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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JURNAL FARMASIMED (JFM) Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Majalah Kesehatan Pharmamedika Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research IJOEP : International Journal of Ecophysiology International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Cakradonya Dental Journal Journal of Pharmaceutical and Sciences.
Aminah Dalimunthe
Departement Of Pharmacology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary

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Effect of Tocotrienol Rich Fraction (TRF) Administration on Blood Glucose and Cholesterol in Streptozotocin Induced and High Fat Diet Rats Simangunsong, Irene; Pertiwi, Dewi; Dalimunthe, Aminah; Asfianti, Vivi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/139epr61

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder with a continuously increasing global prevalence and remains a major health problem, characterized by hyperglycemia and dyslipidemia, including elevated Low Density Lipoprotein (LDL) and decreased High Density Lipoprotein (HDL) levels. This study aimed to evaluate the effect of tocotrienol rich fraction administration on blood glucose levels and lipid profile in rats induced with streptozotocin and a high fat diet. The study used 24 white rats divided into six groups: a negative control group, a positive control group treated with glibenclamide, and four treatment groups receiving tocotrienol rich fraction at doses of 50, 100, 200, and 400 mg/kg body weight. The measured parameters included blood glucose, HDL, and LDL levels. The results show that tocotrienol rich fraction significantly reduces blood glucose levels and improves the lipid profile compared to the negative control group. The highest dose demonstrates the most optimal effect and approaches that of the positive control. Tocotrienol rich fraction increases HDL levels and decreases LDL levels in a dose dependent manner. These findings indicate that tocotrienol rich fraction significantly lowers blood glucose levels and improves lipid profile in streptozotocin induced and high fat diet rats in a dose dependent manner. Therefore, tocotrienol rich fraction has potential as an alternative therapeutic agent for diabetes mellitus with dyslipidemia.
Efektivitas Dua Model Intervensi Medication Therapy Management (MTM) dalam Meningkatkan Pengetahuan, Kepatuhan, dan Luaran Klinis pada Pasien Hipertensi Arihta Sri Perangin-angin; Urip Harahap; Aminah Dalimunthe
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1274

Abstract

Hypertension is a major contributor to morbidity and mortality in Indonesia and worldwide. The success of hypertension therapy is strongly influenced by patient knowledge and medication adherence. The 2023 Indonesian Health Survey reported a hypertension prevalence of 30.6% among adults, with a prevalence of 24.4% in North Sumatra. Medication Therapy Management (MTM) represents a strategic approach to optimizing hypertension treatment outcomes. This study aimed to evaluate two MTM intervention models—direct interaction and audio-visual—and assess their effects on knowledge, medication adherence, and clinical outcomes among hypertensive patients at the Aviati Clinic, Medan. This quasi-experimental comparative study employed a three-group pretest–posttest design involving 126 hypertensive patients. Participants were allocated into a control group receiving usual care without structured education, a direct interaction MTM group, and an audio-visual MTM group. Patient knowledge was assessed using the HKLS questionnaire, adherence was measured using the MARS-5 questionnaire, and clinical outcomes were evaluated through blood pressure measurements. Data were analyzed using the Kruskal–Wallis test followed by Bonferroni post hoc analysis. The results demonstrated that both MTM intervention models significantly improved knowledge, medication adherence, and clinical outcomes compared with the control group (p < 0.001). Although both intervention groups were effective, the direct interaction MTM model produced a greater reduction in systolic blood pressure than the audio-visual intervention. These findings indicate that structured MTM interventions, particularly those delivered through direct interaction, are effective in improving therapeutic outcomes in patients with hypertension.
Mutu Simplisia dan Komposisi Kulit Pisang Barangan (M. acuminata Colla) Sebagai Bahan Dental Preventif Dengan Metode Pengeringan Berbeda Astrid Yudhit; Sondang Pintauli; Ellyza Herda; Aminah Dalimunthe
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1391

Abstract

Background: The drying process in the preparation of herbal material affects the quality, chemical compound content, and mineral composition of herbal ingredients. Barangan banana peel (Musa acuminata Colla) has potential as a preventive dental agent due to its phytochemical and mineral content. Objective: This study aimed to analyze the simplicia quality (moisture content and total ash content) as well as the chemical compound and mineral composition of Barangan banana peel dried using two different methods. Methods: This was a qualitative analytical study. Cleaned and chopped Barangan banana peels were divided into two groups: oven-dried (OD; 60°C for 12 hours) and freeze-dried (FD; -65°C for 4 hours followed by 48 hours of freeze drying). The simplicia was ground using a ball mill (500 rpm for 6 hours). Moisture content was determined using the toluene method, while total ash content was measured by heating at 800°C. Identification of chemical compounds and minerals was performed using GC-MS and XRF, respectively. Results: Moisture content of the OD group was 9.23% and of the FD group was 7.11%; total ash content was 10.83% and 10.60%, respectively. Both met the standards of the Indonesian Herbal Pharmacopoeia (moisture content <10%, total ash content <15%). GC-MS identification revealed that the FD group exhibited a greater variety of chemical compounds (12 components) compared to the OD group (7 components). The highest mineral content in both groups was potassium (K), with magnesium (Mg) being higher in the OD group (15.32%) than in the FD group (9.95%). Conclusion: The drying method affects the quality and composition of Barangan banana peel. Freeze drying resulted in lower moisture content and greater phytochemical diversity, whereas oven drying tended to preserve higher mineral content for certain elements. The simplicia of Barangan banana peel from both methods has potential to be developed as a preventive dental material.
Co-Authors . S, Aminah Ade Sri Rohani Amalyuri, Annisa Ghassani Anjelisa Z. Hsb, Poppy Arfita Sipahutar Arianto, Anayanti Arihta Sri Perangin-angin Asfianti, Vivi Astrid Yudhit Darmirani, Yosi Denny Satria, Denny Dewi Pertiwi Effendy De Lux Putra, Effendy De Lux Ellyza Herda Embun Suci Nasution Emil Salim Fragilie, Dimas Hafid Syahputra Hakim Bangun* Hayatun Nufus Herawaty Ginting Iksen, Iksen Julia Reveny Khairunnisa Khairunnisa Khairunnisa Lisda Rimayani Lubis, Arga Lubis, Meiva Amelia Lumbanraja, Linnon Bastian Masfria Muhammad Wahyu, Muhammad Nasri Nasri, Nasri Nasution, Azizah Nazliniwaty Nazliniwaty* Pintauli, Sondang Prayoga, Andre Putri Fiari, Hera Zalia Rexi, Daniel Reza Destri Anggi Ririn Anastasia Butar Butar Rizki Doli Hartama Harahap Sanjaya, Angga Nugraha Simangunsong, Irene Simbolon, Rohana Oktofariday Siswahyudianto Siti Morin Sinaga Sitorus, Panal Sondang Pintauli Sondang Pintauli Sumaiyah Syukur Berkat Waruwu Tarigan, Betharina Br Tarigan, Eunike Victorita Tri Susanti Sirait Urip Harahap Vadhila, Mumtaz Wardono, Sri Wira Septama, Abdi Wiryanto Wiryanto M.S Wiryanto Wiryanto Yuandani Zumaira