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All Journal HAYATI Journal of Biosciences Jurnal Pendidikan Biologi Undiksha Biotika: Jurnal Ilmiah Biologi JURNAL TEKNOLOGI LINGKUNGAN Microbiology Indonesia Buletin Plasma Nutfah Biotropika Bioeksperimen: Jurnal Penelitian Biologi BERITA BIOLOGI BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) JOHME: Journal of Holistic Mathematics Education BIOEDUSCIENCE Jurnal Biologi Tropis Jurnal Kimia Terapan Indonesia Al-Madrasah: Jurnal Ilmiah Pendidikan Madrasah Ibtidaiyah MITRA: Jurnal Pemberdayaan Masyarakat Walisongo Journal of Chemistry Molekul: Jurnal Ilmiah Kimia BAHTERA : Jurnal Pendidikan Bahasa dan Sastra Jurnal Abdi Insani BIO-EDU: Jurnal Pendidikan Biologi Jurnal Ilmiah Biologi UMA (JIBIOMA) Jurnal Pengabdian kepada Masyarakat Nusantara BONAFIDE: Jurnal Teologi dan Pendidikan Kristen Didache: Journal of Christian Education PEADA': Jurnal Pendidikan Kristen Jurnal ComunitA Servizio Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Oryza : Jurnal Pendidikan Biologi Prosiding Konferensi Nasional PKM-CSR JURNAL HUTAN TROPIS Inculco Journal of Christian Education JURNAL BIOLOGI PAPUA Jurnal Teknologi Lingkungan Molekul: Jurnal Ilmiah Kimia Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS) Jurnal Biologi Udayana
WAHYU IRAWATI
Universitas Pelita Harapan
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Journal : bioeduscience

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Penanganan Epilepsi Grand Mal Sebagai Akibat dari Ketidaknormalan Kerja Neuron di Otak Menggunakan Metode Diet Ketogenik Nommensen Pangihutan Ompusunggu; Sabar Manampin Giawa; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (618.578 KB) | DOI: 10.22236/j.bes/617688

Abstract

Background: The nervous system is composed of a complex structure to support its highly organized work. Damage to the working mechanism of nervous systems can exert fatal impacts to the human body. One of the consequences of damage to the mechanism of action potentials is grand mal epilepsy. The purpose of this paper is to determine the structure, function, and mechanism of action of neurons, establish grand mal epilepsy as a result of damage to the working mechanism of neurons, and recognize the ketogenic diet as a non-pharmacological therapy for epilepsy patients. Methods: The research method used is descriptive qualitative research. Results: Nerve cells generally consist of dendrites for receiving stimuli, cell bodies for transmitting stimuli to the axon, and axons for transmitting stimuli to other nerve cells. Grand mal epilepsy is a nervous system disorder caused by the increased activity of sending electrical waves throughout the brain that can reach up to four times faster than normal. However, grand mal epilepsy patients suffer from an excessive number of seizures that may occur at any time. Conclusions: The ketogenic diet method is a high-fat and low-carbohydrate diet method that can reduce electrical activity in the brain. Ketone-containing fats have a stabilizing effect on the central nervous system, contributing to anticonvulsant and antiepileptic effects that may reduce the excessive number of seizures experienced by patients. The application of this diet should be balanced with the provision of additional intake of multivitamins, minerals, and fiber to balance the nutrients the body needs.
Anti-PD-L1 Therapy as a Solution for Non-Melanoma Skin Cancer Basal Cell Carcinoma Rahul Simon Situmeang; Gim Mi Kyong; Rosiva Betaria Purba; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (615.256 KB) | DOI: 10.22236/j.bes/618095

Abstract

Skin cancer is a disease that can cause the loss of the ability to regenerate and protect the skin normally. The types of skin cancer that are known are melanoma and non-melanoma skin cancer. Non-melanoma Basal cell carcinoma is a malignant neoplasm originating from non-keratinizing cells in the basal layer of the skin's epidermis. The treatment itself is carried out through the application of immunotherapy, namely the use of drug therapy Programmed Death Ligand 1 (PD-L1). This study aims to see the effectiveness of PD-L1 Therapy as a treatment for basal cell carcinoma. The focus of the study of the article is the integument system, skin cancer, non-melanoma basal cell carcinoma, and the effect of anti-PD-L1 use. The research method used is a literature review from various sources. Skin cancer Basal cell carcinoma attacks the basal cells of the epidermis, causing disruption. Attacks slowly, but when ignored will spread wider and more severe. Through PD-L1 therapy by binding to PD-1 receptors on immune cells, it causes the activation of T lymphocytes as anti-cancer cells in the body that suppress growth while actively controlling tumor cells. Through the use of PD-L1 therapy in treating cancer that attacks basal cells, it will suppress growth, destroy and shrink cancer cells, and increase the body's immunity against cancer cells.
Radiotherapy Treatment for Melanoma Skin Cancer Disease Tabitha Grace Larasati; Josephine Elsa Diani Putranto; Anggun Anggun; Frichilya Intan Lawa Padang; Wahyu Irawati
BIOEDUSCIENCE Vol 5 No 2 (2021): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/526323

Abstract

Background: Melanoma is a skin disorder caused by malignant degeneration of the pigment cells melanocytes. The disease is characterized by widespread discoloration with irregular and protruding edges. In treating cancer itself, radiotherapy technology, has been found. It is a method of treating cancer using high-energy radiation rays that are focused on cancerous tissue to kill or stop cancer cell division. This study aims to determine the effectiveness of radiotherapy technology as a treatment solution for melanoma skin cancer. The focuses of the study in this paper are the integumentary system and skin structure, melanoma skin cancer, the body's mechanisms for melanoma skin cancer, and radiotherapy as a treatment method. Methods: The research method used is literature study from various sources, to help understand the problem more deeply and completely. Conclusions: Melanoma, which attacks one of the body's integumentary systems, namely the skin, has a close relationship with homeostatic dysregulation and endocrine damage. However, radiotherapy method can be used to cure melanoma skin cancer by shooting X-rays and damaging the cancer cells and also reducing their spread to other parts of the organs. This method is effective because melanoma skin cancer is localized or has not spread to other organs. However, the use of radiotherapy can also have a negative impact on the body and can give unwanted side effects, so consideration is needed before using this method.
Penanganan Epilepsi Grand Mal Sebagai Akibat dari Ketidaknormalan Kerja Neuron di Otak Menggunakan Metode Diet Ketogenik Nommensen Pangihutan Ompusunggu; Sabar Manampin Giawa; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/617688

Abstract

Background: The nervous system is composed of a complex structure to support its highly organized work. Damage to the working mechanism of nervous systems can exert fatal impacts to the human body. One of the consequences of damage to the mechanism of action potentials is grand mal epilepsy. The purpose of this paper is to determine the structure, function, and mechanism of action of neurons, establish grand mal epilepsy as a result of damage to the working mechanism of neurons, and recognize the ketogenic diet as a non-pharmacological therapy for epilepsy patients. Methods: The research method used is descriptive qualitative research. Results: Nerve cells generally consist of dendrites for receiving stimuli, cell bodies for transmitting stimuli to the axon, and axons for transmitting stimuli to other nerve cells. Grand mal epilepsy is a nervous system disorder caused by the increased activity of sending electrical waves throughout the brain that can reach up to four times faster than normal. However, grand mal epilepsy patients suffer from an excessive number of seizures that may occur at any time. Conclusions: The ketogenic diet method is a high-fat and low-carbohydrate diet method that can reduce electrical activity in the brain. Ketone-containing fats have a stabilizing effect on the central nervous system, contributing to anticonvulsant and antiepileptic effects that may reduce the excessive number of seizures experienced by patients. The application of this diet should be balanced with the provision of additional intake of multivitamins, minerals, and fiber to balance the nutrients the body needs.
Anti-PD-L1 Therapy as a Solution for Non-Melanoma Skin Cancer Basal Cell Carcinoma Rahul Simon Situmeang; Gim Mi Kyong; Rosiva Betaria Purba; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/618095

Abstract

Skin cancer is a disease that can cause the loss of the ability to regenerate and protect the skin normally. The types of skin cancer that are known are melanoma and non-melanoma skin cancer. Non-melanoma Basal cell carcinoma is a malignant neoplasm originating from non-keratinizing cells in the basal layer of the skin's epidermis. The treatment itself is carried out through the application of immunotherapy, namely the use of drug therapy Programmed Death Ligand 1 (PD-L1). This study aims to see the effectiveness of PD-L1 Therapy as a treatment for basal cell carcinoma. The focus of the study of the article is the integument system, skin cancer, non-melanoma basal cell carcinoma, and the effect of anti-PD-L1 use. The research method used is a literature review from various sources. Skin cancer Basal cell carcinoma attacks the basal cells of the epidermis, causing disruption. Attacks slowly, but when ignored will spread wider and more severe. Through PD-L1 therapy by binding to PD-1 receptors on immune cells, it causes the activation of T lymphocytes as anti-cancer cells in the body that suppress growth while actively controlling tumor cells. Through the use of PD-L1 therapy in treating cancer that attacks basal cells, it will suppress growth, destroy and shrink cancer cells, and increase the body's immunity against cancer cells.
Radiotherapy Treatment for Melanoma Skin Cancer Disease Tabitha Grace Larasati; Josephine Elsa Diani Putranto; Anggun Anggun; Frichilya Intan Lawa Padang; Wahyu Irawati
BIOEDUSCIENCE Vol 5 No 2 (2021): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/526323

Abstract

Background: Melanoma is a skin disorder caused by malignant degeneration of the pigment cells melanocytes. The disease is characterized by widespread discoloration with irregular and protruding edges. In treating cancer itself, radiotherapy technology, has been found. It is a method of treating cancer using high-energy radiation rays that are focused on cancerous tissue to kill or stop cancer cell division. This study aims to determine the effectiveness of radiotherapy technology as a treatment solution for melanoma skin cancer. The focuses of the study in this paper are the integumentary system and skin structure, melanoma skin cancer, the body's mechanisms for melanoma skin cancer, and radiotherapy as a treatment method. Methods: The research method used is literature study from various sources, to help understand the problem more deeply and completely. Conclusions: Melanoma, which attacks one of the body's integumentary systems, namely the skin, has a close relationship with homeostatic dysregulation and endocrine damage. However, radiotherapy method can be used to cure melanoma skin cancer by shooting X-rays and damaging the cancer cells and also reducing their spread to other parts of the organs. This method is effective because melanoma skin cancer is localized or has not spread to other organs. However, the use of radiotherapy can also have a negative impact on the body and can give unwanted side effects, so consideration is needed before using this method.
Penanganan Epilepsi Grand Mal Sebagai Akibat dari Ketidaknormalan Kerja Neuron di Otak Menggunakan Metode Diet Ketogenik Nommensen Pangihutan Ompusunggu; Sabar Manampin Giawa; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/617688

Abstract

Background: The nervous system is composed of a complex structure to support its highly organized work. Damage to the working mechanism of nervous systems can exert fatal impacts to the human body. One of the consequences of damage to the mechanism of action potentials is grand mal epilepsy. The purpose of this paper is to determine the structure, function, and mechanism of action of neurons, establish grand mal epilepsy as a result of damage to the working mechanism of neurons, and recognize the ketogenic diet as a non-pharmacological therapy for epilepsy patients. Methods: The research method used is descriptive qualitative research. Results: Nerve cells generally consist of dendrites for receiving stimuli, cell bodies for transmitting stimuli to the axon, and axons for transmitting stimuli to other nerve cells. Grand mal epilepsy is a nervous system disorder caused by the increased activity of sending electrical waves throughout the brain that can reach up to four times faster than normal. However, grand mal epilepsy patients suffer from an excessive number of seizures that may occur at any time. Conclusions: The ketogenic diet method is a high-fat and low-carbohydrate diet method that can reduce electrical activity in the brain. Ketone-containing fats have a stabilizing effect on the central nervous system, contributing to anticonvulsant and antiepileptic effects that may reduce the excessive number of seizures experienced by patients. The application of this diet should be balanced with the provision of additional intake of multivitamins, minerals, and fiber to balance the nutrients the body needs.
Anti-PD-L1 Therapy as a Solution for Non-Melanoma Skin Cancer Basal Cell Carcinoma Rahul Simon Situmeang; Gim Mi Kyong; Rosiva Betaria Purba; Wahyu Irawati
BIOEDUSCIENCE Vol 6 No 1 (2022): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/618095

Abstract

Skin cancer is a disease that can cause the loss of the ability to regenerate and protect the skin normally. The types of skin cancer that are known are melanoma and non-melanoma skin cancer. Non-melanoma Basal cell carcinoma is a malignant neoplasm originating from non-keratinizing cells in the basal layer of the skin's epidermis. The treatment itself is carried out through the application of immunotherapy, namely the use of drug therapy Programmed Death Ligand 1 (PD-L1). This study aims to see the effectiveness of PD-L1 Therapy as a treatment for basal cell carcinoma. The focus of the study of the article is the integument system, skin cancer, non-melanoma basal cell carcinoma, and the effect of anti-PD-L1 use. The research method used is a literature review from various sources. Skin cancer Basal cell carcinoma attacks the basal cells of the epidermis, causing disruption. Attacks slowly, but when ignored will spread wider and more severe. Through PD-L1 therapy by binding to PD-1 receptors on immune cells, it causes the activation of T lymphocytes as anti-cancer cells in the body that suppress growth while actively controlling tumor cells. Through the use of PD-L1 therapy in treating cancer that attacks basal cells, it will suppress growth, destroy and shrink cancer cells, and increase the body's immunity against cancer cells.
Co-Authors . PATRICIA Aaron Hasthosaputro Aazokhi Waruwu ABYATAR HUGO BASKORO Al Khadziq, Muhammad Fuadzy Alvionita Thana Alya Leonita Lamonta Ambarita, Polin P. Ambarita, Polin Parulian Andara Frida Sheilaliany Daely Angelica, Apriliana Anggun Anggun Aninditya Sri Nugraheni Argoby Simanullang Argorby Simanullang Artha, David Dharmawan Ashiong P Munthe Ashiong Parheheon Munthe Ayustin, Yohana Delvia Bellen Mouretta Bermuli, Jessica Elfani Bora, Merliana Ina Cantika Dela Kurnia Zendrato Charles Immanuel Chelvieana A. Christanti Christeven Mevotema Christian, Grace Purnamasari Christian, Salomo Clement Khrisman Laia Clement Khrisman Laia Daely, Andara Frida Sheilaliany Damai Yanti Manalu David L Gultom Debora V. Widyanti Delfania Apang Madao Deokward F. Ruga Desi L. Sihombing Destya Waty Silalahi, Destya Waty Dipakalyano Dipakalyano Dipakalyano, Dipakalyano Djoko Prasetyo Dominica Feni Valentina Dr. Adolf J.N. Parhusip Dwany, Naomi Dwi N. Susilowati Egilia Lucky Elisabeth Tita Ellen Nur Endah Pangesti Elysabeth Simatupang Eunike Bunga Marvella Eunike Bunga Marvella Eunike Bunga Marvella Fernando Christofer Fernando Christofer Fernando Corneles Moniharapon Fiska Ivana Pratami Putri Tokede Floreta D. Icasari Frichilya Intan Lawa Padang Gaol, Riris Lumban Geoffrey Darrien Fideli Georgine Gladis Paula Sulardi Gim Mi Kyong Giri, Mutiara Yaemeliza Venderry Grace Charity Mary Cartir Greisnaningsi Greisnaningsi Harefa, Dellania Yvonne HARI HARTIKO Hasanah, Intan Andriani Hayati, Lutfiah Isfa Helen Melenia Sianipar Herna Siahaan Hernawati Siahaan Hutauruk, Kristian I Made Samudra Imanuel Adhitya Wulanata, Imanuel Adhitya Intan Cidarbulan Matita Iren Asima Situmorang Jennie Agatherania Listira JOEDORO SOEDARSONO Josephine Elsa Diani Putranto Karnelasatri, . Keisha Hillary Pangalila Kosi, Ice Frans Krisdarwindah Mardiana Kristin Armis Pasaribu Laia , Clement Khrisman Laia, Clement Khrisman Laoli, Beta Mualiman Lastiar R. Sitompul Lastiar Roselyna Sitompul, Lastiar Roselyna Legesang, Eddowardho Otniel Lucia Kusumawati Lusiana Haris Maha, Paldevina Br Maharaja, Dwi P. Malau, Robeka Risky Manalu, Damai Y. Manalu, Damai Yanti Marcellie, Jessica Margaretha, Cecilia Marvella, Eunike Bunga Melany Djami Meyners, Geraldy John Mia Parhusip Muhamad Ananda Munthe, Ashiong P. Munthe, Sri Wahyu Ningsih Naomi Dwany Nexson Parhusip, Adolf Jan Nicolas Tunggul Adhigandewa Nida Sopiah Nida Sopiah Nida Sopiah Nommensen Pangihutan Ompusunggu Nommensen Pangihutan Ompusunggu Novera, Rusliani S. Novera, Rusliani Sesy Orah, Eklesia Taysa Pahotkon Purba Pangaribuan, Medeliene Christine Patricia Patricia Pebrianti Pebrianti, Pebrianti Pingkan Imelda Wuisan Polin Parulian Ambarita Ponagadi, Merry Adisty Prasetyo, Djoko Purba, Friska Juliana Purwanti, Ester Ayu Sri PutrI, Nadya Aurelia Ratna Rahmawati, Sintia Y. Rahul Simon Situmeang Rani Nurlina Tifen Raudhatunnur Reinhard Pinontoan Resky Megawati Tammu Resti Nopriyanti Rido, Elisabeth M.T. Rimpan, Takashi Reymond Rosiva Betaria Purba Ruben Patrick Adhiwijaya Ruga, Deokward F. Ruth Y. Purba Sabar Manampin Giawa Salomo Christian Selvi Esther Suwu, Selvi Esther Shaday, Vannesa El Sherina Juliana Sherina Juliana Siane Indriani, Siane Siane Indriyani Sianturi, Golda Santiur Silaban, Grace Niche Agnesa Silalahi, Ramses Silvana Putri Tarigan Simamora, Tanti Marsanda Sindy Friska Siringo-ringo, Sisilya Situmorang, Stefani Situmorang, Widya Srigika Natalia Boru Ginting Stephanus Jordan Jans Steven Anggawinata Sudarsono Siburian Sugata, Marcelia Suhartono, Andreas Valiant Sukri, Urbanus Susi Sulistia Susi Sulistia, Susi Tabitha Grace Larasati Tahya, Candra Tahya, Candra J. Tahya, Candra Yulius Tammu, Reisky Megawati Thesalonika Liony Pangemanan Tinambunan , Christine Febriandini Torreno, Jovan Nathanael Tri P. Priyatno Triwibowo Yuwono Valiant, Andreas Vania Austine Callista Timotius Vannesa El Shaday Ruth Advenita Viona Heryani Arla Waruwu, A'azokhi Wuisan, Pingkan Imelda Xaveria, Jessica Yadi Suryadi Yantra Wijaya YENNY SORAYA Yesica C. Rhenata Yohana Ayustin Yohanes Edi Gunanto Yolanda, Shelomita Feby Yovanka P.P Tumakaka Zebua, Satria Putri Aryani Zega, Yeni Angelina