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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Biogenesis: Jurnal Ilmiah Biologi Global Medical and Health Communication Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Berkala Kedokteran Universa Medicina Medical Laboratory Technology Journal Journal Of Vocational Health Studies JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Smart Medical Journal Jurnal Pengabdian Pada Masyarakat Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Mandala of Health : A Scientific Journal Jurnal Pengabdian Pada Masyarakat Medical and Health Journal Jurnal Tumbuhan Obat Indonesia Linggamas: Jurnal Pengabdian Masyarakat
Fitranto Arjadi
Universitas Jenderal Soedirman Purwokerto
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The Effect of Swimming Various Intensities on Creatine Kinase Activity and Histopathological Features of The Musculus Vastus Lateralis in Obese Rats Mubayinul Khoeroh; Wahyu Siswandari; Susiana Candrawati; Sindhu Wisesa; Fitranto Arjadi
JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Vol 9, No 1 (2024): Improve physical competence, fitness, motivation, and enjoyment of physical acti
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpjo.v9i1.66213

Abstract

Obesity is considered a global health problem that has reached epidemic proportions and significantly affects almost all physiological functions of the body. Swimming can reduce fat levels so that it can reduce obesity conditions which can trigger other cases. However, training that exceeds capacity can cause skeletal muscle damage. This study aims to determine the effect of swimming of various intensities (light, moderate and heavy) on creatine kinase (CK) activity and the histopathological appearance of the musculus vastus lateralis in obese rats (Rattus norvegicus). This study used a true experimental using a Completely Randomized Design (CRD) posttest-only control group design approach. The sample in this research; white rat (Rattus norvegicus) male Wistar strain, body weight 150-200 grams, and aged 6-8 weeks. Obesity induction; Pokphand 551, BOLT, cassavas and carrots. The rats were divided into 5 groups and each group consisted of 4 rats. Swimming is given once per day every morning for 14 days. CK activity was measured using UV-Vis spectrophotometer and histopathological preparations of the musculus vastus lateralis using Hematoxyline Eosine (HE) staining. Swimming significantly (p 0.05) reduced CK activity. The best results were found in group 4 with a reduction of 37.29% from obese controls, and an increase of 11.53% from healthy controls. The best CK activity values were obtained by the group that had values closest to those of healthy controls. The histopathology results of group 4 showed histopathological improvement based on reduced inflammatory infiltration, fiber profile abnormalities and the presence of myofiber hypertrophy as a form of cell adaptation. Group 4 (obesity + moderate intensity swimming) is the best treatment to reduce CK activity and improve the histopathology of the musculus vatsus lateralis.
MANFAAT ZAT AKTIF PURWOCENG (Pimpinella pruatjan) SEBAGAI AFRODISIAK, ANTIOKSIDAN, PEMACU ORGANOGENESIS, DAN ANTIBAKTERI Arjadi, Fitranto; Ahmad, Faiq Alaika; Fidnillah, Diva Azka; Ailsa, Shafa; Maulida, Adzkia; Sirajuddin, Mohammad Salman; Zhafira, Adistya Hasna; Hidi, Aulli Rahman
Syifa'Medika Vol 14, No 2 (2024): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v14i2.7518

Abstract

Purwoceng merupakan tanaman obat asli Indonesia yang dipercaya berkhasiat sebagai Afrodisiak (meningkatkan vitalitas seksualitas pria). Purwoceng sebagai afrodisiak mengandung beberapa zat kimia seperti steroid, minyak atsiri, furanocoumarin,flavonoid dan vitamin, yang terdapat pada bagian daun dan akarnya. Tujuan studi pustaka ini adalah   menyusun pemahaman yang lebih komprehensif tentang zat aktif dalam tanaman purwoceng dan manfaatnya bagi kesehatan manusia. Beberapa penelitian dengan hewan coba tikus, menunjukan bahwa zat aktif didalam Purwoceng memiliki efek positif androgenik karena dapat meningkatkan LH, FSH, dan testosteron. Selain itu ekstrak purwoceng memiliki aktivitas antioksidan Bioflavonoidyang memiliki kemampuan menangkap radikal bebas, menurunkan ROS, dan mengurangi stres oksidatif.  Purwoceng memiliki kandungan zat aktif antioksidan yang dapat mencegah stres oksidatif dan bermanfaat meningkatkan kadar hormone LH, FSH, dan testosteron.
Etanolic extract of Ling Zhi Mushroom (Ganoderma lucidum) improves lipid profile, CRP and histopathological of liver in dislipidemia model rats Soegianto, Jap Yulius Billy; Samodro, Pugud; Wisesa, Sindhu; Hernayanti, Hernayanti; Setyono, Joko; Arjadi, Fitranto
Biogenesis: Jurnal Ilmiah Biologi Vol 11 No 2 (2023)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v11i2.38896

Abstract

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VITAMIN D PADA PASIEN ACNE VULGARIS DAN KORELASI DENGAN LUARAN KLINIS: REVIEW SISTEMATIK Pratama, Radya Putra; Arjadi, Fitranto; Mulyanto, Joko
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11004

Abstract

Background: Vitamin D is thought to have a role in the pathogenesis of acne vulgaris through anti-inflammatory effects. Research regarding the relationship between vitamin D and the severity of acne vulgaris still shows mixed results. Objective: To determine the correlation between vitamin D levels and clinical severity in acne vulgaris patients. Method: This systematic review uses Pubmed, Google Scholar, and Science Direct databases. Of the 362 articles, 13 articles that met the inclusion criteria were analyzed narratively. Results: Of 13 studies, 4 showed significant differences in serum vitamin D levels between degrees of acne severity. Meanwhile, the other 9 did not show any significant differences. One study showed significant differences in tissue vitamin D levels with severity. Conclusion: Overall, results are still inconsistent. There is evidence of a higher risk of vitamin D deficiency and decreased tissue vitamin D levels in people with acne vulgaris as severity increases. It is suspected that this is related to the role of vitamin D in suppressing inflammation. Further studies considering confounding factors are needed to clarify this association.
Effect of Sleep Deprivation on the Number of Prefrontal Cortex Neuroglia Cells in Male White Rats (Rattus norvegicus) Arjadi, Fitranto; Kuncoro, Prasetyo Tri; Gumilas, Nur Signa Aini; Harini, Ika Murti; Mustofa, Mustofa; Wisesa, Sindhu
Global Medical & Health Communication (GMHC) Vol 11, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i2.10743

Abstract

Stress induced by sleep deprivation can increase inflammation and oxidative stress, destroying the pyramidal and neuroglia cells in the prefrontal cerebral cortex and interrupting cognitive and behavioral functions. This study aims to observe the difference in the number of pyramidal and neuroglia cells in the prefrontal cortex of male white rats (Rattus norvegicus) after stress induction by paradoxical sleep deprivation (PSD) and total sleep deprivation (TSD). This study was conducted in the Anatomy Laboratory of the Faculty of Medicine, Universitas Jenderal Soedirman, from November 2019 to February 2020. The method of this study was a posttest-only design with a control group approach using ten rats for each group; that was control (K.I.), PSD (KII), and TSD (K.I.). PSD and TSD groups received sleep deprivation treatment for eight days for 20 hours/day and 24 hours/day, respectively. The mean pyramidal cell number decreased in the PSD (66.67±24.55) and TSD (65.90±34.91) compared to the control (77.10±26.11) group, but no significant differences were found between all groups (p>0.05). The mean neuroglial cell number was lower in the PSD (97.78±28.17) and TSD (75.80±22.39) compared to the control (126.00±48.81). Post-hoc Bonferroni test showed a significant difference between control and TSD (p<0.05) but not between control and PSD or PSD and TSD (p>0.05). In conclusion, there was a significant difference in the number of neuroglial cells but not pyramidal cells in the prefrontal cortex of male white rats (Rattus norvegicus) after stress induction with total sleep deprivation (TSD).
EFFECT OF DIFFERENT TYPES OF SLEEP DEPRIVATION AND SLEEP RECOVERY ON SALIVARY PH Handayani, Fani Tuti; Widyaningsih, Pratiwi Nur; Arjadi, Fitranto
Journal of Vocational Health Studies Vol. 4 No. 3 (2021): March 2021 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V4.I3.2021.95-99

Abstract

Background: Salivary pH can rise or fall influenced by intrinsic and extrinsic factors. Sleep deprivation is one example of intrinsic factors. Sleep deprivation causes a reduction in sleep time at a certain time. Purpose: Analyze the effect of different types of sleep deprivations and sleep recovery on salivary pH. Method: This study was experimental research with a post-test only with a control group design. Thirty white Wistar strain rats were randomly divided into 5 groups: healthy control group (KI), partial sleep deprivation (PSD/KII), total sleep deprivation (TSD/KIII), partial sleep deprivation, and continued sleep recovery (PSD+SR/KIV) and total sleep deprivation and continued sleep recovery (TSD+SR/KV). The treatment is carried out on a single platform method. Salivary pH was measured with the help of color-coded pH strips that were given grading after the completion of sleep deprivation induction. Result: The mean decrease in salivary pH was highest in the TSD group. One Way ANOVA test showed significant differences (p <0.05) in the control group with PSD and TSD, the PSD group with PSD+SR, TSD group with PSD+SR and TSD+SR. Conclusion: Sleep deprivation is proven to reduce the pH of Saliva. Total sleep deprivation is a chronic condition that has the most influence on decreasing salivary pH. The effect of decreasing salivary pH due to sleep deprivation is proven to be overcome by sleep recovery.
Prediktor Penyakit Jantung Koroner (PJK) Melalui Pemeriksaan Profil Lipid (HDL, LDL, Trigliserid) Menggunakan Rumus Castelli Dan Indeks Aterogenik Plasma (AIP) di Desa Srowot Kecamatan Kalibagor Kabupaten Banyumas Wahyudin, Wahyudin; Wardana, Tirta; Yusan, Rizak Tiara; Arjadi, Fitranto; Kasum, Kasum; Saad, Nursan
Linggamas: Jurnal Pengabdian Masyarakat Vol 1 No 2 (2024): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2024.1.2.10363

Abstract

Kolesterol berkaitan erat dengan kejadian penyakit jantung koroner atau PJK. Kolesterol yang terlalu banyak di dalam pembuluh darah akan menyebabkan akumulasi plak kolesterol atau sering disebut aterosklerosis. Pemeriksaan kolesterol lengkap yang meliputi low density lipoprotein (LDL), high density lipoprotein (HDL), trigliserida, dan kolesterol total dapat memberikan gambaran atau prediktor resiko PJK dengan menggunakan rumus indeks Castelli dan Indeks aterogenik plasma (IAP). Pemeriksaan kolesterol lengkap dilaksanakan bekerja sama dengan Kader Posyandu, Bidan Desa, dan Perangkat Desa dengan jumlah responden sebanyak 48 orang yang terdiri dari 40 perempuan dan laki-laki sebanyak 8 orang. Hasil pemeriksaan menunjukkan bahwa resiko PJK dengan menggunakan indeks Castelli sebagian besar warga memiliki resiko rendah sebanyak 69% dibanding resiko sedang 27% dan resiko tinggi sebanyak 4 %. Sedangkan dengan menggunakan IAP, menunjukkan bahwa sebagian besar mengalami resiko tinggi PJK sebanyak 38%, resiko sedang 52%, dan resiko rendah hanya mencapai 10%. Kegiatan ini diharapkan menjadi bahan evaluasi bagi warga agar lebih memperhatikan pola makan yang dapat meningkatkan resiko terjadinya PJK, dengan mengurangi makanan-makanan yang mengandung kolesterol yang tinggi
Pemeriksaan Glukosa Darah Dan Kolesterol Serta Penyuluhan Kesehatan Tentang Hiperkolesteronemia dan Komplikasi Diabetes Mellitus Pada Warga Dengan Overweight Dan Obesitas Di Desa Kalibagor, Kecamatan Kalibagor, Kabupaten Banyumas Wahyudin, Wahyudin; Arjadi, Fitranto; Setyanto, Muhamad Rifqi; Pauzi, Rizqi Yanuar; Riyanto, Slamet; Saad, Nursan
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 1 (2024): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2024.2.1.12942

Abstract

Overweight dan obesitas telah menjadi masalah kesehatan global yang serius, termasuk di Indonesia. Kondisi ini tidak hanya mempengaruhi penampilan fisik, tetapi juga meningkatkan risiko berbagai penyakit kronis, seperti diabetes mellitus dan penyakit jantung. Pemeriksaan glukosa darah dan kolesterol secara berkala merupakan langkah penting dalam deteksi dini diabetes mellitus dan hiperkolesteronemia. Diabetes mellitus, suatu kondisi di mana tubuh tidak dapat memproduksi atau menggunakan insulin dengan baik, dapat menyebabkan berbagai komplikasi serius jika tidak ditangani dengan tepat, seperti kerusakan ginjal, saraf, dan penglihatan. Pengabdian masyarakat yang dilakukan yaitu pemeriksaan GDS dan kolesterol total kemudian dilanjutkan dengan penyuluhan kesehatan tentang hiperkolesteronemia dan komplikasi diabetes mellitus. Hasil pemeriksaan diperoleh sebagian besar warga yang hadir mengalami overweight dan obesitas sebanyak 70%, dan sisanya mempunyai berat badan yang normal, yang mengalami diabetes sebanyak 12%. Peningkatan kesadaran masyarakat tentang pentingnya menjaga berat badan dalam rentang normal, bersama dengan pola hidup sehat, dapat membantu menurunkan prevalensi penyakit metabolik di masa depan.
Correlation between platelet indices and preeclampsia with severe features Fuady, Dzicky Rifqi; Yudatmo, Unggul; Ghazali, Muhammad Farid; Rosdiana, Dian; Arjadi, Fitranto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art6

Abstract

Backgrounds: Pre-eclampsia is a pregnancy-related syndrome with a 2-8% prevalence worldwide. In Indonesia, its incidence was 128,273 (5.3%) cases that caused 30-40% of maternal deaths. In 2021, at Karawang General Public Hospital, there are 43% cases of pre-eclampsia with 3% of complication. The pathophysiology is related to the inflammatory and coagulation system that includes platelets. Thus, platelet indices as indicators for platelet changes could be potential laboratory markers for pre-eclampsia.Objective: To examine the relationship between the platelet indices and pre-eclampsia severe features at the Karawang General Public HospitalMethods: The six months cross-sectional study was conducted at the Karawang General Public Hospital for pre-eclampsia pregnant women with at least 28 weeks of gestational age. The pre-eclampsia criteria were blood pressure higher or equal to 140/90 mmHg and qualitative proteinuria dipstick +1. The subjects were divided into two groups: pre-eclampsia with severe features and without severe features. Severe features criteria were thrombocytopenia, impaired liver function, renal insufficiency, pulmonary edema, new onset headache, and visual disturbances. Pregnant women have their blood platelet indices checked in the form of platelet crit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR). Data were analyzed with descriptive analysis (percentage), cut-off analysis, ROC curve, AUC analysis, bivariate Chi-square analysis, and multivariate logistic regression analysis.Results: There was a significant difference (p < 0.05) in the value of PCT, MPV, PDW, and P-LCR between pregnant pre-eclampsia women with severe features and pregnant pre-eclampsia women without severe features. P-LCR has the best sensitivity (52.9%) and specificity (98.9%).Conclusions: There was a significant change in the value of the platelet indices (PCT, MPV, PDW, P-LCR) in pregnant pre-eclampsia women with severe features at the Karawang General Public Hospital.
Preservation of Goat Kidneys Using Low Concentration Formalin for Human Anatomy Learning Wisesa, Sindhu; Muflikhah, Khusnul; Mustofa, Mustofa; Arjadi, Fitranto
Smart Medical Journal Vol 5, No 2 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i2.62820

Abstract

Background: Exposure to formaldehyde from a preserved cadaver can cause several health problems in students, lecturers, and laboratory technicians working in medical anatomy laboratories. These conditions include respiratory tract irritation and cancer due to acute and chronic exposure, respectively. Lowering the frequency of contact with formaldehyde from preserved organs helps to ensure the safety of students, lecturers, and laboratory technicians. Therefore, this study aims to determine the effectiveness of low concentration formalin as a preservative solution for goat kidneys. The organ was selected due to its anatomical structure similarity to humans.Method: Goat kidneys with 50-60 ml of volume were collected, washed, immersed in preservative solution, and stored for two months. The samples were then divided into four groups, which were preserved with different formalin concentrations, namely 30%, 20%, 10%, and 5%. The preservation parameters, namely organ structure and integrity, color, springiness, odor, and mold growth were qualitatively described, while the kidney volume was quantitatively measured.Results: After the samples were preserved for two months, they were observed, and all groups showed similar characteristics. The kidneys preserved with 5% or 10% formalin showed equal volume before and after two months of preservation.Conclusion: Low concentration formalin has the same effectiveness in preserving goat kidneys as the high concentration. It also has the potential to be applied in human anatomy learning.
Co-Authors . HERNAYANTI Ahmad, Faiq Alaika Ailsa, Shafa Alfi Muntafiah Amilia Ramadhani Aminuyati Andromeda Andromeda Baehaqi Christiana Cahyani Prihastuti Denok Tri Hardiningsih Diah Krisnansari Dian Rosdiana, Dian Dinar Faiza Dita Ayu Dewi Laras Sati Diyah Woro Dwi Lestari Dody Novrial Dzicky Rifqi Fuadi Edy Priyanto Edy Priyanto Fani Tuti Handayani, Fani Tuti Fidnillah, Diva Azka Fitri Diah Oktadewi Fuady, Dzicky Rifqi Ghazali, Muhammad Farid Ginus Partadireja Hajid Rahmadianto Harini, Ika Murti Haris Budi Widodo Hernayanti Hernayanti Hidi, Aulli Rahman Ika Murti Harini Joko Mulyanto, Joko Joko Setyono Kasum, Kasum Kuncoro, Prasetyo Tri Lantip Rujito Lientje Setyawan Maurits Lientje Setyawati Maurits Mae Sri Hartati Wahyuningsih Mahindra Awwaludin Romdlon Maulida, Adzkia Mubayinul Khoeroh Muflikhah, Khusnul Mulyono Pangestu Mulyono Pangestu MULYOTO PANGESTU Mulyoto Pangestu Mustofa Mustofa Mustofa Mustofa Nenden Nursyamsi Agustina Nia Krisniawati Norina Agatri Norina Agatri Nur Signa Aini Gumilas Pauzi, Rizqi Yanuar Prasetyo Tri Kuncoro Pratama, Radya Putra Pugud Samodro Qodri Santosa Rangga Wisnu Wardana Rizak Tiara Yusan Saad, Nursan Saefuddin Aziz Saefuddin Aziz Samodro, Pugud Setiawati Setiawati Setyanto, Muhamad Rifqi Sindhu Wisesa Sindhu Wisesa Sirajuddin, Mohammad Salman Soegianto, Jap Yulius Billy Sri Kadarsih Soejono Sri Kadarsih Soejono Susiana Candrawati Tuti Sri Suhesti Vitasari Indriani Wahyu Siswandari Wahyu Siswandari Wahyu Siswandari Wahyudin Wahyudin Wahyudin Wahyudin wardana, Tirta Widiartini, Catharina Widyaningsih, Pratiwi Nur Wisesa, Sindhu Yudatmo, Unggul Yudhi Wibowo Yulia Fauziyah Zhafira, Adistya Hasna