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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal Of Nursing Practice Jurnal Surya Masyarakat Jurnal Kesehatan Islam : Islamic Health Journal Medical Technology and Public Health Journal Medical and Health Science Journal Community Development Journal Biomolecular and Health Science Journal Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang REMIK : Riset dan E-Jurnal Manajemen Informatika Komputer Community Development Journal: Jurnal Pengabdian Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Surya Masyarakat Indonesia Berdaya Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat International Islamic Medical Journal Jurnal Kesehatan Tambusai Prominentia Medical Journal Journal for Quality in Public Health Maslahat
Salim, Hotimah Masdan
Universitas Nahdlatul Ulama Surabaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : biomolecular and health science journal

 1 
The Effects of High-fat Diet on Histological Changes of Kidneys in Rats Hotimah Masdan Salim; Lintan Farizqi Kurnia; Tri Wahyu Bintarti; Handayani Handayani
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.929 KB) | DOI: 10.20473/bhsj.v1i2.9675

Abstract

Introduction Hypercholesterolemia contributes as a risk factor for endothelial dysfunction in the kidneys and worsens the condition of patients with previous kidney damage. This study aimed to examine the effect of hypercholesterol diet in kidney structure.Methods: This was an experimental study, a case control using eight-week-old Rattus novergicus, divided into control and treatment group. High-fat diet (HFD) was administrated orally to treatment group for 14 days. All data statistically analyzed with two-paired ANOVA and post hoc for comparison.Results: Histological analysis using hematoxylin-eosin staining showed degeneration in nephrons, including glomerulosclerosis, segmental necrosis and tubular defects. The mononuclear cell infiltration was Increased in HFD group significantly (P<0.05).Conclusion: We concluded that a high fat diet induced obesity and may lead to renal deformities as a result of histopathological changes such as dilatation, tubular defects, inflammation and connective tissue enlargement of the kidney.
Organ Damage due to Elevation of Blood Pressure on NaCl-induced Hotimah Masdan Salim; Ilham Putra Alam; Widya Dio Kharisma
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22089

Abstract

Introduction: High salt diet is known to induce or aggravate hypertension in hypertensive rats and humans. The elevation of blood pressure by NaCl-induced promotes cardiac hypertrophy, the impairment of left ventricular relaxation, endothelial dysfunction, and kidney injury. This study aimed to examine whether NaCl-induced caused increase blood pressure and weight of organs. Methods: Eight weeks old male Mus musculus were divided to two groups, one group was given NaCl 8% by intraperitoneal injection for 8 hours.Results: Blood pressure was measured previously, in this study systolic and diastolic blood pressure increased significantly (p < 0.05). The increasing of blood pressure was followed by significant increase in organ weight, such as heart and kidney (p < 0.05). Conclusion: This result suggested that NaCl-induced caused hypertension and increased organs weight that may cause early process of damages in organs.
Bactericidal Effects of Extract Basil Leaves in In-vitro Study of Pseudomonas aeruginosa Deny Febriwijaya Romadhani; Achmad Hilman Fahmy; Ilham Putera Alam; Hotimah Masdan Salim
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22090

Abstract

Introduction: Pseudomonas aeruginosa is the most common bacterial cause of nosocomial infections. Bacteria become resistant to antibiotics by various mechanisms, including producing enzymes that can damage antibiotics, change intracellular targets from antibiotics, and efflux pumps. Basil (Ocimum sanctum L.) is a traditional plant that is usually used as ingredients that contain antibacterial compounds including flavonoids, tannins, alkaloids, and eugenol. The aim was to determine the effectiveness of extract basil leaves for inhibiting and killing the growth of Pseudomonas aeruginosa.Methods: We administrated extract basil leaves with a concentration of 100%, 50%, and 25% in the plate contained bacterium Pseudomonas aeruginosa. The result showed that there was no inhibition of bacterial growth in broth dilution for 8 hours and 24 hours. We continued to culture bacteria for 24 hours.Results: The analysis showed extract basil leaves has bactericidal effects in 8 hours and 24 hours incubation significantly (p < 0.05). However, in 24 hours more effective as a bactericidal in 100% of concentration significantly (p < 0.05).Conclusion: From this result, eugenol (a phenol derivative found in the ethanol extract of basil leaves) has the effect of damaging cell membranes. Phenol bonding with bacterial cell walls can disrupt the permeability of transport cell membranes, thus the bacteria will be disrupted and die.
The Effectiveness of Extract Basil Leaves on Motility and Morphology of Spermatozoa Mice Exposed with Cigarette Smoke Bagas Setiawan Ihsan Zaini; Izki Masyaqqoni Pujiana; Evi Octavia Djamaludin; Hotimah Masdan Salim
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22169

Abstract

Introduction: The incidence of infertility is still a problem in the world, including Indonesia (21.3%), and throughout Asia. Fertility in men is strongly influenced by several factors, one of them is smoking. Smoking can increase ROS, reduce antioxidants in semen, cause DNA damage, and morphological abnormalities of spermatozoa. Basil contains flavonoids which are rich in antioxidants, boron, and zinc to stimulate androgen hormones.Methods: This research used eight weeks old Mus musculus, exposed with smoke of 20 cigarettes/day and was administered of extract basil leaves (Ocimum sanctum L.) in dose dependency (100 mg/kg, 200mg/kg, and 300mg/kg) for 4 weeks. We examined the motility and morphology of spermatozoa by microscope. This research consisted of 5 groups. In CS-, CSBL-2 and CSBL-3, it showed that the spermatozoa motility was more progressive than CS+ and CSBL-1.Results: The morphology of spermatozoa in CS+ and CS- found different results with a significance value of 0.10 (p < 0.05) but the results of CSBL- 1, CSBL-2, and CSBL-3 were not significantly different from CS- and CS+ (p > 0.05).Conclusion: There was an effect of giving basil leaves to increase motility and improvement of the morphology of spermatozoa that had been exposed to cigarette smoke especially in dose 300 mg/kgBB, but it was not significant.
Antibacterial mechanism of Kratom (Mitragyna speciosa) methanol extract on Streptococcus pneumoniae and Eschericia coli bacteria Hotimah Masdan Salim; Marinda Dwi Puspitarini; Yuani Setiwati; Michio Shimabukuro
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.28933

Abstract

Introduction: Kratom (Mitragyna speciosa) is a tropical herbal plant native to the North Malay Peninsula, Malaysia and Thailand. In Indonesia, kratom us a typical plant of West Kalimantan, especially in Putussibau. Kratom leaf has many pharmacological effects, one of them is antioxidant. However, the antioxidant and antimicrobial activities of Mitragyna speciosa leaf extracts are lacking. This study was to examine the effect of the methanol extract of Mitragyna speciosa (Rubiaceae Family) leaves on microorganisms Escherichia coli and Strepococcus pneumoniae.Methods: Kratom leaves were extracted with methanol as solvent. In this study, S. pneumoniae and E. coli bacteria have been used. Antibacterial activity tests were carried out at concentrations of 0.78%, 1.56%, 3.125%, 6.25%, 12.5%, 25%, 50% and 100%. Insilico was used to search for secondary metabolites and metabolite interactions in Mytragina speciosa. Results: Mitragyna speciosa leaf methanol extract was effective in inhibiting the growth of E. coli and S. pneumoniae significantly (P<0.001). The growth of e.coli was not identified from a concentration of 25% to 100%. However, there was no bacterial growth in S. pneumoniae from a concentration of 6.25% to 100%. In the insilico study it was found that the secondary metabolite of Mitragyna speciosa is quercetin, which interacts with the ATP1 protein as a predictor in the mechanism of Mitragyna speciosa as an antibacterial. Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.
Co-Authors A., Ratna Ariesta Dwi Abdul Muhith Achmad Hilman Fahmy Aditya Bhayusakti Adyan Donastin Afiyah, R. Khairiyatul Aisyah Aisyah Aji, Audi Ikhfina Tanra Akas Yekti Pulih Asih Alam, Ilham Putera Alam, Ilham Putra Alfina Andasari Algristian, Hafid Andi Roesbiantoro Andreas Putro Ragil Santoso, Andreas Putro Ragil Anggara Kidung Pranata Anggraini, Yasi Ardianti, Ami Arif Rahman Hakim Atika Maulida Inastiti Awwalia, Evi Sylvia Awwaliya, Evi Awwaliyah, Evi Sylvia Awwaliyah, Evy Silvia Bagas Setiawan Ihsan Zaini Bagas Setiawan Ihsan Zaini Bariyah, Khadijah Khairul Bermawi, Bastiana Bintarti, Tri Wahyuni Bintarti, Tri Wahyuni Charissa Balqis Choiriya, Dian Dakwatul Choirotussanijah Choirotussanijah Choirotussanijjah Danny Irawan David Sajid Muhammad Dayu Satriya Wibawa Deny Febriwijaya Romadhani Desi Irawati, Adinda Devyana Dyah Wulandari Dwi Arman Prasetya Dwimantoro EBISINTEI, PRECIOUS Edza Aria Wikurendra Endah Budi Permana Putri Erfina Miftakhul Zannah Ersalina Nidianti Evi Octavia Djamaludin Fadilah Nisa Purwanti Fahrizal Amin Nurfaizi Faraadies, Rangga Azhaar Faradis, RA. Hani Farah Dina Amalia Farhatu Aini Fariska Zata Amani Fatmawati, Ulik Ferdinan Hanafi, Eka Satria Akbar Fifi Khoirul Fitriyah Garfansa, Marchel Putra Hanafi, Eka Satria Akbar Ferdinan Handayani Handayani Handayani, Nanik HAQUE, ZAMIRAH MABARROH EL Hudzaifah Hamidy Ika Mardiyanti Ika Maysaroh Lesparwati Ilham Putera Alam Ilham Putra Alam Ima Kurniastuti Ismail Ibrahim Ismail, Zainul Hadi Wildan Iswahyudi Iswahyudi ISWAHYUDI ISWAHYUDI Izki Masyaqqoni Pujiana Jamhuri, Nur Syazwani Jazuli, Muhammad Aqil Siroj Jessica Puspa Kencana Jinan, Puspita Rahmatul Karina Dwiyanti Kencana, Jessica Puspa Lea Maera Shanty Lintan Farizqi Kurnia Lysa Veterini Machmudah, Machmudah Maria Ulfa Marinda Dwi Puspitarini Marotur Rohima Marselli Widya Lestari Michio Shimabukuro Miftakhul Dwi Ersanti Muhammad Aqil Siroj Jazuli Muhammad, Akbar Reza Muhammad, David Sajid Muhammada, Davida Sajid Mukhtar Adi Nugroho Muliani, Nurlina Mulyadi Mulyadi Mutmainnah Nadia Nisaussholihah Nadzirah Sylvia Nahdatien, Ima Nanda Fadhilah Witris Salamy Nanik Handayani Nisaussholihah, Nadia Novera Herdiani, Novera Nur Azizah AS Nurul Munawaroh Pramesti, Rosandhy Alfiyah Pramesti, Rosandhy Alifyah Pramesti, Rosandhy Alifyah Pramesti Puspitasari, Mia Puspitasari, Renny Novi Putra, Reza Hery Mahendra R.A. Hani Faradis Raniyah Diva Rosalbah Ratna Ariesta Dwi Andriani Reza Mahendra Rezky Dwinda Pratiwi Rihhadatulays, Khuzaimah Nur Juhanifah Rofik, Ainul rofiq, ainul Romadhani, Deny Febriwijaya Rosda Rodhiyana Salfa Salsabilah Zain Savitri, Ardyarini Dyah Siti Nur Hasina Siti Robi’atus Sholiha Sohaimi, Ainur Elliana Sonny Edbert Syafiuddin, Achmad Tri Deviasari Wulan Tri Wahyu Bintarti Ubaidillah Zuhdi Widya Dio Kharisma Wiratama, Rahardyan Dika Yanti, Alfiyah Indah Yasi Anggraini Yenni Arista Cipta Ekalaturrahmah Yuani Setiwati Zannah, Erfina Miftakhul