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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jurnal Surya Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JURNAL FARMASIMED (JFM) Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Majalah Kesehatan Pharmamedika Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research IJOEP : International Journal of Ecophysiology Jurnal Surya Masyarakat International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO International Journal of Science and Society (IJSOC) Cakradonya Dental Journal Journal of Pharmaceutical and Sciences. Journal of Pharmaceutical Sciences and Community
Aminah Dalimunthe
Departemen Farmakologi Dan Farmasi Klinis/Komunitas, Fakultas Farmasi, Universitas Sumatera Utara
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Metabolomics-Driven LC-HRMS Identification and Multi-Target Computational Pharmacology of Shzygium polyanthum Bioactives for Mechanism-Based Precision Management of Type 2 Diabetes Mellitus Said Haikal Alfajar; Urip Harahap; Aminah Dalimunthe; Nur Aira Juwita; Rony Abdi Syahputra
International Journal of Science and Society Vol 8 No 2 (2026): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Type 2 Diabetes Mellitus (T2DM) continues to be a major cause of mortality and metabolic complications in developing nations, highlighting the urgent need for safer and more accessible therapies. Herbal bioactives from Syzygium polyanthum (SYPOL) have gained attention due to their traditional use in managing blood glucose levels. Nevertheless, the molecular mechanisms underlying their antidiabetic effects remain poorly understood. This study employed an integrative in silico approach to evaluate the interactions between SYPOL-derived compounds and ten key protein targets involved in T2DM pathogenesis, including HK2, AKT1, PYGL, INSR, PYGM, IGF1R, PPARG, SLC2A1, MAPK3, and GCK. Ethanolic leaf extracts of SYPOL were analyzed using Liquid Chromatography–High Resolution Mass Spectrometry (LC-HRMS) for phytochemical profiling. Detected compounds were screened for structural availability, toxicity, ADME properties, and compliance with Lipinski's Rule of Five prior to molecular docking. From 9.834 detected phytochemical features, 31 compounds met the selection criteria and were docked against the ten diabetes-related targets. The simulations revealed stable interactions within active site regions, primarily driven by hydrogen bonding and favorable binding energies, suggesting potential modulation of glucose metabolism and insulin signaling pathways. ADME profiling indicated acceptable pharmacokinetic properties, with most compounds satisfying Lipinski's parameters. Toxicity prediction showed a 54.83% probability of nephrotoxicity, emphasizing the importance of safety validation in future studies SYPOL contains multi-target bioactive compounds with potential to regulate glucose homeostasis. This computational analysis provides a mechanistic basis for subsequent experimental research and supports the development of SYPOL-based phytotherapeutics for T2DM management.
Farmakoedukasi Literasi Kesehatan Mental dan NAPZA untuk Siswa SMA/SMK Aminah Dalimunthe; Khairunnisa Khairunnisa; Lisda Rimayani Nasution; Chemayanti Surbakti
Jurnal Surya Masyarakat Vol 8, No 1 (2025): November 2025
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.8.1.2025.84-89

Abstract

Global data shows that one in seven children aged 10-19 experiences mental health disorders. In Indonesia, one in three adolescents (34.9%), equivalent to 15.5 million Indonesian adolescents, experiences at least one mental health issue per year. Mental health disorders are often associated with the use of NAPZA (Narcotics, Psychotropics, and Addictive Substances). This activity aims to enhance the knowledge and awareness of  9th state vocational high school  students about mental health and NAPZA. The community service activities involve socialization and education on mental health and NAPZA abuse, training using Positive bottle and an unspoken word book, and training with "Serene"  application (Self-care, Emotional Resilience, and Empowerment Network for Everyone) as a tool for education and consultation for the students of of  9th state vocational school students Medan. The community service activity successfully improved the understanding of  9th state vocational school students about mental health and the dangers of NAPZA. Education through lectures, demonstrations, and the Serene application showed positive impacts, with students' knowledge increasing from 40% to 60%. The Serene application was considered user-friendly and received positive feedback, supporting students' awareness of the importance of maintaining mental health and preventing NAPZA abuse.
The Effect of Pharmacist Homecare Services on Medication Adherence, Drug-Related Problems, Clinical Outcomes, and Quality of Life of Hypertensive Patients at Sei Mencirim Public Health Center Dimas Fragilie; Aminah Dalimunthe; Khairunnisa Khairunnisa
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d4bc3z22

Abstract

Background: Hypertension is one of the most prevalent chronic diseases in Indonesia (25.8%) and remains a leading cause of death globally, accounting for approximately three million deaths annually. Poor patient adherence to antihypertensive therapy continues to be a major challenge in achieving optimal blood pressure control and preventing cardiovascular complications. Objective: This study aimed to analyze the effect of pharmacist-led homecare interventions on medication adherence, drug-related problems (DRPs), clinical outcomes, and quality of life among hypertensive patients at Sei Mencirim Primary Health Center. Methods: A pre- and post-cohort study was conducted involving 38 hypertensive patients aged over 55 years between April and June 2024. Medication adherence was assessed using the MASES-R (Medication Adherence Self-Efficacy Scale-Revised) questionnaire, DRPs were identified according to the PCNE V9.0 classification, clinical outcomes were evaluated through blood pressure measurements, and quality of life was measured using the SF-36 (Short Form-36) questionnaire. Data were analyzed using the Wilcoxon Signed Rank test. Results: The majority of respondents were female (76.3%) and aged 56–66 years (71.0%). The mean adherence score significantly increased from 16.29 ± 2.35 to 40.97 ± 10.03 (p < 0.001), with adherence rates improving from 0% to 76.3%. A significant reduction was observed in drug-related problems, dropping from 14 to 2 cases, while adverse drug reactions decreased from 18 to 4 cases. The patients’ systolic blood pressure declined from 166.13 ± 17.85 mmHg to 129.07 ± 5.39 mmHg, and diastolic pressure decreased from 86.28 mmHg to 79.26 mmHg (p < 0.001). Furthermore, the average quality-of-life scores increased across all dimensions, including physical function (19.74–87.76), general health (2.19–90.46), and social functioning (4.28–94.41). Conclusion: Pharmacist-led homecare interventions involving continuous education, counseling, and patient support were proven effective in significantly improving medication adherence and quality of life among hypertensive patients. These findings suggest that such interventions should be implemented routinely in primary healthcare settings.
Effect of Tocotrienol Rich Fraction (TRF) Administration on Blood Glucose and Cholesterol in Streptozotocin Induced and High Fat Diet Rats Irene Simangunsong; Dewi Pertiwi; Aminah Dalimunthe; Vivi Asfianti
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/139epr61

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder with a continuously increasing global prevalence and remains a major health problem, characterized by hyperglycemia and dyslipidemia, including elevated Low Density Lipoprotein (LDL) and decreased High Density Lipoprotein (HDL) levels. This study aimed to evaluate the effect of tocotrienol rich fraction administration on blood glucose levels and lipid profile in rats induced with streptozotocin and a high fat diet. The study used 24 white rats divided into six groups: a negative control group, a positive control group treated with glibenclamide, and four treatment groups receiving tocotrienol rich fraction at doses of 50, 100, 200, and 400 mg/kg body weight. The measured parameters included blood glucose, HDL, and LDL levels. The results show that tocotrienol rich fraction significantly reduces blood glucose levels and improves the lipid profile compared to the negative control group. The highest dose demonstrates the most optimal effect and approaches that of the positive control. Tocotrienol rich fraction increases HDL levels and decreases LDL levels in a dose dependent manner. These findings indicate that tocotrienol rich fraction significantly lowers blood glucose levels and improves lipid profile in streptozotocin induced and high fat diet rats in a dose dependent manner. Therefore, tocotrienol rich fraction has potential as an alternative therapeutic agent for diabetes mellitus with dyslipidemia.
Antibacterial Activity and Wound Healing of Excision Gel of Ethanol Extract of Sintrong (Crassochepallum crepidioides)(Benth.) S. Moore.) Leaves in Mice Infected Staphylococcus aureus Candrika Candrika; Aminah Dalimunthe; Hakim Bangun
Journal of Pharmaceutical Sciences and Community Vol. 23 No. 1 (2026)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.v23i1.1081

Abstract

Crassochepallum crepidioides (Benth.) S. Moore.) is a plant demonstrated to be effective in wound treatment, empirically and experimentally. contain secondary metabolites, which contribute to the wound healing process. Further research is required to scientifically validate the antibacterial wound healing properties of sintrong leaf ethanol gel. This study aimed to empirically validate the antibacterial efficacy of a gel formulation derived from the ethanol extract of sintrong leaves. Excision wound healing assessments were conducted using the sintrong leaf ethanol extract gel on excision wounds infected Staphylococcus aureus. Phytochemical screening, the formulation of ethanol extract gel concentrations 10%, 20%, 30%, antibacterial activity testing of the ethanol extract gel. Excision wound healing activity with a depth 1 mm a width of 2 cm. The wound became infected treatment was administered for 15 days to monitor the decrease in wound diameter on days 0, 3, 5, 10, 15 indicated that the ethanol could be formulated and satisfied the preparation evaluation criteria. Ethanol extract gel has antibacterial properties against Staphylococcus aureus. The study on excision wound healing indicated that an increased concentration of extract gel correlates with a greater percentage of healing. On day 10 the healing percentages of the 30% gel and Bioplacenton were similar at 80%. On day 15 the percentages of 30% gel and Bioplacenton were almost equal 30% gel being 98.50%. Bioplacenton being 99.50% and histopathological assay revealed elevated collagen, fibroblast, and angiogenesis levels corresponding to the increasing concentration of the preparation.
Hepatoprotective Activity of Ethanol Extract of Mobe Leaves (Artocarpus lacucha Buch-Ham.) on Total Bilirubin, ALT, and AST Levels, and Macropathology of Liver in Rats Induced by Carbon Tetrachloride Meiva Amelia Lubis; Aminah Dalimunthe; Panal Sitorus; Denny Satria; Arga Lubis
Viva Medika Vol 17 No 3 (2024)
Publisher : LPPM Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v17i3.1490

Abstract

This study evaluates the hepatoprotective effects of ethanol extract of mobe leaves (Artocarpus lacucha Buch-Ham.) in rats induced with carbon tetrachloride (CCl4). The objective was to determine the extract's efficacy in reducing liver damage markers, specifically total bilirubin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and to assess liver macropathology. The ethanol extract was prepared by maceration using 96% ethanol. Results showed that administering 400 mg/kg body weight (BW) of the extract significantly reduced total bilirubin, ALT, and AST levels in CCl4-induced rats. Additionally, liver macropathology observations indicated improved liver conditions in the treatment group. Phytochemical screening revealed bioactive compounds like flavonoids, alkaloids, tannins, saponins, triterpenoids, and glycosides, which are potential antioxidants and hepatoprotective agents. The significant contribution of this research is providing a scientific basis for using mobe leaf extract as a natural hepatoprotective agent, highlighting its potential for safe and effective herbal medicine. Further research and clinical trials are recommended to validate these findings and explore the extract's therapeutic applications.
Efek Ekstrak Etanol Daun Mobe (Artocarpus lacucha Buch-Ham.) terhadap Histopatologi Hati Tikus Diinduksi Karbon Tetraklorida Meiva Amelia Lubis; Aminah Dalimunthe; Panal Sitorus; Denny Satria; Indah Pertiwi; Damayanti S Damayanti S
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1432

Abstract

Background: Liver injury due to exposure to hepatotoxic chemicals remains a major problem in the medical and pharmaceutical fields. Carbon tetrachloride (CCl₄) is a classic hepatotoxic agent that induces oxidative stress, lipid peroxidation, and hepatocyte necrosis through free radical formation. Mobe leaves (Artocarpus lacucha Buch-Ham.) contain bioactive compounds, particularly flavonoids and phenolics, which possess antioxidant and anti-inflammatory properties with potential hepatoprotective effects. Objective: This study aimed to evaluate the effect of ethanol extract of mobe leaves (EEML) on the liver histopathology of rats induced with carbon tetrachloride. Methods: This experimental study used a post-test only control group design. Twenty-five male rats were divided into five groups: negative control (CMC-Na 1% + CCl₄), positive control (silymarin 100 mg/kgBW + CCl₄), and three treatment groups receiving EEML at doses of 50, 100, and 200 mg/kgBW + CCl₄. Hepatotoxicity was induced by intraperitoneal injection of CCl₄ (1 mL/kgBW) twice weekly for 14 days. Liver tissue was processed for hematoxylin-eosin staining, and histopathological changes (hepatocyte degeneration, necrosis, and inflammatory cell infiltration) were assessed semi-quantitatively using a scoring system (0-3). Results: CCl₄ induction caused severe liver damage in the negative control group, characterized by diffuse hydropic degeneration, extensive necrosis, and marked inflammatory infiltration (score 3 for all parameters). EEML administration significantly reduced liver injury in a dose-dependent manner. The 200 mg/kgBW dose showed the most pronounced hepatoprotective effect, with degeneration score 2, necrosis score 1, and inflammation score 2, approaching the protective effect of silymarin (score 1 for all parameters). Conclusion: Ethanol extract of mobe leaves demonstrated hepatoprotective activity against CCl₄-induced liver damage in rats, with the optimal effect at 200 mg/kgBW. These findings support the potential of mobe leaves as a natural hepatoprotective agent.
Co-Authors . S, Aminah Ade Sri Rohani Amalyuri, Annisa Ghassani Anjelisa Z. Hsb, Poppy Arfita Sipahutar Arga Lubis Arianto, Anayanti Arihta Sri Perangin-angin Asfianti, Vivi Astrid Yudhit Candrika, Candrika Chemayanti Surbakti Damayanti S Damayanti S Darmirani, Yosi Denny Satria Denny Satria Denny Satria, Denny Dewi Pertiwi Dimas Fragilie Effendy De Lux Putra, Effendy De Lux Ellyza Herda Embun Suci Nasution Emil Salim Hafid Syahputra Hakim Bangun Hakim Bangun* Herawaty Ginting Iksen, Iksen Indah Pertiwi Irene Simangunsong Julia Reveny Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Lisda Rimayani Lisda Rimayani Nasution Lumbanraja, Linnon Bastian Masfria Meiva Amelia Lubis Muhammad Wahyu, Muhammad Nasri Nasri, Nasri Nasution, Azizah Nazliniwaty Nazliniwaty* Nur Aira Juwita Panal Sitorus Pintauli, Sondang Prayoga, Andre Putri Fiari, Hera Zalia Rexi, Daniel Reza Destri Anggi Ririn Anastasia Butar Butar Rizki Doli Hartama Harahap Said Haikal Alfajar Sanjaya, Angga Nugraha Simbolon, Rohana Oktofariday Siswahyudianto Siti Morin Sinaga Sitorus, Panal Sondang Pintauli Sondang Pintauli Sumaiyah Syahputra , Rony Abdi Syukur Berkat Waruwu Tarigan, Betharina Br Tarigan, Eunike Victorita Tri Susanti Sirait Urip Harahap Urip Harahap Vadhila, Mumtaz Wardono, Sri Wira Septama, Abdi Wiryanto Wiryanto M.S Wiryanto Wiryanto Yuandani Zumaira