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Eksplorasi Kimia Medisinal untuk Terapi Kolesterol Tinggi : Analisis Struktur-Aktivitas dan Target Molekuler Obat Saeful Amin; Putri Nasywa Nabilah Ma’rifatillah; Intan Permatasari; Siti Maryam
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4392

Abstract

Hypercholesterolemia is a significant global health problem, with a high prevalence in Indonesia. Although conventional therapies such as statins have been the mainstay of treatment, limited efficacy and side effects necessitate the development of new, more effective and selective drugs. This article explores the role of medicinal chemistry in the discovery and development of cholesterol-lowering drugs, focusing on structure-activity analysis (SAR) and molecular targets. Through structure-based approaches, compounds such as statins and PCSK9 inhibitors have been optimized to increase affinity for biological targets. In addition, exploration of new targets and formulation innovations have shown great potential in improving therapeutic efficacy. Thus, medicinal chemistry contributes significantly to providing safer and more effective therapeutic solutions for the management of hypercholesterolemia.
Servant Leadership dan Komitmen Organisasi Terhadap Kinerja Karyawan: Studi pada Karyawan CV. Cisarua Cianjur Intan Permatasari; Nor Norisanti; Faizal Mulia Z
Al-Kharaj: Jurnal Ekonomi, Keuangan & Bisnis Syariah Vol. 6 No. 11 (2024): Al-Kharaj: Jurnal Ekonomi, Keuangan & Bisnis Syariah
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/alkharaj.v6i11.3547

Abstract

The company always expects employees to always perform in carrying out their duties and responsibilities to solve problems and prove the hypothesis by collecting data through interviews and questionnaires. The questionnaire was given to 42 respondents, to be further analyzed using multiple linear regression, multiple correlation, F Test and T - Test. Based on the results of calculations using the IBM SPSS Statistics Version 24 program, the results obtained servant leadership has a positive and significant effect on employee performance at CV. Cisarua Cianjur. This means that the better the implementation of servant leadership, the higher the employee performance at CV. Cisarua Cianjur. Organizational commitment has a positive and significant effect on employee performance at CV. Cisarua Cianjur. This means that the more organizational commitment from employees increases, the higher the employee performance at CV. Cisarua Cianjur. Servant leadership and organizational commitment have a positive and significant effect on employee performance at CV. Cisarua Cianjur. This means that the better the implementation of servant leadership and the more organizational commitment from employees increases, the more employee performance at CV. Cisarua Cianjur.
PENERAPAN PERMAINAN LOTTO UNTUK MENINGKATKAN KONSENTRASI BELAJAR PADA ANAK TUNA GANDA (ADHD DAN BIF) DI SDN GROBOGAN 02 KEC. JIWAN KAB. MADIUN Adam Satriyo Putra Madhani; Prastyo Budiningsih; Febri Tri Marthadiputri; Emilia Julaika; Monika Dyah Arwidiavin Diantri; Dian Agestiningsih; Intan Permatasari; Murtadlo; Endang Pudjiastuti
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 01 (2025): Volume 10 Nomor 1, Maret 2025
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i01.20880

Abstract

This study aims to improve the concentration of learning of children with multiple disabilities with ADHD and BIF in Inclusive Schools. This type of research is an experiment with a single subject experiment type or Single Subject Research, A-B-A design, the subject of this study is a child with multiple disabilities (ADHD and BIF) who shows symptoms of being unable to fully focus on objects. In this study, the data collection technique is to use duration to find out how long children are able to focus their attention during a learning session, which lasts for 20 minutes. Data were analyzed using visual graphic techniques.
Pengaruh Variasi Jenis Pakan Terhadap Laju Pertumbuhan Berat Ikan Mas (Cyprinus carpio) dalam Sistem Akuakultur Dimas Ardiansyah; Intan Permatasari
Insight of Biology Vol. 1 No. 1 (2025): Insight of Biology, June 2025
Publisher : Lembaga Publikasi Ilmiah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70716/inbio.v1i1.205

Abstract

This study aims to evaluate the effect of different feed types on the growth rate, feed efficiency, and survival rate of common carp (Cyprinus carpio) in an aquaculture system. The experiment was conducted for 60 days using a completely randomized design with four feed treatments: commercial feed, plant-based feed, animal-based feed, and a combination of plant- and animal-based feeds, each with three replications. Growth performance was assessed by measuring weight gain, specific growth rate (SGR), feed conversion ratio (FCR), and survival rate (SR). The results showed that the combination feed produced the highest growth rate, with an average final weight of 60 g, SGR of 3.52%/day, FCR of 1.05, and 100% survival rate. The animal-based feed also showed good performance, while the plant-based feed resulted in the lowest growth and feed efficiency. Statistical analysis revealed significant differences (p<0.05) among the treatments. The study concludes that the combined plant-animal feed provides a balanced nutritional profile that optimizes growth performance and feed efficiency in common carp culture, making it a recommended feed formulation for aquaculture practices.
Co-Authors . Suhartono A. Battania Damayani Achmad Syamsudin Achsien Hidayat Adam Satriyo Putra Madhani Adianto " Adji Darmawan Azmi Ahmad Fauzi Hendratmoko Ahmad Hafas Rasyidi Aita Rahma Dewati Aldi Laga Kurnia Dharmawan Alsafina Maratus S Andika Setyo Budi Lestari Andini Ramadhani Anik Malikah Anis Rahma Cahyani Annisa Setiawati Nursani Arnita Niroha Halawa Astri Senania, Astri ATTI SHOLIHAH Barudin Barudin Boby Suryawan Chika Setyorini Cindy Nidaul Husna Dassucik Denari Dhahana Edtiyarsih Dian Agestiningsih Dimas Ardiansyah Ekki Malik Ibrahim Emilia Julaika Emilia Sari Endah Susilowati Endang Pudjiastuti Etty Zuliawati Zed Fahrul Islam Faizal Mulia Z Fathia Sangadah Febri Tri Marthadiputri Fitra Audina FITRI DARA Fuat Gani Haryana Hardiyanto Hardiyanto Hasnia Ahmad Hasti Setya Utami Heni Marliany I Gusti Ayu Indah Ardani Ida Ayu Triana Ilham Insani Firdos Irma Firnanda Irna Melani Putri Jiaulhaq Hisyam Annajam Kamilah, Lala Kamelia Karyawan, I Dewa Made Alit Khusnul Khatimah Lale Sundari Djolo Puri Lalu Haerul Abdulloh Lisa Rahmayana Made Surya Bhuana Makhdalena Makhdalena May Linda P Mia Nila Firdaus Miftaahur Rahmawati Mila Nurmila Moh. Amin Moh. Arif Nur Reza Sayyidul Latif Monika Dyah Arwidiavin Diantri Muchlis Muchlis Muhammad Fikriy F Muhammad Wadji Muhammad Yogi S MURTADLO Nabila Maulida Azzahra Siregar Najimatul Badi’ah Nanda Aprilia Ni Made Mega Puspitasari Nina Risnawaty Nor Norisanti Nur Khotimatun F Nur Moch Alif Julianto BPS Nuvailah Rosyiah Oryza Tannar Panjaitan, Simon Andriano Panji Satya Mahadireza Pascalian Hadi Pradana Prastyo Budiningsih PUTRI HANDAYANI Putri Nasywa Nabilah Ma’rifatillah Putri Rahmatika Reyhan Besari Ragil Tri Wibowo Rahmah Febriyanti Regita Anggi Olivia Pramesti Regita Putri Cahyani Rimba Nadi P Rizki Nurhidayah RM Soerjo Adji Romadhon Fahmi Putra Roziana Zahro Saeful Amin Saeful Fachri Safira Monica Nuryuliana SAMBAS SAMBAS Siti Maryam Sofi Arifiana Mawadah Sri Dayaningsih Suci Mulyati Ramdhani Suci Permatasari Suryo Suminar Suwoko Tya Wicaksono T. Mhd. Sofyan Astsauri Tanjung, Kartika Permata Sari Tika Paramitha C Tomi Erfando Vip Paramarta Wahyono Wahyono Welly Sheila Apriana WIDYARANI WIDYARANI Wilda Nanda Agustin Harahap Wildan Khisbullah Suhma Willy Santika Dewi Winda Agustyawati Yudhi Permana Zahara Nur O Zahrani Purnita Sari