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All Journal Jurnal MIPA PHARMACON Jurnal Dinamika Pengabdian (JDP) Universa Medicina Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Biomedika dan Kesehatan The Studies of Social Sciences Vivabio : Jurnal Pengabdian Multidisiplin Jurnal Kesehatan Tambusai Jurnal Lentera Farma
Hosea Jaya Edy
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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FORMULASI DAN EVALUASI VARIASI BASIS GEL AIR PERASAN TEMUAWAK (Curcuma xanthorrhiza R.) SEBAGAI ANTISEPTIK TANGAN Fathoni, Kristiani W. S. W.; Edy, Hosea Jaya; Jayanti, Meilani
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32751

Abstract

ABSTRACT Temulawak (Curcuma xanthorrhiza R.) is a plant that contains antimicrobial properties of essential oil and curcumin compounds. The purpose of this study was to formulate temulawak juice into gel preparations by varying the HPMC and Carbomer gel bases with each base concentration of 1%, testing the effectiveness of the antiseptic preparations and evaluating the physical preparations of the gel. This study used laboratory experimental methods. temulawak is soaked in aquadest then filtered and centrifuged to obtain temulawak juice and formulated in a gel preparation. Testing the effectiveness as a hand antiseptic using the replica method. The results showed that the temulawak water gel met the physical properties of the gel preparation which included organoleptic test, homogeneity test, pH test, spreadability test, adhesion test, and syneresis test. The percentage of colony decline using the HPMC base was 29.53% and the Carbomer base was 14.74%. This shows that the gel preparation of Temulawak juice cannot reduce the normal flora of the skin so that it does not affect an antiseptic for hands. Key Words : Antiseptic, gel preparations, Curcuma (Curcuma xanthorrhiza R.)  ABSTRAK Temulawak (Curcuma xanthorrhiza R.) merupakan tanaman yang memiliki kandungan senyawa minyak atsiri dan kurkumin yang bersifat antimikroba. Tujuan dari penelitian ini untuk memformulasikan air perasan temulawak menjadi sediaan gel dengan memvariasikan basis gel HPMC dan Karbomer dengan masing-masing konsentrasi basis sebesar 1 %, menguji efektivitas antiseptik sediaan dan mengevaluasi sediaan fisik dari gel tersebut. Penelitian ini menggunakan metode eksperimental laboratorium. Temulawak direndam dengan aquadest kemudian disaring dan disentrifuse untuk mendapatkan air perasan temulawak dan diformulasikan dalam sediaan gel. Pengujian efektivitas sebagai antiseptik tangan menggunakan metode replika. Hasil penelitian menunjukkan bahwa gel air perasan temulawak memenuhi persyaratan sifat fisik sediaan gel yang meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji sineresis. Presentase penurunan koloni menggunakan basis HPMC sebesar 29,53 % dan basis Karbomer sebesar 14,74 %. Hal ini menunjukkan bahwa sediaan gel air perasan temulawak tidak dapat menurunkan jumlah flora normal kulit sehingga tidak memiliki efek sebagai antiseptik tangan.  Kata Kunci : Antiseptik, sediaan gel, Temulawak (Curcuma xanthorrhiza R.)
FORMULASI SEDIAAN PERONA PIPI EKSTRAK ETANOL UBI JALAR UNGU (Ipomoea batatas L.) DALAM BENTUK STICK Purnomo, Novia Hanna; Edy, Hosea Jaya; Siampa, Jainer Pasca
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32769

Abstract

ABSTRACTColor is one of the determining factors in quality in cosmetics. Usage of synthjetic dye in blush on could cause irritation on facial skin, irritation on respiratory tract, and damage to the liver. The aim of this study was to formulate and to evaluate the physical characterization of the blush on preparation by using natural dye from the purple sweet potato extract (Ipomoea batatas L.) with the variation concentration on 20%, 25%, and 30%. Formulation of stick blush on used fusion method. The extract is obtained by means of maceration using ethanol solvent 96%. Organoleptics, color homogeneity, pH, stability toward light, polish test and preference test were included in the evaluation of the physical properties of the preparation. The result of the physical properties test showed the preparation’s color ranged from pale purple to dark pink, a distinctive scent of oleum rose perfume, soft texture, all preparation had homogenous arrangement, pH value of the preparation  ranged from 6.00-6.61, the best polish were on concentration 25% and 30% this is characterized by a one-time polishing of the ready has given a clear color when polished on the skin of the back of the hand, color observation at all preparation did not had any changes in 14 days, and the preferred preparation by the panelists were the preparation with pigment concentration of 20%, 25% and 30%. It can be concluded that the combination of the purple sweet potato extract (Ipomoea batatas L.) can be used as a natural dye in blush on preparation. Keywords: Ipomoea batatas L., Blush on, Formulation  ABSTRAK Warna adalah salah satu faktor penentu mutu kosmetika. Penggunaan pewarna sintesis pada perona pipi dapat menyebabkan iritasi pada kulit wajah, iritasi pada saluran pernapasan, dan kerusakan pada hati. Tujuan Penelitian ini untuk memformulasi serta mengetahui evaluasi fisik sediaan perona pipi dengan memanfaatkan pewarna alami dari ekstrak ubi jalar ungu (Ipomoea batatas L.) dengan konsentrasi 20%, 25% dan 30%. Pembuatan sediaan perona pipi menggunakan metode peleburan. Evaluasi fisik sediaan meliputi organoleptik, homogenitas warna, pH, stabilitas terhadap cahaya, uji poles dan uji kesukaan. Hasil pengujian sifat fisik menunjukkan bahwa sediaan yang dihasilkan memberikan warna ungu pucat hingga merah muda tua, bau khas parfum oleum rose, teksturnya lembut, semua sediaan memiliki susunan yang homogen, nilai pH sediaan 6,00-6,61, polesan terbaik pada konsentrasi 25% dan 30% hal ini ditandai dengan satu kali pemolesan sediaan telah memberikan warna yang jelas saat dipoleskan pada kulit punggung tangan , selama 14 hari pengamatan warna pada semua sediaan tidak mengalami perubahan terhadap cahaya, dan sediaan yang disukai oleh panelis adalah sediaan dengan konsentrasi zat warna 20%, 25% dan 30%. Dengan demikian dapat disimpulkan bahwa ekstrak etanol Ubi Jalar Ungu (Ipomoea batatas L.) dapat digunakan sebagai pewarna alami dalam sediaan perona pipi. Kata kunci: Ipomoea batatas L., Perona pipi, Formulasi
FORMULASI DAN UJI EFEKTIVITAS ANTIOKSIDAN SEDIAAN KRIM EKSTRAK ETANOL DAUN SALAM (Syzygium Polyanthum (Wight) Walpers.) DENGAN MENGGUNAKAN METODE DPPH (1,1-diphenyl-2-picrylhydrazyl) Apitalau, Etserlisa A.; Edy, Hosea Jaya; Mansauda, Karlah L.R.
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32764

Abstract

ABSTRACTBay leaf (Syzygium Polyanthum (Wight) Walpers.) is known contains flavonoids, saponins, tannins and vitamin C. Flavonoids and vitamin C have an antioxidant activity, since they have the ability to remove and effectively reduce a damaging oxidizer species. The aim of the study is to determine the impact of  the bay leaf ethanol extract enhancement concentration towards  an antioxidant activity of cream preparation by using the DPPH method. This research used laboratory experimental methods. Cream formulations are made with various concentrations 1%, 3%, 6% and 9%. The evaluation results of the bay leaf cream preparation has fulfilled the requirements of homogeneity, organoleptic, pH, adhesion, dispersion, and centrifugation. The results of the antioxidant activity test using the DPPH method using the UV-Vis spectrophotometer which was the most effective as an antioxidant cream from bay leaf extract was 3% with a value IC_50 = 1.4630 ppm and vitamin C as a comparison with a value IC_50 = 0.1131 ppm. From this research, it can be concluded that the cream formulation of bay leaf ethanol extract has fulfilled the physical test parameters, stabile, and had a powerful antioxidant activity.Keywords: : Bay Leaf (Sysigium Polyanthum (Wight) Walpers.), Antioxidant Cream, DPPH (1.1-Diphenyl-2-Picrylhydrazyl) Method  ABSTRAKDaun salam (Syzygium Polyanthum (Wight) Walpers.) diketahui mengandung flavonoid, saponin, tanin dan vitamin C. Senyawa flavonoid dan vitamin C memiliki aktivitas sebagai antioksidan, karena memiliki kemampuan untuk menghilangkan dan secara efektif mengurangi spesies pengoksidasi yang merusak. Penilitian ini bertujuan untuk mengetahui pengaruh peningkatan kosentrasi ekstrak etanol daun salam terhadap aktivitas antioksidan pada sediaan krim dengan menggunakan metode DPPH. Penelitian ini mengggunakan metode eksperimental laboratorium. Formulasi sediaan krim dibuat dengan variasi konsentrasi 1%, 3%, 6% dan 9%. Hasil evaluasi sediaan krim daun salam memenuhi persyaratan homogenitas, organoleptis, pH , daya lekat, daya sebar, sentrifugasi. Hasil uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometer UV-Vis yang paling efektif sebagai krim antioksidan dari ekstrak daun salam adalah 3% memiliki nilai = 1,4630 ppm dan vitamin C sebagai pembanding memiliki nilai = 0,1131 ppm. Dari penilitian ini dapat disimpulkan bahwa sediaan krim ekstrak etanol daun salam memenuhi parameter uji fisik, stabil dan memiliki aktivitas antioksidan yang sangat kuat. Kata kunci : Daun Salam (Sysigium Polyanthum (Wight) Walpers.) Krim Antioksidan, Metode DPPH (1.1-Diphenyl-2-Picrylhydrazyl)
UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN KRIM EKSTRAK ETANOL DAUN KEMANGI (Ocimum basilicum L.) TERHADAP Staphylococcus aureus Tondolambung, Axcel H.; Edy, Hosea Jaya; Lebang, Julianri S.
PHARMACON Vol 10, No 1 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.32752

Abstract

ABSTRACT Basil leaves (Ocimum basilicum  L.) contain flavonoid, saponins and tannins that have antibacterial activity. This study is aims to make basil cream then determine antibacterial activity of cream against Staphylococcus aureus. The cream  was made with five concentrations of extract 3%, 6%, 9%, 12%, 15% respectively. The extract was obtained by maceration using 96% ethanol solvent. Antibacterial test was carried out by using the well method. The results of the evaluation of physical properties for the organoleptic test and homogeneity test showed that the cream dosage form met the requirements, the average pH value is 4.92±0.27, average value of dispersion test is 3.30±0.0 cm, average value of adhesion test is 7.92±0.29 seconds. Antibacterial effectiveness test showed an average diameter value for formula I (3%) is 8.94±1.60 mm, formula II (6%) 9.46±6.85 mm, formula III (9%) 10.30±3.28 mm, formula IV (12%) 15.18±8.04 mm, formula V(15%) 16.23±4.16 mm. The statistical test proves that formula V has the best resistance  and can be concluded that the antibacterial cream dosage form of the ethanol extract of basil leaves can be formulated into a cream that is good, physically stable and can inhibit bacterial growth. Keywords: Basil Leaves (Ocimum basilicum  L.), Cream, Antibacterial. ABSTRAK Daun Kemangi (Ocimum basilicum  L.) memiliki kandungan senyawa flavonoid, saponin dan tannin yang bersifat sebagai antibakteri. Penelitian ini bertujuan untuk membuat sediaan krim ekstrak etanol daun kemangi yang stabil secara fisik dan mengetahui daya hambat krim antibakteri terhadap bakteri Staphylococcus aureus. Krim dibuat menggunakan lima variasi konsentrasi ekstrak yaitu 3%, 6%, 9%, 12%, 15%. Ekstrak diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Uji antibakteri dilakukan dengan metode sumuran. Hasil evaluasi sifat fisik untuk uji organoleptik dan uji homogenitas menunjukkan sediaan krim memenuhi persyaratan, nilai pH rata-rata 4,92±0,27 nilai rata-rata daya sebar 3,30±0,0 cm; niai rata-rata uji daya lekat 7,92±0,29 detik. Uji efektivitas antibakteri menunjukkan nilai rata-rata diameter untuk formula I (3%); 8,94±1,60 mm; formula II (6%) 9,46±6,85 mm; formula III (9%) 10,30±3,28 mm; formula IV (12%) 15,18±8,04 mm; dan formula V (15%) 16,23±4,16 mm. Uji statistika membuktikan bahwa formula V memiliki daya hambat yang paling baik dan disimpulkan bahwa ekstrak etanol daun kemangi dapat diformulasikan menjadi sediaan krim yang baik dan stabil secara fisik dan dapat menghambat pertumbuhan bakteri. Kata Kunci: Daun Kemangi (Ocimum basilicum  L.) , Krim, Antibakteri
POTENSI ANTIMIKROBA CENGKEH : REVIEW LITERATUR Kalalo, Marko Jeremia; Gratia, Berta; Bidulang, Crunny Bidhya; Djafar, Fadillah; Edy, Hosea Jaya
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 3, No 2 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (785.643 KB) | DOI: 10.35799/pmj.3.2.2020.32882

Abstract

ABSTRACT Popularity of bioactive compounds from plants as a treatment for microbial infections have increased. The content of chemical compounds in cloves can produce various biological activities. The chemical compounds contained in cloves are phenol, flavonoid, hydroxybenzoate, and hydrokinetic acid, with the main chemical compound being eugenol. This review was prepared using secondary data from the scientific literature databases of Google Scholar, PubMed, and CORE. This review aims to collect, compile, study, and highlight the potential of cloves as an antimicrobial agent from existing literature and databases. The effectiveness of cloves in treating microorganisms has a broad spectrum, including bacteria, fungi, protozoa, and viruses. The antimicrobial activity of ethanol, methanol, acetone extract, and clove essential oil provided antimicrobial activity against Gram-positive and Gram-negative bacteria. Cloves show bacteriostatic and bacteriocidic activity with mechanism of action in disrupting or damaging cell wall. Keywords : antimicrobial, clove.   ABSTRAKPopularitas senyawa bioaktif tanaman sebagai penanganan infeksi mikroba kian meningkat. Kandungan senyawa kimia cengkeh dapat menghasilkan berbagai aktivitas biologi. Senyawa kimia yang terkandung dalam cengkeh adalah fenol, flavonoid, hidroksi benzoat, dan asam hidrokinetik, dengan kandungan senyawa kimia utama eugenol. Review ini dibuat menggunakan data sekunder dari database literatur ilmiah Google Scholar, PubMed, dan CORE. Review ini bertujuan untuk mengumpulkan, menyusun, mengkaji, dan menyorot potensi cengkeh sebagai agen antimikroba dari literatur dan database yang ada. Efektivitas cengkeh dalam menghabat mikroorganisme memiliki spektrum yang luas mencakup bakteri, jamur, protozoa, dan virus. Aktivitas antimikroba ekstrak etanol, metanol, aseton, minyak atsiri cengkeh memberikan aktivitas antimikroba pada bakteri Gram positif dan Gram negatif. Cengkeh menunjukkan aktivitas bakteriostatik dan bakteriosidik dengan mekanisme merusak dinding sel. Kata kunci : antimikroba, cengkeh
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN SABUN CAIR EKSTRAK ETANOL DAUN SIRSAK (Annona muricata Linn) TERHADAP BAKTERI Staphylococcus Legi, Angelika Pretty; Edy, Hosea Jaya; Abdullah, Surya Sumantri
PHARMACON Vol 10, No 3 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.35610

Abstract

ABSTRACTSoursop leaves (Annona muricata Linn) contain tannins, alkaloids, saponins, and flavonoids that function as antibacterial. The purpose of this study was to formulate liquid soap soursop leaf extract ethanol which is good physically and to test the inhibitory power of soursop leaf extract liquid soap with a concentration of 1%; 3%; 5%; and 7% against Staphylococcus aureus. This research uses laboratory experimental methods. Based on the results of the study, it showed physical evaluations such as organoleptic (green and dark green, peppermint oil, liquid), foam height test was 70-73.33 mm, water content test was 42.79-36.62%, alkali content test free 0.051-0.074%, and the pH test was 8.99-9.74. Liquid soap with ethanolic extract of soursop leaves has antibacterial activity with an average diameter of F1 (2.8 mm) in the weak category, F2 (7.6 mm) in the weak category, F3 (10.6 mm) in the strong category, and F4 (12.3 mm) is in a strong category. In conclusion, the ethanolic extract of soursop leaves can be formulated into liquid soap that are physically good and have the greatest antibacterial activity at a concentration of F4 (12.3 mm). Keywords: Soursop leaves, Liquid Soap, Antibacterial.  ABSTRAKDaun sirsak (Annona muricata Linn) memiliki kandungan senyawa tanin, alkaloid, saponin, dan flavonoid yang berfungsi sebagai antibakteri. Penelitian ini bertujuan untuk memformulasikan sabun cair ekstrak etanol daun sirsak yang baik secara fisik serta menguji daya hambat sabun cair ekstrak daun sirsak dengan konsentrasi 1%; 3%; 5%; dan 7% terhadap bakteri Staphylococcus aureus. Penelitian ini menggunakan metode eksperimental laboratorium. Berdasarkan hasil penelitian menunjukan evaluasi fisik seperti organoleptik (berwarna hijau dan hijau tua, beraroma khas peppermint, berbentuk cair), uji tinggi busa yaitu 70-73,33 mm, uji kadar air yaitu 42,79-36,62%, uji kadar alkali bebas 0,051-0,074%, dan uji pH yaitu 8,99-9,74. Sabun cair ekstrak etanol daun sirsak memiliki aktivitas antibakteri dengan diameter rata-rata untuk F1 (2,8 mm) berada dikategori lemah, F2 (7,6 mm) berada dikategori lemah, F3 (10,6 mm) berada dikategori kuat, dan F4 (12,3 mm) berada dikategori kuat. Kesimpulannya, ekstrak etanol daun sirsak dapat diformulasikan menjadi sediaan sabun cair yang baik secara fisik dan memiliki aktivitas antibakteri paling besar yaitu pada konsentrasi F4 (12,3 mm). Kata Kunci: Daun Sirsak, Sabun Cair, Antibakteri.
FORMULASI SEDIAAN SALEP EKSTRAK ETANOL BAWANG PUTIH (Allium sativum L.) SEBAGAI ANTIBAKTERI Rajab, Mustika Nur; Edy, Hosea Jaya; Siampa, Jainer Pasca
PHARMACON Vol 10, No 3 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.35604

Abstract

ABSTRACTGarlic (Allium sativum L.) is a plant white bulbs onion  that contains antibacterial compounds such as alicin, flavonoid, and saponin. The aim of this study was to formulate an ointment extract of white bulbs onion  (Allium sativum L.) with various concentrations of 2,5%; 5%; 7,5%; and 10%, and then evaluated the ointment according to the physical evaluation requirements. The diffusion method was utilized to test the activity of the ointment preparation towards Staphylococcus aureus and Staphylococcus epidermidis. The results showed that garlic (Allium sativum L.) could be formulated as an antibacterial ointment and met the requirements of the ointment evaluation test according to the results of the organoleptic test based on the white ointment, F1 and F2 were pale yellow, and F3 and F4 were brownish yellow with odor lemon. The homogeneity tests indicated no lumps in the ointment preparation, and the pH test revealed that it was within the range of 4.5 to 6.5. The spreadability  test met the requirements of 5 - 7 cm, and the adhesion test met the requirements of more than 4 seconds. The results showed that the ethanol extract ointment of garlic (Allium sativum L.) could inhibit the growth of Staphylococcus aureus and Staphylococcus epidermidis bacteria which concentrations of 10 % Staphylococcus aureus resulted in the zone of inhibition of 15.5 mm is categorized as strong and Staphylococcus epidermidis bacteria resulted in the zone of inhibition of 15.1 mm is categorized as strong and F4 is the best formula for generating the zone of inhibition.Keywords: Garlic (Allium sativum L.), Antibacterial ointment, Staphylococcus aureus, Staphylococcus epidermidisABSTRAKBawang Putih (Allium sativum L.) merupakan tanaman umbi bawang putih yang memiliki kandungan senyawa alicin, flavonoid dan saponin yang mampu memberikan efek antibakteri. Tujuan dari penelitian ini untuk memformulasikan salep ekstrak etanol bawang putih (Allium sativum L.) dengan berbagai konsentrasi 2,5%; 5%; 7.5%; 10% dan mengevaluasi sediaan salep sesuai dengan persyaratan evaluasi fisik. Pengujian aktivitas sediaan salep terhadap bakteri Staphylococcus aureus dan Staphylococcus epidermidis dilakukan dengan metode difusi. Hasil penelitian menunjukkan bahwa  bawang putih (Allium sativum L.) dapat diformulasikan sebagai sediaan salep antibakteri dan memenuhi persyaratan uji evaluasi sediaan salep sesuai dengan hasil uji organoleptik basis salep berwarna putih, F1 dan F2 berwarna kuning pucat, dan F3 dan F4 berwarna kuning kecoklatan berbau lemon. Uji homogenitas menunjukkan tidak adanya gumpalan pada sediaan salep, uji pH sesuai dengan persyaratan yaitu 4.5 – 6.5. Uji daya sebar sesuai dengan persyaratan yaitu 5 – 7 cm, dan uji daya lekat sesuai dengan persyaratan yaitu lebih dari 4 detik. Hasil menunjukkan bahwa salep ekstrak etanol bawang putih (Allium sativum L.) dapat menghambat bakteri Staphylococcus aureus dan Staphylococcus epidermidis dimana konsentrasi 10 % bakteri Staphylococcus aureus menghasilkan zona hambat 15.5 mm termasuk kategori kuat dan bakteri Staphylococcus epidermidis menghasilkan zona hambat 15.1 mm termasuk kategori kuat dan  formula F4 merupakan formula terbaik dalam menghasilkan zona hambat.Kata Kunci : Bawang putih (Allium sativum L.), Salep antibakteri, Staphylococcus aureus, Staphylococcus epidermidis
Edukasi Pentingnya Vaksinasi Covid-19 Melalui Program Kemitraan Masyarakat Pada Kolom 13 GMIM Siloam Edy, Hosea Jaya; Suoth, Elly Juliana
The Studies of Social Sciences Vol 3, No 2 (2021): The Studies of Social Sciences
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35801/tsss.2021.3.2.36119

Abstract

The global pandemic caused by the corona virus is still ongoing and continues to cause casualties. The Indonesian government has carried out a COVID-19 vaccination program for citizens to prevent the spread of the corona virus. The program that has been carried out in this activity has provided information and education about the importance of the covid-19 vaccination program. The education that has been provided includes information that the covid-19 vaccine used is safe and halal. The public has been educated that the covid-19 vaccination is very important in the process of increasing the body's immunity against the corona virus. Activities were conducted for the community in column 13 of GMIM Siloam, Sosonopan, Paniki with the method of educational information campaign. Public knowledge that the COVID-19 vaccine is safe and halal will increase after receiving education so that they are willing to participate in the vaccination program.  Keywords: Virus; corona; vaccine; safe; halal AbstrakPandemi global yang disebabkan oleh virus corona masih berlangsung dan terus menimbulkan korban jiwa. Pemerintah melakukan program vaksinasi covid-19 kepada masyarakat Indonesia untuk mencegah penyebaran virus corona. Program yang dilakukan dalam kegiatan ini adalah memberikan informasi dan edukasi tentang pentingnya program vaksinasi covid-19. Edukasi meliputi informasi bahwa  vaksin covid-19 yang digunakan aman dan halal. Masyarakat juga diedukasi bahwa vaksinasi covid-19 sangat penting dalam proses peningkatan kekebalan tubuh terhadap virus corona. Kegiatan dilakukan terhadap masyarakat kolom 13 GMIM Siloam, Sosonopan, Paniki dengan metode  kampanye informasi edukasi (KIE). Pengetahuan masyarakat bahwa vaksin covid-19 aman dan halal akan meningkat setelah mendapat edukasi sehingga bersedia mengikuti program vaksinasi.Kata kunci: Virus; corona; vaksin; aman; halal
Efek Antibakteri Ekstrak Etanol Daun Kelor (Moringa oleifera Lam.) dan Sediaan Masker Gel ¬Peel-Off Ekstrak Etanol Daun Kelor (Moringa oleifera Lam.) Tunas, Theresia H.; Edy, Hosea Jaya; Siampa, Jainer Pasca
Jurnal MIPA Vol 8, No 3 (2019)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jmuo.8.3.2019.25778

Abstract

Daun Kelor (Moringa oleifera Lam.) bermanfaat untuk menghambat aktivitas pertumbuhan bakteri karena adanya kandungan senyawa flavonoid , alkaloid, dan fenol. Penelitian ini bertujuan untuk menguji aktivitas antibakteri dari ekstrak etanol daun Kelor dan sediaan masker gel peel-off ekstrak etanol daun Kelor terhadap bakteri Staphylococcus aureus. Penelitian ini menggunakan metode eksperimental laboratorium, ekstrak etanol daun kelor dan sediaan masker gel peel-off ekstrak etanol daun Kelor dibuat dengan konsentrasi 1, 3, 5, 7, dan 9%. Ekstrak daun Kelor diperoleh dengan cara maserasi dengan menggunakan pelarut etanol 96%. Pada pengujian antibakteri menggunakan metode sumuran. Diameter zona hambat paling besar yang ditimbulkan oleh ekstrak etanol daun Kelor yaitu pada konsentrasi 7% dengan diameter zona hambat sebesar 5,75 mm, sedangkan pada sediaan masker gel peel-off tidak menunjukkan adanya daya hambat. Dapat disimpulkan bahwa ekstrak etanol daun Kelor memiliki aktivitas antibakteri yang termasuk dalam kategori sedang.Moringa oleifera Lam. (Moringa oleifera) leaves are useful for inhibiting bacterial growth activity due to the presence of flavonoid, alkaloid, and phenol compounds. This study aims to test the antibacterial activity of the Moringa leaf ethanol extract and the gel peel-off mask preparation of Moringa leaf ethanol extract against Staphylococcus aureus bacteria. This study uses laboratory experimental methods, Moringa leaf ethanol extract and gel mask peel-off preparation for Moringa leaf ethanol extract made with concentrations of 1, 3, 5, 7, and 9%. Moringa leaf extract was obtained by maceration using 96% ethanol solvent. In antibacterial testing using the well method. The biggest inhibition zone diameter caused by ethanol extract of Moringa leaves is at a concentration of 7% with a inhibition zone diameter of 5.75 mm, whereas the peel-off gel mask preparation did not show any inhibitory power. It can be concluded that the ethanol extract of Moringa leaves has antibacterial activity which is included in the medium category.
ISOLASI DAN IDENTIFIKASI SENYAWA SAPONIN DARI EKSTRAK METANOL BATANG PISANG AMBON(Musa paradisiaca var. sapientum L.) Suharto, M. Agung Pratama; Edy, Hosea Jaya; Dumanauw2, Jovie M.
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.914

Abstract

Bananais a plant thatcanbe used asthe basis fortreatment.Banana trunk containssaponincompounds, flavonoids, andtannins.The purpose of this study was to isolate saponin compound in methanol extract of Ambon banana (Musa paradisiaca var. sapientum L.) using preparation of Thin Layer Cromatography method. Identification of absorbance value of saponin was done in maximum wave length using UV-Vis spectrophotometer. Methanol extract of Ambon banana trunk was obtained by maceration. Saponinsis said to be contained in banana trunk if the foam formed is stablewith the height of2-3 cmhighfor 30secondsin the addition ofone drop ofhydrochloricacid2Nandcolor testLiebermannBurchard(LB) whichproducesbrownringindicatestriterpenesaponin.Resultsofisolationusingeluentchloroform: methanol: water (13:7:2) gave the greenstainspotsonsilicagelplatessprayedwith reagentLBso it is saidthat the samplealso containssteroidalsaponinstypeswith Rfvalue of0.275; 0.325; 0.375.Based on theresults ofidentification usingultravioletvisiblespectrophotometry, absorbance valuewas2.754saponinat209nmmaximum wavelength. Keywords: isolation, saponin, methanol extract, Ambon banana trunk
Co-Authors Abdullah, Surya Sumantri Ade Novia Mokodompit Adithya Yudistira Agnes S. G. Sahuleka Anisa Puspa Juwita Apitalau, Etserlisa A. Arsianita Ester Wawo Bidulang, Crunny Bidhya Ciptanti Putri Prakarsa Citra Tompunu David Tjahyadi Debora Tandy Djafar, Fadillah Djebli, Noureddine Eka Mulya Muthalib Ekadelania Buyung Elly Suoth Falles Raintung The Fathoni, Kristiani W. S. W. Fatimawali . Gayatri Citraningtyas Gratia, Berta Hairunisa, Nany Hamidah Sri Supriati Hardy Senjaya Haris Maupa Herny E.I. Simbala Hisan, Annisa Khoirotun Husnun Amalia I Made Putra Suwertayasa Inriani MarlinMareyke Rumayar Jainer Pasca Siampa Jayanto, Imam Jonathan Christofel Rumangkang Jovie M. Dumanauw2 Kalalo, Marko Jeremia Karlah L. R. Mansauda Korengkeng, Nathania Anabel Lebang, Julianri S. Legi, Angelika Pretty Lestari, Monica Dewi M. Agung Pratama Suharto Mallaka, Indriyani MANGUNE, GLORYA DORCHICYLHIA Marko Jeremia Kalalo Meilani Jayanti Missyeling Fransisca Saerang ML Edy Parwanto Mumu, Britney Stevani Nathania Anabel Korengkeng Novel Kojong Oladimeji, Ashaolu Victoria Parwanto, Edy Paulina yamlean Pongsapan, Abdul David Prayoga, Deshanda Kurniawan Puluh, Esterlina Aldora Purnomo, Novia Hanna Rajab, Mustika Nur Rambi, Salfa Efata Glory Redwik, Danni Umbu Wira Romario Aldi Rompas Santika Angela Van Gobel Sarwan, Sarwan Sergio Christiano Mandagi JR Siampa, Jainer P Siampa, Jainer Pasca Somba, Gichella C.J Sri Murti Sari Syamsuddin Sri Sudewi, Sri Sukartiningsih, Yulita Ni Nyoman Surya Sumantri Abdullah Tiara Mappa Tondolambung, Axcel H. Tunas, Theresia H. Valencia Lumantow Viondy Damogalad Vyta N Sari Sinrang Weny Wiyono Widdhi Bodhi Yosua Jaya Edy