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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Folia Medica Indonesiana WMJ (Warmadewa Medical Journal) HIGEIA (Journal of Public Health Research and Development) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Medik Veteriner Biomolecular and Health Science Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Parasite Science Cardiovascular and Cardiometabolic Journal (CCJ) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Buletin Pengabdian
Prabowo, Gwenny Ichsan
Departemen Ilmu Faal Dan Biokimia Kedokteran, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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THE CORRELATION BETWEEN THE SEVERITY OF LIVER CIRRHOSIS WITH ESOPHAGEAL VARICES IN RSUD DR SOETOMO SURABAYA Deva Medisika Hertiti; Poernomo Boedi Setiawan; Gwenny Ichsan Prabowo
Current Internal Medicine Research and Practice Surabaya Journal Vol. 3 No. 2 (2022): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v3i2.38065

Abstract

Introduction: Liver cirrhosis is the end stage of chronic liver disease. The morbidity and mortality associated with complications of liver cirrhosis are very high. In cases of death caused by cirrhosis of the liver, it tends to increase from around 676,000 in 1980 to more than one million in 2010, globally equivalent to 2% of all mortality in the world (Mokdad et al., 2014). The mortality rate increases if there are complications such as ascites, hepatic encephalopathy, esophageal varices, and liver cancer, with success rates of 20-60%, 50%, 70-90% (D'Amico, 2014). In liver cirrhosis with esophageal varices, it is reported that patients with mild and severe liver cirrhosis risk 40% and 85% for varicose veins. So, this research is to determine the correlation between the severity of liver cirrhosis with esophageal varices in Dr. Soetomo General Hospital Surabaya. Methods: This study was an analytic observational with a cross-sectional study design. The research subjects used in this study were patients diagnosed with liver cirrhosis with esophageal varices from January 2015 - December 2016. Data were collected from medical records and analyzed using the spearman correlation test. Sampling was carried out in total sampling. Results: Of 26 subjects, most of the subjects were men (69.32%), the highest severity of liver cirrhosis from the Child B group (53.85%), and the highest esophageal varices were grade II and III (46,15%). The most results from each group based on the severity of liver cirrhosis were Child A with grade II esophageal varices (66.7%), and Child B with grade II esophageal varices (64.3%), and Child C with esophageal varices grade III esophagus (88.9%). A correlation coefficient was obtained at 0.659 (p <0.005). Conclusion: This research concludes a significant correlation between the severity of liver cirrhosis and esophageal varices.
Methylene Blue: a Potential Novel Treatment in Diabetic Foot Ulcer Lintang Cahyaning Ratri; Annisa Salsabilla Dwi Nugrahani; Gwenny Ichsan Prabowo; Jongky Hendro Prajitno
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16 No 2 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i2.4792

Abstract

Diabetes is a chronic metabolic disease that can lead to serious consequences that impair one's quality of life, if not adequately controlled. One of the undesirable complications is diabetic foot ulcer. It is estimated globally that every 30 seconds a leg is amputated due to diabetic foot, and thus can lower the quality of life. Recent studies have used a low-cost dye known as methylene blue as an anti-microorganism agent, and this sparks the idea of exploring more of its possible benefits. This literature review aimed to outline the beneficial roles of methylene blue in diabetic foot ulcer treatment. According to the findings, it is said that methylene blue may play a role as an anti-microorganism agent through its contribution in wound healing and invasive surgical prevention such as limb amputation. All the pooled articles showed a promising outcome of MB from the reduction of wound size in a shorter healing period with none adverse effects reported. Hence, methylene blue may have a promising role to be an effective agent in treating diabetic foot ulcer.
Detection and Prevalence of Soil Transmitted Helminths Contaminating Several Vegetables in Several Traditional Markets in Surabaya Yuhenanda Dary Pratama; Indah Setyawati Tantular; Gwenny Ichsan Prabowo; Heru Prasetya
Journal of Parasite Science Vol. 7 No. 2 (2023): Journal of Parasite Science
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jops.v7i2.47482

Abstract

A total of 100 fresh vegetable samples consisting of yardlong bean, cabbage, lettuce, and lemon basil were purchased from five traditional markets in Surabaya. Each sample was washed with tap water, water washing examined using flotation method to find soil-transmitted helminths. The overall prevalence of soil-transmitted helminths contamination was 41% (41/100). The most predominant parasite was hookworms (20%), followed by Strongyloides stercoralis larvae (14%) and Ascaris lumbricoides eggs (7%). The highest prevalence of contamination was found in lettuce, with a prevalence rate of 56% (14/25), while the lowest prevalence of contamination was found in yardlong bean, with a prevalence rate of 24% (6/25). Sequentially, the prevalence of soil-transmitted helminths contamination of fresh vegetable samples from Pabean traditional market (55%), Keputran traditional market (50%), Wonokromo traditional market (50%), Lakarsantri traditional market (35%) and Mulyosari traditional market (15%), respectively. The present study demonstrated that consumption of vegetables with parasite contamination in this area represents a potential route for the transmission of soil-transmitted helminths infection.
Aktivitas Antiangiogenesis Ekstrak Daun Dewandaru (Eugenia uniflora L.) pada Retina Tikus Wistar yang Diinduksi Streptozotocin Nilamsari, Karina Ayu; Fatimah, Nurmawati; Prabowo, Gwenny Ichsan
Jurnal Medik Veteriner Vol. 3 No. 1 (2020): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.807 KB) | DOI: 10.20473/jmv.vol3.iss1.2020.9-16

Abstract

Retinopati diabetik adalah komplikasi vaskular yang paling spesifik dari kedua tipe diabetes. Penyebab retinopati diabetik adalah adanya angiogenesis. Angiogenesis diinduksi oleh aktivasi Vascular Endothelial Growth Factor (VEGF). Kandungan Quercetin, salah satu flavonoid yang ada dalam daun Dewandaru (Eugenia uniflora L.) dapat menghambat VEGF. Penelitian ini bertujuan untuk mengetahui akativitas angiogenesis ekstrak Eugenia uniflora L. pada retina tikus yang diinduksi Streptozotocin (STZ). Penelitian ini menggunakan True Experimental Laboratory melalui metode Randomized Posttest Only Controlled Group Design dengan tikus wistar jantan yang dibagi menjadi 5 kelompok, yaitu kelompok kontrol negatif (K-) yang hanya diberikan diet standar tikus, pemberian STZ yaitu dengan dosis 40 mg/kgBB secara injeksi di intraperitoneal diberikan pada kelompok kontrol positif (K+), dan kelompok perlakuan (P1, P2, P3) dan dosis pemberian ekstrak Eugenia uniflora L. yaitu P1=50mg/kgBB, P2=100mg/kgBB, dan P3=200mg/kgBB secara peroral sehari sekali. Selama 1 bulan perlakuan, hasil glukosa darah 1 dan 2, kelompok K (-), K (+), dan P3 menunjukkan  peningkatan kadar glukosa, sedangkan P1 dan P2 menunjukkan penurunan kadar glukosa. Selama penelitian K (-), K (+), P1, P2, P3 menunjukkan peningkatan berat badan. Hasil pewarnaan HE didapatkan penurunan jumlah pembuluh darah pada kelompok perlakuan dengan perbedaan signifikan antara kelompok penelitian (p<0.05). Dapat disimpulkan bahwa pemberian ekstrak Eugenia uniflora L. pada retina tikus Wistar yang diinduksi STZ berpotensi menurunkan respon angiogenesis pada retina tikus yaitu dengan menurunkan jumlah pembuluh darah retina tikus.
Risk Factor Profile and Role of Cardiovascular Disease Outreach Program by Experts in Rural Communities: A Pilot Study in Magetan Regency, Indonesia Wungu, Citrawati Dyah Kencono; Elvaretta, Clarissa; Palupi, Dian Eka Roro; Qurnianingsih, Ema; Susilo, Hendri; Lukitasari, Lina; Humairah, Ira; Khaerunnisa, Siti; Soetjipto, Soetjipto; Handajani, Retno; Safitri, Indri; Ummah, Fithriyah Cholifatul; Waskito, Langgeng Agung; Prabowo, Gwenny Ichsan; Wiratama, Bayu Satria; Amin, Indah Binti Mohd
Jurnal Keperawatan Soedirman Vol 19 No 2 (2024): Jurnal Keperawatan Soedirman (JKS)
Publisher : Fakultas Ilmu-ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jks.2024.19.2.10947

Abstract

Cardiovascular outreach programs and risk factors profiling have been regarded as key strategy in preventing and controlling cardiovascular diseases as the leading global causes of death worldwide, especially when being conducted by a professional. This pilot study aims to evaluate the effectiveness of a cardiovascular outreach program in Plaosan District, Magetan Regency, to improve knowledge and influence changes in the community’s behavior related to cardiovascular risk factors. This study was conducted by providing educational interventions and profiling cardiovascular risk factors on 90 adults using consecutive sampling method. Health education was performed by experts and evaluated by pre-post tests before and after the material delivery. Statistical analysis was used to assess the relationship of risk factors that can contribute to cardiovascular disease. This study showed a significant increase in the participants' knowledge score after the intervention (p = 0.007). There were several risk factors for cardiovascular disease in the participants, with the highest risk prevalence being diabetes mellitus (33.33%). Six participants (6.67%) had abnormal electrocardiography results. In conclusion, our study showed a high prevalence of cardiovascular risk factors in rural communities and the importance of cardiovascular outreach programs by experts to improve the understanding of cardiovascular disease in a specific community.
Peningkatan pengetahuan untuk pencegahan stunting melalui sosialisasi dan demo pembuatan makanan balita berbahan dasar protein hewani bagi kelompok istri peternak sapi pedaging rumahan di Desa Lando, Lombok Timur, Nusa Tenggara Barat [Increasing knowledge for stunting prevention through socialization and demonstration for creating animal protein-based toddler food for a group of wives of home-based beef cattle farmers in Lando Village, East Lombok, West Nusa Tenggara] Qurnianingsih, Ema Ema; Rusyda, Aqila sabila; Hamzah, Arshq Mirza; Rachmawati, Kadek; Humairah, Ira Ira; Lukitasari, Lina; Khaerunnisa, St; Wungu, Citrawati Dyah Kencono; Ummah, Fithriyah Cholifatul Ummah; Kholik, Kholik; Riwu, Katty Hendriana Priscilia; Pradana, Munawer; Yansri, Alifianita Anake; Hidayat, Muhammad; Prabowo, Gwenny Ichsan
Buletin Pengabdian Vol 4, No 3 (2024): Bull. Community. Serv.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/bulpen.v4i3.40293

Abstract

Stunting is a condition of failure to thrive in children under five (toddlers) which can hinder the child's physical and mental development. Data from the 2023 Indonesian Health Survey (SKI) shows that the number of stunted toddlers in West Nusa Tenggara (NTB) Province is still quite high, namely 24.6%. Stunting cannot be cured but can be prevented. One of the prevention efforts is to increase the knowledge of mothers or prospective mothers regarding stunting and preventing it by providing food with high nutrition. This Community Service Activity (PKM) was carried out with the aim of educating mothers and wives of home-based beef cattle farmers in Lando Village, East Lombok, NTB about preventing stunting by providing highly nutritious supplementary food (PMT) and stunting detection. The methods used were socialization and demonstration of making toddler food. The results of this PKM activity were that there was a significant increase in participants' knowledge regarding the material being socialized (p0.0001). The conclusion that can be drawn is that There had been an increase in knowledge among PKM participants regarding stunting and preventing stunting through providing food with high protein content.
Effectiveness of Radioiodine Therapy for Graves' Hyperthyroidism: A Quality-of-Life Assessment Fauzi, Machfud; Prajitno, Jongky Hendro; Prabowo, Gwenny Ichsan; Novida, Hermina
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.53131

Abstract

Introduction: Graves' disease, an autoimmune disorder characterized by hyperthyroidism, is commonly managed through radioactive iodine therapy, antithyroid drugs, and thyroidectomy. Previous reports suggest that individuals undergoing radioactive iodine therapy exhibit superior overall quality of life and satisfaction compared to those opting for alternative therapeutic modalities. This study systematically reviewed evidence on the effectiveness of radioiodine therapy for Graves' hyperthyroidism, specifically emphasizing its impact on patients' quality of life. Methods: A systematic review was conducted on studies evaluating the quality of life of adult patients with Graves’ hyperthyroidism following radioiodine therapy. A literature search was carried out utilizing the PubMed, ScienceDirect, and Sage Journals online databases. The search results were screened according to the eligibility criteria for inclusion in a narrative synthesis. Results: The search yielded 203 items, of which four articles fulfilled the eligibility criteria and were included in the review. radioiodine therapy demonstrated improvements in the quality of life of patients with Graves' disease compared to other therapeutic modalities or no treatment at all. Enhancement in quality of life was observed across various scales, encompassing physical symptoms (goiter, hyperthyroidism, eye symptoms, and hypothyroidism), psychological symptoms (depression and anxiety), functioning and well-being (fatigue, cognitive impairment, and emotional vulnerability), and participation (social life disruptions, daily life interference, and cosmetic complaints). Conclusion: Findings concerning quality of life underscore the long-term effectiveness of radioiodine therapy as a preferred intervention for Graves' disease, contributing valuable insights for clinical decision-making.   Highlights: 1. This systematic review comprehensively synthesizes research findings regarding the impact of radioiodine therapy on the long-term quality of life of patients with Graves’ hyperthyroidism compared to surgery or antithyroid medication. 2. The findings suggest that radioiodine therapy offers improvement in the quality of life, which may be indicated by physical and psychological symptoms, functioning, well-being, and participation.
Association between HbA1c and Non-HDL-Cholesterol in Type 2 Diabetes Mellitus at a Tertiary Hospital in Indonesia Putri, Karina Widya; Soelistijo, Soebagijo Adi; Prabowo, Gwenny Ichsan
Cardiovascular and Cardiometabolic Journal (CCJ) Vol. 6 No. 2 (2025): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v6i2.2025.73-82

Abstract

Abstract: Diabetic dyslipidaemia is considered a modifiable risk factor for cardiovascular disease (CVDs). Non-high-density lipoprotein-cholesterol (non-HDL-C) is a better predictive measure of CVD compared to glycosylated haemoglobin (HbA1c) in type 2 diabetic. This study aims to explore the intricate link between these variables, which contribute significantly to the health risks of T2DM, particularly in a clinical environment like Dr. Soetomo's Endocrinology Polyclinic. Material and Methods: This study used a cross-sectional method with observational analytics design to determine the correlation between HbA1c and non-HDL cholesterol in Type 2 Diabetes Mellitus. Data was collected at Dr. Soetomo Surabaya's Endocrinology Polyclinic from April 2022 to May 2023, focusing on medical records of Type 2 Diabetes Mellitus (T2DM) patients with dyslipidaemia. The study involved T2DM outpatients meeting specific criteria and excluded those with incomplete records or stage 5 Chronic Kidney Disease (CKD) diagnosis at the clinic. The data processing utilized the SPSS statistical program to examine the correlation between independent and dependent variables, employing Pearson or Spearman Correlation based on the data's distribution. Results: The study included mostly women (66.67%) averaging 52.11 years old (SD 4.61). Simvastatin was the most prescribed statin (60.92%). Mean values for HbA1c, total cholesterol, HDL, LDL, and non-HDL cholesterol were 8.155%, 217.29 mg/dL, 46.61 mg/dL, 141.37 mg/dL, and 170.68 mg/dL. Most had poor glycemic control and cholesterol ≥ 130 mg/dL. The Spearman test showed a strong positive correlation between HbA1c and non-HDL cholesterol (r=0.534; p<0.001) and a moderate positive correlation with LDL cholesterol (r=0.473; p<0.001). Conclusion: There is a strong correlation between HbA1c and non-HDL cholesterol in Type 2 Diabetes Mellitus. -- Highlights: 1. A significant positive correlation was observed between HbA1c and non-HDL cholesterol levels in patients with Type 2 Diabetes Mellitus, indicating a linked progression of glycemic and atherogenic profiles. 2. The findings support non-HDL cholesterol as a reliable and cost-efficient parameter for assessing cardiovascular risk, complementing or surpassing LDL cholesterol in clinical evaluation.
Perbedaan Kontrol Glikemik Terapi Metformin Dibandingkan Glimepiride pada Pasien Diabetes Melitus Tipe 2 di RSI Jemursari Surabaya pada Tahun 2018 Nariswari, Rachma Putri; Prabowo, Gwenny Ichsan; Novida, Hermina; Hasanatuludhhiyah, Nurina
Majalah Kedokteran Indonesia Vol 71 No 1 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.1-2021-281

Abstract

Introduction: Type 2 diabetes mellitus is caused by decreased tissue sensitivity to insulin. The prevalence of diabetes in the world has almost doubled since 1980, from 4.7% to 8.5% in adult population. Early diagnosis and treatment aimed at normalizing glycemic control are very important. The objective of this study was to evaluate and compare glycemic control of metformin and glimepiride in monotherapy of type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya. Method: This was a retrospective observational study using secondary data (medical record), include glycemic control (RPG) before and two months after receiving therapy of outpatients’ type 2 diabetes mellitus with metformin or glimepiride therapy in 2018. 96 samples were found that fit the inclusion criteria. The data were analyzed by Mann-Whitney test. Result: Most patients were female, aged 50-69 years old, and dosage of metformin therapy 1500 mg/day or glimepiride therapy 2 mg/day. There was no significant difference (p greater than 0.05) of glycemic control (RPG) of metformin compared to glimepiride therapies in type 2 diabetes mellitus patients at Islamic Jemursari Hospital Surabaya in 2018. Conclusion: Metformin and glimepiride were not significantly different in glycemic control (RPG). There were patients with RPG greater than 200 mg/dl after two months of metformin or glimepiride therapy.
Co-Authors . Kholik Afrina Zulaikah Agustianto, Rafiv Fasya Amin, Indah Binti Mohd Annisa Salsabilla Dwi Nugrahani Arifa Mustika Ayesie Natasha Zulka Bakhtiar, Arief Bayu Satria Wiratama Birgitta Henny Perwitasari Deby Kusumaningrum Deva Medisika Hertiti Dwi Susanti Elvaretta, Clarissa Ely Rahmatika Nugrahani Fatimah, Nurmawati Fauzi, Machfud Fis Citra Ariyanto Ginanjar Sasmito Adi Hamzah, Arshq Mirza Harianto Notopuro Hendri Susilo Hendy Muagiri Margono Hermina Novida, Hermina Heru Prasetya Humairah, Ira Indah Setyawati Tantular, Indah Setyawati Indri Safitri Indri Safitri, Indri Jongky Hendro Prajitno Jongky Hendro Prajitno Kadek Rachmawati Khaerunnisa, Siti Lintang Cahyaning Ratri Lukitasari, Lina Margarita Maramis, Margarita Marisabell Giovanni Mochamad Amin Muhammad Hanun Mahyuddin Muhammad Hidayat Nariswari, Rachma Putri Nilamsari, Karina Ayu Nurina Hasanatuludhhiyah Nyilo Purnami Palupi, Dian Eka Roro Poernomo Boedi Setiawan Poernomoboedi Setiawan Pradana, Munawer Putri, Karina Widya Qurnianingsih, Ema Retno Handajan Retno Handajani Riwu, Katty Hendriana Priscilia Rusyda, Aqila sabila Siti Khaerunnisa Siti Khaerunnisa Soelistijo, Soebagijo Adi SOETJIPTO SOETJIPTO . Soetjipto Soetjipto Sony Wibisono Suhartati Susi Wahyuning Asih Suwandito Suwandito Syafa’ah, Irmi Ulfa Kholili Ummah, Fithriyah Cholifatul Ummah, Fithriyah Cholifatul Ummah Waskito, Langgeng Agung Widati Fatmaningrum Wungu, Citrawati Dyah Kencono Yuhenanda Dary Pratama Yulianti, Erikavitri Zain Budi Syulthoni Zuhrotul Eka Yulis Anggraeni