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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Biogenesis: Jurnal Ilmiah Biologi Global Medical and Health Communication Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Berkala Kedokteran Universa Medicina Medical Laboratory Technology Journal Journal Of Vocational Health Studies JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Smart Medical Journal Jurnal Pengabdian Pada Masyarakat Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesian Journal of Global Health research JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Mandala of Health : A Scientific Journal Jurnal Pengabdian Pada Masyarakat Medical and Health Journal Jurnal Tumbuhan Obat Indonesia Linggamas: Jurnal Pengabdian Masyarakat
Fitranto Arjadi
Universitas Jenderal Soedirman Purwokerto
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Antibacterial Extract of Bandotan (Ageratum Conyzoides L.) Sytematis Review Naibaho, Debora Paramita; Arjadi, Fitranto
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6173

Abstract

Antibacterial extract leaf Bandotan (Ageratum conyzoides L.) shows that effectiveness antimicrobial plant This is results synergy compound bioactives , such as flavonoids, tannins, saponins, and terpenoids, which are successful extracted optimally use solvent organic . Use solvent methanol and ethanol proven increase acquisition compounds said , which then contribute to mechanism Work antimicrobial through effect antioxidants and damage membrane cell bacteria . Innovative approaches such as green nanoparticle synthesis have also been shown to have the potential to improve the stability of the extract, thus supporting the development of alternative therapeutic applications to overcome antibiotic resistance. Objective: this study was to evaluate the antibacterial activity of methanol extract of Bandotan leaves against S. aureus and identify bioactive compounds, as well as highlight the integration of traditional knowledge with research innovations in the treatment of skin infections. This systematic review was conducted using the PRISMA method. The literature search process was carried out through Google Scholar, PubMed, and Science Direct databases, focusing on studies published between 2020 and 2024. Articles that met the inclusion criteria were observational studies that tested the antibacterial activity of Bandotan leaf extract. Of the 1086 articles initially identified, based on the PICO method, the systematic review's study selection. Initially, 1086 records were identified from databases like Google Scholar and PubMed. After removing 61 duplicates, 1025 records underwent screening. Exclusions included 249 systematic reviews, 270 irrelevant Bandotan studies, 112 with inadequate methods, 200 lacking exclude full text unvailable, and 189 outside the research scope. Finally 5 studies include criteria . Results: the study showed that Bandotan leaf extract, both extracted with ethanol and methanol, effectively inhibited the growth of various pathogenic bacteria, such as Staphylococcus aureus, Streptococcus pyogenes, Methicillin-Resistant Staphylococcus aureus (MRSA), and Propionibacterium acnes. In vitro tests conducted for 24 hours using the agar diffusion method revealed a dose-response correlation, where increasing extract concentrations resulted in wider inhibition zones. In addition, the integration of the extract into product formulations, such as anti-acne sheet masks, suggests that this extract also has potential for skin care applications. Conclusion: these findings support further development of the use of Bandotan leaf extract as an alternative source of natural active ingredients in infection therapy and as a basis for the development of antibacterial cosmetic products.
Prediktor Penyakit Jantung Koroner (PJK) Melalui Pemeriksaan Profil Lipid (HDL, LDL, Trigliserid) Menggunakan Rumus Castelli Dan Indeks Aterogenik Plasma (AIP) di Desa Srowot Kecamatan Kalibagor Kabupaten Banyumas Wahyudin, Wahyudin; Wardana, Tirta; Yusan, Rizak Tiara; Arjadi, Fitranto; Kasum, Kasum; Saad, Nursan
Linggamas: Jurnal Pengabdian Masyarakat Vol 1 No 2 (2024): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2024.1.2.10363

Abstract

Kolesterol berkaitan erat dengan kejadian penyakit jantung koroner atau PJK. Kolesterol yang terlalu banyak di dalam pembuluh darah akan menyebabkan akumulasi plak kolesterol atau sering disebut aterosklerosis. Pemeriksaan kolesterol lengkap yang meliputi low density lipoprotein (LDL), high density lipoprotein (HDL), trigliserida, dan kolesterol total dapat memberikan gambaran atau prediktor resiko PJK dengan menggunakan rumus indeks Castelli dan Indeks aterogenik plasma (IAP). Pemeriksaan kolesterol lengkap dilaksanakan bekerja sama dengan Kader Posyandu, Bidan Desa, dan Perangkat Desa dengan jumlah responden sebanyak 48 orang yang terdiri dari 40 perempuan dan laki-laki sebanyak 8 orang. Hasil pemeriksaan menunjukkan bahwa resiko PJK dengan menggunakan indeks Castelli sebagian besar warga memiliki resiko rendah sebanyak 69% dibanding resiko sedang 27% dan resiko tinggi sebanyak 4 %. Sedangkan dengan menggunakan IAP, menunjukkan bahwa sebagian besar mengalami resiko tinggi PJK sebanyak 38%, resiko sedang 52%, dan resiko rendah hanya mencapai 10%. Kegiatan ini diharapkan menjadi bahan evaluasi bagi warga agar lebih memperhatikan pola makan yang dapat meningkatkan resiko terjadinya PJK, dengan mengurangi makanan-makanan yang mengandung kolesterol yang tinggi
Pemeriksaan Glukosa Darah Dan Kolesterol Serta Penyuluhan Kesehatan Tentang Hiperkolesteronemia dan Komplikasi Diabetes Mellitus Pada Warga Dengan Overweight Dan Obesitas Di Desa Kalibagor, Kecamatan Kalibagor, Kabupaten Banyumas Wahyudin, Wahyudin; Arjadi, Fitranto; Setyanto, Muhamad Rifqi; Pauzi, Rizqi Yanuar; Riyanto, Slamet; Saad, Nursan
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 1 (2024): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2024.2.1.12942

Abstract

Overweight dan obesitas telah menjadi masalah kesehatan global yang serius, termasuk di Indonesia. Kondisi ini tidak hanya mempengaruhi penampilan fisik, tetapi juga meningkatkan risiko berbagai penyakit kronis, seperti diabetes mellitus dan penyakit jantung. Pemeriksaan glukosa darah dan kolesterol secara berkala merupakan langkah penting dalam deteksi dini diabetes mellitus dan hiperkolesteronemia. Diabetes mellitus, suatu kondisi di mana tubuh tidak dapat memproduksi atau menggunakan insulin dengan baik, dapat menyebabkan berbagai komplikasi serius jika tidak ditangani dengan tepat, seperti kerusakan ginjal, saraf, dan penglihatan. Pengabdian masyarakat yang dilakukan yaitu pemeriksaan GDS dan kolesterol total kemudian dilanjutkan dengan penyuluhan kesehatan tentang hiperkolesteronemia dan komplikasi diabetes mellitus. Hasil pemeriksaan diperoleh sebagian besar warga yang hadir mengalami overweight dan obesitas sebanyak 70%, dan sisanya mempunyai berat badan yang normal, yang mengalami diabetes sebanyak 12%. Peningkatan kesadaran masyarakat tentang pentingnya menjaga berat badan dalam rentang normal, bersama dengan pola hidup sehat, dapat membantu menurunkan prevalensi penyakit metabolik di masa depan.
Correlation between platelet indices and preeclampsia with severe features Fuady, Dzicky Rifqi; Yudatmo, Unggul; Ghazali, Muhammad Farid; Rosdiana, Dian; Arjadi, Fitranto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art6

Abstract

Backgrounds: Pre-eclampsia is a pregnancy-related syndrome with a 2-8% prevalence worldwide. In Indonesia, its incidence was 128,273 (5.3%) cases that caused 30-40% of maternal deaths. In 2021, at Karawang General Public Hospital, there are 43% cases of pre-eclampsia with 3% of complication. The pathophysiology is related to the inflammatory and coagulation system that includes platelets. Thus, platelet indices as indicators for platelet changes could be potential laboratory markers for pre-eclampsia.Objective: To examine the relationship between the platelet indices and pre-eclampsia severe features at the Karawang General Public HospitalMethods: The six months cross-sectional study was conducted at the Karawang General Public Hospital for pre-eclampsia pregnant women with at least 28 weeks of gestational age. The pre-eclampsia criteria were blood pressure higher or equal to 140/90 mmHg and qualitative proteinuria dipstick +1. The subjects were divided into two groups: pre-eclampsia with severe features and without severe features. Severe features criteria were thrombocytopenia, impaired liver function, renal insufficiency, pulmonary edema, new onset headache, and visual disturbances. Pregnant women have their blood platelet indices checked in the form of platelet crit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR). Data were analyzed with descriptive analysis (percentage), cut-off analysis, ROC curve, AUC analysis, bivariate Chi-square analysis, and multivariate logistic regression analysis.Results: There was a significant difference (p < 0.05) in the value of PCT, MPV, PDW, and P-LCR between pregnant pre-eclampsia women with severe features and pregnant pre-eclampsia women without severe features. P-LCR has the best sensitivity (52.9%) and specificity (98.9%).Conclusions: There was a significant change in the value of the platelet indices (PCT, MPV, PDW, P-LCR) in pregnant pre-eclampsia women with severe features at the Karawang General Public Hospital.
Co-Authors . HERNAYANTI Agatri, Norina Ahmad, Faiq Alaika Ailsa, Shafa Alfi Muntafiah Amilia Ramadhani Aminuyati Andromeda Andromeda Christiana Cahyani Prihastuti Denok Tri Hardiningsih Diah Krisnansari Dian Rosdiana, Dian Dinar Faiza Dita Ayu Dewi Laras Sati Diyah Woro Dwi Lestari Dody Novrial Dody Novrial, Dody Dzicky Rifqi Fuadi Edy Priyanto Edy Priyanto Fani Tuti Handayani, Fani Tuti Fidnillah, Diva Azka Fitri Diah Oktadewi Fuady, Dzicky Rifqi Ghazali, Muhammad Farid Ginus Partadireja Hajid Rahmadianto Harini, Ika Murti Haris Budi Widodo Hernayanti Hernayanti Hidi, Aulli Rahman Ika Murti Harini Joko Mulyanto, Joko Joko Setyono Kasum, Kasum Khusnul Muflikhah Kuncoro, Prasetyo Tri Lantip Rujito Lientje Setyawan Maurits Lientje Setyawati Maurits Mae Sri Hartati Wahyuningsih Mahardhika, Gembong Satria Mahindra Awwaludin Romdlon Mas'ud, Ahmad Fawzy Maulida, Adzkia Mubayinul Khoeroh Mulyono Pangestu Mulyono Pangestu MULYOTO PANGESTU Mulyoto Pangestu Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Naibaho, Debora Paramita Nenden Nursyamsi Agustina Nia Krisniawati Nitiprodjo, Abdul Hakim Nor Sri Inayati, Nor Sri Norina Agatri Norina Agatri Nur Signa Aini Gumilas Pauzi, Rizqi Yanuar Prasetyo Tri Kuncoro Pratama, Radya Putra Pugud Samodro Putri, Prima Maharani Qodri Santosa Rangga Wisnu Wardana Rizak Tiara Yusan Saad, Nursan Saefuddin Aziz Saefuddin Aziz Samodro, Pugud Setiawati Setiawati Setiawati Setiawati Setyanto, Muhamad Rifqi Sindhu Wisesa Sindhu Wisesa Sindhu Wisesa Sirajuddin, Mohammad Salman Slamet Riyanto Soegianto, Jap Yulius Billy Sri Kadarsih Soejono Sri Kadarsih Soejono Susiana Candrawati Thianti Sylviningrum Tuti Sri Suhesti Vitasari Indriani Vitasari Indriani Vitasari Indriani Wahyu Siswandari Wahyu Siswandari Wahyu Siswandari Wahyudin Wahyudin Wahyudin Wahyudin wardana, Tirta Widiartini, Catharina Widyaningsih, Pratiwi Nur Wisesa, Sindhu Yudatmo, Unggul Yudhi Wibowo Yulia Fauziyah Zhafira, Adistya Hasna