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Journal : Journal of Global Pharma Technology

Enhancing Dissolution and Bioavaibility of Purely Water Insoluble Natural Compounds by Solid Dispersion with Hot Melt Extrusion Technique Sofi Nurmay Stiani; Taofik Rusdiana; Anas Subarnas
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

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Abstract

The use of herbal remedies is still a trend in the world, especially Indonesia as the second largest country after Brazil is rich in medicinal plants, in addition to having many pharmacological properties also have low side effects. The most common problems with biopharmaceutically related natural substances are low drug solubility, low biopharmaceutics, stability problems and active substance absorption. Bioavailability is an important factor in achieving the effects of drug therapy. Low bioavailability may occur due to low water solubility, instability in the digestion, and difficulty passing through the membrane. To overcome the problem of bioavaibility of natural material compounds should be made efforts to improve it, one of them with solid dispersion method. The solid dispersion is the dispersion of one or more active ingredients in an inert solid carrier. Technique of Dispersion in the carrier can be by way of hot spin mixing, co-evaporation, co-precipttion, freeze-drying, spray drying and HME. Techniques that are still rarely used in Indonesia is hot melt extrusion (HME). This study aims to explore characteristics of the chemical properties of natural materials, efforts to increase the bioavailability of natural compounds, and solid dispersion techniques.Keywords: Bioavailability, Natural compounds, solid dispersion, hot melt extrusion
Co-Authors Abdasah, Marline Aep W Irwan Aep W Irwan, Aep W Afra, Dinda Nur Ajeng Diantini, Ajeng Alfaqeeh, Mohammed Aliya Nur Hasanah Amelia Soyata Ami Tjitraresmi, Ami Amira Nur Hasanah ANANG SUBGHAN Anas Subarnas Anas Subarnas Anis Khorunisa Anis Khorunisa, Anis Anis Y. Chaerunisaa Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa, Anis Yohana Anis Yohana Chaerunnisa Arna Ningsih1, Endah ARVENDA REZKY PRATAMA Asep Nurrahman Yulianto Azizul Hakim Camellia Panatarani CINDY MELINDA SOFYANI Dani Sujana Dessy Ikasari Desy Nawangsari Desy Nawangsari Dewi Mayasari Dewi Mayasari Dewi, Febrina Aulia Dika P. Destiani Dilal Adlin Fadil Dolih Gozali Dwi Retno Sari Eka Riza Maula Eli Halimah, Eli Elis Lisnawati Elizabeth, Maria Ella Fazila Fadil, Dilal Adlin Fadil, Dilal Adlin FAJAR SETIAWAN Febrina Aulia Dewi Firman Gustaman Firmansya, Ardianes Fitrileni - Fitrileni -, Fitrileni Fitrileni Fitrileni Gaharani, Prodio Efa Gracia Anastasya GUSTIN HIDAYATI Hindun, Siti I Made Joni Ina Widia Insyirah, Ariani Iyan Sofyan, Iyan Iyan Sopyan Jajan Solahudin Jajan Solahudin, Jajan Keri Lestari Khairinisa, Miski A. Lana Labibah Lanny Indah Permatasari, Lanny Indah Linda Apriyanti LINDA APRIYANTI, LINDA Lusi Nurdianti, Lusi Lutfi Sulaiman M. Abdul Aziz Prakoso Mardhiani, Yanni Dhiani Mardhiani, Yanni Dhiani Maria Elizabeth Marline Abdasah Marline Abdassah Marline Abdassah Marline Abdassah Marline Abdassah Marline Abdassah, Marline Mentari Luthfika Dewi Mohamad Aprianto Paneo Mohammad R. Akbar Muchtaridi Muchtaridi Muhammad Habil Abrar Alhamdra Muhammad Lukman Nur Hakim Multiani S Latif Mutakin Mutakin Nagina Gulab Belali Nagina Gulab Belali Nasrul Wathoni NOPI RANTIKA Norisca A. Putriana Norisca A. Putriana Norisca A. Putriana Norisca Aliza Putriana Norisca Aliza Putriana Patihul Husni PATIHUL HUSNI Patihul Husni Pratama, Rizky Farhan Putri, Norisca A. Putri, Norisca A. Rambia, Ikhsan Ratu Kania, Yulien RENATA VANIA Reti Hindritiani Revika - Rachmaniar RIFA NURFAUZIAH Rizki Akbar Rizki Akbar, Rizki SABNABILA KHOERUN NISA Selifiana, Nita Shinta Lestari Shofiyyah Sayyidah Silvia, Nurfianti Siti Hindun Sri A Sumiwi Sri A Sumiwi, Sri A Sri Adi Sumiwi Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sriwidodo Stiani, Sofi Nurmay Suseno Amin Suseno Amin, Suseno Suwandi, Deden Winda Tina Rostinawati Wirna Grace Tua Sihombing Yedi Herdiana, Yedi Yoga Windhu Wardhana Yuli Agung Prasetyo Yulianto, Asep Nurrahman Yulien Ratu Kania YUNIKE KARUNIA PUTRI Yuti Mutiawati Yuti Mutiawati Yuti Mutiawati, Yuti