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OCCURRENCE OF ENCEPHALITIS AND HEPATITIS FROM COLIBACILLOSIS CASES IN PIGLETS Febe Adonia Renandra Hermawan; I Nengah Kerta Besung; I Ketut Berata; I Nyoman Mantik Astawa; Ida Ayu Pasti Apsari
Buletin Veteriner Udayana Bul. Vet. Udayana. October 2024 Vol. 16 No. 5
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2024.v16.i05.p15

Abstract

Pig farming management cannot be separated from various obstacles that can hamper the productivity of a farm, one of which is infection in livestock, both piglets and adult pigs. One of the diseases that can attack pigs is colibacillosis. Colibacillosis is an infection in pigs in the lactation and weaning phase caused by Eschenrichia coli. Infection of E. coli most cause disease and death in newborn and newly weaned pigs. This research aims to establish a diagnosis of the death of piglets originating from one of the farms in Catur Village, Kintamani, Bangli, Bali. The case pig is a Landrace type, 52 days old, weighing 4 kg, female and kept in a cage. The pigs started to look sick and had no appetite for approximately 1 week, totaling 26 pigs, including 3 sows and 23 puppies. A total of 5 piglets were sick for one week and 2 piglets were found dead. Dead pigs were examined for anatomical pathology, histopathological changes and isolation and identification of bacteria. In anatomical pathology and histopathology, the case animals experienced encephalitis, hemorrhagic pneumonia, hepatitis, hemorrhagic and necrotizing enteritis. The results of bacterial identification show on the media Eosin Methylene Blue Agar (EMBA) colonies appear metallic and shiny, round shape, smooth edges. Gram-negative rod-shaped bacteria, with biochemical tests such as Escherichia coli. Based on the anamnesis, epidemiology of the disease, post-mortem changes, visible lesions in several organs, as well as the results of isolation and identification of bacteria, the cause was diagnosed as Escherichia coli. Owners can prevent disease by maintaining pig farm sanitation.
MACROSCOPIC ANALYSIS OF INCISION WOUND HEALING IN WHITE RATS TREATED WITH PLATELET-RICH PLASMA DERIVED FROM PORCINE BLOOD Made Sandy Widhi Raharja; I Wayan Wirata; Anak Agung Sagung Kendran; I Gusti Ngurah Sudisma; I Wayan Gorda; I Ketut Berata
Buletin Veteriner Udayana Bul. Vet. Udayana. April 2025 Vol. 17 No. 2
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i02.p10

Abstract

Platelet-rich plasma (PRP) has been identified as a potential therapeutic agent to mitigate factors that impede healing. PRP, which is enriched with growth factors, plays a critical role in accelerating tissue regeneration across various stages of wound repair. This study aimed to investigate the effects of PRP derived from porcine blood on the healing of incisional wounds in white rats (Rattus norvegicus). Macroscopic parameters, including wound length, wound color, moisture levels, and crust formation, were evaluated. The study employed an experimental design, utilizing a split-time completely randomized design (CRD) with statistical analysis. The results demonstrated significant improvements in wound closure, as evidenced by reduced wound length, accelerated changes in wound color, maintained wound moisture leading to faster drying, and enhanced crust formation, all of which contributed to a reduction in wound size (P < 0.05). These findings indicate that PRP derived from porcine blood significantly accelerates the healing process of incisional wounds in white rats, as reflected by macroscopic healing indicators. Further research is recommended to determine the optimal shelf life of PRP to ensure its efficacy and stability during prolonged storage, thereby supporting its sustainable clinical application.
ISTOPATHOLOGY OF THE BRAIN OF WHITE RATS UPON ADMINISTRATION OF MIMOSIN FROM SIMPLISIA OF LEUCAENA LEAVES Yuyun Setia Ningsih; I Ketut Berata; Ni Luh Eka Setiasih; I Made Kardena; Samsuri; I Made Merdana
Buletin Veteriner Udayana Bul. Vet. Udayana. June 2025 Vol. 17 No. 3
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i03.p46

Abstract

Lamtoro (Leucaena leucocephala) is a widely used cattle feed in Indonesia due to its high protein, flavonoid, and tannin content. However, it contains mimosine, a compound whose effects on the liver remain poorly understood. This study aimed to investigate the histopathological effects of mimosine on the liver of experimental animals. Twenty male Wistar rats (Rattus norvegicus), aged 2 months (150–200 g), were divided into four groups: a negative control (P0), a positive control given pure mimosine (5 mg/head/day, P1), and two groups administered mimosine from lamtoro leaf simplisia at 50 mg/head/day (P2) and 150 mg/head/day (P3). Treatments were administered orally for 14 days. On day 15, liver samples were collected, fixed in 10% neutral buffered formalin (NBF), and processed for histopathological analysis using hematoxylin-eosin (H&E) staining. Lesions (congestion, inflammation, and necrosis) were scored on a scale of 0 (normal) to 3 (severe). Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. Results showed that pure mimosine (5 mg) and lamtoro simplisia (50 mg and 150 mg) induced significant hepatic congestion compared to controls, while inflammation was not statistically significant. Necrosis was not observed in any group. No significant difference was found between the two doses of lamtoro simplisia. These findings suggest that mimosine, whether pure or derived from lamtoro leaves, induces mild to moderate liver damage, primarily congestion, but further research is needed to clarify its long-term effects.
Co-Authors Afrizal Choirul Umam Agnes Endang Tri H Aida Lousie Tenden Rompis Ainul - Hidayah Alviana Rizqiyah Utami Amelia, Ni Kadek Shita Anak Agung Ayu Mirah Adi Anak Agung Gde Arjana Anak Agung Gde Jaya Wardhita, Anak Agung Gde Jaya Anak Agung Gde Jaya Warditha Anak Agung Oka Anak Agung Sagung Kendran Anak Agung Sagung Kendran Apsari, Ni Luh Putu Nadia Ardi Sandriya Aristawati, I Dewa Agung Ayu Irma Astari, Ni Putu Widya Astini, Ni Putu Sri Ayu Aulia Insani, Aulia Ayu Prawitasari Citra Pratama Bina Ichsantya Budiartawan, I Komang Alit Damara, Doni Darmawan, I Gusti Ayu Chintya Darmayanti, Mahda Dwi Delima Marsinta Ida Pasaribu Devira, Dinda Dewa Ayu Dwita Karmi Dhinar Wahyu Prasetyo Dini Hilary Manullang DORTY PRIHASTINA SALBAHAGA Duwiri, Christine Valeri Dwi Muslifah Nur Hijayani DWI SURYANTO Dzikri Nurma'rifah Takariyanti Elisabeth Karina Elsa Hidayati Elti Febilani Elyda . Erwanti Siti Rabiah, Erwanti Siti Farhan Abdul Hasan, Farhan Abdul Febe Adonia Renandra Hermawan Febrianty, Ni Made Dhea Fitri Irawan Rahmawandani Franky Samuel Milenyano Chandra Gde Jasmara Muda Gheasella Fia Gunawan Ginting, Regina Bonifasia Br Gunawan, Stefanus Andre Gunawati, Luh Sri Guru, Yohana Cendyka Kartika Dewi Gusti Agung Ayu Alecia Putri Anugrahaeni Gusti Agung Ayu Putu Adriyati, Gusti Agung Ayu Gusti Ayu Yuniati Kencana Hamong Suharsono Hapsari Mahatmi Hendrina Konda M Meha, Hendrina Konda M Humaira, Sarah Husnul Khatimah I Dewa Made Adhiwitana I GEDE ENDRA KUSUMA I Gusti Bagus Sathya Dharma, I Gusti Bagus Sathya I Gusti Ketut Suarjana I Gusti Ketut Suarjana I Gusti Ngurah Kade Mahardika I Gusti Ngurah Sudisma I Gusti Putu Tovan Mahottama I KETUT ELI SUPARTIKA I Ketut Eli Supartika I Ketut Eli Supartika I Ketut Puja I Ketut Suatha I Ketut Suatha I Ketut Sumadi I Ketut Wirata I Made Damriyasa I Made Dwinata I Made Dwinata I Made Indrayadnya Swarayana I Made Kardena I Made Kardena I Made Merdana I Made Merdana I Made Merdana I Made Putra Wiadnyana I Made Sukada I N. T. ARIANA I Nengah Kerta Besung I NYOMAN ADI SURATMA I NYOMAN MANTIK ASTAWA I Nyoman Mantik Astawa I Nyoman Sulabda I Putu Suparman I W BUDIARSA SUYASA I Wayan Gorda I Wayan Sudira I Wayan Sudira I Wayan Wirata I Wayan Wirata Ida Ayu Pasti Apsari Ida Ayu Pasti Apsari Ida Bagus Kade Suardana Ida Bagus Kade Suardana Ida Bagus Komang Ardana Ida Bagus Made Oka Ida Bagus Made Oka Ida Bagus Oka Winaya Ida Bagus Windia Adnyana Iwan Harjono Utama Janardani, Ni Made Kunti Jayawardhita, Anak Agung Gde Kadek Karang Agustina Kadek Karina Dewi Wijayanthi Kartika, Erena Hajar Ketut Budiasa Ketut Eli Supartika Ketut Novi Kusmayani Ketut Tono Pasek Gelgel Kevin Dominika Kristi Agusti Putri, Kristi Agusti Kusuma, Putu Winatha Laila Gianita Veralyn Luh Gde Sri Surya Heryani Luh Made Sudimartini Luh Made Sudimartini Luh Made Sudimartini Luh Putu Syamadina Pramesya Nareswari Lusiana Flora Ndagu Made Oka Adinata Made Rahayu Kusumadewi Made Ramadhinita Desrianti Made Sandy Widhi Raharja Marissa Divia Dayanti Marson, Fransiska Gratia Sonita MAS DJOKO RUDYANTO Muhamad Furkam Fadilah Muhsi, Ach Moh Abd Nesia Masniari Helena Sibarani Ni Luh Eka Setiasih Ni Luh Eka Setiasih Ni Luh Eka Setiasih Ni Luh Eka Setiasih Ni Luh Eka Setiasih Ni Made Ayu Suastami Ni Nyoman Werdi Susari Ni Nyoman Werdi Susari Ni Nyoman Werdi Susari Nofantri, Lidia Noviriolla Maria Nugraha, Putri Nurhasyiat Nasaruddin Nyoman Adi Suratma Oktaviandari, Putu Risma Palagan Senopati Sewoyo Pangesti, Thiara A. Pramesti, Ni Komang Lady Prista Oktafebri Yulestari Pujaswarini, Ni Made Hani Purnama, Komang Andika Purnata, I Dewa Nyoman Alit Putra, I Putu Agus Antara Putri Yuliana Mangindaan Putu Agus Trisna Kusuma Antara Putu Henrywaesa Sudipa Putu Suastika Raharjo, Yudha Yaksa Crada Yoga Arum Rahmat Grahadi RAHMI MUSTABA Sam suri Samsuri Samsuri Samsuri Samsuri Sari Sartini, Sari Setianingsih, Ni Luh Eka Setyawati, Luh Gede Sewoyo, Palagan Senopati Sihotang, Tanti Fitri Sri Kayati Widyastuti Suranjaya I .Gd Tanuwijaya, Phebe Amadea Vaswani Samaria Napitupulu Wahyu Semadi Putra Waskitha, Melati Pusparini Widia Insani Wulandari, Meidi Andira Yanne Yanse Rumlaklak Yesi Veronica Sitepu Yustisia, Anggia Yuyun Setia Ningsih Zumara Mufida Hidayati