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Sleep Quality Affects Humoral Response in Recipients of Two-Dose Sinovac Vaccines Hananta, Linawati; Larasati, Victoria; Surilena, Surilena
Jurnal Kesehatan Masyarakat Vol 18, No 4 (2023)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v18i4.41950

Abstract

To curb the COVID-19 pandemic, the government distributed Sinovac vaccines. Sleep mediates immune function, including post-vaccination antibody response. This study aimed to analyze whether there was a difference in post-vaccination antibody levels in Sinovac vaccine recipients with poor and good sleep quality. This study used analytical observations of recipients of the two-dose Sinovac vaccine in 2021. Primary data included age, sex, the Pittsburgh Sleep Quality Index (PSQI) questionnaire, and post-vaccination IgG-SARS-CoV-2 antibody levels. The PSQI and IgG SARS-CoV-2 antibody levels were measured a month after the second vaccination. Participants with non-reactive antibody levels before the first vaccination were included, and participants with incomplete data were excluded. The Mann-Whitney test was used to look for associations between sleep quality and post-vaccination IgG SARS-CoV-2 levels. Univariate analysis showed that of 54 participants, 37 (68.5%) were male, and 28 (51.9%) had poor sleep quality. 15 participants (27.78%) were in the 36-45 age group, and median antibody levels in participants who received the second Sinovac Vaccine was 223.5 (199.01) units/mL. Post-vaccination IgG SARS-CoV-2 antibody levels were significantly associated with sleep quality (p=0.036).
Pemeriksaan Kesehatan dan Pengobatan pada Anak-Anak Komunitas Pemulung di TPU Pondok Kelapa Hananta, Linawati; Tandi, Sherly; Soegiarto, Bertha; Ageng, Leonardo; Amelia, Margareta; Oenang, Nydia; Yudy
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v2i2.5168

Abstract

Kesehatan perkotaan menjadi fokus kegiatan pengabdian kepada masyarakat Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya (FKIK UAJ). Bekerjasama dengan Persatuan Alumni Kedokteran (Plataran) Atma Jaya dan Lembaga Daya Dharma Keuskupan Agung Jakarta (LDD KAJ), kami melayani masyarakat kecil, lemah, miskin, marginal, dan penyandang disabilitas khususnya di wilayah KAJ. Kami bertujuan untuk mewujudkan hak anak atas kesehatan, pendidikan, pengajaran (pendidikan informal), identitas hukum, dan perlindungan dari kekerasan dan eksploitasi. Kita mengacu pada Undang-Undang Nomor 35 Tahun 2014 tentang Perlindungan Anak. Kita memaksimalkan pertumbuhan, perkembangan, dan kesehatan anak dan mengoptimalkan perkembangan fisik dan mentalnya. Kegiatan tersebut meliputi pemeriksaan kesehatan, edukasi, dan pemberian makanan bergizi kepada anak-anak komunitas pemulung di kawasan TPU Pondok Kelapa, Jakarta Timur. Jumlah peserta kegiatan sebanyak 77 orang, dengan rincian 59 orang (76,63%) anak di bawah 12 tahun dan 18 orang (23,37%) peserta di atas 12 tahun. Hasil pemeriksaan dokter, dari 77 peserta, anak sehat sebanyak 11 orang (14,3%), dan penyakit yang paling banyak diderita adalah ISPA (Infeksi Saluran Pernafasan Akut) sebanyak 14 orang (18,18%) dan nasofaringitis sebanyak 13 orang (16,9%). Kegiatan bakti sosial kolaboratif ini memberikan dampak positif bagi orang tua dan anak untuk lebih sadar akan kesehatan, khususnya mengenai pentingnya gizi bagi tumbuh kembang anak. 
EVALUASI STRES DAN KECEMASAN PADA CAREGIVERS: PERAWATAN PALIATIF DI RUMAH SINGGAH Hananta, Linawati; Wijaya, Jullyany Waty; Suwangto, Erfen Gustiawan; Amelia, Margareta; Widodo, Jerico Tristan; Chandra, Gerard Justin; Theja , Berliana Elyza Suryadi; Eriady, Angely Margaretha; Marcella, Laurie; Yolanda, Ellysa; Gonga, Audrey Aprilia; Sulisthio , Manuel Omar Weki; Kesuma , Deony Maria; Labaran, Victor Carolus Christiputra
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 3 No. 1 (2025)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v3i1.6042

Abstract

Perawatan paliatif merupakan elemen penting dalam memberikan perawatan berkualitas tinggi bagi pasien dengan penyakit kronis atau serius. Penyakit serius berhubungan dengan risiko kematian yang tinggi dan memberikan dampak besar pada aspek fisik, psikologis, maupun spiritualitas pasien, caregiver, ataupun keluarga. Peran caregiver dalam perawatan pasien dengan penyakit terminal atau serius sering kali membawa beban emosional dan fisik yang berat, yang dapat menimbulkan kecemasan dan stres. Perawatan paliatif berperan dalam mengelola gejala serta memenuhi kebutuhan pasien dan keluarga, yang pada akhirnya meningkatkan kualitas hidup pasien, caregiver, maupun keluarga. Kegiatan pengabdian masyarakat (abdimas) ini dilaksanakan di lima rumah singgah di Jakarta (RHI, WNH, CISC1, CISC2, dan RSL), dengan melakukan terapi seni yaitu inkblot dan mengevaluasi menggunakan kuesioner Perceived Stress Scale (PSS) untuk menilai tingkat stres dan kuesioner Generalized Anxiety Disorder-7 (GAD) untuk menilai tingkat kecemasan caregiver. Hasil asesmen menunjukkan bahwa sebagian besar caregiver mengalami tingkat kecemasan rendah (44,8%) hingga sedang (20,7%) dan memiliki tingkat stres ringan (41,4%) hingga sedang (51,7%). Dukungan sosial, spiritual, dan religius sangat penting, disertai dengan beberapa teknik relaksasi seperti meditasi, yoga, dan olahraga sehingga membantu mengurangi stres dan kecemasan.
Pemeriksaan Kesehatan dan Pengobatan pada Anak-Anak Komunitas Pemulung di TPU Pondok Kelapa Hananta, Linawati; Tandi, Sherly; Soegiarto, Bertha; Ageng, Leonardo; Amelia, Margareta; Oenang, Nydia; Yudy
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 2 No. 2 (2024)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v2i2.5168

Abstract

Kesehatan perkotaan menjadi fokus kegiatan pengabdian kepada masyarakat Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya (FKIK UAJ). Bekerjasama dengan Persatuan Alumni Kedokteran (Plataran) Atma Jaya dan Lembaga Daya Dharma Keuskupan Agung Jakarta (LDD KAJ), kami melayani masyarakat kecil, lemah, miskin, marginal, dan penyandang disabilitas khususnya di wilayah KAJ. Kami bertujuan untuk mewujudkan hak anak atas kesehatan, pendidikan, pengajaran (pendidikan informal), identitas hukum, dan perlindungan dari kekerasan dan eksploitasi. Kita mengacu pada Undang-Undang Nomor 35 Tahun 2014 tentang Perlindungan Anak. Kita memaksimalkan pertumbuhan, perkembangan, dan kesehatan anak dan mengoptimalkan perkembangan fisik dan mentalnya. Kegiatan tersebut meliputi pemeriksaan kesehatan, edukasi, dan pemberian makanan bergizi kepada anak-anak komunitas pemulung di kawasan TPU Pondok Kelapa, Jakarta Timur. Jumlah peserta kegiatan sebanyak 77 orang, dengan rincian 59 orang (76,63%) anak di bawah 12 tahun dan 18 orang (23,37%) peserta di atas 12 tahun. Hasil pemeriksaan dokter, dari 77 peserta, anak sehat sebanyak 11 orang (14,3%), dan penyakit yang paling banyak diderita adalah ISPA (Infeksi Saluran Pernafasan Akut) sebanyak 14 orang (18,18%) dan nasofaringitis sebanyak 13 orang (16,9%). Kegiatan bakti sosial kolaboratif ini memberikan dampak positif bagi orang tua dan anak untuk lebih sadar akan kesehatan, khususnya mengenai pentingnya gizi bagi tumbuh kembang anak. 
EVALUASI STRES DAN KECEMASAN PADA CAREGIVERS: PERAWATAN PALIATIF DI RUMAH SINGGAH Hananta, Linawati; Wijaya, Jullyany Waty; Suwangto, Erfen Gustiawan; Amelia, Margareta; Widodo, Jerico Tristan; Chandra, Gerard Justin; Theja , Berliana Elyza Suryadi; Eriady, Angely Margaretha; Marcella, Laurie; Yolanda, Ellysa; Gonga, Audrey Aprilia; Sulisthio , Manuel Omar Weki; Kesuma , Deony Maria; Labaran, Victor Carolus Christiputra
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 3 No. 1 (2025)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v3i1.6042

Abstract

Perawatan paliatif merupakan elemen penting dalam memberikan perawatan berkualitas tinggi bagi pasien dengan penyakit kronis atau serius. Penyakit serius berhubungan dengan risiko kematian yang tinggi dan memberikan dampak besar pada aspek fisik, psikologis, maupun spiritualitas pasien, caregiver, ataupun keluarga. Peran caregiver dalam perawatan pasien dengan penyakit terminal atau serius sering kali membawa beban emosional dan fisik yang berat, yang dapat menimbulkan kecemasan dan stres. Perawatan paliatif berperan dalam mengelola gejala serta memenuhi kebutuhan pasien dan keluarga, yang pada akhirnya meningkatkan kualitas hidup pasien, caregiver, maupun keluarga. Kegiatan pengabdian masyarakat (abdimas) ini dilaksanakan di lima rumah singgah di Jakarta (RHI, WNH, CISC1, CISC2, dan RSL), dengan melakukan terapi seni yaitu inkblot dan mengevaluasi menggunakan kuesioner Perceived Stress Scale (PSS) untuk menilai tingkat stres dan kuesioner Generalized Anxiety Disorder-7 (GAD) untuk menilai tingkat kecemasan caregiver. Hasil asesmen menunjukkan bahwa sebagian besar caregiver mengalami tingkat kecemasan rendah (44,8%) hingga sedang (20,7%) dan memiliki tingkat stres ringan (41,4%) hingga sedang (51,7%). Dukungan sosial, spiritual, dan religius sangat penting, disertai dengan beberapa teknik relaksasi seperti meditasi, yoga, dan olahraga sehingga membantu mengurangi stres dan kecemasan.
Transcriptional Regulation of CYP2D6 by Nrf2 and Its Implications in Breast Cancer Therapy: Bioinformatics and Experimental Evidence Siswanto, Ferbian Milas; Handayani, Maria Dara Novi; Lonah, Lonah; Dewi, Rita; Arieselia, Zita; Hananta, Linawati; Andarisuta, Putu Suwarastra
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3194

Abstract

BACKGROUND: Tamoxifen (TAM) resistance in patient with breast cancer is the leading cause of mortality among women globally. Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of TAM, and recently NF-E2-related factor 2 (Nrf2) has recently been found as its regulator. However, the impact of Nrf2-mediated CYP2D6 regulation in the context of breast cancer and TAM resistance are currently unknown. Therefore, this study was conducted to examine the role of CYP2D6 and Nrf2 in breast cancer prognosis. MEDTHODS: The roles of CYP2D6 and Nrf2 were investigated in the T47D breast cancer cell line and T47D-derived TAM-resistant cells by examining the gene expression, cell viability, and transcriptional regulation by quantitative reverse transcription polymerase chain reaction (qRT-PCR), MTT, and reporter gene assay, respectively. Additionally, comprehensive in silico analysis of the transcriptomic and clinical data from The Cancer Genome Atlas database were performed to uncover the prognostic role of CYP2D6 and its regulator in breast cancer patients. RESULTS: CYP2D6 mRNA was low and Nrf2 protein was high in TAM-resistant T47D cells compared to parental cells. Nrf2 knockdown upregulated CYP2D6 mRNA levels and enhanced the cytotoxicity of TAM. Similarly, in silico analysis revealed that low CYP2D6 mRNA and high Nrf2 protein were related to a lower probability of survival. The rs1238662089 within the identified Nrf2-binding site was found to greatly affect CYP2D6 expression levels, indicating its role as predictor for better prognosis. CONCLUSION: This study revealed for the first time that Nrf2 regulates CYP2D6expression in breast cancer and is involved in TAM sensitivity; thus, plays a role in breast cancer patient prognosis.KEYWORDS: breast cancer, CYP2D6, Nrf2, pharmacoepigenetics, SNPs
Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats Jusni, Louis Fabio Jonathan; Chandra, Valencia; Djuartina, Tena; Notario, Dion; Arieselia, Zita; Hananta, Linawati
Makara Journal of Health Research Vol. 26, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Hyperlipidemia is a condition that is characterized as an increase in total cholesterol and triglyceride levels in the blood. Lactoferrin is a protein that can serve as an antioxidant. This study aims to determine whether lactoferrin can reduce total cholesterol and triglyceride levels. Methods: This study used 24 Sprague–Dawley rat strains, which were divided into six groups: normal group; negative control; positive control; and dose groups 1, 2, and 3. The normal group was given standard feed, whereas the other group was given high cholesterol and fat. The positive control group and dose groups 1, 2, and 3 were given 1.5 mg/kg BW of simvastatin and 100, 200, and 400 mg/kg of BW lactoferrin, respectively. After 6 weeks, total cholesterol and triglyceride levels were measured. Results: This study showed that lactoferrin doses of 100, 200, and 400 mg/kg BW could significantly reduce total cholesterol and triglyceride levels (p < 0.05). Lactoferrin could also significantly reduce activated Kupffer cell and steatosis area in the liver (p < 0.05). Conclusions: Lactoferrin can reduce total cholesterol and triglyceride levels. Thus, further research is needed to address the existing bias and confirm that lactoferrin can reduce cholesterol and triglyceride levels.
THE RELATIONSHIP BETWEEN VITAMIN D LEVELS AND URIC ACID LEVELS IN THE ELDERLY AT SANTA ANNA NURSING HOME Harita, Ester Elida O; Kurniawan, Felicia; Hananta, Linawati; Sahusilawane, Isadora Gracia
Journal of Social Research Vol. 3 No. 2 (2024): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i2.1929

Abstract

As a person ages, the physiological function of the body decreases so that the risk of vitamin D deficiency and gout. The increasing elderly population can create a new era, namely the aging population. This study aims to see the relationship between vitamin D levels and uric acid levels in the elderly at Santa Anna Nursing Home. This study is an analytical observational study with a cross-sectional design with 70 elderly respondents living in Santa Anna Nursing Home, Jakarta. The correlation test is performed using the Pearson Correlation Test. There is a significant negative relationship between vitamin D levels and uric acid levels. In 23 elderly obtained average vitamin D levels of 36.9 + 8.4 ng / mL while high uric acid as many as 23 elderly (46%) with an average of 6.24 ± 1.9 mg / mL. From bivariate analysis, vitamin D levels were significantly associated with uric acid levels (r: -0.295, p: 0.037). There was a significant relationship between vitamin D levels and uric acid levels in the elderly at Santa Anna Nursing Home with a value of p = 0.041 (p < 0.05)
Non-communicable disease risk factors and Covid-19 antibody levels after vaccination Wea, Brigitta Yuliana; Hananta, Linawati; Astiarani, Yunisa
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art3

Abstract

Background: Non-communicable diseases (NCDs) have been identified as predictors of the severity of Coronavirus Disease 2019 (Covid-19). Some factors like smoking, alcohol consumption, and physical inactivity, which are associated with NCDs, may potentially hinder the efficacy of vaccines, reducing their ability to prevent the severity and complications of infectious diseases such as the Covid-19. Objective: This study investigated the NCD, risk factors associated with the levels of quantitative antibodies after the second Covid-19 vaccination.Methods: A cross-sectional study was conducted at a Covid-19 vaccination centre in Jakarta. Ninety subjects, aged ≥18, completed demographic and NCDs risk factor questionnaires. Blood samples were collected and analysed by using the electro chemiluminescence immunoassay analyser (ECLIA) method to measure quantitative antibody levels 30 days after 2nd Covid-19 vaccination. The bivariate analysis was performed to explore associations among the variables. The logistic regression was subsequently performed to identify the factors that remained independent in influencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody status. Results: The mean value of antibody level in this study was 191 U/ml. The results indicated that 35.5% (n=32) of respondents had SARS-CoV-2 antibody levels below average. The regression results suggested that the odds of having higher antibody levels were reduced for individuals with hypertension (Adjusted Odd Ratio [AOR] = 0.74, p value = 0.022), diabetes (AOR = 0.82, p value = 0.038) comorbidities accompanied with smoking (AOR = 0.55, p value = 0.044), drinking alcohol (AOR = 0.92, p value = 0.030), and low physical activity levels (AOR = 0.67, p value = 0.043). Conclusion: The study found that 35.5% of participants had SARS-CoV-2 antibody levels below the average. Factors such as hypertension, diabetes, comorbidities with smoking, alcohol consumption, and low physical activity were associated with reduced odds of higher antibody levels.
Talk show Edukasi Skabies: Upaya Promotif di Desa Babakan Madang, Bogor Wijaya, Meiliyana; Gaverio, Nicholas Francisco; Olivia, Vera; Joprang, Freggy Spicano; Hananta, Linawati
Jurnal SOLMA Vol. 14 No. 3 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i3.19150

Abstract

Background: Scabies, also known as "kudis," is a skin disease commonly found in areas with high population density and poor sanitation, such as rural regions. This study aimed to increase the knowledge and awareness of residents regarding scabies through an educational talk show. The activity was conducted in Babakan Madang Village, Bogor, West Java, an area with a high incidence of scabies. Methods: This community engagement activity was conducted through a two-way interactive educational approach in the form of a talk show, commencing with a pre-test, followed by an expert-led interactive discussion on the identification, prevention, and treatment of scabies, a question-and-answer session, a post-test, and the provision of appropriate scabies medication to residents diagnosed with the condition. Results: The results showed a significant increase in post-test scores compared to pre-test scores, indicating an improvement in residents' knowledge about Sarcoptes scabiei, the causative agent of scabies, including its symptoms and proper treatment. Conclusions: In conclusion, the talk show method proved effective in raising public awareness about scabies and equipping affected residents with appropriate treatment ointments, thereby supporting government efforts to reduce the prevalence of scabies in the region.
Co-Authors Ageng, Leonardo Ahmad Hamim Sadewa Amelia, Margareta Andarisuta, Putu Suwarastra Arrang, Sherly Tandi Bai Apris Bansai Immanuel Bertha Soegiarto, Bertha Bryan Junius Winata Budiyanti, Ecie Chandra, Gerard Justin Chandra, Valencia Darojatun Ida Dharmalau, Richanda Surya Dion Notario Dion Notario Divara Ariesta Sekar Suryadi, Made Edward Surjono, Edward Endrardewi, Naomi Arumratri Erfen Gustiawan Suwangto, Erfen Gustiawan Eriady, Angely Margaretha Evi Ulina Margaretha Situmorang Fan, Tan Fei Felicia Kurniawan, Felicia Fenny Mariska Ferbian Milas Siswanto Gaverio, Nicholas Francisco Ghea Mangkuliguna Gonga, Audrey Aprilia Hardi, Nicholas Hari Kusnanto Harita, Ester Elida O Havian Daulung Telium Isadora Gracia, Isadora Jonny Setiawan Jonny Setiawan Jonny Setiawan Jontari Hutagalung Joprang, Freggy Spicano Jusni, Louis Fabio Jonathan Kesuma , Deony Maria Kik Hao Samuel Kurniadi, Angela Kurniawan, Sandy Vitria Labaran, Victor Carolus Christiputra Larasati, Victoria Lee, Jocelyn Viony Lieputra, Andrew Adhytia Lonah, Lonah Mahaputra Mahaputra Marcella, Laurie Margareta Amelia Maria Dara Novi Handayani, Maria Dara Novi Mariani Santosa, Mariani Mega Tyas Prihatin Meiliyana Wijaya Monalisa Heryani Mora Octavia Nathalie, Evadia Nawanto Agung Prastowo Novijanti Rintis Oenang, Nydia Olivia, Vera P. Purwono Prayoga Tjendratama, Jason Puspa Bunardi, Dewi Putri, Indira Ayu Rita Dewi Rita Dewi Rita Dewi S. Supargiyono Sahusilawane, Isadora Gracia Satyagraha Ari Winasti Sri Hapsari Wijayanti Sulisthio , Manuel Omar Weki Surilena Hasan Tandi, Sherly Tena Djuartina Tena Djuartina, Tena Theja , Berliana Elyza Suryadi Triwibowo A. Garjito Vallerie Satyadi, Richelle Veronika Maria Sidharta Vetinly Vetinly Via Dolorosa Halilintar Wea, Brigitta Yuliana Widodo, Jerico Tristan Wijaya, Jullyany Waty Wijaya, Meiliyana Yaparto, Selfianti Yolanda, Ellysa Yudy Yuliana Yuliana Yulius Evan Christian Yunisa Astiarani Zita Arieselia