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All Journal Farmaka Indonesian Journal of Pharmaceutical Science and Technology JURNAL PHARMASCIENCE IDJP (Indonesian Journal of Pharmaceutics) Jurnal Kesehatan Bakti Tunas Husada IKRA-ITH Teknologi Jurnal Sains dan Teknologi Journal of Pharmacopolium Majalah Farmasetika Pharmacoscript Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Riset Kefarmasian Indonesia Indonesia Natural Research Pharmaceutical Journal (INRPJ) Science Midwifery Jurnal Farmasi Kryonaut Karya Kesehatan Siwalima Jurnal Pengabdian Masyarakat (Jupemas) Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Jurnal Kesehatan Bakti Tunas Husada Jurnal Sains Farmasi dan Kesehatan Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Analit: Analytical And Environmental Chemistry Journal of Pharmascience
Garnadi Jafar, Garnadi
Universitas Bhakti Kencana
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Journal : jurnal pharmascience

 1 
Formulasi Solid Lipid Nanoparticle Ceramide Jafar, Garnadi; Darijanto, Sasanti Tarini; Mauludin, Rachmat
JURNAL PHARMASCIENCE Vol 2, No 2 (2015): JURNAL PHARMASCIENCE
Publisher : JURNAL PHARMASCIENCE

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Abstract

ABSTRAK Ceramide merupakan senyawa golongan Phytosphingosine yang secara alami terdapat didalam kulit disekitar stratum korneum yang memiliki efek sebagai menjaga kelembaban kulit. Ceramide yang terdapat dikulit secara alami akan berkurang seiring dengan penuaan dan faktor lainnya yang mengakibatkan kulit menjadi kering. Untuk mengatasi masalah ini maka pada penelitian ini dilakukan pengembangan formula solid lipid nanoparticle (SLN) ceramide sintetik yang diinkorporasikan kedalam sediaan gel agar membentuk sistem oklusif pada kulit untuk membantu dalam mengatasi TEWL (Transepidermal Water Loss). Pembuatan SLN yang digunakan yaitu ultraturax dan ultrasonik probe dengan pemilihan 3 jenis lipid padat (asam stearat, gliserol monostearat dan apifil) serta 2 jenis surfaktan (tego care dan planta care). Karakterisasi SLN meliputi analisis ukuran partikel, indeks polidispersitas, zeta potensial, morfologi (TEM) dan stabilitas fisik. SLN ceramide yang stabil terbentuk dengan kapasitas pemuatan ceramide 4 %  dengan kapasitas apifil 4 % dan planta care 1 % memiliki diameter globul 113.5 ± 3.60 nm dan indeks polidisperitas 0.263 ± 0.01. Selama penyimpanan 2 bulan kandungan ceramide relative stabil dengan nilai 92.26 %. Kata Kunci : ceramide, SLN, kelembaban. ABSTRACTCeramide is a substance from Phytosphingosine group that naturally occured around stratum corneum region within our skin, possessing skin moisturizing activity. Along with aging process, ceramide will progressively reduce in number, bringing dryness to the skin. In this research, solid lipid nanoparticle (SLN) formulation containing synthetic ceramide was developed and later incorporated into gel and cream dosage forms that formed occlussive system on skin surface to reduce Transepidermal Water Loss (TEWL). SLN manufactured by ultrathurax and probe ultrasonic using 3 types of solid lipids (stearic acid, glycerol monostearate, and apiphyl) and 2 types of surfactants (tego care and planta care). SLN characterisation including particle size analysis, polydispersity index, zeta potensial determination, morphology (TEM), and physical stability. Ceramide SLN then incorporated into gel or cream dosage form. Physical stability conducted were organoleptic, pH, and viscosity tests in room temperature storage and also in accelerated stability test condition. Cream dosage forms before and after stability test (freeze-thaw instability test) were compared, showing viscosity reduction after 5cycles. Moisturity test was later conducted using CM 825 corneometer. Stable ceramide SLN was formed with 4 % ceramide loading capacity using 4 % apiphyl and 1 % planta care, having globules diameter of 113.5 ± 3.60 nm and polydispersity index of 0.263 ± 0.01. During 2 months storage, ceramide was relatively stable with concentration of 92.26 %.Keywords : ceramide, SLN, gel, cream, moisturity
Co-Authors Abdul Mulki Irpani Agung Laksono S, Moch Agus Sulaeman Agus Sulaeman Ahmad Bagus Mindiarto Al-fira Putriyanti Al-fira Putriyanti Al-fira, Putriyanti Aligita, Widhya Aliyya Kurniasih Agustiani Amalia Putri, Amalia Ani Anggriani, Ani Arif Rubianto Arip Saifurrohman Ariqa Hidayatun Nisa Bachrudin, Panji Buana Irviana Prita Choerrunisa Choerrunisa Choerrunisa, Choerrunisa Dadih Supriadi Damayanti, Hilda Deden I Dinata Deden Indra Dinata, Deden Indra Deny Puryani Dila Anggraeni Dinayanti, Westi Nur Dini Auliya Azmi Dudy Agustian Hidayat Dwi C, Alya Dzakiyya Nur Dhiya Eka Priana Elis Susilawati Elisabeth Weya Elsa Yunita Septiani Elvano, Deki Rifa Embas Saraswati, Dewa Ayu Emma Emawati, Emma Entis Sutrisno ERISKA AGUSTIN Faisha Farras Kartanagara Fathurahman Ari Senjaya Fatmawati Fenti Fatmawati Karim Fatmawati, Fenti Fenti Fatmawati Fenti Fatmawati Fenti Fatmawati Fenti, Fatmawati Ghea Nadira Shinta Gustana, Erick Kurniawan Halizah, Arin Nur Hanaya, Cicia Rosa Hasballah Zakaria Helen Fitri Novianti Herni Kusriani, R. Iceu Mulyati Iin Siti Aminah, Iin Siti Ika Kurnia Sukmawati Imelda Matruty Intan Meilani Ira Adiyati Irviana Prita, Buana Jajang Japar Sodik Karim, Fatmawati Khiong, Tjia Khie Latifah, Zahra Alfa Mahran A, Ghani Maisyah, Aini Marita Kaniawati Marliani, Lia Mindiarto, Ahmad Bagus Muhamad Reza Pahlevi Muthmainah, Siti Saidah Nadhira Zakiyah Ningrum, Windi Pratama Novianti, Tamia Rizqi Nurfadillah, Rizal Nurfaiza, Putri Nurul Rahmalia Olivia Eka Putri Pahlevi, Muhamad Reza Panji Bachrudin Patonah Hasimun Patonah Patonah Patonah, Patonah Pebriawati, Silpi Pramudiahwardani, Ananda Rota Pratama, Reza Putriyanti Al-fira Putriyanti, Al-fira R Herni Kusriani R. Awaludin Nazal N Rachmat Mauludin Rachmat Mauludin Rahmat Santoso Raisya Salsabila Ramadhoni, M Ayodia Ranti Fitriani Ratu Fania Aprilyanti Reformia Avianningsih Reza Pahlevi, Muhamad Ria Riantini Riantini, Ria Rieztya Aliza Rieztya Aliza Rismawanti, Rusi Roganda Situmorang Rosyana, Nasywa Rusi Rismawanti Sagita, Novaliana Devianti Saleh Wikarsa Salsabilla, Syifa Sasanti Tarini Darijono Septianti, Regina Dwi Shelvy E Suherman Siti Jamilah Siti Raeyuni Maulidia Belina Siti Saidah Muthmainah Situmorang, Roganda Sofian, Ryan Soni Muhsinin Sukmawati, ika kurnia Sulthan Abdul Basith Ratmoko Sutiyah, Siti Sutrisno, Entris Syarfa, Ahmad Syerliana Syerliana Tambunan, Irisanna Tamia Rizqi Novianti Wahyu Wijayanti Wijaya, Teguh Pradinata Winasih Rachmawati Winasih Rachmawati Yani Mulyani Yani Mulyani Yani, Mulyani Yolanda Putri Aloenida Yuyun Yuyun Zakiyah, Nadhira Zalfa Dary Pernadi