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All Journal Jurnal Kesehatan Andalas Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Respirologi Indonesia Unri Conference Series: Community Engagement Respiratory Science Bioscientia Medicina : Journal of Biomedicine and Translational Research Co-Value : Jurnal Ekonomi, Koperasi & Kewirausahaan Jurnal Impresi Indonesia Jurnal Ilmu Kesehatan Indonesia (JIKSI) Eduvest - Journal of Universal Studies Detector: Jurnal Inovasi Riset Ilmu Kesehatan Sriwijaya Journal of Internal Medicine Jurnal Sains, Teknologi dan Kesehatan (Medical Scientific Journal) MESINA International Journal of Health and Medicine Jurnal Kesehatan
Herman, Deddy
Bagian Pulmonologi Dan Kedokteran Respirasi Fakultas Kedokteran Universitas Andalas, Padang 25163, Indonesia
Religion Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Platelet-to-Lymphocyte Ratio as a Predictor of Exacerbation Severity and Hospital Length of Stay in Acute Exacerbation of COPD: A Dual-Center Study in West Sumatra, Indonesia Herry Saputra Yunior; Masrul Basyar; Deddy Herman
Sriwijaya Journal of Internal Medicine Vol. 4 No. 1 (2026): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v4i1.271

Abstract

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a leading driver of morbidity, mortality and health-care expenditure, and simple admission biomarkers that grade severity are needed in resource-limited settings. The platelet–lymphocyte ratio (PLR) integrates thrombo-inflammation and relative lymphopenia, yet Indonesian evidence linking it to exacerbation severity and length of stay (LOS) remains limited. Objective: To evaluate admission PLR as a predictor of exacerbation severity and prolonged length of stay in hospitalised patients with AECOPD. Methods: In this dual-center analytical cross-sectional study, 141 hospitalised AECOPD patients at Dr. M. Djamil General Hospital, Padang and RS Madina Bukittinggi (January–December 2024) were analysed. Admission PLR was related to Anthonisen severity and LOS (>7 days) using Kruskal–Wallis and Mann–Whitney tests, Spearman correlation, ROC analysis and multivariable logistic regression (adjusted odds ratios, aOR). Results: Most patients were male (86.5%) and heavy smokers (87.5%). Mean PLR rose across severity strata (mild 126.8, moderate 192.3, severe 444.9; p<0.001) and correlated moderately with severity (ρ=0.534) but weakly with LOS (ρ=0.295). PLR discriminated severe exacerbation with excellent accuracy (AUC 0.929; cut-off ≥216.3, sensitivity 100%, specificity 73.2%). After adjustment, PLR independently predicted severe exacerbation (aOR 3.73 per 50 units, 95% CI 1.87–7.42), whereas prolonged stay was driven by pneumonia (aOR 6.40) rather than PLR. Conclusion: Admission PLR is an inexpensive, widely available biomarker that accurately identifies severe AECOPD and may support early risk stratification, although it should not be used alone to predict length of stay, which is governed chiefly by comorbidity.
Exercise-Induced Asthma: Challenges of Exercise and Management Vicennia Serly; Masrul Basyar; Deddy Herman
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.43688

Abstract

Exercise-Induced Asthma (EIA), also known as exercise-induced bronchospasm (EIB), is a condition in which the airways become blocked after exercise. Although exercise can cause asthma attacks, a lack of exercise can make asthma worse. Apart from taking medication, exercise can help control asthma attacks, and help improve the quality of life of the asthmatic population. Exercise can be done by people with mild to moderate degrees of airway obstruction, just like healthy people. Swimming, walking, cycling, playing ball and aerobics are good sports for asthma patients. Exercise-Induced Asthma (EIA) can also prevent asthma patients from exercising and affect their quality of life. The diagnosis of EIA is based on symptoms and spirometry or bronchial provocation tests. Nonpharmacological approaches, including avoidance of precipitating factors, are essential. SABA before exercise is also widely used and recommended as first-line therapy. Inhaled corticosteroids are recommended when asthma control is less than optimal. Leukotriene receptor antagonists (LTRA) and mast cell stabilizing agents (MCSA) are potential options.
Bysinosis: Occupational Lung Disease in The Textile Industry and Challenges in its Management Vicennia Serly; Deddy Herman; Dessy Mizarti; Masrul Basyar
Eduvest - Journal of Universal Studies Vol. 5 No. 2 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i2.43689

Abstract

Byssinosis, also known as brown lung disease or Monday fever/Monday dyspnea, is a form of respiratory symptoms caused by exposure to raw non-synthetic textile materials during the production process in the industrial sector and is considered as a form of occupational lung disease. An increase in the prevalence of occupational lung diseases has been found in developing countries, particularly in South Asia. The etiology of byssinosis is the exposure to cotton dust in the textile industry, caused by exposure to endotoxins from the cell walls of gram-negative bacteria found in the dust of various plant fibers, including cotton. Diagnosing byssinosis requires taking a medical history, performing a physical examination, and conducting supporting examinations such as chest X-ray, high-resolution chest CT scan, and pulmonary function tests. In pulmonary function testing using spirometry, a decrease in the FEV1/FVC ratio may be observed. Based on clinical symptoms and lung function tests, the severity of byssinosis can be assessed using Schilling criteria. Inhalation medications such as short-acting and long-acting beta-agonists are choices for pharmacological management of byssinosis. Inhaled corticosteroids can be used in severe clinical conditions.
Risk of Amiodarone-Induced Pulmonary Toxicity Versus Placebo in Patients with Cardiac Arrhythmias and Heart Failure: A Meta-Analysis of Randomised Controlled Trials Dzaki Murtadho; Dewi Wahyu Fitrina; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 8 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i8.1641

Abstract

Background: Amiodarone is the most effective antiarrhythmic agent for maintaining sinus rhythm, yet its long-term use is constrained by extracardiac toxicity, of which pulmonary toxicity is the most feared because it carries appreciable mortality and is frequently misdiagnosed. No contemporary meta-analysis has isolated amiodarone-induced pulmonary toxicity as the single primary endpoint across cardiac arrhythmia and heart-failure populations; this study quantified that risk. Methods: PubMed/MEDLINE, Scopus and Web of Science were searched for placebo- or usual-care-controlled randomised controlled trials (RCTs) of oral amiodarone in adults with cardiac arrhythmia or heart-failure indications reporting pulmonary toxicity. Two reviewers extracted 2×2 data and assessed risk of bias with Cochrane RoB 2.0. Because the outcome was dichotomous, the risk ratio (RR) was pooled using a DerSimonian–Laird random-effects model, with the odds ratio (OR) and Peto OR as corroborative measures. Results: Nine RCTs comprising 6,209 patients (3,175 amiodarone; 3,034 control) were included. Pulmonary toxicity occurred in 77 of 3,175 amiodarone-treated patients (2.43%) versus 42 of 3,034 controls (1.38%). Amiodarone significantly increased pulmonary-toxicity risk (RR 1.70, 95% CI 1.17–2.45, p = 0.005), with no detectable heterogeneity (I² = 0%). The OR (1.74) and Peto OR (1.81) were concordant, and the estimate remained harmful under every single-study deletion (RR 1.46–2.64). Higher-dose strata showed a numerically larger effect (RR 2.50) than lower-dose strata (RR 1.69; subgroup p = 0.48). Conclusion: Amiodarone was associated with an approximately 70% relative increase in pulmonary-toxicity risk versus placebo, a robust and homogeneous finding. The absolute excess was modest (about one additional case per 95 patients treated), supporting continued use with structured baseline and periodic pulmonary surveillance, particularly at higher maintenance doses and longer durations.
Managing Catamenial Pneumothorax: Challenges of Diagnosis and Therapy, Literature Review Fadel Ahmad Pratama; Russilawati Russilawati; Deddy Herman
Jurnal Impresi Indonesia Vol. 4 No. 5 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i5.6522

Abstract

Catamenial pneumothorax (CP) is a rare and recurrent spontaneous pneumothorax in women, typically occurring from 24 hours before menstruation to 72 hours afterward. While once considered uncommon, CP is now recognized in up to 30% of pneumothorax cases among women. This study aims to provide a comprehensive literature-based analysis of the etiology, diagnosis, and multidisciplinary management of CP. The research method used is a literature review that analyzes clinical cases, diagnostic imaging, histopathological findings, and treatment outcomes from various databases and published case reports. Findings suggest that while the etiology remains multifactorial—including diaphragmatic defects, lymphovascular dissemination, and hormonal influences—the use of video-assisted thoracic surgery (VATS) combined with pleurodesis and postoperative hormonal therapy (e.g., GnRH analogs) significantly reduces recurrence rates, down to 0% in some combined therapy cases. Imaging modalities like MRI during menstruation increase diagnostic accuracy. The study also underscores the importance of surgical timing, hormonal therapy continuity, and long-term monitoring for recurrence prevention. Implications of this study include the need for standardized treatment protocols and the incorporation of gynecological and thoracic collaboration in managing CP. Future research should explore biomarkers and prospective multicenter trials to refine diagnostic and therapeutic strategies.
Hyperbaric Oxygen: A Critical Treatment for Carbon Monoxide Intoxication Ricky Permata Irzal; Deddy Herman; Oea Khairsyaf
Jurnal Kesehatan - STIKes Prima Nusantara Vol 16 No 2 (2025): Jurnal Kesehatan Volume 16 Nomor 2 Tahun 2025
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hyperbaric Oxygen Therapy (HBOT) is a medical intervention that involves administering pure oxygen at high pressure for various conditions like decompression sickness, severe anemia and including carbon monoxide (CO) poisoning. This literature review aims to evaluate the effectiveness of HBOT in reducing neurocognitive symptoms caused by CO poisoning, as well as to review the mechanisms, indications, contraindications, and application of Hyperbaric Oxygen Therapy in Carbon Monoxide Poisoning. The review findings indicate that HBOT significantly enhances tissue oxygenation and accelerates the healing process, which can reduce the risk of neurocognitive damage. Hyperbaric Oxygen Therapy has also been found to modulate inflammatory responses, which play a crucial role in the recovery of patients with CO poisoning. However, some studies show variations in the long-term effectiveness of HBOT on neurocognitive symptoms, highlighting the need for further research. This literature review concludes that HBOT offers significant benefits in the treatment of CO poisoning; however, further research is needed to optimize clinical use and ensure its long-term effectiveness.
Co-Authors Abdiana Abdiana, Abdiana Afriani Sandra Ahmad Rafid Almurdi Almurdi Amel Yanis Delmi Sulastri Dessy Mirzati Dessy Mizarti Dessy Mizarti Dessy Mizarti Dessy Mizarti Dewi Wahyu Dewi Wahyu Fitrina Dewi Wahyu Fitrina Dewi Wahyu Fitrina Dimas Bayu Firdaus Dimas Bayu Firdaus Dwitya Elvira, Dwitya Dzaki Murtadho Dzaki Murtadho Efrida Efrida Elly Usman Elsa Purnama Sari Elsesmita, Elsesmita Ermayanti, Sabrina Ermayanti, Sabrina Eryati Darwin Fadel Ahmad Pratama Fadhilah, Dwi Rizki Fadhilla Annisa Efendi Farina Angelia Fathiyyatul Khaira, Fathiyyatul Fenty Anggraini Fenty Anggraininy Fenty Anggrainy Fenty Anggrainy Fitrina, Dewi Wahyu Habib El Binampiy Busnia Hamni Tanjung Handayani, Friska Hasmiwati Herry Saputra Yunior Ilham Irvan Madison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Irvan Medison Isnaniyah Usman Julizar Julizar Junaidi, Katerine Katerine Junaidi Laisa Azka Mahata, Liganda Endo Malinda Meinapuri Masrul Basyar Masrul Basyar Masrul Basyar Masrul Basyar Masrul Basyar Masrul Basyar Masrul Basyar Monica Bil Geni Novita Ariani Nur Indrawaty Lipoeto Nurul Husna Muchtar Oea Khairsyaf Oea Khairsyaf Oea Khairsyaf Povi Pada Indarta Rahmadina, Rahmadina Rahmadina, Rahmadina Ricky Permata Irzal Rina Gustia Rizanda Machmud Rizanda Machmud Romaito Nasution Rosfita Rasyid Rosi Maulini Rullian, Harry Pasca Russilawati Russilawati Russilawati, Russilawati Sabrina Ermayanti Sari, Popy Puspita Sulastri Sulastri Susanti Sabri4, Yessy Susanti Sabri Syandrez Prima Putra Trisuliandre, Muhammad Rizki Ulfahimayati Ulfahimayati Utami, Sherly Putri Vicennia Serly Vicennia Serly Yanni, Mefri Yasmin Nabila Ramadhani Yati Ernawati Yessy S Sabri Yessy Susanty Sabri Yulistini, Yulistini Zaki Arbi Ismani