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All Journal Jurnal Kesehatan Andalas Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Respirologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Unri Conference Series: Community Engagement Respiratory Science Bioscientia Medicina : Journal of Biomedicine and Translational Research Co-Value : Jurnal Ekonomi, Koperasi & Kewirausahaan Jurnal Impresi Indonesia Jurnal Ilmu Kesehatan Indonesia (JIKSI) Eduvest - Journal of Universal Studies Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Sains, Teknologi dan Kesehatan (Medical Scientific Journal) MESINA International Journal of Health and Medicine
Herman, Deddy
Bagian Pulmonologi Dan Kedokteran Respirasi Fakultas Kedokteran Universitas Andalas, Padang 25163, Indonesia
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HUBUNGAN KADAR D-DIMER DENGAN DERAJAT KEPARAHAN PENYAKIT DAN ANGKA KEMATIAN PASIEN CORONAVIRUS DISEASE 2019 Trisuliandre, Muhammad Rizki; Herman, Deddy; Yulistini, Yulistini; Efrida, Efrida; Meinapuri, Malinda; Hasmiwati, Hasmiwati
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 1 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i1.973

Abstract

Objective: This study aims to determine the relationship between D-dimer levels and the severity of the disease and the mortality rate of Coronavirus Disease 2019 patients treated at Dr. M. Djamil Padang General Hospital for the period June-August 2021. Method: This type of research is observational analytic using a retrospective cohort study design by taking a sample of 75 people through medical record data. Results: Most of the characteristics of the Coronavirus Disease 2019  patients were found in the age group of 56-65 years, male sex, most of them had an increased D-dimer value, and most of the patients did not die. This study found that there is a relationship between D-dimer levels and the severity of the disease and the mortality rate of Coronavirus Disease 2019 patients. Based on the Odd Ratio value obtained of 2.04 (1.53-2.71), it can be interpreted that people who have D -dimer increases have a risk of dying 2 times. Conclusion: There is a relationship between D-dimer levels and the severity of the disease and the mortality rate of 2019 Coronavirus Disease patients at Dr. M. Djamil Padang for the June-August 2021 period.
High-Frequency Chest Wall Oscillation versus Conventional Airway Clearance Techniques in Non-Cystic Fibrosis Bronchiectasis: A Meta-Analysis Dzaki Murtadho; Irvan Medison; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1255

Abstract

Background: Non-cystic fibrosis bronchiectasis (NCFB) is a chronic lung disease characterized by irreversible airway dilation and impaired mucociliary clearance, leading to chronic cough, sputum production, and recurrent infections. This meta-analysis aims to compare the efficacy of high-frequency chest wall oscillation (HFCWO) with conventional airway clearance techniques (CACT) in adults with NCFB. Methods: A systematic search of PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases was conducted from January 2013 to March 2024. Randomized controlled trials (RCTs) comparing HFCWO with CACT (postural drainage, percussion, active cycle of breathing technique, positive expiratory pressure therapy) in adults with NCFB were included. The primary outcomes were a change in forced expiratory volume in one second (FEV1) and sputum weight. Secondary outcomes included quality of life, exacerbation frequency, and adverse events. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Data were pooled using a random-effects model, and heterogeneity was assessed using the I² statistic. Results: Nine RCTs involving a total of 485 participants were included. The meta-analysis showed no statistically significant difference in FEV1 change between HFCWO and CACT (mean difference [MD] 0.05 L, 95% confidence interval [CI] -0.02 to 0.12; I² = 45%). HFCWO was associated with a statistically significant increase in sputum weight compared to CACT. SGRQ total score showed a statistically significant improvement in the HFCWO group compared to CACT (MD -4.21, 95% CI -7.88 to -0.54; I² = 58%). Conclusion: HFCWO may provide a modest benefit in terms of increased sputum clearance and improved quality of life compared to CACT in adults with NCFB. However, there was no significant difference in lung function (FEV1) or exacerbation frequency. The moderate to high heterogeneity in some outcomes suggests that further research is needed to confirm these findings and identify patient subgroups who may benefit most from HFCWO.
A Case of Concurrent COPD Exacerbation, Osteoporosis, and Fracture: Unveiling the Interplay Fadhilla Annisa Efendi; Masrul Basyar; Deddy Herman; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1257

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition with systemic effects, including an increased risk of osteoporosis and fractures. This case report presents a patient with acute COPD exacerbation, osteoporosis, and vertebral fractures, highlighting the complex interplay between these conditions. Case presentation: A 68-year-old male patient presented with acute exacerbation of COPD. He had a history of smoking, hypertension, and a previous diagnosis of pulmonary tuberculosis. Clinical examination revealed signs of respiratory distress, and imaging confirmed emphysema, pneumonia, osteoporosis, and vertebral fractures. The patient received treatment for COPD exacerbation and osteoporosis, showing improvement in respiratory symptoms and pain. Conclusion: This case underscores the importance of recognizing the association between COPD, osteoporosis, and fractures. Early diagnosis and appropriate management of these co-morbidities are crucial for improving patient outcomes and quality of life.
Hubungan Kadar Enzim Transaminase Pasien COVID-19 dengan Derajat Keparahan Penyakit di RSUP Dr. M. Djamil Padang Rahmadina, Rahmadina; Herman, Deddy; Efrida, Efrida; Almurdi, Almurdi; Russilawati, Russilawati; Elvira, Dwitya
Jurnal Kesehatan Andalas Vol. 13 No. 1 (2024): March 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v13i1.2205

Abstract

Liver injury can be caused by coronavirus disease 2019 (COVID-19), characterized by increased levels of transaminase enzymes (aspartate aminotransferase/AST and alanine aminotransferase/ALT). Objective: To determined the correlation between transaminase enzyme levels and the severity of COVID-19 in Dr. M. Djamil Central Public Hospital, Padang. Methods: This was an observational analytic study with a cross-sectional design. Data were obtained randomly from medical records of confirmed COVID-19 patients hospitalized in Dr. M. Djamil Hospital from June to August 2021, with moderate, severe, and critical severity based on Indonesian Ministry of Health criteria. Data were analyzed using the Chi-square test to examine the distribution and correlation between variables and a simple logistic regression test to assess the level of risk between variables. Results: 57,80% had abnormal AST, and 44,95% had abnormal ALT. The median AST was highest in the critical group, while the median ALT was highest in the severe group. The distribution of sex and age group were significantly different based on AST and ALT levels, and the distribution of patients with coronary heart disease was significantly different based on ALT levels. Transaminase enzyme levels had a significant correlation with the severity of COVID-19 (p-value = 0,00). Patients with critical degrees had the highest risk for abnormal AST and severe degrees had the highest risk for abnormal ALT. Conclusion: Transaminase enzymes have a significant correlation with the severity of COVID-19.Keywords:  COVID-19, liver injury, transaminases, disease severity
Faktor-Faktor yang Berhubungan dengan Perilaku Merokok Pada Mahasiswa Kedokteran Universitas Andalas Sari, Popy Puspita; Herman, Deddy; Abdiana, Abdiana
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 3 (2024): September 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i3.1021

Abstract

Abstrak Latar Belakang: Indonesia merupakan negara dengan prevalensi perokok laki-laki tertinggi di Association of Southeast Asian Nations (ASEAN) dan memiliki jumlah perokok terbanyak ketiga di dunia. Prevalensi perokok usia 15 tahun atau lebih di Indonesia terus meningkat setiap tahunnya. Semakin tinggi tingkat pendidikan seseorang, maka ia cenderung tidak merokok. Mahasiswa kedokteran lebih memahami bahaya rokok bagi kesehatan tubuh. Objektif: Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan perilaku merokok pada mahasiswa kedokteran Universitas Andalas. Metode: Desain penelitian ini adalah cross-sectional. Penelitian ini dilaksanakan di Fakultas Kedokteran Universitas Andalas. Pengumpulan data dilakukan pada bulan Agustus 2020 hingga Desember 2022. Teknik pengambilan sampel adalah total sampling dimana semua populasi menjadi sampel, yaitu 153 orang. Instrumen yang digunakan dalam penelitian ini adalah kuesioner Depression Anxiety Stress Scale (DASS) dan kuesioner Global Youth Tobacco Survey (GYTS), kemudian dianalisis menggunakan uji chi-square. Hasil: Hasil analisis cross tab didapatkan stres (p = 0,250) dan pengaruh orang tua (p = 0,067) memiliki nilai p>0,05, sedangkan pengaruh teman sebaya (p = 0,001) dan iklan rokok (p = 0,016) memiliki nilai p<0,05. Kesimpulan: Faktor-faktor yang berhubungan dengan perilaku merokok, yaitu pengaruh teman sebaya dan iklan rokok, sedangkan stres dan pengaruh orang tua tidak berpengaruh. Kata kunci: perilaku merokok, stres, pengaruh orang tua, pengaruh teman sebaya, iklan rokok
Clinical Characteristics, Outcomes, and Predictors of Severity in Acute Eosinophilic Pneumonia (AEP): A Meta-analysis Zaki Arbi Ismani; Deddy Herman; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1320

Abstract

Background: Acute eosinophilic pneumonia (AEP) is a rare, potentially life-threatening respiratory illness characterized by rapid onset of symptoms, diffuse pulmonary infiltrates, and marked eosinophilia in bronchoalveolar lavage (BAL) fluid. This meta-analysis aimed to synthesize published data to provide robust estimates of clinical characteristics, outcomes, and predictors of severity in patients diagnosed with AEP. Methods: A systematic literature search was conducted in PubMed, Embase, Scopus, and Web of Science databases for studies published between January 1st, 2014, and December 31st, 2024. Inclusion criteria specified observational studies reporting on clinical features, diagnostic findings, and clinical outcomes in patients meeting standard AEP diagnostic criteria. Data extraction and quality assessment (using the Newcastle-Ottawa Scale) were performed independently by two reviewers. Pooled proportions and means were calculated using a random-effects model. Heterogeneity was assessed using the I² statistic. Potential predictors of MV requirement were evaluated by pooling odds ratios (ORs) where available. Results: Six studies met the inclusion criteria, comprising a total of 315 patients diagnosed with AEP. The pooled mean age was 29.5 years (95% CI: 26.8-32.2), with a predominance of male patients (pooled proportion: 78%, 95% CI: 71%-84%, I²=45%). A strong association with recent smoking initiation or change was confirmed (pooled proportion: 85%, 95% CI: 78%-91%, I²=55%). Common presenting symptoms included dyspnea (95%), fever (92%), and cough (88%). While peripheral eosinophilia was variable at presentation (pooled mean: 650 cells/µL, 95% CI: 450-850), BAL eosinophilia was markedly elevated (pooled mean percentage: 42%, 95% CI: 37%-47%, I²=78%). The pooled proportion of patients requiring mechanical ventilation was substantial (38%, 95% CI: 30%-46%, I²=68%). Overall in-hospital mortality remained low (pooled proportion: 1.8%, 95% CI: 0.5%-3.5%, I²=0%). Significant heterogeneity was observed for most pooled estimates. Factors significantly associated with an increased likelihood of requiring mechanical ventilation included a shorter time from symptom onset to presentation (<3 days) (pooled OR: 3.1, 95% CI: 1.8-5.3, I²=35%) and higher initial C-reactive protein (CRP) levels (analyzed descriptively due to varied reporting). Conclusion: This meta-analysis confirms that AEP typically affects young male smokers and presents acutely with severe respiratory symptoms. Despite variable peripheral eosinophilia, marked BAL eosinophilia is a diagnostic hallmark. A significant proportion requires mechanical ventilation, highlighting the potential severity. However, mortality is low with appropriate treatment, typically corticosteroids. Very acute onset and higher inflammatory markers may predict the need for ventilatory support, warranting close monitoring in these patients. Further research with standardized reporting is needed to refine predictors and optimize management strategies.
Exercise-Induced Asthma: Challenges of Exercise and Management Serly, Vicennia; Basyar, Masrul; Herman, Deddy
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.43688

Abstract

Exercise-Induced Asthma (EIA), also known as exercise-induced bronchospasm (EIB), is a condition in which the airways become blocked after exercise. Although exercise can cause asthma attacks, a lack of exercise can make asthma worse. Apart from taking medication, exercise can help control asthma attacks, and help improve the quality of life of the asthmatic population. Exercise can be done by people with mild to moderate degrees of airway obstruction, just like healthy people. Swimming, walking, cycling, playing ball and aerobics are good sports for asthma patients. Exercise-Induced Asthma (EIA) can also prevent asthma patients from exercising and affect their quality of life. The diagnosis of EIA is based on symptoms and spirometry or bronchial provocation tests. Nonpharmacological approaches, including avoidance of precipitating factors, are essential. SABA before exercise is also widely used and recommended as first-line therapy. Inhaled corticosteroids are recommended when asthma control is less than optimal. Leukotriene receptor antagonists (LTRA) and mast cell stabilizing agents (MCSA) are potential options.
Bysinosis: Occupational Lung Disease in The Textile Industry and Challenges in its Management Serly, Vicennia; Herman, Deddy; Mizarti, Dessy; Basyar, Masrul
Eduvest - Journal of Universal Studies Vol. 5 No. 2 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i2.43689

Abstract

Byssinosis, also known as brown lung disease or Monday fever/Monday dyspnea, is a form of respiratory symptoms caused by exposure to raw non-synthetic textile materials during the production process in the industrial sector and is considered as a form of occupational lung disease. An increase in the prevalence of occupational lung diseases has been found in developing countries, particularly in South Asia. The etiology of byssinosis is the exposure to cotton dust in the textile industry, caused by exposure to endotoxins from the cell walls of gram-negative bacteria found in the dust of various plant fibers, including cotton. Diagnosing byssinosis requires taking a medical history, performing a physical examination, and conducting supporting examinations such as chest X-ray, high-resolution chest CT scan, and pulmonary function tests. In pulmonary function testing using spirometry, a decrease in the FEV1/FVC ratio may be observed. Based on clinical symptoms and lung function tests, the severity of byssinosis can be assessed using Schilling criteria. Inhalation medications such as short-acting and long-acting beta-agonists are choices for pharmacological management of byssinosis. Inhaled corticosteroids can be used in severe clinical conditions.
Managing Catamenial Pneumothorax: Challenges of Diagnosis and Therapy, Literature Review Pratama, Fadel Ahmad; Russilawati, Russilawati; Herman, Deddy
Jurnal Impresi Indonesia Vol. 4 No. 5 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i5.6522

Abstract

Catamenial pneumothorax (CP) is a rare and recurrent spontaneous pneumothorax in women, typically occurring from 24 hours before menstruation to 72 hours afterward. While once considered uncommon, CP is now recognized in up to 30% of pneumothorax cases among women. This study aims to provide a comprehensive literature-based analysis of the etiology, diagnosis, and multidisciplinary management of CP. The research method used is a literature review that analyzes clinical cases, diagnostic imaging, histopathological findings, and treatment outcomes from various databases and published case reports. Findings suggest that while the etiology remains multifactorial—including diaphragmatic defects, lymphovascular dissemination, and hormonal influences—the use of video-assisted thoracic surgery (VATS) combined with pleurodesis and postoperative hormonal therapy (e.g., GnRH analogs) significantly reduces recurrence rates, down to 0% in some combined therapy cases. Imaging modalities like MRI during menstruation increase diagnostic accuracy. The study also underscores the importance of surgical timing, hormonal therapy continuity, and long-term monitoring for recurrence prevention. Implications of this study include the need for standardized treatment protocols and the incorporation of gynecological and thoracic collaboration in managing CP. Future research should explore biomarkers and prospective multicenter trials to refine diagnostic and therapeutic strategies.
Differences In Interleukin-6 and Liver Enzyme Level Based On Clinical Severity of COVID-19 Patients at Dr. M. Djamil General Hospital, Padang Elsesmita, Elsesmita; Medison, Irvan; Herman, Deddy
Respiratory Science Vol. 5 No. 3 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i3.171

Abstract

Background: COVID-19 pathogenesis involves the release of proinflammatory cytokines and chemokines, known as a "cytokine storm." Interleukin-6 (IL-6) plays a key role in initiating cytokine storms. Cytokine storm causes multiple organ complications. Liver injury affects 14% to 53% of COVID-19 patients and is manifested by increased liver enzymes. This study evaluated differences in IL-6 and liver enzyme levels based on clinical severity in COVID-19 patients. Method: A retrospective cross-sectional study was conducted. COVID-19 patients treated at Dr. M. Djamil General Hospital, Padang, from January 1, 2021, to December 31, 2021, and who met the inclusion and exclusion criteria, were the research subjects. The Kruskal-Wallis test was performed to analyze differences in IL-6, SGOT, and SGPT levels based on clinical severity. Results: Most participants (42.06%) were under 50 years old, half were female (56.15%), obesity was the most common comorbidity (41.39%), and moderate severity was most common (42.06%). The majority of the subjects, 87.47%, had elevated IL-6 levels (≥7 pg/mL). SGOT levels of ≥32 IU/L (46.76%) and SGPT levels of ≥31 IU/L (41.39%) were found in less than half of the subjectsClinical severity was significantly associated with IL-6 levels, resulting in a significant difference in IL-6 levels (P<0.05). The clinical severity of COVID-19 patients at Dr. M. Djamil General Hospital, Padang, resulted in a significant difference in SGOT and SGPT levels (P<0.05). Conclusion: IL-6 levels differed based on clinical severity in COVID-19 patients. SGOT and SGPT levels also differed by clinical severity.
Co-Authors Abdiana Abdiana, Abdiana Afriani Afriani Ahmad Rafid Almurdi Almurdi Amel Yanis Delmi Sulastri Dessy Mirzati Dessy Mizarti Dessy Mizarti Dessy Mizarti Dewi Wahyu Dewi Wahyu Fitrina Dewi Wahyu Fitrina Dimas Bayu Firdaus Dimas Bayu Firdaus Dwitya Elvira, Dwitya Dzaki Murtadho Efrida Efrida Efrida Elly Usman Elsa Purnama Sari Elsesmita, Elsesmita Ermayanti, Sabrina Ermayanti, Sabrina Eryati Darwin Fadhilah, Dwi Rizki Fadhilla Annisa Efendi Farina Angelia Fathiyyatul Khaira, Fathiyyatul Fenty Anggraini Fenty Anggraininy Fenty Anggrainy Fenty Anggrainy Fitrina, Dewi Wahyu Gustia Rina Habib El Binampiy Busnia Hamni Tanjung Handayani, Friska Hasmiwati Ilham Irvan Madison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Isnaniyah Usman Julizar Julizar Junaidi, Katerine Katerine Junaidi Laisa Azka Mahata, Liganda Endo Malinda Meinapuri Masrul Basyar Masrul Basyar Masrul Basyar Masrul Basyar Masrul Basyar Mefri Yanni Mizarti, Dessy Monica Bil Geni Novita Ariani Nur Indrawaty Lipoeto Nurul Husna Muchtar Oea Khairsyaf Oea Khairsyaf Oea Khairsyaf Povi Pada Indarta Pratama, Fadel Ahmad Rahmadina, Rahmadina Rahmadina, Rahmadina Rizanda Machmud Rizanda Machmud Romaito Nasution Rosfita Rasyid Rosi Maulini Rullian, Harry Pasca Russilawati, Russilawati Sabrina Ermayanti Sari, Popy Puspita Sulastri Sulastri Susanti Sabri4, Yessy Susanti Sabri Syandrez Prima Putra Trisuliandre, Muhammad Rizki Ulfahimayati Ulfahimayati Utami, Sherly Putri Vicennia Serly Yasmin Nabila Ramadhani Yati Ernawati Yessy S Sabri Yessy Susanty Sabri Yessy Susanty Sabri Yulistini, Yulistini Zaki Arbi Ismani