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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Majalah Kesehatan Pharmamedika Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research IJOEP : International Journal of Ecophysiology International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Cakradonya Dental Journal Journal of Pharmaceutical and Sciences.
Aminah Dalimunthe
Departement Of Pharmacology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary

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The Effect of Ethanol Extract of Avocado Leaf (Persea Americana Mill.) on Reduction of Gastric Acid in Aspirin Induced Rats Simbolon, Rohana Oktofariday; Dalimunthe, Aminah; Bangun, Hakim
Journal La Medihealtico Vol. 5 No. 3 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i3.972

Abstract

One of the most prevalent dangerous illnesses is arthritis. The pathophysiology of gastritis is an imbalance of aggressive and protective factors. Nonsteroidal anti-inflammatory drugs are known as aggressive agents for the development of gastritis. Gastritis can be managed using avocado leaves. Finding out how an avocado leaf ethanol extract changed the amount of stomach acid in aspirin-treated rats was the aim of the investigation. Secondary metabolite content and characterisation were examined in the avocado leaf ethanol extract. Gastric acid reduction was performed by examining gastric acid concentration, number of ulcers, ulcer index, and pH in aspirin-induced rats. Ethanol extract of avocado leaves contains alkaloids, flavonoids, saponins, steroids, tannins and glycosides. Characterization obtained moisture content of 12.60%, total ash content of 1.34% and acid insoluble ash content of 0.17%. Acid concentration in the administration of avocado leaf ethanol extract 400 mg/KgBW is 16.00 ± 2.65 significantly different from the negative control 27.67 ± 2.52. The number of ulcers on the administration of avocado leaf ethanol extract 400 mg/KgBW 1.67 ± 2.08 is significantly different from the negative control 5.33 ± 0.58. When avocado leaf ethanol extract 400 mg/ kgBW is administered, the ulcer index (0.003 ± 0.005) differs significantly from the negative control (0.014 ± 0.013). pH in the administration of avocado leaf ethanol extract 400 mg / kgBW 5.53 ± 0.57 is significantly different from the negative control 2.57 ± 0.12. The ethanol extract of avocado leaf 400 mg/kgBW has a reducing gastric acid effect.
Comparison of Antibacterial Activity of Ethanol Extract and Nanoparticles of Crassocephallum Crepidioides S.Moore Against Staphylococcus Aureus Candrika, Candrika; Dalimunthe, Aminah; Bangun, Hakim
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1160

Abstract

This research seeks to examine the width of the inhibitory zone of extracts and nanoparticles of Crassocephalum crepidioides leaf simplisia, which have many advantages such as wound therapy, diarrhea relief, anti-inflammatory properties, and antibacterial effects. The antibacterial activity of Crassochepallum crepidioides (Benth) was evaluated by using the ethanol extract and nanoparticles. S. Moore departs. The agar diffusion technique was used to test it on paper plates. 0.1 ml of bacterial inoculum was introduced into a sterile petri dish, followed by the addition of 15 ml of Mueller Hinton agar media at a temperature range of 45-50ºC. Subsequently, multiple paper plates were immersed in a test solution containing a strong leaf ethanol extract and nanoparticles with different concentrations. Characterization reveals that Crassocephalum crepidioides is composed of many bioactive components, including alkaloids, flavonoids, saponins, tannins, and steroids. The analysis of the extract revealed that it contained 5.92% water, 12.86% total ash, 1.55% acid-insoluble ash, 14.33% water-soluble essence, and 9.34% ethanol-soluble essence. The nanoparticles had a size of 64.37 nm and exhibited antibacterial activity of extract ethanol at a concentration of 50% with a diameter of 12,00 mm. The minor concentration of the extract had a diameter of 3,166 mm, while the nanoparticles showed antibacterial activity at a concentration of 50% with a diameter of 10,53 mm. The minor concentration of the nanoparticle had a diameter of 3,00 mm The activity test results of the ethanol extract of Crassochepallum crepidioides with nanoparticles demonstrated that the inhibitory diameter of the ethanol extraction results remained more strong compared to the nanoparticles of simplisia powder.
Implementation of Pharmaceutical Care or Hypertension Patients in Communty Health Center of Lubuk Pakamdeli Serdang Darmirani, Yosi; Dalimunthe, Aminah; Khairunnisa, Khairunnisa
Journal La Medihealtico Vol. 5 No. 3 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i3.1447

Abstract

The objective of this research was to provide pharmaceutical care to patients with Hypertension and assess its effects on the occurrence of drug-related problems (DRPs), clinical outcomes, adherence levels, and quality of life of Hypertension patients at Puskesmas (Community Health Center) Lubuk Pakam. This research used a comparative experimental approach using a prospective cohort study design to assess the effects of an intervention on 73 individuals with Hypertension between March and August 2021. The PCNE V9.00 instrument was used to identify the occurrence of Drug-Related Problems (DRPs). Adherence level data was collected through the MMAS-8 questionnaire. Random blood glucose (RBG) data and Blood Pressure values were obtained by directly examining patients. The EQ-5D-3L questionnaire was used to gather data on the quality of life. The data were analyzed using the Wilcoxon Signed-Rank test and Friedman test in the SPSS V22.0 software. The findings indicated that the average occurrence of drug-related problems (DRPs) before to the intervention was 1.436 ± 0.502, however after the intervention, it decreased to 0.282 ± 0.456 (α <0.05). The mean blood pressure before to the intervention was 278.58 ± 75.278 mmHg, whereas after the intervention it decreased to 179.68 ± 14.008 mmHg (α <0.05). There was a substantial rise in the mean adherence score before to the intervention, from 5.00 ± 0.89 to 8.48 ± 0.77 (α<0.05). Similarly, the average quality of life score increased from 0.878 ± 0.176 to 1 ± 0.09 after the intervention (α<0.05).
Hepatoprotective effects of ethanol extract of mobe leaves/eeml (artocarpus lacucha buch-ham.) against carbon tetrachloride induced hepatotoxicity in rats: English Lubis, Meiva Amelia; Dalimunthe, Aminah; Sitorus, Panal; Satria, Denny
International Journal of Ecophysiology Vol. 6 No. 2 (2024): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v6i2.17505

Abstract

This study evaluates the protective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) on ALT, AST, and bilirubin levels in rats induced with carbon tetrachloride (CCl4) on Liver. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg BW of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The study concludes that mobe leaf extract has potential as a therapeutic agent to protect the liver from toxic damage. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended.
Efek Pasta Nanopartikel Kulit Pisang Barangan (Musa Paradisiaca Colla) Terhadap Permukaan Enamel Gigi Menggunakan Scanning Electron Microscopy Arfita Sipahutar; Sondang Pintauli; Aminah Dalimunthe
Cakradonya Dental Journal Vol 16, No 2 (2024): Agustus 2024
Publisher : FKG Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/cdj.v16i2.40140

Abstract

Karies gigi terjadi karena ketidakseimbangan antara demineralisasi dan remineralisasi gigi yang berlangsung terus-menerus. Pisang barangan (Musa paradisiaca Colla) bermanfaat dalam mencegah karies gigi. Penelitian ini bertujuan untuk menganalisis efek pemberian pasta nanopartikel kulit pisang barangan dengan konsentrasi 1, 2, dan 3% terhadap permukaan enamel gigi. Penelitian ini merupakan pra-eksperimen dengan desain pre dan post-test control group. Sampel yang digunakan adalah 25 gigi premolar yang dibagi 5 kelompok. Kelompok 1 diberi aplikasi pasta kosong (kontrol negatif), Kelompok 2 diberi aplikasi pasta CPP-ACP (kontrol positif), Kelompok 3 diberi aplikasi pasta nano kulit pisang barangan 1%, Kelompok 4 diberi aplikasi pasta nano kulit pisang barangan 2%, dan Kelompok 5 diberi aplikasi pasta nano kulit pisang barangan 3%. Hasil analisis SEM menunjukkan adanya penutupan porositas dan permukaan enamel yang lebih halus pada kelompok perlakuan 2-5, sedangkan pada kelompok 1 tidak menunjukkan perubahan. Berdasarkan hasil tersebut dapat disimpulkan bahwa pasta nanopartikel kulit pisang barangan yang diaplikasikan pada permukaan enamel gigi selama tujuh hari dapat mengurangi porositas pada permukaan enamel gigi.
Cardio Protective Effect of Ethanolic Extract Vernonia Amygdalina Delile on Rats Induced L-NAME Harahap, Rizki Doli Hartama; Harahap, Urip; Dalimunthe, Aminah
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.30981

Abstract

This study aimed to analyse the effects of ethanol extract of African leaves (Vernonia Amygdalina Del.) on the levels plasma renin, IL-6 and cardiac histopathology in L-NAME-induced rats. This research stage includes the preparation of ethanol extract of African leaves, standardization of extracts and testing the effectiveness of African leaves on rat heart damage. Data were analysed using one-way ANOVA with p<0.05. testing the cardioprotective effectiveness of ethanol extract of African leaves in hypertension model rats and then examining heart histopathology using HE staining and analysing parameters, namely plasma renin and IL-6 levels. This study used 6 groups, each group consisted of 5 male rats, namely the normal group, negative control by administering L-NAME 40 mg/kgBB, positive control by administering L-NAME plus lisinopril 2.5 mg/kgBB, EEDA 100 mg/kgBB, EEDA 300 mg/kgBB and EEDA 500 mg/kgBB. L-NAME responds to heart damage such as degeneration and necrosis of heart cells. In the negative group, plasma renin levels were 40.60 ± 9.98 ng/mL while the EEDA group with a dose of 500 mg/kgBB experienced the highest decrease in plasma renin compared to other EEDA groups and positive controls, namely 13.80 ± 1.30 ng/mL. The positive control group obtained plasma renin levels of 14.20 ±1.79 ng/mL. In the negative group, IL-6 levels were 4.80 ± 1.30 pg/mL while the group given EEDA, the group with a dose of 500 mg/kgBB experienced a decrease in IL-6, namely 1.52 ±0.96 ng/mL. The positive control group experienced a decrease in IL-6 levels of 0.77 ± 0.20 ng/mL. The result can be concluded that EEDA reduces plasma renin, IL-6 levels, improves the condition of cardiac cell degeneration and necrosis.
The Impact of Pharmaceutical Care Implementation on The Incidence of Drug-Related Problem and Clinical Outcome of Hypertension Patients at Puskesmas Lubuk Pakam in 2021 Darmirani, Yosi; Dalimunthe, Aminah; Khairunnisa; Iksen
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 1 (2023): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i1.5609

Abstract

The role of pharmacists in the implementation of pharmaceutical care has been shown to improve the outcome of therapy in hypertension patients in various countries. This study aimed to implement pharmaceutical care for hypertension patients and determine its impact on the incidence of drug-related problems (DRPs) and clinical outcomes of hypertension patients in Puskesmas Lubuk Pakam. This study used a comparative experimental method before and after the intervention of 73 hypertension patients in March-August 2021. Identification of the of DRPs was using the PCNE V9.00 standard and blood pressure values were obtained from direct examination of patients. Data were analyzed using the Wilcoxon Signed-Rank test. The results showed that the average DRPs incidence was significantly reduced after the intervention (observation, interview, and education) on the hypertension patients. The average blood pressure before intervention was 154.38 ± 16.20 mmHg and after intervention became 144.04 ± 15.94 mmHg (p value = 0.000). Based on the results of the study, it can be concluded that the application of pharmaceutical care can reduce the incidence of DRPs and improve clinical outcomes in hypertension patients in Puskesmas Lubuk Pakam.
Pengaruh Konseling Apoteker Terhadap Pengetahuan Pasien Diabetes di Apotek Kf 27 Medan Butar, Ririn Anastasia Butar; M.S, Wiryanto; Dalimunthe, Aminah
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47397

Abstract

Abstract This study aimed to analyze the effect of pharmacist counseling on the knowledge of patients with Type 2 Diabetes Mellitus (T2DM) at Kimia Farma 27 Pharmacy, Medan. The study employed a quasi-experimental design with a one-group pretest-posttest approach. A total of 112 T2DM patients participated, selected through total sampling. Data were collected using a validated questionnaire administered before and after pharmacist counseling. The results showed a significant increase in the average knowledge score from 3.07 ± 1.69 to 7.36 ± 1.70, with a p-value of 0.000. The direct counseling sessions, supported by written educational materials, effectively improved patients’ understanding. These findings highlight the strategic role of pharmacists in enhancing medication literacy in primary healthcare settings. This intervention serves as a strong foundation for developing standardized pharmacy counseling modules in community pharmacies. Keywords: pharmacist counseling, medication literacy, type 2 diabetes mellitus, patient education, community pharmacy.
IDENTIFICATION AND CHARACTERIZATION OF ANCHOVY (Stolephorus commersonnii) PRODUCED IN TANJUNG TIRAM VILLAGE BATU BARA REGENCY Rexi, Daniel; Pintauli, Sondang; Dalimunthe, Aminah; Nasri, Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.20636

Abstract

Anchovy is a widely consumed marine food source in Indonesia and has the potential to serve as a vital nutritional resource. This study aimed to analyze the primary nutrient contents of anchovy, including protein, total fat, phosphorus, calcium, and iron levels. Nutritional composition analysis was conducted through laboratory testing using scientifically validated standard methods. The results were analyzed descriptively to provide an overview of the chemical composition of anchovy. The findings revealed that anchovy contains 31.5% protein, indicating its value as a rich source of animal protein. The total fat content was measured at 4.76%, suggesting a relatively low to moderate fat level. Furthermore, phosphorus content was recorded at 227.8 mg/kg, calcium at 2.45%, and iron at 36.1 mg/kg—all essential minerals for physiological functions. Based on these results, anchovy demonstrates strong potential as a highly nutritious local food source that could significantly contribute to meeting the community's nutritional needs.
OPTIMIZED HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF ARTIFICIAL SWEETENERS, PRESERVATIVES, AND CAFFEINE IN CARBONATED SOFT DRINKS Wardono, Sri; Putra, Effendy De Lux; Sinaga, Siti Morin; Dalimunthe, Aminah; Nasri, Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 8 No. 01 (2025): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v8i01.20975

Abstract

Sweeteners, preservatives, and caffeine in soft drinks can pose health risks if consumed excessively. This study aimed to develop a method for the simultaneous determination of acesulfame, saccharin, cyclamate, aspartame, caffeine, benzoate, and sorbate in carbonated soft drinks. The analysis was conducted using reversed-phase high-performance liquid chromatography (RP-HPLC) with a dual-wavelength PDA detector (Shimadzu LC-20AD), a C18 column (Shimadzu), and a UV-Vis spectrophotometer (Shimadzu). Standard materials included acesulfame-K, saccharin-Na, cyclamate-Na, aspartame, caffeine, benzoate-Na, and sorbic acid. Samples were obtained from a supermarket in Medan, Indonesia. Optimization parameters included detection wavelength, mobile phase pH, column oven temperature, and mobile phase composition. Validation parameters assessed were linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, precision, and selectivity. The optimized method employed a mobile phase of phosphate buffer (pH 3.8) and methanol (80:20, v/v) at a flow rate of 0.55 mL/min and column oven temperature of 40 °C. Detection was carried out at 200 nm for cyclamate, caffeine, aspartame, and benzoate, and at 220 nm for acesulfame, saccharin, and sorbate. Validation results showed the method met all requirements, with recovery rates ranging from 95.21% to 99.82%, system suitability values of 1.0%–1.9%, and precision values between 1.65% and 2.48%. The method also demonstrated good selectivity. The concentrations of acesulfame, saccharin, cyclamate, caffeine, benzoate, and sorbate in the analyzed samples did not exceed the maximum permissible limits.
Co-Authors . S, Aminah Ade Sri Rohani Amalyuri, Annisa Ghassani Anjelisa Z. Hsb, Poppy Arfita Sipahutar Arianto, Anayanti Butar, Ririn Anastasia Butar Candrika, Candrika Darmirani, Yosi Denny Satria, Denny Effendy De Lux Putra, Effendy De Lux Embun Suci Nasution Emil Salim Hafid Syahputra Hakim Bangun* Harahap, Rizki Doli Hartama Hayatun Nufus Herawaty Ginting Iksen, Iksen Julia Reveny Khairunnisa Khairunnisa Khairunnisa Lisda Rimayani Lubis, Arga Lubis, Meiva Amelia Lumbanraja, Linnon Bastian M.S, Wiryanto Masfria Muhammad Wahyu, Muhammad Nasri Nasri, Nasri Nasution, Azizah Nazliniwaty Nazliniwaty* Pintauli, Sondang Prayoga, Andre Putri Fiari, Hera Zalia Rexi, Daniel Reza Destri Anggi Sanjaya, Angga Nugraha Simbolon, Rohana Oktofariday Siti Morin Sinaga Sitorus, Panal Sondang Pintauli Sumaiyah Tarigan, Betharina Br Tarigan, Eunike Victorita Tri Susanti Sirait Urip Harahap Vadhila, Mumtaz Wardono, Sri Waruwu, Syukur Berkat Wira Septama, Abdi Wiryanto Wiryanto Wiryanto Yuandani Zumaira