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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jurnal Surya Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JURNAL FARMASIMED (JFM) Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Majalah Kesehatan Pharmamedika Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research IJOEP : International Journal of Ecophysiology Jurnal Surya Masyarakat International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO International Journal of Science and Society (IJSOC) Cakradonya Dental Journal Journal of Pharmaceutical and Sciences. Journal of Pharmaceutical Sciences and Community
Aminah Dalimunthe
Departemen Farmakologi Dan Farmasi Klinis/Komunitas, Fakultas Farmasi, Universitas Sumatera Utara
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Teratogenic Effects of Arabica Coffee (Coffea arabica L) on Rats During the Organogenesis Period Reza Destri Anggi; Yuandani; Dalimunthe, Aminah
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4311

Abstract

The purpose of the research was to evaluate the teratogenic effect caused by theprovision of Arabica coffee solution with variations of 0.36 ml, 0.72 ml and 1.08 ml withpositive control of caffeine at a dose of 300 mg / kg bw to rats during organogenesis. Themeasurement parameters in this study are the appearance of reproduction, externalmalformations and scalal malformations. The results in this study found that theadministration of Arabica coffee solution with a volume of 1.08 ml and caffeine 300 mg /kg bb caused an abnormality in the reproductive appearance of weight loss and body length,whereas for extrenal malformation and scalal malforation no abnormalities were found ineach administration of the solution Arabica coffee and caffeine.  
Hematological and Biochemical Alterations of Andaliman (Zanthoxylum Acanthopodium Dc) with Doxorubicin Induced in White Wistar Rat Prayoga, Andre; Dalimunthe, Aminah; Zumaira; Salim, Emil
International Journal of Ecophysiology Vol. 7 No. 1 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i1.20188

Abstract

Doxorubicin, a well-known chemotherapy drug, is associated with cardiac toxicity primarily due to oxidative stress. This oxidative stress leads to the production of reactive oxygen species and a subsequent decline in antioxidant levels. As doxorubicin induces the formation of free radicals and decreases endogenous antioxidants, it triggers various hematological and biochemical abnormalities. Consequently, the use of antioxidants has been proposed as a strategy to mitigate this damage. This study focuses on the administration of ethanol extract from Andaliman (EAF) fruit, recognized for its rich array of metabolites and antioxidant properties, which may serve as a cardioprotective agent against the adverse effects of doxorubicin. The research involved comprehensive observations, including hematological and clinical chemistry examinations. The findings indicate that EAF demonstrates protective effects by enhancing hematological and clinical chemistry parameters in male Wistar rats subjected to doxorubicin. Notably, these improvements were statistically significant when compared to the control group. Given its promising results, further exploration of EAF as a protective agent for hematological and biochemical health warrants attention and development.
Antibacterial Potential Of Ethanol Extract Of Tamarind Seed Bark (Tamarindus indica L.) And Formulation Of Anti-Acne Nanogel Amalyuri, Annisa Ghassani; Reveny, Julia; Dalimunthe, Aminah
International Journal of Science, Technology & Management Vol. 3 No. 3 (2022): May 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i3.522

Abstract

Acne is a skin disease that affects a large number of sufferers. Acne occurs due to active oil glands under the skin. This activity is stimulated by androgen hormones. The active compound content of proanthocyanidin is the main compound in the ethanolic extract of tamarind seed bark, which can inhibit the growth of acne-causing bacteria, namely Propionibacterium acnes and Staphylococcus epidermidis. The purpose of this study was to formulate a nanogel from tamarind seed bark extract and test the antibacterial potential of an ethanol extract of tamarind seeds against acne-causing bacteria. The antibacterial potency test consisted of variations in concentration and was 0.5, 1, 5, 25, 50, 75, 100, 125, 150, and 300 (in mg/mL). The concentration of the formulated nanogel preparations was 2.5%, 5%, and 7.5%. The MIC results showed that the minimum inhibitory concentration (MIC) was at a concentration of 1 mg/mL with a zone of inhibition of 6.50 ± 0.44 mm (Propionibacterium acnes) and 6.40 ± 0.10 mm (Staphylococcus epidermidis). The minimum bactericidal concentration (MBC) was at a concentration of 25 mg/mL with a percentage reduction of 98.18% (Propionibacterium acnes) and 98.06% (Staphylococcus epidermidis). The results of the nanogel formulations showed that the particle sizes were 49.88 ± 0.11 nm (Formula I), 51.92 ± 0.09 nm (Formula II), and 59.13 ± 0.10 nm (Formula III). Conclusion The ethanolic extract of tamarind seed bark has effectiveness in inhibiting the growth of acne-causing bacteria and can be formulated as an anti-acne nanogel.
Phytochemical Screening and Antibacterial Potential Ethanol Extract of Kemangi Leaves (Ocimum basilicum L.) Towards Staphylococcus aureus Sanjaya, Angga Nugraha; Harahap, Urip; Dalimunthe, Aminah
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.630

Abstract

An infectious disease is a disease with the highest prevalence in the world, with a great risk of transmission. Staphylococcus aureus is a pathogen that can cause several infectious diseases. The use of kemangi leaves as vegetables can be used as an invention in treating infections caused by bacteria. The purpose of this study was a phytochemical screening test to determine what metabolites are contained and their potential activity against Staphylococcus aureus. The research method is to carry out a qualitative phytochemical screening test using reagents and an antibacterial potential test against Staphylococcus aureus using the Kirby-Bauer method (diffusion agar) with varying concentrations. The results showed that kemangi leaves extract showed positive results on the secondary metabolite compounds, were alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The diameter of the inhibition zone at a concentration of 500 mg/mL showed the diameter of the inhibition zone was 11.93 ± 0.25 mm with the strong category group. The conclusion is that the ethanolic extract of kemangi leaves shows the ethanolic extract of kemangi leaves has potential as an antibacterial.
Phytochemical Screening of Cinnamon Bark (Cinnamomum burmanii) (C. Ness & T. Ness) C. Ness ex Blume Ethanol Extract and Antioxidant Activity Test with DPPH (2,2-diphenyl-1-picrylhydrazyl) Method. Sirait, Tri Susanti; Arianto, Anayanti; Dalimunthe, Aminah
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.739

Abstract

Cinnamon (Cinnamomum burmanii) is one of the spices that can be used as cosmetic preparations in the pharmaceutical industry because it contains potent antioxidants. Examples of cosmetic products containing cinnamon are body scrubs, body showers, and moisturizers. This study aimed to determine the antioxidant activity of cinnamon extract using the DPPH method. Cinnamon was extracted using the maceration technique with 96% ethanol solvent, and phytochemical screening was carried out. The results of phytochemical screening from cinnamon bark extract were alkaloids, saponins, tannins, triterpenoids, and flavonoids. Antioxidant activity obtained an IC50 value of 25.35 ppm. Based on these results, the cinnamon extract has a very strong antioxidant activity value.
Cardio Protective Effect of Ethanolic Extract Vernonia Amygdalina Delile on Rats Induced L-NAME Rizki Doli Hartama Harahap; Urip Harahap; Aminah Dalimunthe
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.30981

Abstract

This study aimed to analyse the effects of ethanol extract of African leaves (Vernonia Amygdalina Del.) on the levels plasma renin, IL-6 and cardiac histopathology in L-NAME-induced rats. This research stage includes the preparation of ethanol extract of African leaves, standardization of extracts and testing the effectiveness of African leaves on rat heart damage. Data were analysed using one-way ANOVA with p<0.05. testing the cardioprotective effectiveness of ethanol extract of African leaves in hypertension model rats and then examining heart histopathology using HE staining and analysing parameters, namely plasma renin and IL-6 levels. This study used 6 groups, each group consisted of 5 male rats, namely the normal group, negative control by administering L-NAME 40 mg/kgBB, positive control by administering L-NAME plus lisinopril 2.5 mg/kgBB, EEDA 100 mg/kgBB, EEDA 300 mg/kgBB and EEDA 500 mg/kgBB. L-NAME responds to heart damage such as degeneration and necrosis of heart cells. In the negative group, plasma renin levels were 40.60 ± 9.98 ng/mL while the EEDA group with a dose of 500 mg/kgBB experienced the highest decrease in plasma renin compared to other EEDA groups and positive controls, namely 13.80 ± 1.30 ng/mL. The positive control group obtained plasma renin levels of 14.20 ±1.79 ng/mL. In the negative group, IL-6 levels were 4.80 ± 1.30 pg/mL while the group given EEDA, the group with a dose of 500 mg/kgBB experienced a decrease in IL-6, namely 1.52 ±0.96 ng/mL. The positive control group experienced a decrease in IL-6 levels of 0.77 ± 0.20 ng/mL. The result can be concluded that EEDA reduces plasma renin, IL-6 levels, improves the condition of cardiac cell degeneration and necrosis.
Pengaruh Konseling Apoteker Terhadap Pengetahuan Pasien Diabetes di Apotek Kf 27 Medan Ririn Anastasia Butar Butar; Wiryanto M.S; Aminah Dalimunthe
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.47397

Abstract

Abstract This study aimed to analyze the effect of pharmacist counseling on the knowledge of patients with Type 2 Diabetes Mellitus (T2DM) at Kimia Farma 27 Pharmacy, Medan. The study employed a quasi-experimental design with a one-group pretest-posttest approach. A total of 112 T2DM patients participated, selected through total sampling. Data were collected using a validated questionnaire administered before and after pharmacist counseling. The results showed a significant increase in the average knowledge score from 3.07 ± 1.69 to 7.36 ± 1.70, with a p-value of 0.000. The direct counseling sessions, supported by written educational materials, effectively improved patients’ understanding. These findings highlight the strategic role of pharmacists in enhancing medication literacy in primary healthcare settings. This intervention serves as a strong foundation for developing standardized pharmacy counseling modules in community pharmacies. Keywords: pharmacist counseling, medication literacy, type 2 diabetes mellitus, patient education, community pharmacy.
Efektivitas Dua Model Intervensi Medication Therapy Management (MTM) dalam Meningkatkan Pengetahuan, Kepatuhan, dan Luaran Klinis pada Pasien Hipertensi Arihta Sri Perangin-angin; Urip Harahap; Aminah Dalimunthe
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1274

Abstract

Hypertension is a major contributor to morbidity and mortality in Indonesia and worldwide. The success of hypertension therapy is strongly influenced by patient knowledge and medication adherence. The 2023 Indonesian Health Survey reported a hypertension prevalence of 30.6% among adults, with a prevalence of 24.4% in North Sumatra. Medication Therapy Management (MTM) represents a strategic approach to optimizing hypertension treatment outcomes. This study aimed to evaluate two MTM intervention models—direct interaction and audio-visual—and assess their effects on knowledge, medication adherence, and clinical outcomes among hypertensive patients at the Aviati Clinic, Medan. This quasi-experimental comparative study employed a three-group pretest–posttest design involving 126 hypertensive patients. Participants were allocated into a control group receiving usual care without structured education, a direct interaction MTM group, and an audio-visual MTM group. Patient knowledge was assessed using the HKLS questionnaire, adherence was measured using the MARS-5 questionnaire, and clinical outcomes were evaluated through blood pressure measurements. Data were analyzed using the Kruskal–Wallis test followed by Bonferroni post hoc analysis. The results demonstrated that both MTM intervention models significantly improved knowledge, medication adherence, and clinical outcomes compared with the control group (p < 0.001). Although both intervention groups were effective, the direct interaction MTM model produced a greater reduction in systolic blood pressure than the audio-visual intervention. These findings indicate that structured MTM interventions, particularly those delivered through direct interaction, are effective in improving therapeutic outcomes in patients with hypertension.
Mutu Simplisia dan Komposisi Kulit Pisang Barangan (M. acuminata Colla) Sebagai Bahan Dental Preventif Dengan Metode Pengeringan Berbeda Astrid Yudhit; Sondang Pintauli; Ellyza Herda; Aminah Dalimunthe
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1391

Abstract

Background: The drying process in the preparation of herbal material affects the quality, chemical compound content, and mineral composition of herbal ingredients. Barangan banana peel (Musa acuminata Colla) has potential as a preventive dental agent due to its phytochemical and mineral content. Objective: This study aimed to analyze the simplicia quality (moisture content and total ash content) as well as the chemical compound and mineral composition of Barangan banana peel dried using two different methods. Methods: This was a qualitative analytical study. Cleaned and chopped Barangan banana peels were divided into two groups: oven-dried (OD; 60°C for 12 hours) and freeze-dried (FD; -65°C for 4 hours followed by 48 hours of freeze drying). The simplicia was ground using a ball mill (500 rpm for 6 hours). Moisture content was determined using the toluene method, while total ash content was measured by heating at 800°C. Identification of chemical compounds and minerals was performed using GC-MS and XRF, respectively. Results: Moisture content of the OD group was 9.23% and of the FD group was 7.11%; total ash content was 10.83% and 10.60%, respectively. Both met the standards of the Indonesian Herbal Pharmacopoeia (moisture content <10%, total ash content <15%). GC-MS identification revealed that the FD group exhibited a greater variety of chemical compounds (12 components) compared to the OD group (7 components). The highest mineral content in both groups was potassium (K), with magnesium (Mg) being higher in the OD group (15.32%) than in the FD group (9.95%). Conclusion: The drying method affects the quality and composition of Barangan banana peel. Freeze drying resulted in lower moisture content and greater phytochemical diversity, whereas oven drying tended to preserve higher mineral content for certain elements. The simplicia of Barangan banana peel from both methods has potential to be developed as a preventive dental material.
Farmakoedukasi Literasi Kesehatan Mental dan NAPZA untuk Siswa SMA/SMK Aminah Dalimunthe; Khairunnisa Khairunnisa; Lisda Rimayani Nasution; Chemayanti Surbakti
Jurnal Surya Masyarakat Vol 8, No 1 (2025): November 2025
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.8.1.2025.84-89

Abstract

Global data shows that one in seven children aged 10-19 experiences mental health disorders. In Indonesia, one in three adolescents (34.9%), equivalent to 15.5 million Indonesian adolescents, experiences at least one mental health issue per year. Mental health disorders are often associated with the use of NAPZA (Narcotics, Psychotropics, and Addictive Substances). This activity aims to enhance the knowledge and awareness of  9th state vocational high school  students about mental health and NAPZA. The community service activities involve socialization and education on mental health and NAPZA abuse, training using Positive bottle and an unspoken word book, and training with "Serene"  application (Self-care, Emotional Resilience, and Empowerment Network for Everyone) as a tool for education and consultation for the students of of  9th state vocational school students Medan. The community service activity successfully improved the understanding of  9th state vocational school students about mental health and the dangers of NAPZA. Education through lectures, demonstrations, and the Serene application showed positive impacts, with students' knowledge increasing from 40% to 60%. The Serene application was considered user-friendly and received positive feedback, supporting students' awareness of the importance of maintaining mental health and preventing NAPZA abuse.
Co-Authors . S, Aminah Ade Sri Rohani Amalyuri, Annisa Ghassani Anjelisa Z. Hsb, Poppy Arfita Sipahutar Arga Lubis Arianto, Anayanti Arihta Sri Perangin-angin Asfianti, Vivi Astrid Yudhit Candrika, Candrika Chemayanti Surbakti Damayanti S Damayanti S Darmirani, Yosi Denny Satria Denny Satria Denny Satria, Denny Dewi Pertiwi Dimas Fragilie Effendy De Lux Putra, Effendy De Lux Ellyza Herda Embun Suci Nasution Emil Salim Hafid Syahputra Hakim Bangun Hakim Bangun* Herawaty Ginting Iksen, Iksen Indah Pertiwi Irene Simangunsong Julia Reveny Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Lisda Rimayani Lisda Rimayani Nasution Lumbanraja, Linnon Bastian Masfria Meiva Amelia Lubis Muhammad Wahyu, Muhammad Nasri Nasri, Nasri Nasution, Azizah Nazliniwaty Nazliniwaty* Nur Aira Juwita Panal Sitorus Pintauli, Sondang Prayoga, Andre Putri Fiari, Hera Zalia Rexi, Daniel Reza Destri Anggi Ririn Anastasia Butar Butar Rizki Doli Hartama Harahap Said Haikal Alfajar Sanjaya, Angga Nugraha Simbolon, Rohana Oktofariday Siswahyudianto Siti Morin Sinaga Sitorus, Panal Sondang Pintauli Sondang Pintauli Sumaiyah Syahputra , Rony Abdi Syukur Berkat Waruwu Tarigan, Betharina Br Tarigan, Eunike Victorita Tri Susanti Sirait Urip Harahap Urip Harahap Vadhila, Mumtaz Wardono, Sri Wira Septama, Abdi Wiryanto Wiryanto M.S Wiryanto Wiryanto Yuandani Zumaira