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Journal : jurnal kesehatan

Identification Target Genes for Potential Biomarkers in Endometriosis from Transcriptomics Database Zahlina, Dian; Iskandar, Benni; Adikusuma, Wirawan; Yusuf, Muhammad; Tiara Fani, Rifia; Ocktariyana, Ocktariyana; Darmawi, Darmawi
Jurnal Kesehatan - STIKes Prima Nusantara Vol 17 No 1 (2026): Jurnal Kesehatan Volume 17 Nomor 1 Tahun 2026 (on progress)
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v17i1.1281

Abstract

Endometriosis is a common benign gynecological disease characterized by the ectopic growth of endometrial tissue. Its pathogenesis is influenced by complex genetic and epigenetic factors, making diagnosis and treatment challenging. This study aimed to identify molecular pathways and candidate genes associated with endometriosis using transcriptomic data. Three datasets (GSE7307, GSE23339, and GSE25628) were retrieved from the Gene Expression Omnibus (GEO) database and analyzed to identify differentially expressed genes (DEGs). A total of 339 intersecting DEGs were obtained and subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The results indicated enrichment in biological processes related to epithelial cell proliferation and angiogenesis, cellular components associated with the lysosomal lumen and extracellular matrix, and molecular functions involving Wnt-activated receptor activity and low-density lipoprotein particle binding. Ten genes (TAGLN, C7, TCF21, GATA6, GPC3, FZD7, TCEAL2, KLF2, FMO1, and HOXC6) were identified as potential candidate biomarkers. These findings provide preliminary molecular insights into endometriosis and may support future experimental and clinical studies for biomarker development.
Co-Authors A, Yufrizal Ademi, Gressha Vionalle Aini, Sabrina Ambiyar, Ambiyar Amiruddin Amiruddin Anas, Marnisyah Aneka Firdaus Angraini, Nani Angreini, Meliyantika Annisa, Aiza Apriyan, Dian Arenja, Regina Trisya Arman Sayuti Arsih, Ulfi Widi Arwizet Arwizet, Arwizet Awaluddin Awaluddin BENNI ISKANDAR Beočanin, Anđelija Budi Syahri budianto panjaitan Chatarina Umbul Wahyuni Cut Nanda Defira, Cut Nanda Dewi Anggraini Dion, Selin Dwinna Aliza Dwisnu, Erlian Erianza, Dava Erwin Erwin Esha, Indi Etriwati E Fadhil Fuad Rachman Fakhruddin Fakhruddin Ferdian, Riyan Firdaus Firdaus Fitriyani Fitriyani Giovani, Edo Habibie, Maulana Hasan, Denny Irmawati Hasan, Maryatun Helmi, T. Zahrial Heni Pujiastuti Husni Hidayat Idi Warsah Iko imelda arisa, Iko imelda INDRA YOVI Irma Dewiyanti Irwin Bizzy Jamil, Kurnian Fitri Kamaludin, Saman Khairani, Muhammad Khairussyifa, Najmi Kurnia F. Jamil Kusuma, Herwin Wijaya Lalu Muhammad Irham Liansyah, Tita M. M Amin Indra Putra M. Nur Salim M. Syukri Ismail Maimun Syukri, Maimun Maryanti, Yossi Moliwati, Moliwati MS, Firdaus Muhammad Yusuf Mukamal, M. Farda Insan Muslim Akmal N. Nazaruddin Nathania, Auren Ningrum, Sania Devita Nora Usrina Nurani, Erla Nurhaspika, Nurhaspika Nuzul Asmilia Ocktariyana, Ocktariyana Ofiani, Oktawini Pangaribuan, Machyuddin Tumpak Marojahan Prawana, Yogi Ramadhani, Fitria Sari Razali Daud Razali, Renardy Reza Roza, Putri Diana S, Donel Safika S, Safika Saud, Eddy Setiawan, Sepdirama Sibuan, Sibuan Siti Aisyah Siti Nurkasanah Solly Aryza Sri Melati Munir Sugeng Prasetyo Sugito - Suhandri, Wiwin Sukma, Zahwa Tamara Sumanto Sumanto Suparno Suparno Syafruddin Syafruddin Tabrani, Tabrani Taufiq Taufiq Teuku Zahrial Helmi Tiara Fani, Rifia Ummu Balqis Usman, Said Wenny Novita Sari Winarto Winarto Wirawan Adikusuma Wiwit Ade Fidiawati Yenni Yusriani Yuliani Yuliani Yura, Sawva Zahlina, Dian Zahra, Leina Putri Zahtamal Zahtamal ZAINAL ABIDIN MUCHLISIN Zamzami, Rumi Sahara Zarfiardy Aksa Fauzi Zikra, Izza Fattalia Zulkifli, Baidillah Zuraidawati Zuraidawati, Zuraidawati