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All Journal HAYATI Journal of Biosciences VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu dan Teknologi Hasil Ternak The Journal of Experimental Life Sciences (JELS) The Indonesian Green Technology Journal Natural B The Journal of Pure and Applied Chemistry Research Journal of Mathematical and Fundamental Sciences JURNAL PENGABDIAN KEPADA MASYARAKAT Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) JKPK (Jurnal Kimia dan Pendidikan Kimia)

Arie Srihardyastutie

Chemistry Department Brawijaya University

Author-ID : 2844125

Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Social Sciences Other

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The Potency of Monoterpenes Contained in Essential Oils of Canary Sap (Canarium indicum L.) as Anti-inflammatory Agent on Asthmatic Rats (Rattus norvegicus) Velayaty Labone Azzahra; Chanif Mahdi; Arie Srihardyastutie; Aulanni’am Aulanni’am
The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018
Publisher : Chemistry Department, The University of Brawijaya

Asthma is a chronic airway disease characterized by significant exacerbation of bronchial spasm (bronchospasm) and airway inflammation. Asthma symptoms become more severe by oral infectious due to exposure of Gram-negative bacterial lipopolysaccharide (LPS). The essential oils (EO) of the canary sap (Canarium indicum L.) contained linalool, p-cymene and γ-terpinene as an anti-inflammatory agent. The aim of this study to determine the potency EO canary therapy toward level of malondialdehyde (MDA) and lung histopathology of asthmatic rats. The asthmatic rats were prepared by sensitization of allergent conducted by intraperitonial injection and nebulized of ovalbumin (OVA) also intrasulcular injection of Lipopolysaccaride from Phorphyromonas gingivalis bacteria. Five groups of rats (Rattus norvegicus) were used in this research; ie the control group, the asthmatic group, and three groups with therapy of EO canary the dose of 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW for 7 days. The contain of EO canary were analyzed by Gas chromatography–mass spectrometry (GCMS). The MDA levels were measured using the Thiobarbituric Acid (TBA) technique and histopatology of bronchial stained using Hematoxilin-Eosin (HE) and observed microscopically. The data were analyzed by One Way ANOVA with Tukey test (α = 0.05). The result showed that EO canary significantly (p < 0.05) decrease MDA levels and repair lung histopatology of asthmatic rats. The analysis EO canary performed by GCMS composed of l-phellandrene; p-cymene; γ-terpinene; linalool; camphor; limonene and 1,8-cineole. It can be concluded EO canary has potency as anti-inflammatory agent of asthmatic condition. The most effective dose therapy was obtained as high as 100 mg/kgBW that decreased 46.56 % level of MDA.

Potential of Anthocyanin From Purple Sweet Potato (Ipomoea batatas) To Increase BDNF Level and VEGF Expression in The Cerebellum of Ischemic Stroke Rats Eny Rahma Wati; Sasangka Prasetyawan; Chanif Mahdi; Arie Srihardyastutie; Made Oka Adnyana; Aulanni’am Aulanni’am
The Journal of Pure and Applied Chemistry Research Vol 7, No 1 (2018): Edition January-April 2018
Publisher : Chemistry Department, The University of Brawijaya

This research studies the effect of anthocyanin from purple sweet potato in the cerebellum of stroke ischemic rats by MCAO (Middle Cerebral Artery Occlusion) technique. This technique was carried out by ligating the blood flow in ECA and CCA region for 3 hours, followed by reperfusion. The MCAO technique proved as a technique for preparing ischemic stroke rats. This technique induces releasing of BDNF and VEGF in the cerebellum of ischemic stroke rats. The level of BDNF measured by ELISA technique and VEGF expression used immunohistochemistry technique. The results showed that anthocyanin from purple sweet potato increased the level of both BDNF and VEGF expression in the cerebellum in ischemic stroke rats. It is suggested that anthocyanin could be used as a therapeutic agent for ischemic stroke.

Studies of In Vitro and In Silico of Immobilized Xylanase on Zeolite Matrix Activated with Hydrochloric Acid Janatun Na’imah; Sasangka Prasetyawan; Arie Srihardyastutie
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

Xylanase is a hydrolase enzyme that can hydrolyze hemicellulose into xilo-oligosaccharide and xylose. This research is aimed to investigate the in vitro and in silico xylanase (isolated from the fungus Trichoderma viride) immobilized on the zeolite matrix activated with HCl 0.4 M solution. The study was performed using in silico docking molecular methods to investigate the interaction between the xylanase primarily to its ligand. Xylanase activity was determined by reducing sugar produced (xylose) by 1 mL of enzyme per minute. The optimum conditions of immobilized xylanase were measured according to the time agitation and concentration of xylanase. The time variation agitation used were 1, 2, 3, 4, and 5 hours, while variations in the concentrations of a xylanase used were 11.500, 15.653, 20.444, 25.875, and 31.944 mg/mL. The optimum conditions of immobilized xylanase was obtained in the shaking time for 3 hours at a concentration of xylanase 15.653 mg/mL and immobilized xylanase activity generated at 46.755 μg.g-1.min-1. Immobilized xylanase activity was greater than the purified xylanase (15.976 μg.mL-1.min-1). These results were due to the cofactors Al (AlO4) and Si (SiO4) of zeolite was able to increase the kinetic energy caused the reaction rate between xylanase with the larger substrates. Cofactor also increased the kinetic energy and can enhance the rate of reaction between a xylanase with its substrate, in order to give greater activity. Immobilized xylanase was stable and its reusability as much as 6 times which afforded the activity 21.331 μg.g-1.min-1 and the efficiency of 56.77%.

Effects of Root Extract of Ruellia tuberosa L. on Kidneys of Diabetic Rats Anna Safitri; Arie Srihardyastutie; Anna Roosdiana; Aulanni`am Aulanni`am; Eva Nur Laili Octaviana
Journal of Mathematical and Fundamental Sciences Vol. 51 No. 2 (2019)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2019.51.2.3

The aim of this research was to study the antidiabetic activity of root extract of Ruellia tuberosa L. on rats (Rattus novergicus) induced by multiple low doses of streptozotocin. The parameters investigated were blood glucose levels, protease activities, and the histopathologic profiles of the kidneys. Three groups of rats, i.e. control, diabetic, and treatment, were used. R. tuberosa L. extracts were given orally for treatment at a dose of 250 mg/kg body weight per day for 21 consecutive days. The induced diabetes group treated with root extract of R. tuberosa L. (group III) had 60.3% lower glucose levels (119 mg/dL) compared to the group with induced diabetes only. Moreover, antidiabetic activity of R. tuberosa L extract was evidenced by the 55% lower protease activity in the treatment group compared to the untreated diabetic group. Finally, a positive effect from root extract of R. tuberosa L. was shown from the less damaged renal glomerulus and smaller gap between extracellular matrices and epithelium cells in the histopathologic profiles of the kidneys in the extract treatment group. These results show the potential of root extract of R. tuberosa L. as a natural product anti-diabetic agent.

THE POTENTIOMETRIC UREA BIOSENSOR USING CHITOSAN MEMBRANE Ani Mulyasuryani; Anna Roosdiana; Arie Srihardyastutie
Indonesian Journal of Chemistry Vol 10, No 2 (2010)
Publisher : Universitas Gadjah Mada

Potentiometric urea biosensor development is based on urea hydrolysis by urease resulted CO2. The biosensor is used chitosan membrane and the H3O+ electrode as a transducer. The research was studied of effecting pH and membrane thickness to the biosensor performance. The best biosensor performance resulted at pH = 7.3 and 0.2 mm of membrane thickness. The biosensor has a Nerntian factor 28.47 mV/decade; the concentration range is 0.1 up to 6.00 ppm; and the limit of detection is 0.073 ppm. The response time of this biosensor is 280 seconds, efficiency 32 samples and accuracy 94% up to 99%.

Directed Study of Abietic Acid Reaction in Pine Rosin under Non-Precious-Metal Catalyst Siti Nurul Afifah; Masruri Masruri; Arie Srihardyastutie; Moh. Farid Rahman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 1, May 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i1.22802

Pine rosin of Pinus merkusii Jung at de Vriese is produced industrially from a distillation process of pine sap. The high total Indonesian production leads the primary derivatization strategy into several derivates to fulfill the market demand. Abietic acid (AA) is a major compound in pine rosin, used as the object of observation in this study. The general methodology for transformation reported involves using palladium (Pd) and platinum (Pt)-based catalysts. Both are precious metal catalysts to proceed with oxidative dehydrogenative-aromatization of the rosin. The synthesized product provides dehydroabietic acid (DHA) derivatives in high yield. This paper reports that non-precious metal-based catalysts such as iron (Fe), zinc (Zn), or copper (Cu) with iodine (I2) were applied to deliver the reaction by steam cracking without nitrogen (N2) and oxygen (O2) for economical, efficient, and greenway’s catalyst. It was found that a similar product was isolated, including several by-products. Under high temperatures with a various metal transitions and halogen by FeCl3-I2 and Cu(NO3)2.3H2O and ZnCl2 catalyst, four compounds were identified employing spectroscopic methods in the reaction product: 7-hydroxy-dehydroabietic acid (5), 1,7-dihydroxy-dehydroabietic acid (6), 7-isopropyl-1-methylphenanthren-9-ol (7) and polymer (8). This modified pine rosin was mainly used as an emulsifier for the synthetic rubber industry, varnish, ink, paper sizing, etc. The products are determined based on LC-MS/MS, UV-Vis, and ATR-FTIR spectroscopy.

Mikroenkapsulasi Berbasis Gum Arabik dari Ekstrak Air Pletekan (Ruellia tuberosa L.) dan Aktivitas Inhibisi Terhadap Alpha Amilase Firza Rajasa Gunawan; Arie Srihardyastutie; Anna Roosdiana; Anna Safitri
The Indonesian Green Technology Journal Vol. 11 No. 2 (2022)
Publisher : Postgraduate School Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.igtj.2022.011.02.05

Tanaman pletekan (Ruellia tuberosa L.) diketahui memiliki kandungan metabolit sekunder seperti flavonoid, fitosterol, sehingga diusulkan memiliki aktivitas biologis sebagai inhibitor enzim alpha-amilase. Mikroenkapsulasi merupakan metode yang dapat melindungi serta mengontrol pelepasan senyawa aktif. Penelitian ini bertujuan untuk melakukan fabrikasi terhadap ekstrak air pletekan dengan menggunakan bahan penyalut gum Arabik dan menguji aktivitasnya sebagai inhibitor untuk enzim alpha-amilase, serta mengetahui karakter mikrokapsul ekstrak air pletekan yang dihasilkan. Mikroenkapsulasi dilakukan pada variasi pH (3, 4, 5, dan 6) dan waktu pengadukan (30, 60, 90, dan 120 menit). Kondisi optimum mikrokapsul ditentukan berdasarkan penentuan efisiensi mikroenkapsulasi. Hasil penelitian menunjukkan bahwa pH 5 merupakan kondisi optimum dengan nilai efisiensi mikroenkapsulasi sebesar 51,3%. Sedangkan waktu pengadukan 90 menit merupakan kondisi optimum dengan nilai efisiensi mikroenkapsulasi sebesar 52,7%. Uji aktivitas inhibisi enzim alpha-amilase pada mikrokapsul dilakukan pada kondisi optimum menghasilkan nilai IC50 sebesar 71,61 µg/mL.. Karakterisasi menggunakan spektrofotometer FTIR menghasilkan bilangan gelombang 3401,51 cm-1 (O-H), 1608,77 cm-1 (C=C), dan 1081,07 cm-1 (C-O-C) yang menandakan terbentuknya mikrokapsul ekstrak air pletekan. Sedangkan hasil karakterisasi menggunakan SEM menunjukkan bahwa permukaan mikrokapsul yang dihasilkan masih heterogeny, dengan kecenderunagn berbentuk bulat, dan menghasilkan ukuran yang beragam berkisar antara 0,933 – 3,08 µm. Kata kunci: alpha-amilase, flavonoid, mikroenkapsulasi, pH, R. tuberosa L., waktu pengadukan

The Addition of Red Dragon Fruit and Lemon Peels for the Improvement of Fermented Beverage Products Sofi Nabila; Arie Srihardyastutie; Sasangka Prasetyawan; Aulanni’am; Rurini Retnowati
Science and Technology Indonesia Vol. 8 No. 1 (2023): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.1.100-107

Coconut water is part of the coconut fruit, that has bioactive compounds that are thought to own high inhibitor activity to the presence of tannin compounds. However, this compound is antinutritional because it can interfere with macromolecule out there within the body. Considering chance of tannins, these parts are often reduced by fermentation techniques using lactic acid bacteria. This analysis aims to review the addition of dragon fruit and lemon peels in fermentation coconut water using lactic acid bacteria in order to reduce tannin levels and its potential capability as antioxidants. Coconut water fermented drink was prepared by fermentation technique using lactic acid bacteria with the addition of variations in mass of dragon fruit peel and lemon peel consisting of 5 treatments. The optimum conditions for fermentation of coconut water were determined from the decrease in tannin levels, total acid, and the highest total lactic acid bacteria. The optimum conditions for fermentation of coconut water were then tested using an HPLC instrument. Finally, the antioxidantactivity was tested using the FRAP (Ferric Reducing Antioxidant Power) method. The results showed that the addition of dragon fruit and lemon peels in fermented coconut water can reduce tannin levels, can increase total acid levels and the number of lactic acid bacteria formed in coconut water fermented drinks. The best proportion was obtained in the treatment of rasio of mass 1:2 resulted in the highest decrease in tannin content of 83.94 mg/100 g followed by a total acid value of 1.13% and the number of lactic acid bacteria was 8.4 × 107 CFU/mL. The HPLC chromatogram showed that fermented coconut water using lactic acid bacteria contained organic acid compounds such as lactic acid, acetic acid, and ascorbic acid. The highest antioxidant activity test was 82.37 mmgAAE/g. This study confirmed that the addition of dragon fruit and lemon peels affected the degradation of tannins and increased antioxidant activity during coconut water fermentation using lactic acid bacteria.

PEMBERDAYAAN PEREMPUAN SEBAGAI AGEN PENGGERAK DALAM PENGOLAHAN SAMPAH DAPUR MENJADI ECO ENZYME Agustina Shinta Hartati Wahyuningtyas; Anisa Aprilia; Tri Ardyati; Kiki Fibrianto; Fahriyah Fahriyah; Riyanti Isaskar; Arie Srihardyastutie; Destyana Ellingga Pratiwi; Vi’in Ayu Pertiwi; Yusri Fajar
JMM (Jurnal Masyarakat Mandiri) Vol 7, No 1 (2023): Februari
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v7i1.12000

Abstrak: Peningkatan jumlah penduduk mengakibatkan adanya peningkatan produksi sampah, utamanya limbah organik rumah tangga yang dapat menimbulkan dampak buruk bagi lingkungan maupun kesehatan masyarakat jika tidak diimbangi dengan pengelolaan sampah yang tepat. Tujuan kegiatan pengabdian ini adalah untuk mengembangkan pengetahuan, kesadaran, dan kebiasaan baik terutama bagi kaum perempuan agar mampu mengolah sampah atau limbah rumah tangga menjadi eco enzyme. Metode pengabdian meliputi persiapan, sosialisasi, dan pelatihan. Mitra dari kegiatan ini adalah kelompok ibu-ibu PKK RW VII Kelurahan Lesanpuro, Kecamatan Kedungkandang, Kota Malang dengan jumlah peserta yang terlibat sebanyak 86 20 orang. Hasil dari kegiatan tersebut, yaitu peserta dapat membuat dan melestarikan eco enzyme yang didukung dengan hasil evaluasi di mana peserta memiliki peningkatan pemahaman terkait pengolahan sampah dari aspek pengetahuan, kebiasaan, dan kepedulian.Abstract: The growth of population causes the increase of waste production, especially household waste which can cause a negative impact for environment and health if it isn't used the right waste’s management. The community service aims to increase the knowledge, awareness, and good habits to manage household waste into eco enzymes. The first method of this service is preparation, and then followed by socialization. And also training. The partners are the women of RW VII, who are the member of PKK group in the Kelurahan Lesanpuro of Kecamatan Kedungkandang, Kota Malang. There are 86 women involved. The result of the activity shows that participants can make and preserve eco enzymes, which is supported by the evaluation result. It shows that the participants understanding about organic waste management have increased based on the aspects of knowledges, habits, and care.

Effect of Casein Tablet Made from Goat Milk Yogurt on Liver Histopathological Profile, Dioxin Residue, and Malondialdehyde level in Broiler Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Nur Aeni; Arie Srihardyastutie; Chanif Mahdi
Jurnal Ilmu dan Teknologi Hasil Ternak (JITEK) Vol. 15 No. 3 (2020)
Publisher : Faculty of Animal Science Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitek.2020.015.03.1

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic compound of organic pollutants that is very persistent in the environment. This compound can accumulate in the body through contaminated food and can cause various adverse effects on human health. The purpose of this study was to observe the effect of casein tablets made from goat milk yogurt on Liver histopathological profile, residual TCDD and malondialdehyde (MDA) levels in broiler chicken exposed to 50 ng/mL TCDD. A total of 18 male broiler chickens aged 3 weeks were used in this study and were divided into 3 experimental groups based on a completely randomized design (CRD): 1 (negative control group), 2 (positive control group), 3 (therapeutic group) which were administered by 750 mg of casein from goat milk yogurt for 21 days. TCDD residue and MDA levels in the liver were measured using a UV-Vis spectrophotometer and thiobarbituric acid reactive substances test, respectively. The liver histopathological profile was observed using hematoxylin-eosin staining. The results showed that the administration of casein tablets decreased the level of TCDD residue and MDA by 5.75% and 43.74%, respectively. Moreover, the liver histopathological profile of the therapeutic group was better than that of the positive control group. It is suggested that casein tablet made from goat milk yogurt possesses anti-dioxin and antioxidant capacities.

Co-Authors Achmad Rudijanto Agustina Shinta Hartati Wahyuningtyas Akhmad Sabarudin Alyaa Farrah Dibha Andreas Budi Wijaya Angelina Rosmawati Ani Mulyasuryani Anisa Aprilia Anna Roosdiana Anna Roosdiana Anna Roosdiana Anna Roosdiana Asyfariatus Zulfa Azhar Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Aulanni`am Aulanni`am Aulanni’am Aulanni’am Aulanni’am Aulanni’am Aulanni’am Aulanni’am Aulanni’am, Aulanni’am Azor Yulianus Tefa Barlah Rumhayati Barlah Rumhayati Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Chanif Mahdi Danar Purwonugroho Danar Purwonugroho Destyana Ellingga Pratiwi Destyana Ellingga Pratiwi Devi Ramadani Diah Mardiana Dolly Irnawati Neno Dyah Kinasih Wuragil Endah Setiani Astuti Eny Rahma Wati Eva Nur Laili Octaviana Fahmi, Ahmad Luthfi Fahriyah Fahriyah Faijal Fachrudin Mbabho Fiddaroini, Saidun Firza Rajasa Gunawan Fitria Rahmawati Hani Susanti, Hani Janatun Na’imah Karti'a, Galuh Wahyu KIKI FIBRIANTO Latifah Tribuana Dewi Luluk Indri Astuti Made Oka Adnyana Made Oka Adnyana Maria Natalia Wewo Masruri Masruri Moh. Farid Rahman Muhammad Asadullah Nabila, Sofi Naila Azmi Adiba Nur Aeni Nur Lailah Nur Samsu Pertiwi, Viâ€™in Ayu Pertiwi, Vi’in Ayu Putranty Widha Nugraheni Qonitah Fardiyah Riawati Riawati Riyanti Isaskar Roja’i, Abdul Munir Rulli Rosandi Rurini Retnowati Safitri, Anna Salsabila, Isadora Evani Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Sasangka Prasetyawan Siti Nurul Afifah Sofi Nabila Sutrisno Sutrisno Tri Ardiyati Tri Ardyati Velayaty Labone Azzahra Vi’in Ayu Pertiwi Warsito Warsito Warsito Warsito Yudita Prihatini Puji Rahma Sari Yulianti Antula Yuniar Ponco Prananto Yusri Fajar

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