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Gunanti .
Departemen Klinik, Reproduksi Dan Patologi Fakultas Kedokteran Hewan Institut Pertanian Bogor, Bogor
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EFFECTIVENESS OF STEM CELL THERAPY IN MYOCARDIAL INFARCTION BASED ON ENZYME ACTIVITY AND LIVER HISTOPATOLOGY Rahmi, Riska Asria Sa'adatur; Gunanti, Gunanti; Noviana, Deni; Harlina, Eva
Jurnal Kedokteran Hewan Vol 18, No 4 (2024): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i4.30881

Abstract

This research aims to study the effectiveness of single placenta stem cell therapy (ST) or a combination of cardiomyocyte co-cultures in pigs with myocardial infarction based on enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity as well as liver histopathology. Nine pigs were divided into three treatment groups (K1, K2, and K3) consisting of three pigs per group. Blood sampling was performed one-hour pre-surgery, post-ST-elevation, and eight weeks post-therapy. The experimental animals were treated for eight weeks, then euthanized and necropsied for liver removal. ALT and AST values were analyzed using one-way analysis of variance (ANOVA) and followed by Tukey's test. Histopathological changes in liver tissue were analyzed using Image J 1.53 software, and the measured data were analyzed using oneway ANOVA. The results showed an increase in the ALT and AST values of the three treatment groups on post-ST-elevation blood sampling but were still within normal limits except for K1. ALT and AST values decreased significantly (P0.05) in the group treated with single placental stem cell (K2) or combined cardiomyocyte co-culture (K3). The ALT value of K3 decreased but not significantly (P0.05) compared to K2. The AST value of K3 decreased significantly (P0.05) but was not significantly different (P0.05) compared to K2. The liver tissue showed circulatory disturbances in the central venous congestion, portal vein, sinusoidal dilatation and congestion, and hepatocyte changes in the form of centrilobular necrosis and hydropic degeneration. Stem cell therapy alone (K2) or in combination with cardiomyocyte co-culture (K3) had similar percentage of centrilobular necrosis which was significantly lower than K1 (P0.05). Hepatocyte hydropic degeneration on K2 was classified as mild, whereas on K3 was classified as moderate. As conclusion, administration of placental stem cell therapy alone or in combination with cardiomyocyte co-culture can reduce ALT and AST values and could repair liver tissue.
EFFECTIVENESS OF SUGAR DRESSING TREATMENT OF LAWANG SUGAR CANE ORIGIN ON INCISIONS WOUND HEALING OF RABBIT SKIN Rezeki, Sri; Gunanti, Gunanti; Subangkit, Mawar
Jurnal Kedokteran Hewan Vol 18, No 3 (2024): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i3.33524

Abstract

The aim of this research was to determine the effectiveness of sugar dressing treatment from Lawang sugar cane on incision wound healing process of rabbit skin. Nine New Zealand white rabbits were divided into three treatment groups with three rabbits per group. In negative control group (KN), the wounds were only treated with distilled water, while in SD60 and SD100 groups, the wounds were treated with 60% and 100% sugar solution, respectively. The treatment was given once daily for 7 days. The results showed that the sugar dressing treatments have significant effect (P0.05) on the size of the wound area and increased the collagen density, but did not have significant effect on the remaining length of the wound.Based on the results of the study, it can be concluded that sugar dressing dressing treatment from Lawang sugar cane is effective in increasing collagen density in the wound healing process.
EFFECTIVENESS OF STINGLESS BEE HONEY IN INCREASING COLLAGEN IN THE SKIN WOUND HEALING OF RATS Maulana, M Ridha; Gunanti, Gunanti; Subangkit, Mawar
Jurnal Kedokteran Hewan Vol 19, No 1 (2025): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v19i1.44574

Abstract

The purpose of this study was to determine the effectiveness of stingless bee honey in healing incision wounds on rat skin based on collagen formation. A total of 30 Sprague-Dawley rats were divided into 3 observation days (n= 10 rats). The incisions performed on all rats but given different treatments. In negative control group, the incision wound was not treated, while in positive control, the incision was treated with bioplacentom. Rats in treatment 1 and treatment 2, the incision wound were treated with 75% and 100% stingless bee honey treatment was given once a day for 7 days. The results showed that the 75% and 100% stingless bee honey groups showed a significant effect on reducing the wound length and increasing the collagen density (P0.05). As conclusion, stingless bee honey is effective in increasing collagen density in the wound healing process of rat.
Pengenalan Bulan Hijriah Melalui Media Smart Box Terhadap Santri TP Al-Qur’an Syuhada Sardimi, Sardimi; Gunanti, Gunanti; Amelia Putri, Yusika; Surawan, Surawan
JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) Vol. 6 No. 2 (2025)
Publisher : Politeknik Piksi Ganesha Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37339/jurpikat.v6i2.2375

Abstract

Artikel ini dilatarbelakangi oleh minimnya penggunaan media dalam penyampaian materi yang menarik seperti Smart Box di TP Al-Qur'an Syuhada. Smart Box merupakan alat peraga berbentuk persegi yang terdiri dari empat sisi yang berisi kartu gambar dan kartu kata. Pentingnya penggunaan media Smart Box dalam kegiatan pembelajaran adalah untuk menarik minat siswa dalam mempelajari materi yang disampaikan, salah satunya materi bulan Hijriah. Penggunaan media pembelajaran Smart Box diharapkan dapat menjadi solusi inovatif untuk meningkatkan pemahaman dan keterlibatan siswa dalam mempelajari materi tersebut. Metode yang digunakan adalah Service Learning (SL). Berdasarkan hasil penggunaan media Smart Box dalam penyampaian materi bulan Hijriah telah banyak mengalami kemajuan, antara lain: meningkatnya pemahaman dan keterampilan siswa serta semangat belajar terkait materi bulan Hijriah. Adapun untuk penelitian selanjutnya diharapkan dapat menggunakan media atau strategi yang menarik dalam pembelajaran, sebagai salah satu cara untuk meningkatkan pemahaman, semangat, dan keterampilan siswa.
Laporan Kasus: Suspek Hidronefrosis akibat Tumor Prostat pada Anjing di Rumah Sakit Hewan Pendidikan (RSHP) Sekolah Kedokteran Hewan dan Biomedis (SKHB) IPB University Wibowo, Deny Setyo; Wulansari, Retno; Esfandiari, Anita; Widhyari, Sus Derthi; Wijaya, Agus; Gunanti, Gunanti; Fitri, Arni Diana
Jurnal Sain Veteriner Vol 43, No 1 (2025): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.102272

Abstract

Seekor anjing jantan ras domestik berumur 16 tahun dibawa ke Rumah Sakit Hewan Pendidikan (RSHP), Sekolah Kedokteran Hewan dan Biomedis (SKHB), IPB University. Pasien datang dengan keluhan tidak mau makan hingga dua hari, berdiri dan jalan tidak stabil, muntah, nistagmus, dan sempat jatuh terguling. Pemeriksaan fisik palpasi abdomen menunjukkan adanya pembesaran serta nyeri pada kelenjar prostat. Setelah dilakukan pemeriksaan penunjang hematologi, anjing menunjukkan penurunan jumlah eritrosit, hemoglobin, hematokrit, trombosit, dan PCT. Hasil pemeriksaan kimia darah menunjukkan penurunan kadar SGOT serta peningkatan kadar BUN dan kreatinin. Hasil pemeriksaan USG menunjukkan adanya formasi kristal pada pyelum ginjal kiri, perubahan batas antara korteks dengan medula dan atrofi ginjal kanan, peningkatan ketebalan vesika urinaria, serta perubahan ekogenitas parenkim dan ukuran prostat. Hasil pemeriksaan radiografi menunjukkan adanya pembesaran pada prostat dan preputium. Hasil pemeriksaan urinalisis menunjukkan peningkatan UPC serta adanya protein, darah, kreatinin, dan leukosit. Kasus ini memiliki diagnosa banding yaitu hidronefrosis, tumor prostat, prostatitis, dan neuron injury dengan prognosis infausta. Penanganan pada kasus ini dilakukan dengan pemberian terapi berupa infus asering, suplemen, bronkodilatator, diuretik, serta antiemetik.  
Penguatan Karakter Melalui Local Wisdom Dalam Mening-katkan Hasil Belajar Siswa M.Luqman Hakim; Gunanti Gunanti; Elvira Adyaputri; Muhammad Kamal; Muhammad Redha Anshari
Ikhlas : Jurnal Ilmiah Pendidikan Islam Vol. 2 No. 3 (2025): Juli: Ikhlas : Jurnal Ilmiah Pendidikan Islam
Publisher : Asosiasi Riset Ilmu Pendidikan Agama dan Filsafat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/ikhlas.v2i3.999

Abstract

This study examines the strengthening of students' character through the integration of local wisdom in education in Indonesia. In facing the challenges of globalization, education must not only focus on improving academic quality, but also on character building. The purpose of this study is to analyze the application of methods that integrate local wisdom in the learning process and its impact on student learning outcomes. The proposed methods include identification of local wisdom, curriculum development, implementation of active learning, and assessment and evaluation. The results showed that the application of this method increased the average student grade from 70 to 85 and the graduation percentage from 60% to 90%. These findings indicate that the integration of local wisdom not only increases learning motivation but also contributes to the development of students' character and identity. Thus, this study concludes that strengthening character through local wisdom is an effective strategy to improve the quality of education in Indonesia, as well as encourage the younger generation to love their culture and identity more.
Efektivitas penggunaan iopamidol sebagai bahan kontras gastrointestinal pada kucing Siswandi, Riki; Bermani, Fadeli; Prastiwi, Nurul Anjar; Bensa, Matilde Surtini; Rahmiati, Dwi Utari; ., Gunanti; Noviana, Deni
ARSHI Veterinary Letters Vol. 6 No. 3 (2022): ARSHI Veterinary Letters - Agustus 2022
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.6.3.57-58

Abstract

Iopamidol merupakan media kontras yang larut dalam air dan bersifat non-ionik. Tulisan ini melaporkan efektifitas penggunaan iopamidol pada seekor kucing domestik jantan berusia 3 tahun, memiliki bobot badan 6 kg, yang dibawa oleh pemiliknya ke klinik dengan keluhan tidak defekasi selama 5 hari dan memiliki nafsu makan yang baik. Pemeriksaan penunjang dilakukan dengan radiografi kontras gastrointestinal dengan menggunakan iopamidol. Pengambilan x-ray dilakukan pada menit ke-0, 30, 60, 150 dan 240. Motilitas gastrointestinal dievaluasi dengan penilaian semi kuantitatif. Kucing terlihat tidak mengalami gangguan motilitas lambung dan usus halus, namun obstruksi ditemukan pada usus besar. Tidak terlihat adanya efek samping maupun komplikasi dari penggunaan iopamidol baik selama prosedur maupun sampai hari ke 5 setelah prosedur. Iopamidol dinilai dapat dijadikan sebagai bahan kontras gastrointestinal.
THE EFFECTIVENESS OF STEM CELL THERAPY IN MYOCARDIAL INFARCTION REVIEWED FROM UREUM, CREATININE AND KIDNEY HISTOPATHOLOGY LEVELS Rahmi, Nur; Gunanti, Gunanti; Noviana, Deni; Harlina, Eva
Jurnal Kedokteran Hewan Vol 18, No 3 (2024): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i3.30831

Abstract

This study aims to study the effectiveness of single placental stem cell therapy or cardiomyocyte combination in pigs experiencing myocardial infarction in terms of urea, creatinine and kidney organ histopathology values. A total of 9 pigs were divided int o three groups: without therapy (K1), single placental stem cell therapy (K2), and cardiomyocyte coculture combination therapy (K3). All pigs underwent circumflex artery ligation of the proximal coronary artery branch to stimulate cardiac ischemia and therapy was given after myocardial infarction and ST-elevation were formed. The pigs were then treated for eight weeks, euthanized and necropsied for kidney organ removal. The re sults showed a significant decrease in urea and creatinine values (P0.05) in K2 and K3 as compared to K1. Histopathology results showed a decrease in glomerular atrophy values (K2: 10.260.93 and K3: 12.441.21), tubular necrosis (K2: 13.673.76 and K3: 17.230.55), and tubular dilation (K2: 16.361.26 and K3: 18.031.76) and these values were significantly different than those observed in K1. It was concluded that the administration of placental stem cell therapy or combined with cardiomyocyte coculture could reduce urea, creatinine values, and improve kidney tissue histopathologically.
CARDIOTHORACIC RATIO IN SUNDA PORCUPINE (Hystrix javanica) Suparmin, Yuliani; Noviana, Deni; Gunanti, Gunanti; Agungpriyono, Srihadi
Jurnal Kedokteran Hewan Vol 17, No 4 (2023): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i4.32213

Abstract

The present study aimed to standardize cardiothoracic ratio (CTR) in clinically healthy Sunda porcupine. This study was an explorative study using four Sunda porcupines, male and female, with an estimated age of 6 months-2years. The sampled animals were radiographed in ventrodorsally projection using a digital X-ray machine with 50 kVp and 6 mAs. Each animal was injected with xylazine as sedation agent at 2 mg/kg BW, intramuscularly route in the dorsal part of animals tail. The radiogram showed that Sunda porcupine heart tends to be round and more massive, characterized as the convex edge of the heart. The cardiothoracic ratio (CTR) showed that the ratio of the broadest expansion of the heart relative to the thoracic width in a ventrodorsally projection ranged from 0.48-0.55 with an average 0.52. Standard heart size was less than half of the largest thoracic diameter (normal CTR0.5). Sunda porcupine heart tends to be round and larger characterized as the convex edge of the heart. The CTR values obtained were 0.48-0.55.
ULTRASOUND IMAGING OF THE SPLEEN, STOMACH, LIVER, KIDNEYS, BLADDER, AND PROSTATE IN PIGLETS (Sus scrofa domestica) Gunanti, Gunanti; Khairunnisa, Carina; Annisa, Fadhilah Nur; Retnani, Elok Budi; Amin, Akhmad Arif; Rahmiati, Dwi Utari
Jurnal Kedokteran Hewan Vol 15, No 4 (2021): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i4.21784

Abstract

This study aims to describe ultrasonographic imaging of the spleen, stomach, liver, kidney, bladder, and prostate in piglets (Sus scrofa domestica). Ultrasonography was performed on six male piglets aged 1 month with a body weight of 4-8 kg. Ultrasonography of the spleen, stomach, liver, urinary bladder, and prostate was observed in the dorsal-recumbency position, and the kidney was observed in the lateral-recumbency position. The ultrasound examination used the Chison EBit 60, which is a linear type transducer with a frequency of 9 MHz, transverse and sagittal positions, and a gain of about 55-80. Ultrasonography of the spleen showed that the shape of the spleen head varied in each individual. The results of gastric ultrasonography showed the gastric lining clearly and the similarity of the position, shape, structure, echogenicity, and size of the stomach. The results of liver ultrasonography showed that the echogenicity of the liver tended to be hyperechoic, the kidneys were hyperechoic, and the bladder was hypoechoic due to the use of improper gain. The average length of the right kidney was 4.730.50 cm and the left kidney was 4.080.26 cm. The bladder wall thickness was 1.30.31 mm. Imaging of the bladder showed changes in wall size and echogenicity. Prostate ultrasound results obtained an average length of 2.680.45 cm, width 1.690.35 cm. The results of this study can be used as a reference for normal data on organ position, organ structure, and organ echogenicity of the spleen, stomach, liver, kidney, bladder, and prostate in piglets.
Co-Authors . Erwin Afidatunnisa, Kholis Afifa, Selma Afiqah Binti Abd Latif Agik Suprayogi Agus Hadi Santosa Wargadipura Agus Wijaya Ahmad Arif Amin Ainul Khadija Saleema Ali Iskandar Zulkarnain, Ali Iskandar Amelia Putri, Yusika Amin, Ahmad Arif Amir S. Madjid, Amir S. Angesti, Shavrillia Anhu Raja Anita Esfandiari Anita Rahmayanti Annisa Rofiqoh Syafikriatillah Annisa, Fadhilah Nur Annita Vury Nurjunitar Antonius H. Pudjiadi Ardi Sandriya Arni Fitri Bambang Pontjo Priosoeryanto Bambang Supriyatno Basrul Hanafi Beata LYL Ayu Bensa, Matilde Surtini Bermani, Fadeli Budianto Panjaitan budianto panjaitan Carina Khairunnisa D Ardiansyah D U Rahmiati Damiana Rita Ekastuti Deni Noviana Deny Setyo Wibowo Devi Paramitha Dina Zuhdina Rahman Dwi Endrawati Dwi Endrawati Dwi Gustiono Dwi Utari Rahmiati E Fitriana Ega Iftahul Rizky Ekowati Handharyani Elok Budi Retnani Elvira Adyaputri Erwin Erwin Erwin Erwin Erwin Erwin Eva Harlina Fadhilah Nur Annisa Febryanto, Agung Fitri, Arni Diana Galih Satria Kusumanto Harits Abdullah Munir Hastjarjo Fleuryantari Hayati, Najma Helny Rosita Supriadi Helny Rosita Supriadi Helny Rosita Supriadi Heryudianto Vibowo Himah Nuradilah I Gusti Agung Ngurah Arphan Eka Putra I Gusti Ngurah Sudisma IETJE WIENTARSIH Iman, Bintang Nurul Intan Khoirunnisa Irda Khaeriyah Irza Sukmana Irza Sukmana, Irza Jessica Anggun Safitri Kasim, Salamah Khairunnisa, Carina Kholis Afidatunnisa Ki Agus Dahlan Kiagus Dahlan Kiagus Dahlan Kiagus Dahlan Laras Weningtyas Lijar Pastilah Lina Noviyanti Sutardi Liza Oktafani M. Fakhrul Ulum M.Luqman Hakim Martapuri Rani Wijaya Masaji Washio Maulana, M Ridha Melpa Susanti Purba Melpa Susanti Purba Mokhamad Fakhrul Ulum, Mokhamad Muhammad Abhi Purnomosidi Muhammad Fajrul Falah Muhammad Kamal Muhammad Redha Anshari Munar Lubis Murtiningrum, Fitria Senja Nabila Latifa Hafizsha Nadya Amanda Putri Najma Hayati Ni Rai Fertilini Hanira Jelantik Nindya Dwi Utami Nur Fitri Utami Nuzula Ramadian Peter Ian Limas Prastiwi, Nurul Anjar Rachmi Ridho Raden Mohamad Herdian Bhakti Raden Roro Soesatyoratih Rahmi, Riska Asria Sa'adatur Rahul Ajie Saksena Ramadian, Nuzula Ravi, Sugganya Retno Wulansari Riana Nurul Maulani Riki Siswandi Riski Rostantinata Rismala Dewi Sardimi, Sardimi Selma Afifa Selma Laily Nur Afifa Selma Laily Nur Afifah Septi Nurcholida Sari Shavrillia Angesti Shavrillia Inovanny Angesti Shayrilia Ivanovanny Angesti Sitaria Siallagan Siti Zaenab Siti Zaenab Sri Rezeki Srihadi Agungpriyono Subangkit, Mawar Sugganya Ravi Suparmin, Yuliani Surawan, Surawan Sus Derthi Widhyari Sus Derthi Widyari Syafikriatillah, Annisa Rofiqoh TATI NURHAYATI Tri Isyani Tungga Dewi Tytha Nadhifa Winarto Ulum, M. Fakhrul Viyata Pratiwi Risky Yuliani Suparmin Zultinur Muttaqin