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All Journal Jurnal Veteriner Microbiology Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Biomedical Engineering Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) YARSI Medical Journal Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Folia Medica Indonesiana
Retno Handajani
Department Of Biochemistry, 00Faculty Of Medicine, Universitas Airlangga, Surabaya
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Jurnal Veteriner

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Ekstrak Buah Delima Terstandar Menurunkan Derajat Fibrosis Hati pada Hewan Model Tikus Putih (STANDARDIZED POMEGRANATE FRUIT EXTRACT REDUCES LIVER FIBROSIS DEGREE ON ALBINO RATS (RATTUS NORVEGICUS) AS AN ANIMAL MODEL) Wiwik Misaco Yuniarti; Retno Handajani; Hernomo Ontoseno Kusumobroto; Ketut Sudiana
Jurnal Veteriner Vol 14 No 4 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The objective of this study was to analyse the effect of standadized pomegranate fruit extracton liver fibrosis due to biliary obstruction.  Liver fibrosis was induced with bile duct ligation (BDL)technique.  Examinations were performed on the expressions of collagen type 1 and the degree ofliver fibrosis. Thirty two male albino rats (Rattus norvegicus), 2.5 month old, weighing 160-190grams were divided into four experimental groups.  The first group (P0) consisted of rats  whichunderwent laparotomy and treated with 2 ml of  carboxymethyl cellulose (CMC) 0.3%.  Three othergroups consisted of rats which underwent laparotomy and bile duct ligation (BDL) but receiveddifferent treatments.  Group P1 was given carboxymethyl cellulose (CMC) 0.3%, P2 was treatedwith standardized pomegranate fruit extract 150 mg/kgBW/po/day within CMC 0.3% , and P3 wasgiven ellagic acid (EA) 60 mg/kgBW/po/day of equal volume.  Treatments were administered on thesecond day after BDL for 21 days.  The livers were excised one day after the last administration.Observations were made on the expressions of collagen type 1 and the degree of liver fibrosis. Theresults showed that standardized pomegranate extract can inhibit the expression of collagen type Isignificantly in the P2 and P3 compared with P1 group (p <0.05). Treatment with standardizedpomegranate fruit extract also significantly suppressed the progression of liver fibrosis comparedto P1, eventhough there was more liver fibrosis compared to P0 (p<0,05).  The degree of liverfibrosis was not significantly different between P2 and P3, and between P3 and P1 (p>0,05).The administration of standardized pomegranate fruit extract 150 mg/kgBW/po/day  exertedantifibrotic effect by inhibiting the increase the expression of collagen type I and the degree of liverfibrosis.
Co-Authors A Kentjono, Widodo Adi, Ginanjar Sasmito Afrina Zulaikah Amin, Indah Binti Mohd Anggraeni, Zuhrotul Eka Yulis Ayesie Natasha Zulka B Notopuro, Paulus Bakhtiar, Arief Bakhtiar, Arief Bayu Satria Wiratama David S. Perdanakusuma Edhi Rianto Elvaretta, Clarissa Ely Rahmatika Nugrahani Ely Rahmatika Nugrahani, Ely Rahmatika Fis Citra Ariyanto Gatut Suhendro Ginanjar Sasmito Adi HAK HOTTA Harianto Notopuro Hendri Susilo Hendy Muagiri Margono Henydhar Bramastivira Mahdani Hernomo Ontoseno Kusumobroto Humairah, Ira I Gusti Agung Komang Diafari Djuni Hartawan Indri Safitri Indri Safitri, Indri Juniastuti Juniastuti Kawilarang, Arthur Pohan Khaerunnisa, Siti Luki Indriaswati Lukitasari, Lina Lukitasari, Lina Margarita Maramis, Margarita MARIA INGE LUSIDA Maria Inge Lusida MOCHAMAD AMIN MOCHAMAD AMIN Mochamad Amin Mochamad Yusuf Alsagaff Mochammad Amin Mochammad Thaha MOCHAMMAD THAHA Nurwasis Nurwasis Nyilo Purnami Palupi, Dian Eka Roro Poernomo Boedi Setiawan Prabowo, Gwenny Ichsan Pranawa Pranawa Priyo Budi Purwono Qurnianingsih, Ema Radias Dwi Padmani Rizaliyana, Sitti Ruby Riana A Ruby Riana Asparini Ruslan, S. Eriaty N. S. Perdanakusuma Samira Assegaf Siti Khaerunnisa SOETJIPTO SOETJIPTO . SOETJIPTO . Soetjipto Soetjipto Sulistyo Mulyo Agustini Supiana Dian Nurtjahyani Susi Wahyuning Asih Susi Wahyuning Asih, Susi Wahyuning Suwandito Suwandito Suwandito, Suwandito Syafa'ah, Irmi Syafa’ah, Irmi TAKAKO UTSUMI Ulfa Kholili Ummah, Fithriyah Cholifatul Ummi Maimunah Waskito, Langgeng Agung Wiwik Misaco Yuniarti Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono YOSHIHIKO YANO YOSHITAKE HAYASHI Yulianti, Erikavitri Zain Budi Syulthoni Zuhrotul Eka Yulis Anggraeni Zulka, Ayesie Natasha