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All Journal HAYATI Journal of Biosciences VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu dan Teknologi Hasil Ternak The Journal of Experimental Life Sciences (JELS) Indonesian Green Technology Journal Jurnal Pembangunan dan Alam Lestari Natural B The Journal of Pure and Applied Chemistry Research Journal of Mathematical and Fundamental Sciences JURNAL PENGABDIAN KEPADA MASYARAKAT Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JKPK (Jurnal Kimia dan Pendidikan Kimia)
Arie Srihardyastutie
Chemistry Department Brawijaya University
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Degradable Bioplastic Developed from Pine-Wood Nanocellulose as a Filler Combined with Orange Peel Extract Alyaa Farrah Dibha; Masruri Masruri; Arie Srihardyastutie
Indonesian Journal of Chemistry Vol 23, No 1 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.75520

Abstract

This research presents the degradable bioplastics developed from pinewood nanocellulose as a filler in PVA matrices. The steps involve the isolation and characterization of cellulose and nanocellulose. Meanwhile, the manufacturing of degradable bioplastic involves the combination of PVA, nanocellulose, and with or without orange peel extract. The effect of bioplastics without the addition of citric acid and orange peel extract is also reported as a comparison. It is found that orange peel extract improves the tensile strength (1708.54 kPa), elastic modulus (42.71 kPa), elongation (40%), and degradability (78.44% in 2 weeks) compared to bioplastic without the orange peel extract. These results indicate that orange peel extract acts as a reinforcing agent in PVA-nanocellulose bioplastic.
Dietary Rice Bran Plays A Significant Role in the Hepatoprotective Effect in Hypercholesterolemic Rats Yulianti Antula; Dolly Irnawati Neno; Arie Srihardyastutie; Chanif Mahdi
The Journal of Experimental Life Science Vol. 9 No. 2 (2019)
Publisher : Postgraduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1016.513 KB) | DOI: 10.21776/ub.jels.2019.009.02.08

Abstract

Cholesterol is obtained through biosynthesis and diet. When a level of cholesterol is above the normal level, this condition caused hypercholesterolemia. Long-term administration of synthetic chemical drugs can cause liver damage. Therefore, alternative natural medication is needed. One of the alternatives that can be used is the rice bran (RB), which contains antioxidant and crude fiber. This study is aimed at finding out the potential utilization of RB on total cholesterol level, liver enzyme as aspartate aminotransferase (AST) and alanine aminotransferase (ALT), malondialdehyde (MDA), and the changes in liver tissue. This study uses five groups of rats: the negative control group, positive control group, and three therapy groups with the dosage of 270 mg kg-1, 540 mg kg-1, and 810 mg kg-1 of body weight. This study shows that therapy using RB can significantly decrease the cholesterol level, AST, ALT, and MDA (p<0.01). The total cholesterol level is 21%, AST and ALT activities can be reduced to 54% and 64%, the level of MDA reduced to 79% and can repair the liver tissue. This study shows that RB can be effectively used as hepatoprotective in rats with hypercholesterolemia. Keywords: AST and ALT, Hypercholesterolemia, Rice Bran, Total Cholesterol Level.
Hibridisasi Sintesis dan Uji Aktivitas Antikanker Turunan Baru Asam Karboksilat secara In-Silico dan In-Vitro Asyfariatus Zulfa Azhar; Warsito Warsito; Arie Srihardyastutie
Jurnal Penelitian Pendidikan IPA Vol. 9 No. 9 (2023): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i9.3439

Abstract

Design of new compounds as active ingredients of drugs must be selective and efficient to achieve therapeutic efficacy and minimize resulting side effects. Hybridization synthesis approaches using major components of essential oils can reliably generate new molecules that are superior as active ingredients of anti-cancer drugs due to their cytotoxic properties. This study synthesized a hybrid molecule of citronellyl salicylate by an esterification reaction using Steglich and Fisher method under ultrasonic assistance. The Steglich esterification is more efficient in producing citronellyl salicylate during 30 minutes reaction, yield 12.45%. Analysis of the synthesized product by FTIR is characterized by the presence of typical absorptions of the ester group at ῡ 1650 cm-1 and 1270 cm-1, while LC ESI-MS shows m/z 294 is indicated [M+NH4]+. Anticancer activity was tested in-silico for protein receptors MMP-9, MMP-2, Cyclin-A, p53, and BAK using Molecular Docking Pyrx 9.0 and the highest activity was shown binding affinity value -8.4 kcal/mol for the MMP-9 protein receptor. Similarly, the results of the in vitro activity assay of citronellyl salicylate to 4T1 breast cancer cells showed that the morphology of cancer cells was damaged and the viability of cancer cells was lower than that of normal cells
PENDAMPINGAN ECO-LITERASI DALAM MENDUKUNG GERAKAN SEDEKAH SAMPAH INDONESIA (GRADASI) MENUJU SEKOLAH ADIWIYATA SE-KOTA MALANG Isaskar, Riyanti; Pratiwi, Destyana Ellingga; Pertiwi, Vi’in Ayu; Srihardyastutie, Arie; Fajar, Yusri
JURNAL PENGABDIAN KEPADA MASYARAKAT Vol 30, No 1 (2024): JANUARI-MARET
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkm.v30i1.50400

Abstract

Permasalahan lingkungan tengah menjadi sorotan hingga kancah internasional. Adiwiyata merupakan salah satu bentuk perilaku hijau di lingkungan sekolah mengingat program adiwiyata memiliki tujuan untuk menciptakan kondisi sekolah yang baik dan nyaman melalui lingkungan sekitar sekolah. Sikap eco-literasi di tingkat sekolah dapat dipupuk dengan cara menerapkan prinsip 3R (Reduce, Reuse, dan Recycle). Prinsip Reduce (mengurangi) terdapat pada program gradasi, sedangkan Reuse dan Recycle terdapat pada program pembuatan Eco Enzyme dan produk turunannya. Gradasi merupakan program yang diadakan untuk mengurangi jumlah sampah plastik yang kian hari semakin meningkat. Kegiatan pengabdian masyarakat yang diberi nama BRILIAN dilaksanakan pada rentang waktu 27 Juni - 19 Agustus 2022. kegiatan yang melibatkan siswa, metode yang digunakan adalah presentasi dan praktik. Materi yang disampaikan diantaranya adiwiyata, GRADASI, eco-enzyme, dan kompos. Tahapan kegiatan program BRILIAN terbagi menjadi tiga tahapan yakni pra-kegiatan, kegiatan inti dan pasca-kegiatan. Pra-kegiatan berisi webinar untuk mengetahui sekolah yang belum atau sudah berpredikat adiwiyata, kegiatan inti berisi kegiatan sosialisasi dan praktik di sekolah yang melibatkan guru dan siswa dan pasca-kegiatan berisi kegiatan monitoring dan evaluasi dari kegiatan yang sudah dilakukan. 
Study of Eugenol and Salicylic Acid Interactions in Hybrid Molecule Encapsulated for Enhanced Antioxidant Endah Setiani Astuti; Warsito, Warsito; Srihardyastutie, Arie
Indonesian Green Technology Journal Vol. 12 No. 2 (2023)
Publisher : Sekolah Pascasarjana, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.igtj.2023.012.02.02

Abstract

Drug development continues to be carried out so that drugs can work effectively. Creating a drug formula can be achieved by combining two or more synergistic drug compounds by hybridization, blending, or synthesis. This study reports findings of antioxidant activity using the good DPPH method from the synthesis of eugenol and salicylic acid using the encapsulation technique. The encapsulation technique uses chitosan as a coating material to protect the active ingredients, taking advantage of its unique functional characteristics, including the ability to form bonds with the crosslink agent sodium tripolyphosphate (Na-TPP) at a speed of 13,500 rpm with a pH of 4.2 to optimize the formulation. The encapsulation system produced majority particles measuring 241.0 ± 19.8 nm, with an encapsulation efficiency of 58.29 ± 0.40%. The results of the compound antioxidant test (CS-ES NP) showed better results than pure ES, with an IC50 value of 1.64 ?g/mL. The morphology results after encapsulation showed round and dense particles, indicating that the ES compound was successfully encapsulated. Keywords: encapsulation, antioxidant, eugenyl salicylate, blending
MES surfactant-based liquid soaps added with eco-enzyme and pandan wangi leaf extract (Pandanus amaryllifolius Roxb) on physical-chemistry properties, and antibacterial activity," Riawati, Riawati; Mardiana, Diah; Srihardyastutie, Arie
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.88856

Abstract

The growing demand for liquid soap has spurred innovations in soap formulations, particularly using methyl ester sulfonate (MES) as a surfactant base combined with natural ingredients like eco-enzyme and fragrant pandan leaf extract. This study aimed to determine the optimal liquid soap formulation by evaluating physicochemical properties and antibacterial activity against Staphylococcus aureus. The research was conducted in two stages. First, liquid soap was produced at different temperatures (20°C, 50°C, and 100°C) to identify the optimal temperature based on maximum lipase activity. In the second stage, various formulations were prepared, incorporating eco-enzyme and fragrant pandan leaf extract at the identified optimal temperature. The six formulations tested were: F1 (MES-based soap), F2 (20% eco-enzyme), F3 (15% eco-enzyme and 5% fragrant pandan leaf extract), F4 (10% eco-enzyme and 10% fragrant pandan leaf extract), F5 (5% eco-enzyme and 15% fragrant pandan leaf extract), and F6 (20% fragrant pandan leaf extract). The formulations were assessed for lipase activity, pH, density, and viscosity. The most effective formulation was further tested for antibacterial activity using the disc diffusion method with six treatments, including MES-based soap and controls. Statistical analysis using One-Way ANOVA revealed that adding eco-enzyme and fragrant pandan leaf extract significantly affected the soap's properties. The optimal formulation, containing 5% eco-enzyme and 15% fragrant pandan leaf extract, exhibited a lipase activity of 15,778 U/mL, a pH of 5.02, a density of 1.06 g/mL, a viscosity of 3.59 cP, and an antibacterial zone of 37.22 mm, making it the best candidate for further development
Preparation, characterization, and in vitro antibacterial activity of Cu(II)-pyrazinamide complexes, Karti'a, Galuh Wahyu; Purwonugroho, Danar; Srihardyastutie, Arie; Prananto, Yuniar Ponco
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.86189

Abstract

Transition metal complexes, including copper(II) complexes, are being investigated as potential next-generation antibacterial agents. This study aims to prepare several Cu(II)-pyrazinamide (Cu(II)-pza) complexes using Cu(II) salts (acetate, chloride, nitrate, sulphate) through a direct mixing technique. Different Cu(II) salts are anticipated to yield distinct complexes, resulting in varied antibacterial properties. The Cu(II)-pza complexes were characterized using melting point analysis, infrared spectroscopy, and powder X-ray diffraction (XRD). Melting point analysis provides insights into the physical properties of the complexes. Infrared spectroscopy identifies functional groups and predicts chemical bonds within the complexes. Powder XRD analyzes the characteristic diffraction patterns of the complexes. Experimental data reveal that the infrared spectra of all Cu(II)-pza complexes exhibit typical absorption bands of the pyrazinamide ligand (N-H, C=O, C-N, and C=N). Powder XRD analysis shows different diffraction patterns for each complex, indicating the formation of different compounds due to variations in anion and metal-ligand interactions, with the sulphate complex matching a previously reported complex. Melting point tests indicate the decomposition of the complexes within the range of 215–225 °C, except for the acetate complex, which decomposes at 275 °C. The antibacterial activities of these complexes against S. aureus and E. coli were examined in vitro based on inhibition zone diameter and MIC value. The sulphate, nitrate, and chloride complexes exhibit MIC values of 1,000 ppm and MBC values of 6,000 ppm, demonstrating better antibacterial activity against S. aureus than E. coli. These findings suggest the potential of Cu(II)-pza complexes as antibacterial agents. Further studies, such as crystal structure determination, are necessary to explore the possible mechanisms of antibacterial activity.[1]      N. C. Handayani, A. Kusuma, R. Purwanto, R. E. Prasetya, and A. Budiman, “Pengembangan Agen Potensi Pengembangan Agen Antibakteri dari Senyawa Kompleks Logam Transisi di Indonesia,” The Indonesian Green Technology Journal, vol. 10, no. 1, pp. 9-20, 2021.[2]      R. S. Hellberg and E. Chu, “Effects of climate change on the persistence and dispersal of foodborne bacterial pathogens in the outdoor environment: A review,” Crit. Rev. Microbiol., vol. 42, no. 4, pp. 548–572, 2016. doi: 10.3109/1040841X.2014.967385.[3]      T. Li, Y. Wang, X. Zhang, J. Chen, and L. Sun, “Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health,” Sci. Total Environ., vol. 860, p. 160148, 2023. doi: 10.1016/j.scitotenv.2022.160148.[4]      N. A. Church and J. L. 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Gaertner, “New Antimicrobial Strategies Based on Metal Complexes,” Chemistry, vol. 2, no. 4, pp. 849–899, 2020. doi: 10.3390/chemistry2040067.[10]    G. Borthagaray, L. Quintana, F. Brocal, and L. A. Rodríguez, “Infectious Diseases and Epidemiology Essential Transition Metal Ion Complexation as a Strategy to Improve the Antimicrobial Activity of Organic Drugs,” J. Infect. Dis. Epidemiol., vol. 2, no. 2, p. 14, 2016.[11] S. Mittapally, R. Taranum, and S. Parveen, “Metal ions as antibacterial agents,” Journal of Drug Delivery and Therapeutics, vol. 8, pp. 411–419, 2018. doi: 10.22270/jddt.v8i6.2018.[12]    J. Ara Shampa, “Physiochemical and Antibacterial Activity Investigation on Noble Schiff Base Cu(II) Complex,” Am. J. Heterocycl. Chem., vol. 3, no. 4, p. 37, 2017.[13] A. E. Ali, M. El-Ghamry, M. H. Saker, and A. K. Hussein, “Spectral, thermal studies and biological activity of pyrazinamide complexes,” Heliyon, vol. 5, no. 11, p. e02912, 2019. doi: 10.1016/j.heliyon.2019.e02912.[14] Q. C. Burandt, B. L. Knierim, S. Sundström, and F. Jacquet, “Further Limitations of Synthetic Fungicide Use and Expansion of Organic Agriculture in Europe Will Increase the Environmental and Health Risks of Chemical Crop Protection Caused by Copper-Containing Fungicides,” Environ. Toxicol. Chem., vol. 43, no. 1, pp. 19–30, 2024. doi: 10.1002/etc.4995.[15]    M. Vincent, L. Duval, R. Hartemann, J. Noury, and P. Perrin, “Antimicrobial applications of copper,” Int. J. Hyg. Environ. Health, vol. 219, no. 7, pp. 585–591, 2016. doi: 10.1016/j.ijheh.2016.07.003.[16]    M. S. Khan, R. Farooq, M. A. Baig, and H. Shahid, “Computational investigation of pyrazinamide drugs and its transition metal complexes using a DFT approach,” J. Comput. Chem., vol. 45, no. 10, pp. 622–632, 2024. doi: 10.1002/jcc.26563.[17]    E. A. Lamont and N. A. Dillon, “The Bewildering Antitubercular Action of Pyrazinamide,” Microbiology and Molecular Biology Reviews, vol. 84, no. 2, pp. 1–15, 2020. doi: 10.1128/MMBR.00034-19.[18]    N. Raman and R. Jeyamurugan, “Synthesis, characterization, and DNA interaction of mononuclear copper(II) and zinc(II) complexes having a hard-soft NS donor ligand,” J. Coord. Chem., vol. 62, no. 14, pp. 2375–2387, 2009. doi: 10.1080/00958970902932390.[19]    M. M. Khunur and Y. P. Prananto, “Structural analysis of polymeric copper(ii)-pyrazinamide complexes prepared from two different copper(II) salts,” IOP Conf. Ser. Mater. Sci. Eng., vol. 546, no. 6, 2019. doi: 10.1088/1757-899X/546/6/062015.[20]    M. Ahmed, S. H. Naz, M. H. Siddiqui, M. Tahir, and A. S. Farooqi, “Synthesis, characterization and anticancer activity of isonicotinylhydrazide metal complexes,” J. Chem. Soc. Pakistan, vol. 41, no. 1, pp. 113–121, 2019. [Online]. Available: https://jcsp.org.pk/issueDetail.aspx?aid=90.[21]    A. H. Rafika, M. H. Tarafder, K. Mahmood, and S. I. A. Razak, “Effect of drying temperature and drying time on the crystallinity degree of Zn(II)-tartrate complex,” Kuwait J. Sci., vol. 50, no. 4, pp. 596–601, 2023. doi: 10.48129/kjs.v50i4.11354.[22]    S. Tsuzuki, T. Hayashi, K. Muranaka, M. Kamata, T. Iwasaki, and K. Nishimura, “National trend of blood-stream infection attributable deaths caused by Staphylococcus aureus and Escherichia coli in Japan,” J. Infect. Chemother., vol. 26, no. 4, pp. 367–371, 2020. doi: 10.1016/j.jiac.2019.10.014.[23]    A. S. Coia, G. Müller, F. Körner, and H. W. Lang, “Exploring the Role of Transition Metal Complexes in Artistic Coloration through a Bottom-Up Scientific Approach,” J. Cult. Herit., 2024. doi: 10.1016/j.culher.2023.05.004.[24]    M. Manimohan, S. Karthikeyan, M. Ponnuswamy, and M. S. Suriyanarayanan, “Biologically active Co (II), Cu (II), Zn (II) centered water soluble novel isoniazid grafted O-carboxymethyl chitosan Schiff base ligand metal complexes: Synthesis, spectral characterisation, and DNA nuclease activity,” International Journal of Biological Macromolecules, vol. 163, pp. 801-816, 2020. doi: 10.1016/j.ijbiomac.2020.06.118.[25]    W. H. Turner, "Optical Absorption Spectra of Iron in The Rock-Forming Silicates: a Discussion," American Mineralogist: Journal of Earth and Planetary Materials, vol. 52, no. 3-4, pp. 553-555, 1967. doi: 10.2138/am-1967-3-428.[26] Y. Chen, Z. Lu, and X. Zhang, “Applications of Micro-Fourier Transform Infrared Spectroscopy (FTIR) in the Geological Sciences — A Review,” Appl. Spectrosc. Rev., vol. 50, no. 4, pp. 30223–30250, 2015. doi: 10.1080/05704928.2015.1115401.[27]    M. Ali, S. G. Tushar, A. K. Naji, and R. Ahmad, “Design, synthesis and antitubercular evaluation of novel series of pyrazinecarboxamide metal complexes,” Iran. J. Pharm. Res., vol. 17, no. 1, pp. 93–99, 2018. doi: 10.22037/ijpr.2018.2124.[28]    B. Kozlevčar, B. Zupančič, M. Hren, and B. Šket, "Complexes of copper (II) acetate with nicotinamide: preparation, characterization and fungicidal activity; crystal structures of [Cu2(O2CCH3)4(nia)] and [Cu2(O2CCH3)4(nia)2]," Polyhedron, vol. 18, no. 5, pp. 755-762, 1999. doi: 10.1016/S0277-5387(98)00354-7.[29] O. Kristiansson, “Bis(pyrazine-2-carboxamide)bis(trifluoromethanesulfonato)copper(II) monohydrate,” Acta Crystallogr. Sect. E Struct. Reports Online, vol. 58, no. 3, pp. m130–m132, 2002. doi: 10.1107/S1600536802006196.[30]    N. C. Handayani, I. K. Dewi, M. Surya, and S. Utami, “Synthesis, Characterization, and Antibacterial Activity of Anion-Depended Cu (II)-Niacinamide Complexes,” The Indonesian Green Technology Journal, vol. 11, no. 2, pp. 1–12, 2020.[31]    P. Ghanghas, S. K. Ghanghas, and A. S. Thakur, “Coordination metal complexes with Schiff bases: Useful pharmacophores with comprehensive biological applications,” Inorg. Chem. Commun., vol. 130, p. 108710, 2021. doi: 10.1016/j.inoche.2021.108710.[32]    N. C. S. Mykytczuk, P. L. Trevors, and E. B. Twiss, “Fluorescence polarization in studies of bacterial cytoplasmic membrane fluidity under environmental stress,” Prog. Biophys. Mol. Biol., vol. 95, no. 1–3, pp. 60–82, 2007. doi: 10.1016/j.pbiomolbio.2007.03.001.[33]    S. Njobdi, N. T. J. Jebin, and A. J. Ishaku, “Antibacterial Activity of Zingiber officinale on Escherichia coli and Staphylococcus aureus,” J. Adv. Biol. Biotechnol., vol. 19, no. 1, pp. 1–8, 2018. doi: 10.9734/jabb/2018/39840.[34]    G. Kumaravel, R. R. Mounika, S. Harini, and K. K. Nithya, “Bioorganic Chemistry Exploiting the biological efficacy of benzimidazole based Schiff base complexes with L-Histidine as a co-ligand: Combined molecular docking, DNA interaction, antimicrobial and cytotoxic studies,” Bioorg. Chem., vol. 77, pp. 269–279, 2018. doi: 10.1016/j.bioorg.2018.01.022.[35]    M. Shen, L. Li, T. Hu, and J. Fang, “Antibacterial applications of metal–organic frameworks and their composites,” Compr. Rev. Food Sci. Food Saf., vol. 19, no. 4, pp. 1397–1419, 2020. doi: 10.1111/1541-4337.12558.
Crystallization of [Zn(Pyrazinamide)₂(Cl)₂] Complex and In Vitro Antibacterial Activity of the Complex Against E. coli and S. aureus Naila Azmi Adiba; Danar Purwonugroho; Arie Srihardyastutie; Yuniar Ponco Prananto
Jurnal Kimia Sains dan Aplikasi Vol 27, No 9 (2024): Volume 27 Issue 9 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.9.436-443

Abstract

A complex of [Zn(pza)2(Cl)2], pza = pyrazinamide, was successfully crystallized from methanol or ethanol solvents with different morphology. The complex was synthesized using the solution method in ZnCl2: pza mol ratios of 1:2 and 1:4 in both ethanol and methanol solvents. FTIR and single crystal XRD analyses were done to confirm the complex. The complex was then used for in vitro antibacterial test against E. coli and S. aureus. Experimental data shows that the type of solvent and metal-to-ligand mol ratio yields the same compound, resulting in colorless crystals that melt at 234-236°C. Large block crystals were obtained from the methanolic solution, while a higher yield was obtained from the use of a higher mol ratio of 1:4. Infrared spectra analysis confirms the presence of characteristic carbonyl and amide groups of the pza ligand. Meanwhile, single crystal XRD screening indicates that unit cell parameters of the crystals from both solvents are identical to a known zinc(II)-pza complex. In vitro antibacterial tests against E. coli and S. aureus show that the complex had much better activity than the ZnCl2 and the free pza. In addition, the complex performs better antibacterial activity toward gram-positive S. aureus than the gram-negative E. coli.
Nanoparticle-Enhanced 3D-Connector Microfluidic Paper-Based Analytical Device (3D-µPADs) for Sensitive and Cost-Effective Detection of Albumin-Creatinine Ratio in Urine Sample Sabarudin, Akhmad; Fiddaroini, Saidun; Fahmi, Ahmad Luthfi; Roja’i, Abdul Munir; Salsabila, Isadora Evani; Aulanni’am; Srihardyastutie, Arie; Susanti, Hani; Samsu, Nur
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.504-518

Abstract

Chronic kidney disease (CKD) is a global health challenge affecting over 800 million people worldwide. Early detection is crucial to prevent progression to end-stage renal disease (ESRD), where life-saving interventions like dialysis or transplantation are necessary. Among the markers for early kidney damage, the Albumin Creatinine Ratio (ACR) in urine is one of the most reliable. Conventional methods of ACR detection, such as LC/MS-MS and ELISA, are highly accurate but require expensive equipment and skilled personnel, limiting their accessibility, especially in resource-limited settings. To address this, we developed a 3D-connector microfluidic paperbased analytical device (3D-µPADs) enhanced with gold nanoparticles (AuNPs) for sensitive and low-cost ACR detection. The integration of AuNPs amplifies colorimetric signals, enhancing the visual distinction in albumin detection. Our 3D-µPADs werefabricated using chromatographic paper Whatman No. 1 with hydrophobic barriers created by solid wax printing, followed by reagent immobilization for albumin and creatinine detection. The colorimetric and distance responses, based on reactions with Bromocresol Green (BCG) and Chrome Azurol S-Palladium (CAS-Pd2+), were analyzed using ImageJ software to quantify albumin and creatinine levels. The 3D-µPADs exhibited optimal sensitivity and accuracy, with linear detection ranges for albumin and creatinine of 30–400 mg/g. Validation with human urine samples demonstrated an accuracy of 93.04%, suggesting that 3D-µPADs offer a promising alternative for early nephropathy detection. Our findings provide a cost-effective, accessible tool for CKD screening, potentially transforming diagnostics in low-resource environments.
Development of Fermented Coconut Water and Red Ginger using Next Generation Probiotics as a Potential Biological Activity Agent Nabila, Sofi; Srihardyastutie, Arie; Aulanni’am, Aulanni’am; Ardiyati, Tri
HAYATI Journal of Biosciences Vol. 32 No. 5 (2025): September 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.5.1337-1351

Abstract

Degenerative diseases have increased in prevalence worldwide, predominantly in Indonesia. Some studies found that probiotics have an impact on organic substances that address inflammation and gut microbiota imbalance. This study aims to develop a functional beverage based on coconut water and red ginger fermentation using Next Generation Probiotics (NGP) and characterize the product using metagenomic and metabolomic technologies. This experimental study involved the fermentation of coconut water and red ginger using a probiotic starter identified by 16S rRNA sequencing for 120 hours at room temperature. The analysis included microbial characterization using List the probiotics metagenomic sequencing, metabolite profiling by LC-HRMS, particle size by PSA, and in vitro antibacterial and anti-inflammatory activity testing. Metagenomic analysis identified the dominance of the family Acetobacteraceae (45%) and genus Acetobacter 942%. Fermentation reduced the tannin content by 28.5% and increased the number of metabolite compounds from 37 to 54. The fermentation results also showed antibacterial activity against E. coli CNN 0091 (inhibition zone 7.835 mm), and anti-inflammatory activity reached 1,000%. The combination of coconut water, red ginger, and NGP produced a complex metabolite profile with high therapeutic potential. The findings show significant potential for the prevention of degenerative diseases.
Co-Authors Achmad Rudijanto Agustina Shinta Hartati Wahyuningtyas Akhmad Sabarudin Alyaa Farrah Dibha Andreas Budi Wijaya Angelina Rosmawati Ani Mulyasuryani Anisa Aprilia Anna Roosdiana Anna Roosdiana Anna Roosdiana Anna Roosdiana Astuti, Luluk Indri Asyfariatus Zulfa Azhar Aulanni'am, Aulanni'am Aulanni'am, Aulanni'am Aulanni`am Aulanni`am Aulanni’am Aulanni’am Aulanni’am Aulanni’am Aulanni’am Aulanni’am Aulanni’am, Aulanni’am Azhar, Asyfariatus Zulfa Azor Yulianus Tefa Bambang Poerwadi Barlah Rumhayati Barlah Rumhayati Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Danar Purwonugroho Danar Purwonugroho Destyana Ellingga Pratiwi Destyana Ellingga Pratiwi Dewi Permatasari, Dewi Diah Mardiana Dolly Irnawati Neno Elok Zubaidah Endah Setiani Astuti Eny Rahma Wati Eva Nur Laili Octaviana Fahmi, Ahmad Luthfi Fahriyah Fahriyah Faijal Fachrudin Mbabho Fiddaroini, Saidun Firza Rajasa Gunawan Fitria Rahmawati Hani Susanti, Hani Janatun Na’imah Karti'a, Galuh Wahyu KIKI FIBRIANTO Komara, Acep Nana Latifah Tribuana Dewi Made Oka Adnyana Made Oka Adnyana Maria Natalia Wewo Masruri Masruri Maulidiyah, Nuris Shobah Moh. Farid Rahman Mora, Giral Baines Muhammad Asadullah Muhammad Iman Hidayat, Muhammad Iman Nabila, Sofi Naila Azmi Adiba Nur Aeni Nur Lailah Nur Samsu Pertiwi, Vi’in Ayu Pertiwi, Vi’in Ayu Putranty Widha Nugraheni Qonitah Fardiyah Ramadani, Devi Riawati Riawati Riyanti Isaskar Roja’i, Abdul Munir Rulli Rosandi Rurini Retnowati Safitri, Anna Salsabila, Isadora Evani Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Siti Nurul Afifah Sofi Nabila Sutrisno Sutrisno Tri Ardiyati Tri Ardyati Tri Ardyati Velayaty Labone Azzahra Vi’in Ayu Pertiwi Wahyudi, Aleyda Nur Halizah Warsito Warsito Warsito Warsito Wuragil, Dyah Kinasih Yudita Prihatini Puji Rahma Sari Yulianti Antula Yuniar Ponco Prananto Yusri Fajar