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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina International Journal of Biosciences and Biotechnology Buletin Udayana Mengabdi INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Jurnal Farmasi Klinik Indonesia Indonesian Journal of Cancer Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Essential: Essence of Scientific Medical Journal International Journal of Social Service and Research Indonesian Journal of Perinatology Indonesian Journal of Cancer Public Health and Preventive Medicine Archive
I Nyoman Gede Budiana
Gynecology Oncology Division, Obstetrics & Gynecology Department, Sanglah General Hospital
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Characteristics of Cervical Precancerous Lesions at a Tertiary Hospital in Bali, Indonesia I Nyoman Gede Budiana; Ida Bagus Rendra Kurniawan Artha
Indonesian Journal of Cancer Vol 14, No 4 (2020): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.966 KB) | DOI: 10.33371/ijoc.v14i4.731

Abstract

Background: Cervical cancer is one of the biggest women’s health issues in developing countries including Indonesia. This study is aimed to describe the characteristics of cervical precancerous lesions at a tertiary hospital in Bali, Indonesia.Methods: This is a descriptive study using data from the medical records of patients with precancerous cervical lesions who attended the Gynecologic Oncology Outpatient Clinic Sanglah Hospital Denpasar, Bali, Indonesia, from January to December 2017. Results: There were 276 cases (2.88%) of the cervical precancerous lesion during the study period. The majority of cases were diagnosed within the age group of 36-45 years (37.7%), had low education levels (42.7%), obese (53.5%), multiparous (73.9%), had first sexual intercourse at the age of 16-20 years (41.3%), had used IUD as a contraceptive method (41.4%), and had a cytologic diagnosis of atypical squamous cells of undetermined significance (ASC-US) that preceded the histologic diagnosis (43.2%). The most common histologic diagnosis was CIN I (43.1%) and the most common treatment was cryotherapy (56.2%).Conclusions: The majority of cervical precancerous lesion cases were diagnosed among women who were between her third and fourth decade of life, had low education level, were obese, multiparous, had a sexual debut at a younger age, and were IUD users. The majority of cases were low-grade lesions.
Fertility-Sparing Surgery In Early Stage Cervical Cancer IN Gede Budiana; Tjokorda Gede Astawa Pemayun
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.473 KB) | DOI: 10.33371/ijoc.v12i1.553

Abstract

Cervical cancer is a malignancy in women that cause major impacts, not only biologically, but also in various aspects of life. On patients during reproductive age, cervical cancer poses severe sexual and reproductive debilitation. Trend in the onset of first diagnosis is moving towards younger age, and mostly affect women in their reproductive age. This would give a bad impact on the sustainability of the patient’s reproductive function. Until now, fertilitysparing approach for the management of early-stage cervical cancer is still rare in Indonesia. However, some options of conservative surgical therapy are available for patients who desire fertility, namely conization, simple tracellectomy, radical trachelectomy, and also neoadjuvant chemotherapy. These options have been proven effective and safe, while maintaining patients’ reproductive functions. ABSTRAKKanker serviks merupakan suatu penyakit keganasan pada wanita yang memiliki dampak luas, tidak hanya pada tubuh penderita, namun juga berbagai aspek kehidupan penderita. Pada penderita di usia reproduktif, kanker serviks menimbulkan masalah seksual dan reproduksi yang berat bagi penderita. Kini usia dimana terjadinya kanker serviks mulai menunjukkan kecenderungan yang semakin muda yang tentunya memberikan dampak buruk terhadap keberlangsungan fungsi reproduksi pasien. Hingga saat ini, tatalaksana kanker serviks stadium awal dengan pendekatan fertility-sparing masih jarang dilakukan di Indonesia. Namun, beberapa pilihan terapi bedah konservatif tersedia bagi pasien yang menginginkan fertilitas, yakni konisasi, trakelektomi sederhana, trakelektomi radikal. hingga pemberian kemoterapi neo-adjuvant. Pilihan terapi ini telah terbukti efektif dan aman, serta mampu mem pertahankan fungsi reproduksi pasien.
Profil Ekspresi Caspase-3 pada Kanker Ovarium Tipe Epitel I Nyoman Gede Budiana; Suhatno -; Faroek Hoesin; Budiono -
Indonesian Journal of Cancer Vol 7, No 3 (2013): Jul - Sep 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (611.688 KB) | DOI: 10.33371/ijoc.v7i3.283

Abstract

Penelitian ini bertujuan mengetahui profil ekspresi caspase-3 pada kanker ovarium tipe epitel. Rancangan penelitian ini adalah cross-sectional deskriptif. Sampel penelitian adalah pasien kanker ovarium di RSUD Dr. Sutomo, Surabaya, yang jaringan tumor ovariumnya telah diparafinisasi di Laboratorium Patologi Anatomi FK Universitas Airlangga Surabaya. Kriteria inklusi adalah blok parafin telah diperiksa secara histopatologi sehingga telah terdiagnosis pasti kanker ovarium tipe epitel dan catatan medis pasien bisa ditemukan serta terisi lengkap. Kriteria eksklusi adalah pasien pernah menjalani kemoterapi atau radiasi sebelum pembedahan dan blok parafin rusak sehingga tidak dapat digunakan. Ekspresi caspase-3 diperiksa secara imunohistokimia.Dari 42 subjek penelitian, didapatkan ekspresi caspase-3 positif sebanyak 47,6% dan ekspresi caspase-3 negatif sebanyak 52,4%. Ditemukan subjek penelitian dengan derajat diferensiasi sel baik lebih banyak mempunyai ekspresi caspase-3 positif dibandingkan dengan derajat diferensiasi sel sedang dan jelek (p=0,017). Subjek penelitian dengan stadium dini lebih banyak mempunyai ekspresi caspase-3 positif (p<0,001). Demikian juga subjek penelitian dengan residu tumor ? 1 cm lebih banyak mempunyai ekspresi caspase-3 positif (p=0,029).Kesimpulan: Terdapat perbedaan yang bermakna secara statistik ekspresi caspase-3 pada berbagai derajat diferensiasi sel, stadium, dan residu tumor pasca operasi primer pada kanker ovarium tipe epitel.Kata kunci: caspase-3, derajat diferensiasi sel, stadium, residu tumor
Masalah ginekologi pasien remaja di RSUP Sanglah Denpasar pada April 2016 – Maret 2017 Demetria Jesica Lim; IBG Fajar Manuaba; I Gede Mega Putra; I Nyoman Gede Budiana
Intisari Sains Medis Vol. 10 No. 1 (2019): (Available online 1 April 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (218.187 KB) | DOI: 10.15562/ism.v10i1.217

Abstract

Remaja adalah masa peralihan dari anak-anak ke dewasa atau tumbuh menjadi dewasa. Remaja belum dapat dikatakan sebagai dewasa namun juga sudah tidak dapat dikatakan sebagai anak – anak. Definisi remaja menurut WHO adalah seseorang dengan usia 10-19 tahun. Pada masa remaja ini sudah mulai muncul ciri-ciri perkembangan seks primer maupun sekunder seperti tumbuhnya payudara dan menstruasi pada wanita. Proses perkembangan seks sekunder ini tidak semuanya berjalan dengan lancar pada setiap wanita. Sangat mungkin untuk terjadi masalah-masalah pada proses perkembangan ini yang berhubungan dengan kesehatan reproduksi. Tujuan: Untuk mengetahui masalah ginekologi remaja yang berkunjung di RSUP Sanglah Denpasar. Metode: Penelitian ini dilakukan dengan teknik total sampling untuk mendapat angka kejadian gangguan menstruasi, keputihan, tumor ovarium, Polycystic Ovary Syndrome, infeksi Human Papilloma Virus dan kehamilan yang tidak diinginkan pada remaja wanita yang memeriksakan diri di RSUP Sanglah dalam periode April 2016 – Maret 2017. Hasil: Dari 49 sampel yang didapat terdapat 53,06% kasus keputihan, 38,78% kasus gangguan menstruasi dan 8,16% kasus kanker ovarium. Kesimpulan: Tidak ditemukan pasien dengan infeksi Human Papilloma Virus (HPV), Polycystic Ovary Syndrome (PCOS) dan kehamilan yang tidak diinginkan pada periode April 2016 – Maret 2017. 
Skor assessment of different neoplasias in the adnexa (ADNEX) untuk memprediksi keganasan ovarium di RSUP Sanglah Denpasar I Nyoman Gede Budiana; Ketut Suwiyoga; Tjokorda Gde Agung Suwardewa; Anom Suardika; Made Bagus Dwi Aryana; Heni Sunyoto
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i1.1328

Abstract

Introduction: Ovarian cancer is cancer of the female reproductive organs with the highest mortality and is in the third position of female cancer after mammary and cervical cancer. The mortality rate and survival rate of ovarian cancer is mainly determined by the stage at which ovarian cancer is diagnosed. Until now there is no method for early detection of ovarian cancer with good sensitivity and specificity. Assessment of different neoplasias in the adnexa (ADNEX) is a model proposed by international ovarian tumor analysis (IOTA) to help distinguish benign or malignant adnexa tumors.Methods: This study is a observational clinical test to find out the accuracy of ADNEX model to predict ovarian malignancy conducted at the Obstetric and Gynecology Outpatient Ward in Sanglah hospital, Denpasar from November 2019 to April 2020. Consecutive sampling was done and 88 sample was recruited with a diagnosis of ovarian tumors. Then the research sample was sent to the Pathology Anatomy laboratory of Sanglah Hospital for histopathological examination. This result would then be compared to the prediction results of the ADNEX model.Results: 35 samples of benign ovarian tumors and 53 samples of ovarian cancer were found with the ADNEX method. There were 46 samples with malignant tumor both by the ADNEX model and histopathology results, 7 samples of malignant tumor at histopathology result but benign by the ADNEX model, 6 samples of benign tumor according to histopathology but malignant using the ADNEX model, and 29 samples of benign tumor according to histopathology and the ADNEX model. Using cut off of 49,6%, the study reported a sensitivity level of 86.8%, specificity 82.6%, positive predictive value 88.5%, negative predictive value 80.6%, and 85.2% accuracy.Conclusion: The ADNEX model has a high level of specificity, sensitivity and diagnostic accuracy in diagnosing ovarian cancer and can be used in combination with other clinical markers for early detection of malignancy in ovarian tumors.  Pendahuluan: Kanker ovarium merupakan salah satu jenis kanker organ reproduksi wanita dengan mortalitas tertinggi dan berada pada posisi ke-tiga kanker perempuan setelah kanker mammae dan serviks. Angka mortalitas dan survival rate kanker ovarium sangat ditentukan oleh stadium saat kanker ovarium terdiagnosis. Hingga saat ini belum tersedia metode pemeriksaan untuk deteksi dini kanker ovarium dengan sensitivitas dan spesifisitas yang memadai. Assessment of different neoplasias in the adnexa (ADNEX) adalah model yang diajukan oleh International Ovarian Tumor Analysis (IOTA) untuk membantu membedakan tumor adnexa sebagai tumor jinak atau ganas. Metode: Penelitian ini merupakan penelitian observasional uji klinik untuk mengetahui akurasi model ADNEX untuk memprediksi keganasan ovarium yang dilakukan di Poliklinik Kebidanan dan Penyakit Kandungan RSUP Sanglah, Denpasar pada bulan November 2019 hingga April 2020. Sampling dilakukan secara consecutive dan didapatkan 88 orang dengan diagnosis tumor ovarium. Sampel penelitian dikirimkan ke laboratorium Patologi Anatomi RSUP Sanglah dan dilakukan pemeriksaan histopatologi untuk kemudian dibandingkan dengan hasil prediksi dari model ADNEX.Hasil: Dalam penelitian ini didapatkan 35 sampel dengan tumor jinak ovarium dan 53 sampel dengan kanker ovarium dengan menggunakan metode ADNEX. Terdapat 46 sampel dengan hasil pemeriksaan model ADNEX ganas dan hasil pemeriksaan histopatologi ganas, 7 sampel histologi ganas namun model ADNEX jinak, 6 sampel histopatologi jinak namun model ADNEX ganas, dan 29 sampel histopatologi jinak dan model ADNEX jinak. Hasil penelitian memperlihatkan tingkat sensitifitas 86,8%, spesifisitas 82,6%, nilai prediksi positif 88,5%, nilai prediksi negatif 80,6%, dan akurasi 85,2%.Simpulan: Model ADNEX memiliki tingkat spesifisitas, sensitivitas dan akurasi diagnostik yang tinggi dalam mendiagnosis kanker ovarium dan dapat digunakan bersama dengan penanda klinis lain untuk deteksi dini keganasan pada tumor ovarium.
Akurasi kadar serum Secretory Leukocyte Protease Inhibitor (SLPI) dalam menunjang diagnosis kanker ovarium: suatu uji diagnostik Putu Adi Sujana Putra; Ketut Suwiyoga; I Nyoman Gede Budiana; I Wayan Megadhana; I Nyoman Bayu Mahendra; I Made Darmayasa
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.258 KB) | DOI: 10.15562/ism.v13i2.1361

Abstract

Background: Ovarian cancer is one of the most common malignant tumors found in reproductive organs in vitro. Secretory Leukocyte Protease Inhibitor (SLPI) protein is essential for the growth of ovarian cancer cells, a protein that maintains the survival of ovarian cancer cells, inhibits antiproliferative effects, and reverses the proapoptotic effect of elastase. This study aims to evaluate the role of SLPI in diagnosing ovarium cancer. Methods: The research was conducted at the Obstetrics and Gynecology Polyclinic, Sanglah Hospital, Denpasar and the Prodia Laboratory. Sampling of this study has been carried out by previous researchers in research on the accuracy of serum levels of insulin-like growth factor binding protein 2 in diagnosing ovarian cancer. The research sample (intended sample) was women aged 18 years and over with ovarian tumors who came to the Obstetrics and Gynecology Polyclinic, Sanglah Hospital, Denpasar. Data were analyzed using SPSS versi 22 for Windows. Results: The proportion of epithelial types was significantly higher in the ovarian cancer group. In ovarian cancer samples, the most samples were obtained at FIGO III Stage. Median CA125 levels, RMI scores, and SLPI levels were significantly higher in the group with ovarian cancer. The cut off value of serum SLPI used in this study was 54,000 pg/ml which was obtained from preliminary analysis on 26 training samples. Sensitivity: 78.3; specificity:66.7%; Positive predictive value: 78.3%; Negative predictive value: 66.7% Accuracy: 73.6%. Conclusion: In a diagnostic test study to assess the accuracy of SLPI serum in supporting the diagnosis of ovarian cancer, it was found that SLPI serum had good sensitivity, specificity, PPV, NPV, and accuracy values.   Latar Belakang: Kanker ovarium merupakan salah satu tumor ganas yang paling sering ditemukan pada organ reproduksi secara in vitro. Protein Secretory Leukocyte Protease Inhibitor (SLPI) sangat esensial untuk pertumbuhan sel kanker ovarium, protein yang menjaga kelangsungan hidup sel kanker ovarium, inhibisi efek antiproliferatif, dan membalikkan efek proapoptosis dari elastase. Penelitian ini bertujuan untuk mengevaluasi peran SLPI dalam mendiagnosis kanker ovarium. Metode: Penelitian dilakukan di Poliklinik Kebidanan dan Penyakit Kandungan RSUP Sanglah Denpasar dan Laboratorium Prodia. Pengambilan sampel penelitian ini sudah dilakukan oleh peneliti sebelumnya pada penelitian tentang akurasi kadar serum insulin-like growth factor binding protein 2 dalam mendiagnosis kanker ovarium. Sampel penelitian (intended sample) adalah wanita berusia 18 tahun ke atas dengan tumor ovarium yang datang ke Poliklinik Kebidanan dan Penyakit Kandungan RSUP Sanglah Denpasar. Hasil: Proporsi tipe epitelial secara signifikan lebih banyak pada kelompok kanker ovarium. Pada sampel kanker ovarium, didapatkan sampel paling banyak pada Stadium FIGO III. Median kadar CA125, skor RMI, dan kadar SLPI secara signifikan lebih tinggi pada kelompok dengan kanker ovarium. Nilai cut off serum SLPI yang digunakan pada penelitian ini adalah 54.000 pg/ml yang didapatkan dari analisa pendahuluan pada 26 training sample Sensitivitas:78,3; spesifisitas:66,7%; Nilai prediksi positif: 78,3%; Nilai prediksi negatif: 66,7% Akurasi: 73,6%. Kesimpulan: Pada penelitian uji diagnostik untuk menilai akurasi serum SLPI dalam menunjang diagnosis kanker ovarium didapatkan bahwa serum SLPI memiliki nilai sensitivitas, spesifisitas, PPV, NPV, dan akurasi yang baik.
Hubungan antara kadar homosistein (Hcy) dengan kejadian ketuban pecah dini (KPD) pada kehamilan preterm Agrifa Eko Albert Sembiring; Tjokorda Gde Agung Suwardewa; Ketut Surya Negara; I Nyoman Gede Budiana; Ida Bagus Putra Adnyana; Evert Solomon Pangkahila
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.149 KB) | DOI: 10.15562/ism.v13i2.1369

Abstract

Background: Premature rupture of membranes (PROM) has been a problem in obstetrics since ancient times until now. The incidence of PROM in the world ranges from 5% - 15% of all pregnancies, while the incidence in developing countries, especially Indonesia ranges from 4.5% to 7.6% of all pregnancies. Preterm is one of the highest contributors to perinatal mortality and morbidity. The incidence of preterm pregnancy in the world is around 9.6% of all births, while in Southeast Asia is around 11.1% It has been shown to have a significant effect on vascular endothelial pathology.  Methods: The study was conducted with an analytic cross-sectional design involving  70 respondents of pregnant women with gestational age of 20 - < 37 weeks with and without PPROM who came to the outpatient clinic and maternity ward of Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar from May 2021 – July 2021.  Results: The results of the analysis of this study found a statistically significant relationship between homocysteine (Hcy) levels and the incidence of preterm premature rupture of membranes (p = 0.001). The prevalence ratio value of 2.2 means that high homocysteine levels is a risk factor for premature rupture of membranes in preterm pregnancy (RP = 2.2; 95% CI = 1.33-2.94; p = 0.001). Conclusion: High homocysteine level is a risk factor for premature rupture of membranes in preterm pregnancy.   Latar Belakang: Ketuban pecah dini (KPD) preterm merupakan masalah di bidang obstetrik sejak dahulu sampai sekarang. Insiden KPD di dunia berkisar antara 5% - 15% dari seluruh kehamilan. Insiden KPD di negara berkembang khususnya Indonesia berkisar 4,5% - 7,6% dari seluruh kehamilan. Kehamilan preterm menjadi salah satu penyumbang tertinggi angka mortalitas dan morbiditas perinatal. Insiden kehamilan preterm di dunia sekitar 9.6% dari semua kelahiran, sedangkan di Asia tenggara terdapat sekitar 11,1%. Hcy telah terbukti signifikan berpengaruh pada patologi endotel pembuluh darah. Metode: Penelitian dilakukan dengan rancangan cross sectional analitik dengan melibatkan 70 responden wanita hamil dengan usia gestasi 20 - <70 minggu dengan atau tanpa KPD yang dating ke poliklinik dan ruang bersalin RSUP Prof. Dr. I.G.N.G. Ngoerah bulan Mei 2021 – Juli 2021. Hasil: Diperoleh hubungan bermaksana secara statistik antara kadar homocycteine dengan kejadian ketuban pecah dini pada kehamilan preterm (p = 0, 001), dan rasio prevalensi 2,2 berarti kadar homosisteine yang tinggi merupakan faktor risiko terjadinya ketuban pecah dini pada kehamilan preterm (RP = 2.2; 95% CI = 1.33-2.94; p = 0.001). Kesimpulan: Kadar homosistein yang tinggi merupakan faktor risiko terjadinya ketuban pecah dini pada kehamilan preterm.
Anemia as a risk factor of postpartum hemorrhage at dr. R. Soedjono Hospital, Selong, East Lombok Ernawati; Komang Ayu Kartika Sari; Nyoman Gede Budiana; Luh Seri Ani
Public Health and Preventive Medicine Archive Vol. 6 No. 2 (2018)
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53638/phpma.2018.v6.i2.p09

Abstract

Background and purpose: Globally, maternal mortality rate due to labor complications remains high, with postpartum hemorrhage as the most common cause. Studies on the risk factors of postpartum hemorrhage have been widely published, however, its association with maternal anemia is inconsistent. This study aims to explore anemia as a risk factor for postpartum hemorrhage. Methods: A case control study was carried out with 69 women who experienced postpartum hemorrhage as cases and 207 women who had given birth but did not experience hemorrhage as controls. Cases and controls were taken from medical records at the dr. R. Soedjono Hospital, Selong, East Lombok District, West Nusa Tenggara. Cases were selected by systematic random sampling from 147 mothers who experienced postpartum hemorrhage during 2017. Controls were selected in the same way from 2,855 mothers who did not experience postpartum hemorrhage. Cases and controls were matched for birth weight of infants and maternal employment. Data were obtained by medical record extraction in May 2018 consisting of information on hemoglobin concentration, parity, age at pregnancy, birthing method, gestational age, birth spacing and length of labor. Data analysis was performed using logistic regression to determine the adjusted odds ratio (AOR) of anemia. Results: Characteristics of cases and controls were found to be similar in terms of infant birth weight, maternal occupation, parity, gestational age and length of delivery but statistically different by maternal age at pregnancy and birth spacing. Analysis with logistic regression showed that anemia during pregnancy with hemoglobin concentration ≤10 gr/dL was a significant risk factor for postpartum hemorrhage with AOR=16.32 (95%CI: 7.69-34.64). Delivery through caesarean section (SC) or oxytocin drip was also found to significantly reduce the risk of postpartum hemorrhage (AOR=0.03; 95%CI: 0.01-0.13). Conclusion: Anemia during pregnancy with hemoglobin concentration ≤10 gr/dL was found to be a risk factor for postpartum hemorrhage. Prevention and control of anemia in pregnant women need to be enhanced to prevent postpartum hemorrhage.
High Neutrophils to Lymphocytes Ratio in Maternal Blood Serum as Risk Factor for Preterm Premature Rupture of Membrane Nicholas Renata Lazarosony; I Wayan Artana Putra; Ryan Saktika Mulyana; I Made Darmayasa; Ida Bagus Gde Fajar Manuaba; I Gde Sastra Winata; I Nyoman Gede Budiana
International Journal of Social Service and Research Vol. 3 No. 9 (2023): International Journal of Social Service and Research (IJSSR)
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/ijssr.v3i9.518

Abstract

Introduction: Neutrophil-to-lymphocyte ratio (NLR) has been extensively studied as a prognostic factor for various diseases based on systemic inflammation. Premature rupture of membranes (PROM) is an obstetric problem that does not only occur in term pregnancies but can also occur in preterm pregnancies. One of the main etiologies for premature rupture of membranes is inflammation. Knowing the difference in the NLR between preterm prematurerupture of membranes (PPROM) and without PPROM is important to increase understanding of the crucial role of NLR in predicting the incidence of PPROM. Method: This analytic case-control study compared NLR values ??in maternal blood serum between PPROM and without PPROM. This research was conducted in the emergencydelivery room and obstetrics and gynecology outpatient clinic at Prof. dr. I.G.N.G. Ngoerah Hospital Denpasar from February to June 2022. Results: A high NLR in maternal blood serum may be a risk factor for PPROM. Patients with a high NLR had a 4.5 times greater likelihood of experiencing PPROM than those with a low NLR (OR = 4.5; 95% CI = 1.4 – 13.83; p = 0.007). Conclusion: A high NLR in maternal blood serum is a marker of inflammation with an increased risk of 4.5 times for the occurrence of PPROM.
TINGKAT PENGETAHUAN REMAJA MENGENAI KANKER SERVIKS DI DUA SEKOLAH DI KABUPATEN GIANYAR, BALI I Komang Darma Wijaya; I Nyoman Gede Budiana; Ida Bagus Gede Fajar Manuaba; Endang Sri Widiyanti
Essence of Scientific Medical Journal Vol 21 No 2 (2024): Volume 21 No. 2 (Juli - Desember 2023) Essential: Essence of Scientific Medical
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/essential.v21i2.109356

Abstract

ABSTRACT Cervical cancer become the second highest cancer case in Indonesia which attacks women with a mortality rate of up to 50%. The prevalence of this case has increased in recent years. This cancer, which is caused by infection with the HPV virus, can infect women from the age of 20 until the women is not in their reproductive age. The aim of this study was to determine the level of knowledge of adolescents regarding cervical cancer in two schools in Gianyar Regency. This research is descriptive study with a stratified random sampling method. The data collection method used was by giving questionnaires to students attending SMP Negeri 1 Gianyar and SMA Negeri 1 Gianyar. The questionnaire used consists of 2 aspects, namely knowledge of cervical cancer and knowledge of how to prevent cervical cancer. From this research, 209 respondents were obtained from the two schools, there are 30.14% had a good level of knowledge, 60.29% had a fairly good level of knowledge, and 9.57% had a poor level of knowledge.
Co-Authors Agrifa Eko Albert Sembiring Agung Bagus S. Satyarsa Ahmad, Nurmi Anak A. A. W. P. Dewi Anak Agung Istri Ayu Detritha Sarasmarth Anak Agung Istri Mas Sugiantari Anom Suardika Arlando Martino Anapaku Astawa Pemayun, Tjokorda Gede Bayu Mahendra, I Nyoman Budiono - Budiono -, Budiono Charles Richard Thene Demetria Jesica Lim Dewi, Anak A. A. W. P. Dewi, Putu Pradnya Paramitha Endang Sri Widiyanti Eric Gradiyanto Ongko Ernawati Ernawati Ernawati Ernest T. B. Sianturi Evert Solomon Pangkahila Faroek Hoesin Faroek Hoesin, Faroek FEBIANI, MELINDA FLORENCIA Heni Sunyoto I Gd Ngurah Harry W.S I Gd Ngurah Harry W.S2 I Gde Sastra Winata I Gede Indra Kumara I Gede Mega Putra I Gede Ngurah Harry Wijaya Surya I Ketut Surya Negara I Ketut Suwiyoga I Ketut Tunas I Komang Darma Wijaya I Made Darmayasa I Nyoman Hariyasa Sanjaya I Nyoman Satria Pratama I Wayan Artana Putra I Wayan Megadhana I. Lesmana Ida Ayu Dhitayoni Ida Bagus Arjuna Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Ida Bagus Rendra Kurniawan Artha Intan Puspa Jaqueline Sudiman Johan Qalaba K.W.M. Kenwa Kade Yudi Saspriyana Kevin Agastya Duarsa Komang Ayu Kartika Sari Kusuma, Anak Agung Ngurah Jaya L.H. Wirahartato L.P.D. Virayanti Luh Nyoman Mas Amita Luh Seri Ani Made Ayu Prabawaty Indraswari Made Bagus Dwi Aryana Made Yudha Ganesa Wikantyas Widia Mahastya, I Wayan Cahya Marta, Kadek Fajar Melinda Febiani Nara Iswari, Putu Ristya Ni Kadek Ari Chintya Vedantari Ni Kadek Chindy Sarindra Bhavani Ni Kadek Dwi Karlina Nicholas Renata Lazarosony Nyoman Bayu Mahendra Nyoman Damar Widya Dharma Ongko, Eric Gradiyanto P.A.T. Adiputra Pande Kadek Aditya Prayudi Pande Kadek Aditya Prayudi Pande Made Suwanpramana Putra, I Wayan Artana Putra, Wayan Artana Putu Adi Sujana Putra Putu Ayu Indrayathi Putu Doster Mahayasa Putu Harrista Indra Pramana Putu Pradnya Paramitha Dewi Putu Raka Sanistia Sania Savitri Putu Srinata Dampati R. Niruri Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rayvany Uil Rini Noviyani Ryan Saktika Mulyana Sagun Chandra Yowani Sari, Komang Ayu Kartika Stefanus K .H Stefanus K.H SUHATNO - SUHATNO -, SUHATNO Surya, I Gede Ngurah Harry Wijaya Suwardewa, Tjokora Gde Agung Tasia Irma Endriani Tjokorda Gde Agung Suwardewa Tjokorda Gede Astawa Pemayun Widi, Made Yudha Ganesa Wikantyas Widyasari, Putu Kartika Wijaya Surya, I Gede Ngurah Harry Wiradnyana, Anak Agung Putra Wulandari, Putu Kintan