confirmed the superiority of P1, with the lowest sperm abnormalities (5.3±1.53), highest motility (82±7.5), highest viability (85.6±4.58), and the greatest sperm count (53,300±16,653.3). Although testicular histopathology revealed a slight reduction in spermatogenic cells across all treatment groups, the change was not significant in the P1 group compared to the control. Overall, the P1 formulation improved libido and sperm quality more effectively than P3 and the control group, indicating its potential to be developed as an aphrodisiac preparation based on natural essential oils.
Formulation of Emollient Preparation from Rose Essential Oil (Rosa Damascena) Combined with Vanilla Essential Oil (Vanilla Planifolia)in Increasing Body Weight in Baby Rats (Rattus Norvegicus) arsyad, regina; Kintoko; Wahyu Widyaningsih; Tio Widia Astuti Marpaung
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/80n03c83

Abstract

Rose and vanilla essential oils have potential as natural active ingredients in emollient formulations due to their moisturizing and aromatherapeutic relaxation effects. This study aimed to formulate an aromatherapy emollient with four variations in the composition of rose and vanilla essential oils: F1 (0.1 mL:0.4 mL), F2 (0.2 mL:0.3 mL), F3 (0.3 mL:0.2 mL), and F4 (0.4 mL:0.1 mL). Each formula contained a total of 0.5 mL essential oil dissolved in 100 mL sunflower seed oil as the base. Organoleptic evaluation showed that all formulas had a yellowish-white color and liquid texture. The resulting aromas differed among formulas: F1 produced a woody scent, F2 and F3 had an oriental woody fragrance, while F4 exhibited a dominant rose aroma. The pH values ranged from 5.12 to 6.00, which is within the normal skin range. Viscosity values were between 4.92–5.30 cPs, specific gravity ranged from 1.0181–1.0682, and refractive indices were 1.470–1.471, indicating good physical stability. Hedonic testing revealed that Formula F2 was the most preferred by panelists in terms of aroma, texture, and after-feel on the skin. Skin irritation tests on rabbits showed no negative reactions, confirming the formulation’s safety for topical use. Biological activity tests on infant mice demonstrated significant increases in body weight and length compared to the control group. Based on overall results, Formula F2 (0.2 mL rose oil and 0.3 mL vanilla oil) was determined to be the best formulation, offering a balanced aroma, good physical stability, and optimal emollient and relaxation effects.
Antioxidant Activity Test of Black Rice (Oryza sativa L. Indica) Extract and Total Phenolic Test of Soybean Sprout (Glycine max L.) Extract Using 70%, 90%, and 96% Ethanol Variations. Maulizah, Rizlah; Kintoko; Nina Salamah; Elfi Anis Saati
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/v5bg4116

Abstract

Background: The human body requires external antioxidants to neutralize free radicals that cause cellular damage and degenerative diseases. Black rice contains higher anthocyanin levels than red rice, while soybean germination increases flavonoids, phenolic compounds, and secondary metabolites.Objective: This study aimed to determine the total phenolic content of germinated soybeans extracted using three ethanol solvent concentrations (70%, 90%, and 96%) and to valuate the antioxidant activity of soybean and black rice extracts as copigmentation agents. Methods: Soybean extracts were obtained by maceration using different ethanol concentrations, followed by analysis of total phenolic content and antioxidant activity. Black rice extract was evaluated for antioxidant activity using the DPPH method to obtain a stable antioxidant with a very strong IC₅₀ value. Results: The total phenolic content of germinated soybean extracts varied with solvent concentration: ethanol 70% yielded 2.24 mg GAE/g, ethanol 90% yielded 7.14 mg GAE/g, and ethanol 96% yielded 3.36 mg GAE/g. The total anthocyanin content of black rice extract determined by the pH differential method was 8.182 mg/100 g, with an antioxidant activity IC₅₀ of 82.24 ± 3.6 ppm, categorized as strong. The IC₅₀ value of the non-copigmented sample was 83.71 ± 1.6 ppm (moderate), while copigmentation ratios of 1:1, 1:2, and 1:3 resulted in IC₅₀ values of 70.83 ± 0.8 ppm (strong), 62.97 ± 1.2 ppm (strong), and 38.53 ± 0.3 ppm (very strong), respectively. Conclusion: Extraction of germinated soybeans using ethanol 90% significantly increased total phenolic content (p < 0.05). Copigmentation of black rice anthocyanin flavylium with germinated soybean polyphenols at a 1:3 ratio produced very strong antioxidant activity (p < 0.05), indicating its potential as a copigmentation agent in functional food products.
Co-Authors Agung Cendikiawan, Khrisna Amelia Regina Arsyad Arif Budi Setianto arsyad, regina Astutik, Wiwin Dwi Botutihe, Lisa Agustina Deny Hadi Siswanto Ebenezer Bonyah Elfi Anis Saati Eva Kusumahati Fitriana, Eni Hadi Siswanto, Deny Hardi Astuti Witasari Husain, Dewi Putri Husnayanti, Ana Ibrozi, Hardi Astuti Witasari IIN INDAWATI Iwan Santoso, Blegoh Khrisna Agung Cendekiawan Kristina Warniasih M.M. Endang Susetyawati marpaung, Tio Widia A. Maulizah, Rizlah Moch Saiful Bachri Muhammad Yusuf Rambe Nina Salamah Nur Hikmah, Siti Nurhayati Nuryanto, Abid Nuryanto, Edy Oktaviani, Tristine Pertiwi, Yuniariana Pisriwati, Siti Atwano Putri, Nadia Maharani Ramadhanie, Bella Rambe, Muhammad Yusuf Rizky Nurdhillah Robitah, ahmad Rohmah, Lely Arbiati Nur Safira, Rizka Sagiran Sapto Yuliani Sapto Yuliani Siska Candra Ningsih Siswanto, Deny Hadi Siti Atwano Pisriwati Siti Mutmainah Sri Wiyanah SUGIYANTO Suliyanto Sunanti, Titis Susetyawati , M.M. Endang Susetyawati, M.M. Endang Tarso Tio Widia Astuti Marpaung Tsania Taskia Nabila Wahyu Titis Lestariningrum Wahyu Widyaningsih Wardhani, Firdha Aprillia YULIANA, SARI Yuwono Hardi