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All Journal Hemera Zoa Media Veteriner Jurnal Ilmu dan Kesehatan Hewan Buletin Veteriner Udayana Majalah Ilmiah Peternakan Jurnal Veteriner Indonesia Medicus Veterinus Ecotrophic, Journal of Environmental Science Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Media Kedokteran Hewan Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Journal of Veterinary and Animal Sciences Jurnal Medika Veterinaria
I Ketut Berata
Fakultas Kedokteran Hewan Universitas Udayana Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Indonesian Newcastle Disease Virus Field Isolate Reduces c-Jun Expression in Rat Mammary Cancer Models Marson, Fransiska Gratia Sonita; Sewoyo, Palagan Senopati; Astawa, I Nyoman Mantik; Adi, Anak Agung Ayu Mirah; Suardana, Ida Bagus Kade; Winaya, Ida Bagus Oka; Berata, I Ketut
Media Kedokteran Hewan Vol. 36 No. 1 (2025): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v36i1.2025.13-20

Abstract

c-Jun is often found to be overexpressed in various cancers, so this gene might be a target for cancer therapy. Newcastle disease virus (NDV) is recognized for its oncolytic properties and potential as a cancer virotherapy agent, with various mechanisms reported to trigger cancer cell death. This study aimed to assess the c-Jun expression in rat mammary cancer models. Rat mammary cancer models were categorized into two treatment groups: the control group (C) and the virotherapy group (V). Group C was administered with 0.5 cc of sterile PBS, while group V received 7 log 2 HAU per 0.5 cc of the Indonesian NDV field isolate Tabanan-1/ARP/2017 intratumorally. The treatment was carried out for four days in a row. Two weeks after treatment, all rats were humanely euthanized, and mammary cancer tissues were excised for further examination. Mammary cancer tissues were examined histopathologically and analyzed using immunohistochemistry to determine intranuclear c-Jun expression, quantified by the H-Score. The results demonstrated that NDV significantly reduced c-Jun expression. It can be inferred that NDV Tabanan-1/ARP/2017 holds potential as a mammary cancer therapy agent by reducing c-Jun expression. This finding is considered novel, as there have been no previous reports of decreased c-Jun expression following virotherapy with NDV.
Identification of Colisepticemia in Broiler Chicken in Tabanan, Bali Devira, Dinda; Ketut Tono Pasek Gelgel; I Ketut Berata
Jurnal Veteriner dan Biomedis Vol. 3 No. 1 (2025): Maret
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.3.1.1-8.

Abstract

Colisepticemia is a condition where Escherichia coli and its toxins have spread to tissues or organs that can cause organ damage or inflammation. Colisepticemia is a sign of acute colibacillosis in poultry which can result in death and in its subacute form is characterized by pericarditis, airsacculitis and perihepatitis. The incidence of colibacillosis in poultry can result in economic losses due to reduced production, increased medical costs, and even death. The aim of this study was to establish a diagnosis of the death of 15 days old broiler chicken. Based on the necropsy results, characteristic anatomical pathology was found in the form of fibrin membranes on the heart and liver, as well as lesions on other organs. Identification and isolation of bacteria in the laboratory using samples from the heart, liver and intestines showed positive results for Escherichia coli. Parasitological examination using feces did not reveal any parasitic agents involved in this case. Based on clinical symptoms, anatomical pathology examination, histopathology, culture and identification of bacteria, it can be concluded that the cause of chicken death was colisepticemia caused by Avian Pathogenic Escherichia Coli (APEC).
Coccidiosis In Broiler Chicken Aged 27 Days From A Farm In Tunjuk, Marga, Tabanan, Bali: A Case Study Amelia, Ni Kadek Shita; Suratma, Nyoman Adi; Berata, I Ketut; Besung, I Nengah Kerta; Mahardika, I Gusti Ngurah Kade
Jurnal Medika Veterinaria Vol 19, No 2 (2025): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v19i2.48001

Abstract

Coccidiosis, also commonly referred to as bloody diarrhea, is caused by Eimeria spp. and primarily affects the digestive tract. The most pathogenic Eimeria species in chickens are Eimeria tenella and Eimeria necatrix. The subject of this case study was a 27-day-old female broiler chicken from a commercial farm located in Tunjuk Village, Marga Subdistrict, Tabanan Regency, Bali. The chicken had been reported to suffer from bloody diarrhea for five days, accompanied by clinical signs of weakness, anorexia, pale comb, ruffled feathers, and a tendency to huddle in the corner of the pen. This case study aimed to describe the anatomical pathology, histopathology, and laboratory findings to obtain a definitive diagnosis of the disease affecting this chicken. The results of the anatomical pathology examination showed hemorrhage in the cecum. Histopathological examination of the cecum revealed the presence of schizonts, hemorrhage, and inflammatory cell infiltration. Qualitative fecal examination confirmed the presence of Eimeria spp. oocysts, while quantitative fecal examination using the McMaster technique revealed 895,600 oocysts per gram of feces, indicating a severe infection. Based on clinical observations, epidemiological data, gross pathological changes, histopathological findings, and fecal examinations using native, sedimentation, flotation, and McMaster methods, it was concluded that the chicken was affected by coccidiosis.
Co-Authors Afrizal Choirul Umam Agnes Endang Tri H Aida Lousie Tenden Rompis Ainul - Hidayah Alviana Rizqiyah Utami Amelia, Ni Kadek Shita Anak Agung Ayu Mirah Adi Anak Agung Gde Arjana Anak Agung Gde Jaya Wardhita, Anak Agung Gde Jaya Anak Agung Gde Jaya Warditha Anak Agung Oka Anak Agung Sagung Kendran Apsari, Ni Luh Putu Nadia Ardi Sandriya Aristawati, I Dewa Agung Ayu Irma Astari, Ni Putu Widya Astini, Ni Putu Sri Ayu Aulia Insani, Aulia Ayu Prawitasari Citra Pratama Bina Ichsantya Budiartawan, I Komang Alit Damara, Doni Darmawan, I Gusti Ayu Chintya Darmayanti, Mahda Dwi Devira, Dinda Dewa Ayu Dwita Karmi Dhinar Wahyu Prasetyo Dini Hilary Manullang DORTY PRIHASTINA SALBAHAGA Duwiri, Christine Valeri DWI SURYANTO Dzikri Nurma'rifah Takariyanti Elisabeth Karina Elsa Hidayati Elti Febilani Elyda . Erwanti Siti Rabiah, Erwanti Siti Farhan Abdul Hasan, Farhan Abdul Febrianty, Ni Made Dhea Fitri Irawan Rahmawandani Franky Samuel Milenyano Chandra Gde Jasmara Muda Ginting, Regina Bonifasia Br Gunawan, Stefanus Andre Gunawati, Luh Sri Guru, Yohana Cendyka Kartika Dewi Gusti Agung Ayu Putu Adriyati, Gusti Agung Ayu Hendrina Konda M Meha, Hendrina Konda M Humaira, Sarah Husnul Khatimah I Dewa Made Adhiwitana I GEDE ENDRA KUSUMA I Gusti Bagus Sathya Dharma, I Gusti Bagus Sathya I Gusti Ketut Suarjana I Gusti Ngurah Kade Mahardika I Gusti Putu Tovan Mahottama I Ketut Eli Supartika I Ketut Eli Supartika I KETUT ELI SUPARTIKA I Ketut Puja I Ketut Sumadi I Ketut Wirata I Made Damriyasa I Made Indrayadnya Swarayana I Made Kardena I Made Merdana I Made Putra Wiadnyana I Made Sukada I N. T. ARIANA I NYOMAN ADI SURATMA I NYOMAN MANTIK ASTAWA I Nyoman Sulabda I Putu Suparman I W BUDIARSA SUYASA I Wayan Sudira I Wayan Wirata Ida Ayu Pasti Apsari Ida Bagus Kade Suardana Ida Bagus Komang Ardana Ida Bagus Made Oka Ida Bagus Oka Winaya Ida Bagus Windia Adnyana Iwan Harjono Utama Janardani, Ni Made Kunti Jayawardhita, Anak Agung Gde Kadek Karang Agustina Kadek Karina Dewi Wijayanthi Kartika, Erena Hajar Ketut Budiasa Ketut Eli Supartika Ketut Novi Kusmayani Ketut Tono Pasek Gelgel Kevin Dominika Kristi Agusti Putri, Kristi Agusti Kusuma, Putu Winatha Laila Gianita Veralyn Luh Made Sudimartini Lusiana Flora Ndagu Made Oka Adinata Made Rahayu Kusumadewi Marissa Divia Dayanti Marson, Fransiska Gratia Sonita MAS DJOKO RUDYANTO Muhamad Furkam Fadilah Muhsi, Ach Moh Abd Nesia Masniari Helena Sibarani Ni Luh Eka Setiasih Ni Nyoman Werdi Susari Nofantri, Lidia Noviriolla Maria Nugraha, Putri Oktaviandari, Putu Risma Palagan Senopati Sewoyo Pangesti, Thiara A. Pramesti, Ni Komang Lady Prista Oktafebri Yulestari Pujaswarini, Ni Made Hani Purnama, Komang Andika Purnata, I Dewa Nyoman Alit Putra, I Putu Agus Antara Putri Yuliana Mangindaan Putu Agus Trisna Kusuma Antara Putu Suastika Raharjo, Yudha Yaksa Crada Yoga Arum Rahmat Grahadi RAHMI MUSTABA Sam suri Samsuri Samsuri Sari Sartini, Sari Setianingsih, Ni Luh Eka Setyawati, Luh Gede Sewoyo, Palagan Senopati Sihotang, Tanti Fitri Sri Kayati Widyastuti Suranjaya I .Gd Tanuwijaya, Phebe Amadea Vaswani Samaria Napitupulu Wahyu Semadi Putra Waskitha, Melati Pusparini Widia Insani Wulandari, Meidi Andira Yanne Yanse Rumlaklak Yesi Veronica Sitepu Yustisia, Anggia Zumara Mufida Hidayati