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All Journal Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Program Kreativitas Mahasiswa - Penelitian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JURNAL ENGGANO Martabe : Jurnal Pengabdian Kepada Masyarakat Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Jurnal Ilmiah Farmasi Farmasyifa Jurnal Kefarmasian AKFARINDO Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Bioscientist : Jurnal Ilmiah Biologi Pharmaceutical And Biomedical Sciences Journal (PBSJ) Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Pharmacy Reports Jurnal Pharmacopoeia Jurnal Pengabdian Masyarakat Bangsa JAMAS: Jurnal Abdi Masyarakat Journal of Community Empowerment BATOBO: Jurnal Pengabdian Kepada Masyarakat Bencoolen Journal of Pharmacy Jurnal Pengabdian Kepada Masyarakat Bersinergi Inovatif Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Reza Pertiwi
Program Studi S1 Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Bengkulu, Bengkulu
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Pengaruh Pemberian Perasan Lobak Putih (Raphanus sativus L.) dan Bengkuang (Pachyrhizus erosus L.) terhadap Kadar Glukosa Darah pada Mencit Model Diabetes Pertiwi, Reza; Khodijah, Petri Siti; Aniza, Mifta Violina; Kurniawati, Noval; Kurniati, Eni; Handayani, Dian; Lestari, Dian Fita; Notriawan, Doni
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 1 (2022): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i1.3027

Abstract

Kadar glukosa darah adalah jumlah kandungan glukosa yang ada pada plasma darah. Pengukuran kadar glukosa darah puasa merupakan salah satu metode untuk mengidentifikasi penyakit diabetes melitus pada seseorang. Bengkuang memiliki serat larut air yang dapat memperlambat absorpsi glukosa sehingga dapat menurunkan kadar glukosa darah. Lobak putih memiliki kesamaan jenis dengan bengkuang yaitu merupakan jenis tanaman umbi yang diharapkan memiliki efek yang sama dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian perasan lobak putih dan bengkuang terhadap kadar glukosa darah mencit yang diinduksi aloksan sebagai model diabetes. Mencit dibagi menjadi 8 kelompok dengan pembagian secara random dan dipuasakan selama 8 jam, pada hari ke–0 diukur kadar glukosa darahnya sebagai kadar glukosa darah awal. Kelompok I sebagai kontrol normal yang tidak diberi induksi aloksan dan diberi aquades. Pada kelompok II-VI, mencit diinduksi aloksan dengan dosis 200 mg/kg BB secara intraperitoneal. Setelah aloksan diinduksikan, diukur kadar glukosa darah mencit pada hari ke-3. Setelah didapati kadar glukosa darah mencit yang tinggi, kelompok mencit II diberi aquades, kelompok III diberi glibenklamid 0,013 mg/20 gBB mencit, kelompok IV diberi perasan lobak putih 0,1 ml/20 gBB, kelompok V diberi perasan lobak putih dan bengkuang 2:1, kelompok VI diberi perasan lobak putih dan bengkuang 1:1, kelompok VII diberi perasan lobak putih dan bengkuang 1:2, kelompok VIII diberi perasan bengkuang 0,1 ml/20 gBB. Pemberian perasan lobak putih dan bengkuang dapat menurunkan kadar glukosa darah.
Gastroprotective Effect of Chitosan- Based Formulation with Chromolaena odorata L. and Peperomia pellucida L. Extracts in Ethanol-Induced Gastric Injury in Rats Pertiwi, Reza; Prima Yudha, Sal; Notriawan, Doni; Giri Samudra, Agung; Hanuun, Aanisah; Prameswari, Florencaya Prameswari; Bekti Widiansyah, Alif; Saputra, Hendri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.29054

Abstract

Gastroprotection refers to the effect of compounds that protect the gastric mucosa. Peperomia pellucida L. and Chromolaena odorata L. have demonstrated gastroprotective activities. Chromolaena odorata L., in particular, shows inhibition of gastric mucosal damage due to the presence of secondary metabolites such as flavonoids, phenolics, and tannins. Chitosan is a drug carrier that enhances drug bioavailability and allows pharmacological effects to be achieved at lower doses. This study aims to evaluate the gastroprotective activity of chitosan-based formulations containing Peperomia pellucida L. and Chromolaena odorata L. leaf extracts in rats. The contribution of this research lies in demonstrating the synergistic potential of medicinal plant extracts with chitosan as a delivery system, thereby providing a safer, more effective, and innovative therapeutic strategy for gastric ulcer management. Chitosan formulations containing Peperomia pellucida L. and Chromolaena odorata L. extracts were prepared and tested on male rats. The rats were divided into seven groups: Group I (normal control), Group II (negative control), Group III (positive control, treated with sucralfate), Groups IV and V (treated with chitosan-Chromolaena odorata formulations at doses of 100 and 200 mg/kg BW), and Groups VI and VII (treated with chitosan-Peperomia pellucida formulations at doses of 100 and 200 mg/kg BW). Treatments were administered orally for 14 days. On day 14, one hour after the final treatment, all groups except the normal group received oral absolute ethanol at a dose of 5 mL/kg BW to induce gastric injury. Gastric ulcer index, protection ratio, and histopathological changes were evaluated. The ulcer index values for the negative control, positive control, and treatment groups with doses of 100, 200, and 400 mg/kg BW were 4.89, 0.89, 0.33, 0.11, 1.00, and 0.78, respectively. The chitosan-based formulations containing Chromolaena odorata L. and Peperomia pellucida L. extracts demonstrated significant gastroprotective effects in ethanol-induced gastric injury in rats.
Aktivitas Antibakteri Ekstrak Daun Mangrove (Rhizophora mucronata) pada Bakteri Helicobacter pylori Penyebab Tukak Lambung Pertiwi, Reza; S, Salprima Yudha; Wibowo, Risky Hadi; Notriawan, Doni; Nasution, Riski Padilah; Azhar, Afra Wafiqah
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.9957

Abstract

Mangrove (Rhizophora mucronata) is a plant that can be used as an antibacterial because it contains several secondary metabolite compounds such as saponins and flavonoids which can inhibit bacterial growth. This research aims to determinehe antibacterial activity of mangrove leaves (Rhizophora mucronata) in inhibiting the growth of Helicobacter pylori bacteria. This research is an in vitro study using the agar dilution method for 2-5 days. The treatment groups consisted of negative, positive (co-trimoxazole), ethanol extract of mangrove leaves (Rhizophora mucronata) with concentrations of6.25%, 12.5%, 25% and 50%. The treatment was carried out by adding the Helicobacter pylori suspension to a petri dish containing agar media. Observations were made to see whether bacteria grew in the media. The data is then analyzed and broken down from the results of calculating the diameter of the inhibition zone. The test results showed that the ethanol extract of mangrove leaves (Rhizophora mucronata) had antibacterial activity in the weak category in inhibiting the growth of Helicobacter pylori bacteria. This antibacterial activity can be caused because mangrove leaves (Rhizophora mucronata) contain secondary metabolite compounds with an antibacterial mechanism of action, so this is in line with the results of this study.
Evaluasi Kasus Anemia Defisiensi Fe Pada Santri Pesantren Pre Dan Post Konsumsi Pil Tambah Darah Indah Sari, Puput Tri; Putri, Yona Harianti; Martono, Agus; Pertiwi, Reza; Sari, Rose Intan Perma; Rahmawati, Reza
Jurnal Pharmacopoeia Vol 3 No 2 (2024): September 2024
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v3i2.654

Abstract

Anemia adalah penyakit yang sering ditemui pada masyarakat Indonesia. Prevalensi anemia pada remaja putri di Kota Bengkulu cukup tinggi yakni mencapai 43%. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian tablet tambah darah terhadap kadar hemoglobin santri di pondok pesantren Darul Mustofa kabupaten Seluma. Sampel pada penelitian ini sebanyak 60 orang dengan pengambilan sampel metode purposive sampling. Pengumpulan data dilakukan dengan wawancara, menggunakan alat Easy Touch GCHb (Glucose, Cholesterol, Hemoglobin) dan kuesioner. Hasil penelitian menunjukkan bahwa dari 25 santri putri, 9 diantaranya mengalami anemia namun setelah pemberian tablet tambah darah menurun menjadi hanya 3 orang. Pada santri laki-laki sebanyak 35 orang yang tidak mengalami anemia. Dari uji statistik Paired sampel t-test diperoleh hasil P value = 0001 < α (0.05), sehingga bisa disimpulkan bahwa terdapat kenaikan atau perubahan yang signifikan sebelum dan sesudah pemberian tablet tambah darah.
Drug utilization patterns and dosing appropriateness of antirheumatic drugs in outpatients with rheumatoid arthritis at Harapan dan Doa General Hospital, Bengkulu City, Indonesia Juniarti, Silvia; Rahmawati, Reza; Maryanti, Evi; Handayani, Dian; Sari, Delia Komala; Sari, Dwi Dominica; Pertiwi, Reza; Oktarini, Rizki; Wulandari, Septi
Pharmacy Reports Vol. 5 No. 2 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.106

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that requires long-term treatment and careful management. Inappropriate therapy may increase morbidity and mortality; therefore, appropriate drug selection and prescribing are essential to improving healthcare quality, particularly in hospital settings. This study aimed to determine the prescribing patterns of medications for patients with rheumatoid arthritis at Harapan dan Doa General Hospital in Bengkulu City. A descriptive, quantitative design was employed, utilizing a total sampling technique. The results showed that, based on drug combination patterns, most patients received triple-drug therapy (46.66%), followed by dual therapy (31.61%) and monotherapy (21.64%). The most common monotherapy was etoricoxib (8.33%), while the most frequent two-drug combination was methotrexate and methylprednisolone (11.66%). The predominant three-drug combination consisted of methotrexate, methylprednisolone, and meloxicam (15%). Based on therapeutic class, the prescribed drugs included nonsteroidal anti-inflammatory drugs (NSAIDs) (80%), corticosteroids (71.66%), disease-modifying antirheumatic drugs (DMARDs) (61.66%), and analgesics (10%). Although all prescribed drugs followed the recommended dosing guidelines, NSAIDs and corticosteroids were used more frequently than methotrexate. This pattern may reflect variations in clinical practice or differences in patient characteristics.
Assessment of the subchronic toxicity of ethanol extract of Merdeka-leaves (Chromolaena odorata L.) on SGOT, SGPT, and histological alterations in the kidneys and liver of male rats Pertiwi, Reza; Azhar, Afra Wafiqah; Dominica, Dwi; Yudha, Salprima; Rahmawati, Reza; Putri, Yona Harianti
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30278

Abstract

The Merdeka plant (Chromolaena odorata L.) is known for its various pharmacological benefits, including gastroprotection, antibacterial, antihyperglycemic effects, and wound healing promotion. To ensure safe use in the community, it is important to evaluate its potential toxicity. This study examined the effects of ethanol extract of Merdeka leaf (C. odorata) on liver function by measuring the levels of serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvate transaminase (SGPT) in male rats (Rattus norvegicus). Twenty-five male Wistar rats were split into five groups: three treatment groups that received ethanol extract at doses of 150 mg/kg BW, 300 mg/kg BW, and 600 mg/kg BW, a negative control group that received 0.5% Na CMC, and a normal control group that received no treatment. For 28 days, the extract was taken orally every day. Following surgery, liver and kidney tissues were removed for histology on day 29, and blood samples were obtained via the aorta. The findings demonstrated that rats administered 600 mg/kg BW of ethanol extract had significantly greater SGOT and SGPT levels than controls (p < 0.05), suggesting that high dose of Merdeka leaf extract may have an impact on kidney and liver functions.
PENYULUHAN DAN PEMBUATAN PAPER SOAP (SABUN KERTAS) BAGI MASYARAKAT DI KELURAHAN PEMATANG GUBERNUR KOTA BENGKULU UNTUK MENINGKATKAN KESADARAN MENCUCI TANGAN SEBAGAI LANGKAH AWAL PENCEGAHAN WABAH COVID-19 Wibowo, Risky Hadi; Sipriyadi, Sipriyadi; Pertiwi, Reza; Hidayah, Thoriqul; Medani, Della Indah; Wulandari, Gustina Dwi; Rosianti, Nadya
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 4, No 1 (2021): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v4i1.317-324

Abstract

Hand is the main transmission pathogen entry into the body which is the part of the body that is most often in direct contact with other limbs and surrounding objects. The importance of maintaining hand hygiene by always washing hands with soap is the first step in preventing transmission of COVID-19. However, during a pandemic like this, it will be difficult to find soap available everywhere, and tends to be hard to carry all the time. Therefore, this service aims to invite the people of Pematang Gubernur, Bengkulu City, to use paper soap because it is easier to use its use and flexible to carry anywhere besides being an effort to prevent the COVID-19 outbreak, it can also add to new information and skills for residents in making attractive soaps. The feedback response given by the community service implementation team to the community service participants resulted in a positive response to this activity, who initially did not know about making and use of paper soap and became aware of this. 
Hubungan Pengetahuan dengan Status Vaksinasi COVID-19 pada Ibu Hamil di Wilayah DKI Jakarta: Knowledge and COVID-19 Vaccination Status of Pregnant Women in DKI Jakarta Pertiwi, Reza Dara; Ayubi, Dian
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 5 No. 4 (2022): April 2022
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.95 KB) | DOI: 10.56338/mppki.v5i4.2208

Abstract

Latar Belakang: Vaksinasi dibutuhkan untuk menekan angka kejadian COVID-19 terutama pada populasi rentan seperti ibu hamil. Ibu hamil biasanya memiliki keinginan yang lebih rendah dan kekhawatiran yang lebih tinggi mengenai vaksin dibanding populasi umum, hal ini karena kurangnya pengetahuan mengenai vaksin. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dengan status vaksinasi COVID-19 pada ibu hamil di DKI Jakarta setelah mengendalikan variable lain (usia, pekerjaan, penghasilan, pendidikan, usia kehamilan, status gravida, penyakit penyerta, dan pengalaman imunisasi TT). Status vaksinasi dipilih sebagai indikator perilaku terbuka dari perilaku vaksinasi. Metode: Penelitian dilakukan secara kuantitatif menggunakan desain penelitian cross sectional pada ibu hamil yang berdomisili di DKI Jakarta dengan menyebarkan kuesioner melalui google form. Penelitian ini diikuti oleh 149 responden yang memenuhi kriteria inklusi yang sudah ditentukan. Analisis data menggunakan SPSS 22 secara univariat dalam bentuk distribusi frekuensi dan analisis multivariate dilakukan menggunakan regresi logistic ganda model faktor risiko. Hasil: Dari hasil penelitian didapatkan 65,8% ibu hamil telah melakukan vaksinasi dan 64 orang (65,3%) diantaranya sudah tervaksinasi lengkap dua dosis. Pengetahuan memiliki hubungan signifikan dengan status vaksinasi (pValue = 0,001). Kesimpulan: Ibu hamil yang memiliki pengetahuan rendah, memiliki risiko untuk tidak melakukan vaksinasi sebesar 7,062 kali dibandingkan ibu hamil yang memiliki pengetahuan tinggi setelah dikontrol variable penghasilan. Meningkatkan pengetahuan mengenai vaksin COVID-19 dapat menjawab keraguan ibu hamil untuk melakukan vaksinasi.
Co-Authors Aanisah Hanuun Agung Giri Samudra Agus Martono Agustianto, Sandy Alawiya Simanullang, Khairatul Alfarizi, Aziz Aniza, Mifta Violina Asdim Az Zahra, Farah Azhar, Afra Wafiqah Bekti Widiansyah, Alif Delia Komala Sari, Delia Komala Desi Novita Reviana, Desi Novita Dhea Ananda Dian Ayubi Dian Fita Lestari Dian Handayani Dian Handayani Dominica, Dwi Dyah Fitriani Eni Kurniati, Eni Ernis, Gustria Evi Maryanti Fadhila, Muhammad Adeng Fadila Jeni Salsabila Fadila, Muhammad Adeng Feby R.A Putri Fitri Ramadhanti Hanuun, Aanisah Hari Marta Saputra Hari Marta Saputra Harianti Putri, Yona Hendri Saputra Hidayah, Thoriqul Hizkia Puspa Pertiwi Ikhsan Ikhsan Ilfanisari, Vinolla Indah Sari, Puput Tri Iwan Mahmud, Iwan Juniarti, Silvia Kamilla Putri, Dwi Khaliq, Iyas Nur Khodijah, Petri Siti Komala Sari, Delia Kurnia, Ridho Kurniawati, Noval Lestari, Dian Fita Lestari, Mustika Dewi Medani, Della Indah Mutyarini, Afiska Nasution, Riski Padilah Nesbah, Nesbah Nofa Risma Azis, Nofa Risma Notriawan, Doni Noval Kurniawati Nurjali, Zavira Oktarini, Rizki Oky Hermansyah Petri Siti Khodijah Prameswari, Florencaya Prameswari Prima Yudha, Sal Putri Nurlita, Septia Putri, Fadilla Aliyah Putri, Khoirunnisa Awaliyah Putri, Yona Harianti Radestian, Juwita Triananda Rahmawati, Reza Ramadhani, Nasywa Fathia Reni Susanti Riana Versita Risky Hadi Wibowo Rochmah Supriati Rosianti, Nadya SALPRIMA YUDHA S Salsabila, Adinda Okta Sani K, Fathnur Santi Nurul Kamilah Sari, Dwi Dominica Sari, Rose Intan Perma SEPTI WULANDARI Sihombing, Imelda Simatupang, Muhaida Ramzany Sipriyadi Syahidah, Aminah Syalfinaf Manaf Triawan, Deni Agus Tya Chalifatul Welly Darwis Wibowo, Aprillia Devi Wibowo, Risky Wibowo, Risky Hadi Wulandari, Gustina Dwi Yona Harianti Putri