Article Per Year (5 Year)
p-Index From 2021 - 2026
5.149
P-Index
This Author published in this journals
All Journal Indonesian Journal of Geography Tekno : Jurnal Teknologi Elektro dan Kejuruan ELKHA : Jurnal Teknik Elektro Mechatronics, Electrical Power, and Vehicular Technology TELKOMNIKA (Telecommunication Computing Electronics and Control) Jurnal Ilmiah Teknik Elektro Komputer dan Informatika (JITEKI) Jurnal Edukasi dan Penelitian Informatika (JEPIN) Proceeding of the Electrical Engineering Computer Science and Informatics Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan International Journal of Artificial Intelligence Research INTENSIF: Jurnal Ilmiah Penelitian dan Penerapan Teknologi Sistem Informasi Knowledge Engineering and Data Science at-tamkin: Jurnal Pengabdian kepada Masyarakat CYCLOTRON Journal of Computer Science and Informatics Engineering (J-Cosine) JFIOnline Infotekmesin Buletin Ilmiah Sarjana Teknik Elektro Jurnal Karinov TRIDARMA: Pengabdian Kepada Masyarakat (PkM) Frontier Energy System and Power Engineering jurnal syntax admiration Jurnal JEETech Jurnal Abdimas Berdaya : Jurnal Pembelajaran, Pemberdayaan dan Pengabdian Masyarakat Unri Conference Series: Community Engagement International Journal of Robotics and Control Systems International Journal of Advanced Science and Computer Applications Bulletin of Pedagogical Research ALINIER: Journal of Artificial Intelligence & Applications Ilmu Komputer untuk Masyarakat Jurnal Fortech SinarFe7 Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Journal of Scientech Research and Development INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY Reflection Journal Jurnal Inovasi Teknologi dan Edukasi Teknik Lentera: Multidisciplinary Studies Bulletin of Social Informatics Theory and Application Jurnal INFOTEL ABDI UNISAP: Jurnal Pengabdian Kepada Masyarakat Lentera: Multidisciplinary Studies Jurnal FORTECH
Siti Sendari
Universitas Negeri Malang
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

Published : 57 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : JFIOnline

 1 
EFFECTS OF PENTAGAMAVUNONAT-0 SODIUM ON RAT ISOLATED-AORTIC SMOOTH MUSCLE CONTRACTION Nugroho, Agung Endro; Sendari, Siti; Soraya, Fenthy; Margono, Supardjan A.
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 2 (2010)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Natrium pentagamavunonat-0 merupakan bentuk garam dari senyawa pentagamavunon (PGV-0). Modifikasi PGV-0 menjadi bentuk garam dimaksudkan untuk meningkatkan kelarutannya. Pada penelitian ini, natrium PGV-0 diuji pengaruhnya terhadap kontraksi otot polos aorta terisolasi yang diinduksi agonis reseptor a1 adrenergik, yaitu fenilefrin. Disamping itu, natrium PGV-0 juga dipelajari efek relaksasi pada organ tersebut. Hasil penelitian menunjukkan bahwa natrium PGV-0 menghambat kontraksi otot polos aorta tikus secara bermakna. Senyawa tersebut dapat menurunkan baik harga pD2 maupun efek maksimum dari fenilefrin. Disampimg itu, natrium PGV-0 menunjukkan efek relaksasi yang poten pada organ tersebut, dengan nilai pD2 sebesar 4,41. Berdasarkan hasil tersebut disimpulkan bahwa natrium PGV-0 menunjukkan efek yang poten pada otot polos aorta terisolasi yang diinduksi agonis reseptor a1 adrenergik.   ABSTRACT PGV-0 is reported possessing some pharmacological effects such as anti-cancer, anti-allergy, anti-inflammatory, anti-oxidative etc. Its effects are more potent than curcumin. However, this compound has limitation in its solubility. Modifying the compound to its salt form is supposed to overcome this problem. The aim of the research is to investigate the effects of PGV-0 sodium on rat isolated-aortic smooth muscle contraction, and its relaxant effect on the tissue. The study was conducted using an isolated organ technique with an isotonic transducer. The percentage of response either contraction or relaxation was then plotted as a logaritmic scale of concentration-response curve to calculate pD2 value, a negative logaritmic of concentration of drug inducing 50% of maximum effect. The results have shown that treatment of PGV-0 sodium obviously inhibited the contraction of rat isolated-aortic smooth muscle induced by phenylephrine. The compound could decrease both pD2 and Emax values of phenylephrine significantly. The results indicate that PGV-0 sodium could attenuate both potency and intrinsic activity of contraction effect of phephylephrine. Besides, the compound also stimulated relaxant effects to a single phenylephrine contraction with pD2 value of 4.41. The compound could restore phenylephrine-induced tension into baseline level. Based on the results, PGV-0 sodium showed potent effects on rat isolated-aortic smooth muscle.
EFFECTS OF PENTAGAMAVUNONAT-0 SODIUM ON RAT ISOLATED-AORTIC SMOOTH MUSCLE CONTRACTION Nugroho, Agung Endro; Sendari, Siti; Soraya, Fenthy; Margono, Supardjan A.
Jurnal Farmasi Indonesia Vol 5, No 2 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i2.38

Abstract

Natrium pentagamavunonat-0 merupakan bentuk garam dari senyawa pentagamavunon (PGV-0). Modifikasi PGV-0 menjadi bentuk garam dimaksudkan untuk meningkatkan kelarutannya. Pada penelitian ini, natrium PGV-0 diuji pengaruhnya terhadap kontraksi otot polos aorta terisolasi yang diinduksi agonis reseptor a1 adrenergik, yaitu fenilefrin. Disamping itu, natrium PGV-0 juga dipelajari efek relaksasi pada organ tersebut. Hasil penelitian menunjukkan bahwa natrium PGV-0 menghambat kontraksi otot polos aorta tikus secara bermakna. Senyawa tersebut dapat menurunkan baik harga pD2 maupun efek maksimum dari fenilefrin. Disampimg itu, natrium PGV-0 menunjukkan efek relaksasi yang poten pada organ tersebut, dengan nilai pD2 sebesar 4,41. Berdasarkan hasil tersebut disimpulkan bahwa natrium PGV-0 menunjukkan efek yang poten pada otot polos aorta terisolasi yang diinduksi agonis reseptor a1 adrenergik.   ABSTRACT PGV-0 is reported possessing some pharmacological effects such as anti-cancer, anti-allergy, anti-inflammatory, anti-oxidative etc. Its effects are more potent than curcumin. However, this compound has limitation in its solubility. Modifying the compound to its salt form is supposed to overcome this problem. The aim of the research is to investigate the effects of PGV-0 sodium on rat isolated-aortic smooth muscle contraction, and its relaxant effect on the tissue. The study was conducted using an isolated organ technique with an isotonic transducer. The percentage of response either contraction or relaxation was then plotted as a logaritmic scale of concentration-response curve to calculate pD2 value, a negative logaritmic of concentration of drug inducing 50% of maximum effect. The results have shown that treatment of PGV-0 sodium obviously inhibited the contraction of rat isolated-aortic smooth muscle induced by phenylephrine. The compound could decrease both pD2 and Emax values of phenylephrine significantly. The results indicate that PGV-0 sodium could attenuate both potency and intrinsic activity of contraction effect of phephylephrine. Besides, the compound also stimulated relaxant effects to a single phenylephrine contraction with pD2 value of 4.41. The compound could restore phenylephrine-induced tension into baseline level. Based on the results, PGV-0 sodium showed potent effects on rat isolated-aortic smooth muscle.
Co-Authors A'ini, Qurrotul A.N. Afandi Abdul Wafi Abdur Rohman Achmad Jefri Achmad Jefri Achmad Jefri Afnan Habibi, M. Agung Bella Putra Utama Agung Endro Nugroho Agung Sucipto, Putra Wisnu Agus Rahma Dani, Ayunda Aji Prasetya Wibawa Alief Fajar Syahputra Amalia Nurutami Amalia Prameswari Alvina Andi Khoirudin Andis Wijaya Anik Nur Handayani Anisatul Qomariyah Arengga Wibowo, Danang Arengga, Danang Argeshwara, Dityo Kreshna Arifin, Samsul Aripriharta - Arnista Vindriyanti Ashar, Muhammad Ashrofil Muzaki Ayunda Agus Rahma Dani Bagaskoro, Muhammad Cahyo Baliyah Ahmad Fathoni Benny Agung Prasetyo Billah, Egi Nursari Burhanudin Yusuf Abdullah Ar Ramadhan Cahyaning Wulandari Cahyaning Danang Arengga Wibowo Dava Desti Yanti Dendi Mukti Putranto Desti Yanti, Dava Devi Dwi Purwanto Dian Candra Lestari Didik Dwi Prasetya Dwi Mukti Asmoro Sari Dwi Puri Fatmawati Dyah Lestari Eko Noerhayati Elbaith, Ilham ari Eli Hendrik Sanjaya Elista Kartika Sari Faiz Syaikhoni Aziz Fajar Syahputra, Alief Fakhruddin, Dhiyaurrahman Fatma Cahyaningrum Fitri, Shofiana Franky Melky Giri Wahyu Wiriasto Guyub Raharjo Hakiki, A.Riyan Rahman Hakkun Elmunsyah Hanny Prasetya Hariyadi Haq, Sigit Prasetyo Harits Ar Rosyid Hary Suswanto Heru Wahyu Herwanto Hidiyah, Tabita May Hsien-I Lin I Made Wirawan Ilham Ari Elbaith Ilham Ari Elbaith Zaini Ira Kumalasari Irham Fadlika Irvan, Mhd James Aditama Januar Arief Muhammad Joumil Aidil Saifuddin Kamil Faqih Kartika Sari, Elista Khoiruddin Asfanie Kotaro Hirasawa Kumalasari, Ira Langlang Gumilar Listyo Yudha Irawan M. Bagus Arifin Made Radikia Prasanta Mahfud Jiiono Mahfud Jiono Mario Leo Nardo Melky, Franky Melta Dhemahestri Misik Rahayu Oktaningsih Moch. Burhanuddin Alfarobbi Mochamad Farhan Ali Irfani Mochammad Haidar Ridho Mochtar, Norrima Moh. Zainul Falah Mohammad Yussril Asri Mokh Sholihul Hadi Mokhammad Nasrulloh Mokhtar , Norrima Binti Mokthar, Norrima binti Muhamad Syamsu Iqbal Muhammad Aditya Firnanda Muhammad Fajar Saifuddin Muhammad Hanif Abdur Razaq Muhammad Tahfidlul Azmi Muhammad Yoga Pranata Mukti Putranto, Dendi Muladi Mustika, Soraya N. Muzayana Muzayana Nastiti Susetyo Fanani Putri Nastiti Susetyo Fanani Putri Nastiti Susetyo Fanany Putri Ni’am, Faj’run Nobri Wicaksono Nur Halim Nurutami, Amalia Nuzul Zaeni Eki Ramadhanu Pramesti, Fadila Claudia Prana Ihsanuddin, Adika Prasetya Widiharso Prasetya Widiharso Prasetya Widiharso Prastiwi, Mellinia Regina Putri, Nanda Regita Ramadan, Bimastyaji Surya Ramadani, Bakhrul Mukhid Fadilah Ria Rahmawati Rina Dewi Indahsari Rindi Santika Agustin Ristanto Aji Prakoso Rizki Jumadil Putra Rizky Asilia Puspita Sari Rosmin, Norzanah Samsul Arifin Setumin , Samsul Setumin, Samsul Shofiana Fitri Shrestha, Rajendra Prasad Soraya Norma Mustika Soraya, Fenthy Soraya, Fenthy Supardjan A. Margono Susilo, Suhiro Wongso Syaad Patmanthara Syabani, Muhiban Syafaat, Mokhammad Syafiq Ubaidillah Syamsul Arifin Syamsul Bachri Utomo, Imam Tree Wahyu Sakti Gunawan Irianto Wahyu Tri Handoko Waridno, Aji J. T. Wibowo, Danang Arengga Wibowo, Dian S. Wibowo, Fauzy Satrio Wildan Iswahyudi Yogi Dwi Mahandi Yudhi Christianto Yuni Rahmawati Zaeni, Ilham Ari Elbaith Zulkarnain, Aldo Z. A.