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All Journal Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Program Kreativitas Mahasiswa - Penelitian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JURNAL ENGGANO Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Jurnal Ilmiah Farmasi Farmasyifa Jurnal Kefarmasian AKFARINDO Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Bioscientist : Jurnal Ilmiah Biologi Pharmaceutical And Biomedical Sciences Journal (PBSJ) Pharmacy Reports Jurnal Pharmacopoeia Jurnal Pengabdian Masyarakat Bangsa JAMAS: Jurnal Abdi Masyarakat Journal of Community Empowerment BATOBO: Jurnal Pengabdian Kepada Masyarakat Bencoolen Journal of Pharmacy Jurnal Pengabdian Kepada Masyarakat Bersinergi Inovatif Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Reza Pertiwi
Program Studi S1 Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Bengkulu, Bengkulu
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Pengaruh Pemberian Perasan Lobak Putih (Raphanus sativus L.) dan Bengkuang (Pachyrhizus erosus L.) terhadap Kadar Glukosa Darah pada Mencit Model Diabetes Pertiwi, Reza; Khodijah, Petri Siti; Aniza, Mifta Violina; Kurniawati, Noval; Kurniati, Eni; Handayani, Dian; Lestari, Dian Fita; Notriawan, Doni
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 1 (2022): Februari
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i1.3027

Abstract

Kadar glukosa darah adalah jumlah kandungan glukosa yang ada pada plasma darah. Pengukuran kadar glukosa darah puasa merupakan salah satu metode untuk mengidentifikasi penyakit diabetes melitus pada seseorang. Bengkuang memiliki serat larut air yang dapat memperlambat absorpsi glukosa sehingga dapat menurunkan kadar glukosa darah. Lobak putih memiliki kesamaan jenis dengan bengkuang yaitu merupakan jenis tanaman umbi yang diharapkan memiliki efek yang sama dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian perasan lobak putih dan bengkuang terhadap kadar glukosa darah mencit yang diinduksi aloksan sebagai model diabetes. Mencit dibagi menjadi 8 kelompok dengan pembagian secara random dan dipuasakan selama 8 jam, pada hari ke–0 diukur kadar glukosa darahnya sebagai kadar glukosa darah awal. Kelompok I sebagai kontrol normal yang tidak diberi induksi aloksan dan diberi aquades. Pada kelompok II-VI, mencit diinduksi aloksan dengan dosis 200 mg/kg BB secara intraperitoneal. Setelah aloksan diinduksikan, diukur kadar glukosa darah mencit pada hari ke-3. Setelah didapati kadar glukosa darah mencit yang tinggi, kelompok mencit II diberi aquades, kelompok III diberi glibenklamid 0,013 mg/20 gBB mencit, kelompok IV diberi perasan lobak putih 0,1 ml/20 gBB, kelompok V diberi perasan lobak putih dan bengkuang 2:1, kelompok VI diberi perasan lobak putih dan bengkuang 1:1, kelompok VII diberi perasan lobak putih dan bengkuang 1:2, kelompok VIII diberi perasan bengkuang 0,1 ml/20 gBB. Pemberian perasan lobak putih dan bengkuang dapat menurunkan kadar glukosa darah.
Gastroprotective Effect of Chitosan- Based Formulation with Chromolaena odorata L. and Peperomia pellucida L. Extracts in Ethanol-Induced Gastric Injury in Rats Pertiwi, Reza; Prima Yudha, Sal; Notriawan, Doni; Giri Samudra, Agung; Hanuun, Aanisah; Prameswari, Florencaya Prameswari; Bekti Widiansyah, Alif; Saputra, Hendri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.29054

Abstract

Gastroprotection refers to the effect of compounds that protect the gastric mucosa. Peperomia pellucida L. and Chromolaena odorata L. have demonstrated gastroprotective activities. Chromolaena odorata L., in particular, shows inhibition of gastric mucosal damage due to the presence of secondary metabolites such as flavonoids, phenolics, and tannins. Chitosan is a drug carrier that enhances drug bioavailability and allows pharmacological effects to be achieved at lower doses. This study aims to evaluate the gastroprotective activity of chitosan-based formulations containing Peperomia pellucida L. and Chromolaena odorata L. leaf extracts in rats. The contribution of this research lies in demonstrating the synergistic potential of medicinal plant extracts with chitosan as a delivery system, thereby providing a safer, more effective, and innovative therapeutic strategy for gastric ulcer management. Chitosan formulations containing Peperomia pellucida L. and Chromolaena odorata L. extracts were prepared and tested on male rats. The rats were divided into seven groups: Group I (normal control), Group II (negative control), Group III (positive control, treated with sucralfate), Groups IV and V (treated with chitosan-Chromolaena odorata formulations at doses of 100 and 200 mg/kg BW), and Groups VI and VII (treated with chitosan-Peperomia pellucida formulations at doses of 100 and 200 mg/kg BW). Treatments were administered orally for 14 days. On day 14, one hour after the final treatment, all groups except the normal group received oral absolute ethanol at a dose of 5 mL/kg BW to induce gastric injury. Gastric ulcer index, protection ratio, and histopathological changes were evaluated. The ulcer index values for the negative control, positive control, and treatment groups with doses of 100, 200, and 400 mg/kg BW were 4.89, 0.89, 0.33, 0.11, 1.00, and 0.78, respectively. The chitosan-based formulations containing Chromolaena odorata L. and Peperomia pellucida L. extracts demonstrated significant gastroprotective effects in ethanol-induced gastric injury in rats.
Aktivitas Antibakteri Ekstrak Daun Mangrove (Rhizophora mucronata) pada Bakteri Helicobacter pylori Penyebab Tukak Lambung Pertiwi, Reza; S, Salprima Yudha; Wibowo, Risky Hadi; Notriawan, Doni; Nasution, Riski Padilah; Azhar, Afra Wafiqah
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.9957

Abstract

Mangrove (Rhizophora mucronata) is a plant that can be used as an antibacterial because it contains several secondary metabolite compounds such as saponins and flavonoids which can inhibit bacterial growth. This research aims to determinehe antibacterial activity of mangrove leaves (Rhizophora mucronata) in inhibiting the growth of Helicobacter pylori bacteria. This research is an in vitro study using the agar dilution method for 2-5 days. The treatment groups consisted of negative, positive (co-trimoxazole), ethanol extract of mangrove leaves (Rhizophora mucronata) with concentrations of6.25%, 12.5%, 25% and 50%. The treatment was carried out by adding the Helicobacter pylori suspension to a petri dish containing agar media. Observations were made to see whether bacteria grew in the media. The data is then analyzed and broken down from the results of calculating the diameter of the inhibition zone. The test results showed that the ethanol extract of mangrove leaves (Rhizophora mucronata) had antibacterial activity in the weak category in inhibiting the growth of Helicobacter pylori bacteria. This antibacterial activity can be caused because mangrove leaves (Rhizophora mucronata) contain secondary metabolite compounds with an antibacterial mechanism of action, so this is in line with the results of this study.
Evaluasi Kasus Anemia Defisiensi Fe Pada Santri Pesantren Pre Dan Post Konsumsi Pil Tambah Darah Indah Sari, Puput Tri; Putri, Yona Harianti; Martono, Agus; Pertiwi, Reza; Sari, Rose Intan Perma; Rahmawati, Reza
Jurnal Pharmacopoeia Vol 3 No 2 (2024): September 2024
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v3i2.654

Abstract

Anemia adalah penyakit yang sering ditemui pada masyarakat Indonesia. Prevalensi anemia pada remaja putri di Kota Bengkulu cukup tinggi yakni mencapai 43%. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian tablet tambah darah terhadap kadar hemoglobin santri di pondok pesantren Darul Mustofa kabupaten Seluma. Sampel pada penelitian ini sebanyak 60 orang dengan pengambilan sampel metode purposive sampling. Pengumpulan data dilakukan dengan wawancara, menggunakan alat Easy Touch GCHb (Glucose, Cholesterol, Hemoglobin) dan kuesioner. Hasil penelitian menunjukkan bahwa dari 25 santri putri, 9 diantaranya mengalami anemia namun setelah pemberian tablet tambah darah menurun menjadi hanya 3 orang. Pada santri laki-laki sebanyak 35 orang yang tidak mengalami anemia. Dari uji statistik Paired sampel t-test diperoleh hasil P value = 0001 < α (0.05), sehingga bisa disimpulkan bahwa terdapat kenaikan atau perubahan yang signifikan sebelum dan sesudah pemberian tablet tambah darah.
The Effect of Administration Platycerium bifurcatum (Cav.) C.Chr  Extract on Total Bilirubin Levels and Hepatosomatic Index Values of Ethanol-Induced Rats Saputra, Hendri; Pertiwi, Reza; Sari, Delia Komala; Wulandari, Septi; Rahmawati, Reza
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49112

Abstract

The Liver is a vital metabolic organ. Liver injury is related to an inflammatory process that increases the hepatosomatic index (HSI). One indicator of liver damage is increased total bilirubin levels (hyperbilirubinemia). Currently, hyperbilirubinemia treatment is still limited to irradiation therapy and exchange transfusions, because there is no pharmacological specific treatment. This study aimed to evaluate the hepatoprotective effect of Platycerium bifurcatum (Cav.) C.Chr extract on total bilirubin levels and the hepatosomatic index (HSI) in male white rats. A laboratory-based experimental design was employed using a post-test only control group, involving 35 rats randomly assigned to seven groups: normal control, negative control, positive control (sacatonic active), solvent control (Na CMC), and treatment groups receiving ethanol extract at doses of 50 mg/kgBW, 100 mg/kgBW, and 200 mg/kgBW.The treatment was administered orally for 14 consecutive days. On the final day, all rats (except the normal group) were induced with absolute ethanol at 2 mL/200 gBW. After 12 hours, the animals were euthanized for liver and blood sample collection. Total bilirubin levels were measured, and the hepatosomatic index was calculated. Data were analyzed using one-way ANOVA followed by LSD post hoc test. The results demonstrated that administration of Platycerium bifurcatum (Cav.) C.Chr extract significantly reduced total bilirubin levels and HSI, particularly at doses of 50 mg/kgBW and 100 mg/kgBW, compared to the negative control group (p<0.05). These findings suggest that Platycerium bifurcatum (Cav.) C.Chr ethanol extract exhibits a hepatoprotective effect by reducing total bilirubin levels and HIS.
Drug utilization patterns and dosing appropriateness of antirheumatic drugs in outpatients with rheumatoid arthritis at Harapan dan Doa General Hospital, Bengkulu City, Indonesia Juniarti, Silvia; Rahmawati, Reza; Maryanti, Evi; Handayani, Dian; Sari, Delia Komala; Sari, Dwi Dominica; Pertiwi, Reza; Oktarini, Rizki; Wulandari, Septi
Pharmacy Reports Vol. 5 No. 2 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.106

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that requires long-term treatment and careful management. Inappropriate therapy may increase morbidity and mortality; therefore, appropriate drug selection and prescribing are essential to improving healthcare quality, particularly in hospital settings. This study aimed to determine the prescribing patterns of medications for patients with rheumatoid arthritis at Harapan dan Doa General Hospital in Bengkulu City. A descriptive, quantitative design was employed, utilizing a total sampling technique. The results showed that, based on drug combination patterns, most patients received triple-drug therapy (46.66%), followed by dual therapy (31.61%) and monotherapy (21.64%). The most common monotherapy was etoricoxib (8.33%), while the most frequent two-drug combination was methotrexate and methylprednisolone (11.66%). The predominant three-drug combination consisted of methotrexate, methylprednisolone, and meloxicam (15%). Based on therapeutic class, the prescribed drugs included nonsteroidal anti-inflammatory drugs (NSAIDs) (80%), corticosteroids (71.66%), disease-modifying antirheumatic drugs (DMARDs) (61.66%), and analgesics (10%). Although all prescribed drugs followed the recommended dosing guidelines, NSAIDs and corticosteroids were used more frequently than methotrexate. This pattern may reflect variations in clinical practice or differences in patient characteristics.
Co-Authors Aanisah Hanuun Agung Giri Samudra Agus Martono Agustianto, Sandy Alawiya Simanullang, Khairatul Alfarizi, Aziz Aniza, Mifta Violina Asdim Az Zahra, Farah Azhar, Afra Wafiqah Bekti Widiansyah, Alif Delia Komala Sari, Delia Komala Desi Novita Reviana, Desi Novita Dhea Ananda Dian Fita Lestari Dian Handayani Dian Handayani Dominica, Dwi Dyah Fitriani Eni Kurniati, Eni Ernis, Gustria Evi Maryanti Fadhila, Muhammad Adeng Fadila Jeni Salsabila Fadila, Muhammad Adeng Feby R.A Putri Fitri Ramadhanti Hanuun, Aanisah Hari Marta Saputra Hari Marta Saputra Harianti Putri, Yona Hendri Saputra Hizkia Puspa Pertiwi Ikhsan Ikhsan Ilfanisari, Vinolla Indah Sari, Puput Tri Iwan Mahmud, Iwan Juniarti, Silvia Kamilla Putri, Dwi Khaliq, Iyas Nur Khodijah, Petri Siti Komala Sari, Delia Kurnia, Ridho Kurniawati, Noval Lestari, Dian Fita Lestari, Mustika Dewi Mutyarini, Afiska Nasution, Riski Padilah Nesbah, Nesbah Nofa Risma Azis, Nofa Risma Notriawan, Doni Noval Kurniawati Nurjali, Zavira Oktarini, Rizki Oky Hermansyah Petri Siti Khodijah Prameswari, Florencaya Prameswari Prima Yudha, Sal Putri Nurlita, Septia Putri, Fadilla Aliyah Putri, Khoirunnisa Awaliyah Putri, Yona Harianti Radestian, Juwita Triananda Rahmawati, Reza Ramadhani, Nasywa Fathia Reni Susanti Riana Versita Risky Hadi Wibowo Rochmah Supriati SALPRIMA YUDHA S Salsabila, Adinda Okta Sani K, Fathnur Santi Nurul Kamilah Sari, Dwi Dominica Sari, Rose Intan Perma SEPTI WULANDARI Sihombing, Imelda Simatupang, Muhaida Ramzany Sipriyadi Syahidah, Aminah Syalfinaf Manaf Triawan, Deni Agus Tya Chalifatul Welly Darwis Wibowo, Aprillia Devi Wibowo, Risky Wibowo, Risky Hadi Yona Harianti Putri