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All Journal Jurnal Pendidikan Indonesia Al-Manar : English and Arabic Journal AT TA´DIB Jaqfi : Jurnal Aqidah dan Filsafat Islam Jurnal JUMPED (Jurnal Manajemen Pendidikan) Journal of Islamic Medicine JMM (Jurnal Masyarakat Mandiri) IJ-ATL (International Journal of Arabic Teaching and Learning) Jurnal Mandala Pharmacon Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Teknologi Informasi dan Komunikasi Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Advance Sustainable Science, Engineering and Technology (ASSET) Jurnal Ilmiah Wahana Pendidikan The Avicenna Medical Journal International Journal of Humanities Education and Social Sciences Easta Journal of Innovative Community Services Innovative: Journal Of Social Science Research Pelita: Jurnal Pengabdian kepada Masyarakat Najwa Agri Analytics Journal Journal of World Future Medicine, Health and Nursing Medika: Jurnal Ilmiah Kesehatan Jurnal Pengabdian Kompetitif Indonesian Culture and Religion Issues Ameena Journal Jurnal Seumubeuet International Journal of Multidisciplinary Reseach Journal of Humanities Research Sustainability Islamic Studies in the World
Muhammad Amiruddin
Universitas Sebelas Maret
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Journal : The Avicenna Medical Journal

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The Impact of Neem Leaf Extract (Azadirachta indica) on renal hypoxia in Balb/C Mice Infected with Plasmodium berghei Rahmah, Zainabur; Religious, Tafakur Bagus; Akbar, Putri Wulan; Kosbandhono, Erryk; Amiruddin, Muhammad; Nashichuddin, Ach
The Avicenna Medical Journal Vol. 6 No. 2 (2025): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v6i2.46488

Abstract

Background: Millions of people die from malaria every year in tropical areas, making it a severe public health concern. Plasmodium, a genus of protozoa with several species, is the main cause of the disease. Humans contract malaria when bitten by female Anopheles sp. mosquitoes. Malaria is one of the world's deadliest diseases. The WHO's 2020 World Malaria Report indicates that there were 229 million cases of malaria globally in 2019, with 409,000 fatalities resulting from the disease. In nine Southeast Asian countries, malaria is endemic. After India, Indonesia is the second most endemic region. Transcription factors such as the HIF-1α protein are produced by hypoxic cells. Patients with malaria have a blockage of the cytoaderenal pathway. Hypoxia occurs due to vascular disorders that prevent oxygen flow to the kidney tissue. Antimalarial drugs are developed in response to the lethal consequences of hypoxia.  Methods: BALB/c mice aged sixteen weeks were infected with the Plasmodium berghei ANKA strain. For six days, the neem leaf 96% ethanol extract was administered orally at doses of 8 mg, 12 mg, and 16 mg. As comparisons, negative, positive, and healthy controls were also included. The kidneys were isolated, and the mice were surgically removed on the seventh day. HIF-2α expression in kidney tissue, which was measured immunohistochemically using Abcam's anti-HIF-2α (H1α67) ChIP Grade antibody, was a characteristic of kidney hypoxia. One-way ANOVA, post-hoc LSD, and Pearson correlation tests were used to assess the hypotheses. Results: Treatment with neem leaf extract significantly decreased oxygen levels (p<0.000).  The correlation test showed a very strong relationship between neem leaf extract and HIF-2α expression in the kidney (r=16.057). Conclusion: Twelve milligrams of neem leaf extract can reduce the risk of renal hypoxia. Keywords: Neem leaves, malaria, degree of parasitemia, hypoxia, Azadirachta indica
Co-Authors 'Izza, Ahdina Naylal Aan Burhanudin Ach. Nashichuddin Adam, Nurul Suciana Adityapurwoko, Farel Afiidah, Nur Aisya, Carlyna Septi Arie Kurniawan Arifin, Hendy Rifki Saputra Asrofik Asrofik Asrofik, Asrofik Atip Nurwahyunani, Atip Aulia Az-Zahra, Syafira Azizul Ghofar Candra Wicaksono, Azizul Ghofar Candra Badrun Kartowagiran Bambang Hadi Kunaryo Bambang Sutopo Carsoni Carsoni, Carsoni Dwi Anggraini Effendy, Maulina Rosalia Erryk Kosbandhono Farchad Dwi Cahyo, Muhamad Faridhoh, Indah Lailatul Fatmawati, Ajeng Fatmawati, Ajeng Dwi Fauzi, Nurul Fathiyah Fefi Nurdiana Widjayanti Firdaus, Muhammad Rizqi Mudhoffar Firdaus, Rakhmah Mutiara Fitriana , Himmatul Ganggo r, Djibril Gango, Djibril Ginanjar Putri Nastiti Hajra Yansa Hakim, Muhammad Afta Dzikril Hamzah Karim, Siti Aminah Harto Nuroso Haryadi, Mahardika Chory Hasanah, Imrotul Hasna, Zulfa Fakhriyah Hasto, Ken Herlina Juni Risma Saragih Hidayat, Hakmi Ilmiah, Rikhlatul Imadudin Harjanto Indah Rahmawati Ipah Budi Minarti Irna Farikhah Ishaq, Ala' Jusriadi Khoiril Anwar Lengkong, Siti Nur Asyura M. Sutrisno Maas, Rosdiana Maghfira, Bhebyalna Mahasir, Mahasir Margono Margono Marlina Marlina Maulana, Moch Dani Mayu Rahmayanti Meydina Azzahra, Faradita Mubarok, Moh Rizqi Nafiah, Siska Lailatul Nur Ahyani Nur Aksin, Nur Nuranisa, Nuranisa Nurkhasanah Nurkhasanah Nuryani Nuryani Oktavia, Reza Putri Pangadilan Rambe, Pangadilan Praja, Shafa Ananti Pujo Widodo Putri Wulan Akbar Rahim, Irfan Abd Rahmadani, M. Eugine Ramadan, Syahrul Religious, Tafakur Bagus Ridwan, Syafira Chairunnissa Ririen Hardani Rizaldy, Farhan Rahmad Rizkiyah, Rosianti Chairur Rochmadi Rochmadi Rokhmawati, Endang Dian Rosida P. Adam Rozak, Akhmad Khusnur Rustam Rustam Sadli Syarifuddin SAID, MOCH. Salafi, Muchamad Asafin Shomad, Abdus Sihombing, Longga Yestrida L. Simarmata, Maria Junita Slamet Supriyadi Sovian Aritonang Supriyadi , Bilqis Sutaman, Sutaman Teguh Hilmansyah Tokay, Anwar Umar, Aftah Wahab Ibnu Ummi Kaltsum Waez, Abdurrahman Widi, Kahfi Sukma Yuniardyanti, Syafira Yuris Setyoadi Zainabur Rahmah