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All Journal International Journal of Public Health Science (IJPHS) Journal of Educational, Health and Community Psychology Jurnal Kesehatan Masyarakat Althea Medical Journal Damianus Journal of Medicine Indonesian Journal of Biotechnology The Indonesian Biomedical Journal Jurnal SOLMA MITRA: Jurnal Pemberdayaan Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Mandala Pengabdian Masyarakat Journal of Social Research JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Makara Journal of Health Research Room of Civil Society Development Journal of Urban Health Research Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Room of Civil Social Development Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat
Linawati Hananta, Linawati
Department Of Pharmacology, School Of Medicine And Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jl. Pluit Raya No 2, Jakarta 14440
Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Body Mass Index, a Body Shape Index, and Waist-to-Height Ratio in Predicting Elevated Blood Pressure Bryan Junius Winata; Veronika Maria Sidharta; Linawati Hananta; Vetinly Vetinly; Nawanto Agung Prastowo
Althea Medical Journal Vol 9, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n1.2291

Abstract

Background: One of the complications of obesity is an elevation in blood pressure  which can increase the risk of hypertension. This study aimed to explore body mass index (BMI), a body shape index (ABSI), and waist-to-height ratio (WHtR) in predicting elevated blood pressure (BP).Methods: This study was conducted in a cross-sectional design on 215 medical students from October 2019 to September 2020. Respondents measured their own weight, height, waist circumference and BP. Receiver operating characteristics (ROC) curve were analyzed using IBM SPSS v.23. Results: Of the 215 medical students who participated in this study, only 102 met the inclusion criteria. The majority of the students were female (n=71, 69.6%) with a mean age of 19.37 years, and normal blood pressure (n=90, 88.2%). Area under the ROC curve (AUC) of WHtR and ABSI were 0.774 (p-value= 0.002) and 0.766 (p-value= 0.003) respectively, which were still acceptable. However, the AUC of BMI (p-value=0.589) was 0.11, which was considered poor.Conclusion: The indicators of obesity can be used as a screening value for increased blood pressure in adults, with BMI being the weakest indicator compared to ABSI and WHtR. Further research is needed to examine ABSI and WHtR indicators as predictor of increased blood pressure in adults.
The first evaluation of glucose-6-phospate dehydrogenase defciency (G6PD) gene mutation in malaria endemic region at South Central Timor (SCT) district, Eastern Indonesia 2014–2015 Jontari Hutagalung; Hari Kusnanto; S. Supargiyono; P. Purwono; Sadewa Ahmad Hamim; Darojatun Ida; Satyagraha Ari Winasti; Novijanti Rintis; Triwibowo A. Garjito; Mega Tyas Prihatin; Bai Apris; Bansai Immanuel; Kik Hao Samuel; Hananta Linawati
Indonesian Journal of Biotechnology Vol 20, No 2 (2015)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1115.764 KB) | DOI: 10.22146/ijbiotech.24194

Abstract

Primaquine (PQ) is a key drug in the malaria pre-elimination stage. However, PQ can trigger acutehemolysis for people with G6PD defciency (G6PDd). In 2013, 15–25 million Indonesian people were infected with malaria, with 30,000–38,000 deaths each year mostly in eastern Indonesia with API= 15.6 %. Recently, the Ministry of Health of the Republic of Indonesia announced a plan to reach the pre-elimination stage based on WHO guidelines. This study assesses whether eastern Indonesia should proceed with the activities of malaria pre-elimination. A total 555 healthy people in fve subdistricts in eastern Indonesia were selected by systematic random samping. All data were collected using a standard questionnaire, physical examination, and laboratory tests. PCR and DNA sequencing protocols followed respective manufacture’s instructions. Statistical analysis by bivariate with α= 0.05 and 95% CI were performed using the SPSS software package. Based on the nested PCR, the result showed a malaria prevalence of 32.6% with being the dominant species (52.5%). Malaria cases were found in all study sites and not using a bed net was the moost signifcant risk factors with Exp B= 1.54 with 95% CI= 0.99–2.38. G6PDd prevalence was 16.6%, the highest G6PDd ever found in Indonesia with variant molecular dominant 10.883 T>C and one sample with a heterozygous female. Malaria pre-elimination in eastern Indonesia should be delayed. High risk patients should be tested for enzyme G6PD activities before antimalarial administration.
Sedentary Screen Time as a Coping Strategy of Distance Learning-induced Distress during COVID-19 Pandemic Ghea Mangkuliguna; Mahaputra Mahaputra; Veronika Maria Sidharta; Linawati Hananta
Journal of Educational, Health and Community Psychology Vol 10 No 2 June 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jehcp.v10i2.19969

Abstract

During the COVID-19 pandemic, medical students might be vulnerable to excessive screen time exposure to cope with distance learning-induced distress. This study aimed to evaluate the distress and screen time before and after distance learning was initiated. Data were collected from 215 subjects. Statistical significance was accepted at P<0.05. The prevalence of distress among medical students was 25.61% and 27.06% before and after distance learning was executed, respectively. Academic-related stressor (ARS) was reported by 49.28% and 63.29% of students during the first and second surveys. The proportion of students with daily screen time ≥7 hours was 51.21% and 63.77% for the first and second surveys, respectively. ARS, interpersonal and intrapersonal-related stressor (IRS), social-related stressor (SRS), and average daily screen time significantly rose in 3-month-time (P<0.0001, P=0.0014, P=0.0261, P=0.0022). There was a significant association between distress and screen time (P=0.0313). ARS was the leading cause of distress. The majority of respondents had a daily screen time ≥7 hours. Both distress and screen time levels significantly increased as distance learning kept progressing.Keywords: COVID-19; distance learning; mental distress; medical students;                        screen time.
Pharmacogenomic Role in Cytochrome P450 Enzymes-Mediated Metabolism for Drug Therapy Lonah; Zita Arieselia; Jonny Setiawan; Rita Dewi; Maria Dara Novi Handayani; Linawati Hananta
Journal of Urban Health Research Vol. 1 No. 3 (2023): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v1i3.4629

Abstract

The rapid development of genetic science in recent decades has provided opportunities for clinical implementation. In the field of pharmacology, this opens up hope for the use of more targeted drugs with fewer side effects.Genetic variation's influence on pharmacological response has been well-established in practice. Patients' responses to pharmacological therapies can be varied, ranging from positive effects to serious adverse drug reactions (ADRs). Numerous genetic variations have been found to have a major impact on how people react to routinely prescribed medications over time, according to experts. In order to use this genetic information to inform treatment choices, a pharmacogenomic (PGx) profile can be used. PGx works on identifying and validating genomic variations that affect drug response. The generic approach to healthcare has given way to a more individualized and precise treatment paradigm as it has developed. Keywords: Adverse Drug Reactions - Genetic Variants – Pharmacogenomics - Cytochrome P450
Prevalence of E-cigarette Users Students and Determinant Factors Affecting Their Use Behavior Zita Arieselia; Lonah Lonah; Linawati Hananta; Margareta Amelia; Fenny Mariska; Via Dolorosa Halilintar; Mariani Santosa; Meiliyana Wijaya; Rita Dewi; Jonny Setiawan; Monalisa Heryani
Bahasa Indonesia Vol 22 No 2 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i2.3820

Abstract

Pendahuluan: Prevalensi pengguna rokok tembakau pada remaja di Indonesia terus meningkat dari 7,2% pada tahun 2013 menjadi 9,1% pada tahun 2018, tingkat penggunaannya dianggap dapat dikurangi dengan menggunakan rokok elektrik. Namun sebenarnya rokok elektrik belum dapat disebut sebagai terapi berhenti merokok konvensional karena belum terdapat bukti yang cukup kuat dan dampak penggunaannya pada kesehatan yang tidak dapat dikesampingkan. Sementara itu, beberapa studi menunjukkan bahwa penggunaan rokok elektrik juga berdampak buruk bagi kesehatan. Tujuan penelitian ini adalah untuk mengetahui prevalensi pengguna dan faktor determinan yang memengaruhi perilaku penggunaan rokok elektrik pada mahasiswa. Metode: Studi ini merupakan penelitian kuantitatif dengan desain studi potong lintang atau cross sectional. Sampel yang digunakan sebanyak 410 orang dengan kriteria inklusi berupa mahasiswa aktif Unika Atma Jaya serta orang yang telah setuju untuk menjadi responden penelitian setelah membaca informed consent, dan kriteria eksklusi yaitu responden yang mengisi kuesioner dengan tidak lengkap. Perhitungan sampel dilakukan dengan metode proportional stratified random sampling. Pengambilan data responden menggunakan kuesioner secara daring melalui Google Forms. Analisis data menggunakan uji Chi Square dan Mann-Whitney.   Hasil: Prevalensi pengguna rokok elektrik pada mahasiswa sebesar 21,7%. Pada penelitian ini faktor yang berpengaruh pada keputusan penggunaan rokok elektrik adalah jenis kelamin (p<0,001), persepsi (p<0,001), tersedianya suplai (p<0,001), dukungan keluarga (p=0,002), dan dukungan teman (p<0,001). Simpulan: Tingginya tingkat penggunaan rokok elektrik pada mahasiswa menunjukkan perlunya informasi dan edukasi serta promosi kesehatan mengenai dampak merugikan dari penggunaan rokok elektrik.
Second year of COVID-19 pandemic: mental health among Indonesian urban population Hardi, Nicholas; Gracia, Isadora; Hananta, Linawati
International Journal of Public Health Science (IJPHS) Vol 12, No 4: December 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i4.22787

Abstract

Mental health problems, particularly anxiety and depression, have increased since the early pandemic. This phenomenon still occurs when the pandemic reached its second year. The study explored the prevalence of anxiety and depression among the urban population. A cross-sectional study was conducted during Jakarta's third dose of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination programs. The Indonesian version of generalized anxiety disorder-7 (GAD-7) and the patient health questionnaire-9 (PHQ-9) were used to estimate clinically significant anxiety and depression, respectively. Out of the 356 participants, 18.5% and 29.2% of participants presented clinically significant anxiety and depression, respectively. Age differences between the probable anxiety and depression groups with their respective counterparts were statistically significant (p<0.001). Both groups showed a lower mean age. Lower age showed significantly higher anxiety (OR 1.05; 95% CI 1.0-1.1) and depressive problems (OR 1.07; 95% CI 1.0-1.1). Our result indicated that clinically significant anxiety and depression symptoms were prevalent among the urban population during the second year of the pandemic. Age differences might be an important predictive factor for both symptoms. Age-specific interventions are considered helpful to achieve better mental health and reduce the prevalence.
Assessing the Correlation between Spicy Food Consumption and Dyspepsia Symptoms in Medical and Health Students at Atma Jaya Catholic University of Indonesia Lonah; Divara Ariesta Sekar Suryadi, Made; Arieselia, Zita; Vitria Kurniawan, Sandy; Hananta, Linawati; Setiawan, Jonny; Surjono, Edward; Santosa, Mariani; Ulina Margareta Situmorang, Evi; Fan, Tan Fei; Yuliana; Budiyanti, Ecie
Journal of Urban Health Research Vol. 2 No. 3 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v2i3.5463

Abstract

Introduction: The capsaicin (8-methyl-N-vanillyl-6-nonenamide) content in spicy foods can trigger irritation and increase gastric acid production, which potentially damages the stomach mucous layer by increasing chloric acid levels (HCl). It is known that dyspepsia has a variety of causes and one of them can be triggered by the consumption of irritating foods, such as spicy foods. Therefore, the research was conducted to determine whether there was a significant relationship between the consumption of spicy foods and the incidence of dyspepsia in students of the Faculty of Medicine and Health Sciences at the Atma Jaya Catholic University of Indonesia. Methods: This research method is an analytical observational study using cross-sectional methods. The main variables in this study were dyspepsia, measured using the Rome III questionnaire, and the frequency of spicy food consumption measured using the Food Frequency Questionnaire (FFQ). The sample consisted of 107 people randomly selected. The data was analyzed statistically using the Fischer Exact test. Results: This study showed that 56.1% of respondents frequently eat spicy foods, while the majority, as much as 95.3%, also have dyspepsia. There was a significant correlation between spicy eating habits and dyspepsia, with a p-value of 0.014 (p<0.05). Conclusion: The results showed a statistically significant relationship between spicy eating habits and dyspepsia, so it is recommended for students to reduce spicy food consumption as it can affect the onset of dyspepsia. Keywords: dyspepsia - spicy foods - stomach - Rome III questionnaire - food frequency questionnaire
Therapeutic Potential of Bovine Lactoferrin to Reduce Brain Malondialdehyde Levels in Hyperlipidemia-Induced Sprague-Dawley Rats Havian Daulung Telium; Tena Djuartina; Dion Notario; Linawati Hananta
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.72048

Abstract

Hyperlipidemia is a medical condition that can trigger various diseases, one of which is a neurodegenerative or neurological disease. Lactoferrin is known to have multiple protective activities, one of which is antioxidant. This study aimed to determine the potential of lactoferrin bovine to decrease brain MDA levels in Sprague-Dawley (SD) rats induced by hyperlipidemia. This study was an in vivo experimental study using 24 male SD rats divided into six groups: normal, negative control, positive control, low-dose bovine lactoferrin (LLF), intermediate-dose bovine lactoferrin (ILF), and high-dose bovine lactoferrin (HLF). The diet in the normal group was the standard diet, and the other groups were induced by a high-fat diet (HFD). The intervention for the positive control group was simvastatin. In contrast, LLF, ILF, and HLF groups were given bovine lactoferrin doses of 100, 200, and 400 mg/kgBW, respectively. After seven weeks, all rats were necropsied, and their brains were taken to be tested for malondialdehyde (MDA) levels with an MDA assay kit using a spectrophotometer. Data was then analyzed using Shapiro-Wilk and Levene test and continued with one-way ANOVA and post-hoc Tukey test. There were significant differences (p<0.05) between the negative control group (269.99±13.50 nmol/g weight) and every bovine lactoferrin groups (219.92±22.99 nmol/g weight, 151.60±23.43 nmol/g weight, 158.16±12.33 nmol/g weight, respectively) in reducing brain MDA levels. In summary, all bovine lactoferrin groups (100, 200, and 400 mg/kgBW) significantly reduced brain MDA levels of SD rats in hyperlipidemia condition.
Antioxidant, Antimicrobial, Anti-Inflammatory, and Gut Microbiota Modulation Effects of Kombucha: a Literature Review Hananta, Linawati; Kurniawan, Sandy Vitria; Lonah; Arieselia, Zita; Surjono, Edward; Setiawan, Jonny; Lieputra, Andrew Adhytia; Puspa Bunardi, Dewi; Prayoga Tjendratama, Jason; Vallerie Satyadi, Richelle; Dewi, Rita
Journal of Urban Health Research Vol. 3 No. 2 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i2.6445

Abstract

Introduction: The interest in probiotics has increased significantly in recent years. While most probiotic-containing foods are dairy-based, an increasing number of non-dairy probiotic products have emerged, including kombucha. Kombucha is a fermented tea beverage originating from China, known for its high polyphenol content and potential health benefits. Methods: This literature review aims to provide a comprehensive understanding of the health benefits of kombucha. A systematic search of published studies was conducted using the keywords "kombucha," "antioxidant," "anti-inflammatory," "antimicrobial," and "gut microbiota modulation." Only English-language articles were included, and there was no restriction on publication date to capture the full spectrum of research on kombucha. Results: Kombucha exhibits significant antioxidant capacity, with green tea kombucha demonstrating the highest Ferric Ion Reducing Antioxidant Power (FRAP) due to its high polyphenol content. Additionally, kombucha possesses antimicrobial properties attributed to organic acids, lactones, aldehydes, fatty acids, and alkaloids, which act synergistically. It also exhibits anti-inflammatory effects by inhibiting nitric oxide production and downregulating pro-inflammatory cytokines such as IL-1β and TNF-α. Furthermore, kombucha modulates gut microbiota composition by inhibiting the growth of Gram-negative bacteria, leading to reduced systemic inflammation and oxidative stress. Conclusion: Kombucha, a traditional fermented tea, has notable health benefits, including antioxidant, antimicrobial, anti-inflammatory, and gut microbiota-modulating properties. These findings highlight its potential as a functional beverage for health promotion. Keywords: kombucha – antioxidant - anti-inflammatory – antimicrobial - gut microbiota modulation
25-hydroxyvitamin D Serum Level and Risk of Knee Osteoarthritis in the Elderly Putri, Indira Ayu; Kurniawan, Felicia; Sahusilawane, Isadora Gracia; Hananta, Linawati
Althea Medical Journal Vol 12, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n1.3723

Abstract

Background: Osteoarthritis (OA) is a degenerative joint disease that commonly affects the elderly, particularly in the knees. The OA may lead to chronic pain, physical limitations, depression, and significantly impact an individual's ability to participate in social, occupational, and community activities, ultimately reducing quality of life. Vitamin D has been suggested as a factor that may help reduce the risk of knee OA in older adults. This study aimed to investigate the relationship between 25-hydroxyvitamin D levels and the risk of knee OA among elderly.Methods: This cross-sectional study involved elderly residents of a nursing home in North Jakarta, Indonesia. Data was collected through interviews and physical examinations of both knees following the American Rheumatism Knee OA diagnostic criteria. Participants who met these criteria were classified as high-risk for knee OA. Blood samples were taken to measure 25-hydroxyvitamin D (25(OH)D) levels using an enzyme-linked immunosorbent assay. The Chi-square test was used for bivariate analysis.Results: Of the 48 participants involved, the majority were female (64.6%) and aged between 70-79 years (47.9%). A total of 22.9% of participants were classified as 25(OH)D insufficient and 25% were deficient. Interestingly, 62.5% were at high risk of knee OA. There was a significant association between 25(OH)D levels and the risk of knee OA (p=0.031).Conclusions: The 25(OH)D serum level has a significant association with the risk of knee OA. Increasing sunlight exposure through daily outdoor activities and considering vitamin D supplementation can help mitigate the risk of knee OA, thereby improving bone health and preventing OA in the elderly.
Co-Authors Ageng, Leonardo Ahmad Hamim Sadewa Amelia, Margareta Andarisuta, Putu Suwarastra Arrang, Sherly Tandi Bai Apris Bansai Immanuel Bertha Soegiarto, Bertha Bryan Junius Winata Budiyanti, Ecie Chandra, Gerard Justin Chandra, Valencia Darojatun Ida Dharmalau, Richanda Surya Dion Notario Dion Notario Divara Ariesta Sekar Suryadi, Made Edward Surjono, Edward Endrardewi, Naomi Arumratri Erfen Gustiawan Suwangto, Erfen Gustiawan Eriady, Angely Margaretha Evi Ulina Margaretha Situmorang Fan, Tan Fei Felicia Kurniawan, Felicia Fenny Mariska Ferbian Milas Siswanto Gaverio, Nicholas Francisco Ghea Mangkuliguna Gonga, Audrey Aprilia Hardi, Nicholas Hari Kusnanto Harita, Ester Elida O Havian Daulung Telium Isadora Gracia, Isadora Jonny Setiawan Jonny Setiawan Jonny Setiawan Jontari Hutagalung Joprang, Freggy Spicano Jusni, Louis Fabio Jonathan Kesuma , Deony Maria Kik Hao Samuel Kurniadi, Angela Kurniawan, Sandy Vitria Labaran, Victor Carolus Christiputra Larasati, Victoria Lee, Jocelyn Viony Lieputra, Andrew Adhytia Lonah, Lonah Mahaputra Mahaputra Marcella, Laurie Margareta Amelia Maria Dara Novi Handayani, Maria Dara Novi Mariani Santosa, Mariani Mega Tyas Prihatin Meiliyana Wijaya Monalisa Heryani Mora Octavia Nathalie, Evadia Nawanto Agung Prastowo Novijanti Rintis Oenang, Nydia Olivia, Vera P. Purwono Prayoga Tjendratama, Jason Puspa Bunardi, Dewi Putri, Indira Ayu Rita Dewi Rita Dewi Rita Dewi S. Supargiyono Sahusilawane, Isadora Gracia Satyagraha Ari Winasti Sri Hapsari Wijayanti Sulisthio , Manuel Omar Weki Surilena Hasan Tandi, Sherly Tena Djuartina Tena Djuartina, Tena Theja , Berliana Elyza Suryadi Triwibowo A. Garjito Vallerie Satyadi, Richelle Veronika Maria Sidharta Vetinly Vetinly Via Dolorosa Halilintar Wea, Brigitta Yuliana Widodo, Jerico Tristan Wijaya, Jullyany Waty Wijaya, Meiliyana Yaparto, Selfianti Yolanda, Ellysa Yudy Yuliana Yuliana Yulius Evan Christian Yunisa Astiarani Zita Arieselia