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Clinical Characteristics, Outcomes, and Predictors of Severity in Acute Eosinophilic Pneumonia (AEP): A Meta-analysis Zaki Arbi Ismani; Deddy Herman; Fenty Anggrainy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1320

Background: Acute eosinophilic pneumonia (AEP) is a rare, potentially life-threatening respiratory illness characterized by rapid onset of symptoms, diffuse pulmonary infiltrates, and marked eosinophilia in bronchoalveolar lavage (BAL) fluid. This meta-analysis aimed to synthesize published data to provide robust estimates of clinical characteristics, outcomes, and predictors of severity in patients diagnosed with AEP. Methods: A systematic literature search was conducted in PubMed, Embase, Scopus, and Web of Science databases for studies published between January 1st, 2014, and December 31st, 2024. Inclusion criteria specified observational studies reporting on clinical features, diagnostic findings, and clinical outcomes in patients meeting standard AEP diagnostic criteria. Data extraction and quality assessment (using the Newcastle-Ottawa Scale) were performed independently by two reviewers. Pooled proportions and means were calculated using a random-effects model. Heterogeneity was assessed using the I² statistic. Potential predictors of MV requirement were evaluated by pooling odds ratios (ORs) where available. Results: Six studies met the inclusion criteria, comprising a total of 315 patients diagnosed with AEP. The pooled mean age was 29.5 years (95% CI: 26.8-32.2), with a predominance of male patients (pooled proportion: 78%, 95% CI: 71%-84%, I²=45%). A strong association with recent smoking initiation or change was confirmed (pooled proportion: 85%, 95% CI: 78%-91%, I²=55%). Common presenting symptoms included dyspnea (95%), fever (92%), and cough (88%). While peripheral eosinophilia was variable at presentation (pooled mean: 650 cells/µL, 95% CI: 450-850), BAL eosinophilia was markedly elevated (pooled mean percentage: 42%, 95% CI: 37%-47%, I²=78%). The pooled proportion of patients requiring mechanical ventilation was substantial (38%, 95% CI: 30%-46%, I²=68%). Overall in-hospital mortality remained low (pooled proportion: 1.8%, 95% CI: 0.5%-3.5%, I²=0%). Significant heterogeneity was observed for most pooled estimates. Factors significantly associated with an increased likelihood of requiring mechanical ventilation included a shorter time from symptom onset to presentation (<3 days) (pooled OR: 3.1, 95% CI: 1.8-5.3, I²=35%) and higher initial C-reactive protein (CRP) levels (analyzed descriptively due to varied reporting). Conclusion: This meta-analysis confirms that AEP typically affects young male smokers and presents acutely with severe respiratory symptoms. Despite variable peripheral eosinophilia, marked BAL eosinophilia is a diagnostic hallmark. A significant proportion requires mechanical ventilation, highlighting the potential severity. However, mortality is low with appropriate treatment, typically corticosteroids. Very acute onset and higher inflammatory markers may predict the need for ventilatory support, warranting close monitoring in these patients. Further research with standardized reporting is needed to refine predictors and optimize management strategies.

Faktor-Faktor yang Berhubungan dengan Kepatuhan Berobat Pasien Tuberkulosis Paru di Puskesmas Andalas Utami, Sherly Putri; Machmud, Rizanda; Herman, Deddy; Rasyid, Rosfita; Russilawati, Russilawati; Khaira, Fathiyyatul
MESINA (Medical Scientific Journal) Vol 6, No 1 (2025): Medical Scientific Journal (MESINA)
Publisher : Universitas Muhammadiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/msj.v6i1.6390

Ketidakpatuhan pasien tuberkulosis dalam pengobatan merupakan penyebab terpenting kegagalan pengobatan dan menjadi hambatan untuk mencapai kesembuhan Tujuan penelitian ini yaitu untuk mengetahui faktor-faktor yang berhubungan dengan kepatuhan berobat pasien tuberkulosis di Puskesmas Andalas. Penelitian ini adalah penelitian analitik observasional dengan rancangan cross sectional. Teknik pengambilan sampel menggunakan total sampling dengan jumlah sampel sebanyak 53 responden. Sampel penelitian adalah pasien tuberkulosis sensitif obat yang berusia diatas 18 tahun dan memiliki kartu TB-01. Pengumpulan data dilakukan dengan wawancara terstruktur menggunakan kuesioner. Analisis data menggunakan uji Chi-square. Analisis 53 sampel didapatkan sebanyak 43 responden (86,8%) patuh dalam pengobatan, sedangkan sebanyak 7 responden (13,2%) tidak patuh dalam pengobatan TB paru. Hasil penelitian menunjukkan variabel yang berhubungan dengan kepatuhan berobat adalah efek samping obat (p=0,015) dan peran pengawas minum obat (p=0,001), dan variabel yang tidak berhubungan adalah umur (p=0,419), jenis kelamin (p=0,223), tingkat pendidikan (p=0,443), pekerjaan (p=1,000), lama pengobatan (p=0,661) dan jarak rumah (p=0,451). Kesimpulan penelitian ini didapatkan faktor-faktor yang berhubungan dengan kepatuhan berobat pasien TB yaitu, efek samping selama pengobatan dan peran pengawas minum obat

Peranan Kortikosteroid Terhadap Luaran Pasien COVID-19: Sebuah Tinjauan Literatur Ahmad Rafid; Elly Usman; Deddy Herman
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 2 No. 3 (2024): Agustus : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v2i3.4008

Corticosteroid is one of the COVID-19 drug agents that has a pros and cons of its use because there has been a research that shows this drug had a negative impact and also there has been a research that recommend its use.This literature study conducted to discuss about role of corticosteroid towards COVID-19 patient’s outcome. This paper is a literature review that evaluates variant journals of original research with clinical study design about role of corticosteroid towards COVID-19 patient's outcome by selecting through electronic database such as PubMed, ScienceDirect, and CENTRAL with designated keywords. There are 16 literatures of clinical study design found through PubMed, ScienceDirect, and CENTRAL. It is know that the role of corticosteroid depend on patient's clinical characteristic and time given to the patients. It can be concluded that corticosteroid had role on improving oxygenation on patients with moderate-critical symptoms, reducing mortality rate on critical patients with hyperinflammation, and reducing the lenght of stay in the hospital.

Management of Extensive Subcutaneous Emphysema with Blow Hole Infraclavicular Incision and Continuous Suction Installation Junaidi, Katerine; Oea Khairsyaf; Russilawati Russilawati; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 1 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i1.914

Background: Subcutaneous emphysema often occurs in cases of implanted pneumothorax chest tubes and must always be evaluated. Subcutaneous emphysema is a condition where air or gas is found in the tissue under the skin. Case presentation: A 49-year-old man was treated for sudden shortness of breath that occurred after a violent cough accompanied by pain and heaviness in the chest area 1 day before admission to the hospital. The patient had previously received anti-tuberculosis drug treatment for 6 months based on chest X-ray results in 2022, and the patient had undergone a rapid molecular test (TCM) examination, mycobacterium tuberculosis (Mtb), and obtained Mtb results not detected. Lung auscultation obtains sound intensity breath weakness until it disappears in both lung fields. Palpation of the skin revealed widespread crepitus on the face, neck, upper extremities, back, chest, and abdomen. The range of motion areas of the neck, shoulders, and hands are limited due to pain with movement. Evaluation of the chest tube obtained: the chest tube was installed in the anterior axillary line on the right at the level of the 5th intercostal space with number 10 attached to the chest wall and the chest tube well fixed to the chest wall. The end chest tube has been connected to the WSD bottle, and evaluation of the WSD shows that there are undulations and bubbles. Conclusion: The patient was admitted with spontaneous pneumothorax secondary to tuberculosis and was implanted with a chest tube.

One-Way Valve as Management of Chest Tube Ambulation in Pneumothorax Cases Junaidi, Katerine; Oea Khairsyaf; Fenty Anggrainy; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 2 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i2.915

An adequate chest drainage system is the main goal of fluid and air evacuation and restoring negative pressure intrapleural so it can help lung development. The intrapleural is a closed, airtight space filled with a small amount of fluid as a lubricant for lung movement during the breathing process. Accumulation of intrapleural air is known as pneumothorax, and one of the initial management options is the implantation chest tube. Chest tubes, which are connected to a water seal, conventionally show varying results and have shortcomings because they require monitoring and limit patient mobility, so the safety of their use in outpatient settings is questionable. Lungs that are not inflated or have an inflated water seal still show air bubbles even though it has been installed. A chest tube adequate for 48 hours is a condition known as persistent air leak, thus requiring extended usage time from chest tube to the drainage management complex. Use of ambulation management through the use of various tools and equipment devices which can be connected with a chest tube can be an option with the aim of reducing treatment time, lowering funding, increasing comfort and hopefully providing better external results.

Bronchoscopic Lung Volume Reduction as Therapy in Chronic Obstructive Pulmonary Disease (COPD) Patients with Emphysema Rullian, Harry Pasca; Deddy Herman; Dessy Mizarti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 3 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i3.941

BLVR is a combination of non-surgical techniques for lung volume reduction performed via bronchoscopy as an alternative to LVRS in emphysema patients. The techniques most often used in BLVR are bronchial valves (EBV/IBV), coils (lung coil), and thermal vapor (BTVA), while the BioLVR and ABS techniques have begun to be abandoned. BLVR is generally beneficial in improving lung function, exercise capacity, and quality of life in patients with emphysema. There is a need to monitor post-procedure side effects and long-term follow-up to assess the effectiveness of the procedure and reduce complications.

Hubungan Karakteristik dengan Klasifikasi Kejadian Ikutan pasca Imunisasi COVID-19 pada Tenaga Kesehatan di Kota Padang Fadhilah, Dwi Rizki; Ermayanti, Sabrina; Herman, Deddy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i5.15722

Penelitian ini bertujuan untuk meneliti hubungan karakteristik dengan derajat Kejadian Ikutan Pasca Imunisasi (KIPI) COVID-19 pada tenaga kesehatan di Rumah Sakit Umum Se-Kota Padang. Metode penelitian ini adalah retrospektif cohort. Hasil penelitian menunjukkan bahwa kejadian terbanyak adalah reaksi lokal yaitu nyeri pada lokasi suntikan, yang terjadi pada 98% dosis pertama dan 95,3% dosis kedua. Reaksi sistemik terbanyak adalah kelelahan yang dialami oleh 49,8% pada dosis pertama dan 45,9% pada dosis kedua. Umur terbanyak yang mengalami KIPI berkisar 26-35 tahun, dan jenis kelamin yang paling banyak mengalami KIPI adalah perempuan. Tidak ada hubungan signifikansi antara karakteristik dengan klasifikasi KIPI COVID-19 pada tenaga kesehatan di rumah sakit umum se-Kota Padang. Penelitian ini menuturkan bahwa reaksi lokal adalah kejadian terbanyak dan tidak ada hubungan signifikansi antara karakteristik dengan derajat KIPI COVID-19.

Association Between the Severity of Chronic Obstructive Pulmonary Disease and the Probability of Pulmonary Hypertension In a Tertiary Hospital Handayani, Friska; Herman, Deddy; Fitrina, Dewi Wahyu
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.873

Background: Chronic obstructive pulmonary disease (COPD) patients with pulmonary hypertension (PH) have a poor prognosis, which worries doctors. The prevalence of COPD-related PH is unclear. The lack of anatomical criteria for right ventricular hypertrophy may explain research variance. Only type 1 PH patients undergo direct right cardiac catheterization of pulmonary artery pressure. Methods: A cross-sectional analytical descriptive study examined stable COPD patients visiting the pulmonary department at M. Djamil Hospital, Padang, from November 2023 to February 2024 for PH probability. Results: This study included 64 participants, with a majority aged between 40 and 65 years (59.4%), a significant proportion male (82.8%), and a junior high school (29.7%) level of education. Most of the subjects smoked (81.2%), had severe Brinkman Index (75.0%), had severe GOLD criteria (50.0%), and had no comorbidities (53.1%). No correlation was found between the severity of COPD and the likelihood of PH (P=0.591). The Brinkman Index of smokers was a significant risk factor for PH (P=0.010; OR=1.282; 95% CI=0.260-6.315). Conclusion: There is no significant association between the severity of COPD according to GOLD criteria and the likelihood of PH.

Management of Extensive Subcutaneous Emphysema with Blow Hole Infraclavicular Incision and Continuous Suction Installation Junaidi, Katerine; Oea Khairsyaf; Russilawati Russilawati; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 1 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i1.914

Background: Subcutaneous emphysema often occurs in cases of implanted pneumothorax chest tubes and must always be evaluated. Subcutaneous emphysema is a condition where air or gas is found in the tissue under the skin. Case presentation: A 49-year-old man was treated for sudden shortness of breath that occurred after a violent cough accompanied by pain and heaviness in the chest area 1 day before admission to the hospital. The patient had previously received anti-tuberculosis drug treatment for 6 months based on chest X-ray results in 2022, and the patient had undergone a rapid molecular test (TCM) examination, mycobacterium tuberculosis (Mtb), and obtained Mtb results not detected. Lung auscultation obtains sound intensity breath weakness until it disappears in both lung fields. Palpation of the skin revealed widespread crepitus on the face, neck, upper extremities, back, chest, and abdomen. The range of motion areas of the neck, shoulders, and hands are limited due to pain with movement. Evaluation of the chest tube obtained: the chest tube was installed in the anterior axillary line on the right at the level of the 5th intercostal space with number 10 attached to the chest wall and the chest tube well fixed to the chest wall. The end chest tube has been connected to the WSD bottle, and evaluation of the WSD shows that there are undulations and bubbles. Conclusion: The patient was admitted with spontaneous pneumothorax secondary to tuberculosis and was implanted with a chest tube.

One-Way Valve as Management of Chest Tube Ambulation in Pneumothorax Cases Junaidi, Katerine; Oea Khairsyaf; Fenty Anggrainy; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 2 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i2.915

An adequate chest drainage system is the main goal of fluid and air evacuation and restoring negative pressure intrapleural so it can help lung development. The intrapleural is a closed, airtight space filled with a small amount of fluid as a lubricant for lung movement during the breathing process. Accumulation of intrapleural air is known as pneumothorax, and one of the initial management options is the implantation chest tube. Chest tubes, which are connected to a water seal, conventionally show varying results and have shortcomings because they require monitoring and limit patient mobility, so the safety of their use in outpatient settings is questionable. Lungs that are not inflated or have an inflated water seal still show air bubbles even though it has been installed. A chest tube adequate for 48 hours is a condition known as persistent air leak, thus requiring extended usage time from chest tube to the drainage management complex. Use of ambulation management through the use of various tools and equipment devices which can be connected with a chest tube can be an option with the aim of reducing treatment time, lowering funding, increasing comfort and hopefully providing better external results.

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