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All Journal Alchemy : Journal of Chemistry Medical Journal of Indonesia Jurnal Farmasi Klinik Indonesia INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Health Notions JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Majalah Kedokteran Neurosains Jurnal Layanan Masyarakat (Journal of Public Service) Pharmaceutical Sciences and Research (PSR) Riset Informasi Kesehatan Neurona Journal of Fisheries & Marine Journal of Tropical Pharmacy and Chemistry Folia Medica Indonesiana
Junaidi Khotib
Department Of Pharmacy Practice, Faculty Of Pharmacy, Universitas Airlangga, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Health Notions

 1 
Effectiveness of Injectable Alendronat for Bone Defect due to Osteoporosis Aniek Setiya Budiatin; Cantika Suci Adlina Lasandara; Junaidi Khotib; Samirah Samirah
Health Notions Vol 3, No 1 (2019): January
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.692 KB) | DOI: 10.33846/hn.v3i1.291

Abstract

Alendronate is a drug of the bisphosphonate group used for the treatment and prevention of osteoporosis in postmenopausal women. However, when given orally, alendronate can cause indigestion and osteonecrosis of the jaw. It also has a poor bioavailability. Taking these disadvantages into account, an injection formulation of alendronate was created in this study to act on the site locally. Beside alendronate, the injection also contains bovine hydroxyapatite and gelatin as alendronate carriers. Both, besides being able to act as carriers, are also able to reduce bone damage caused by osteoporosis. The aim of this study was to determine the effectiveness of alendronate injection for fractures caused by osteoporosis in mouse models that were ovariectomized. The parameters used in this study were ALP concentration in blood and bone radiology. The results of ALP concentration showed that there were no significant differences in each group. The average ALP concentration of the negative control group was 277.67 ± 46.090, in the positive control group 270.33 ± 189.716, in the BHA-Gel group 406.33 ± 212.547 and in the BHA-Gel Alendronate group 325.00 ± 73.750. Bone radiology results and macroscopic observations still showed bone defects in each group.Yet in the negative control group, the BHAGel-Alendronate group and the BHA-Gel group, bone defects were almost entirely ameliorated. On the contrary, bone defects were still present in the positive control group. Based on the results obtained, it was shown that the injection of alendronate has not been shown to significantly overcome osteoporosis fractures. Keywords: Osteoporosis, Alendronate, Ovariectomy, Bovine hydroxyapatite, Gelatin
Co-Authors A. H. Zaidan Agus, Adhe Septa Ryant Aniek S Budiatin Aondohemba Samuel Nege Ardianto, Chrisnawan Arifa Mustika Arifianti, Lusiana Baiq Risky Wahyu Lisnasari Bambang Sidharta Bambang Subakti Zulkarnain Budi Suprapti Budiatin, Aniek S Budiatin, Aniek Setiya Cantika SC Lasandara Cantika Suci Adlina Lasandara Chrismawan Ardianto Chrismawan Ardianto Dewi Wara Shinta Diana Holidah Didik Hasmono Dwi Ningsih Eddy Rahardjo Elida Zairina Endang Dewi Masithah Fajrin, Fifteen A. Fifteen A. Fajrin Fifteen Aprila Fajrin Fransiska Maria Christianty Hamidah, Khusnul Fitri Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Honey Dzikri Marhaeny Ignasius Agyo Palmado Ika Ayu Mentari Imam Susilo Indriyanti, Niken JOEWONO SOEROSO Joewono Soeroso Joewono Soeroso Kuntoro Kuntoro Lasandara, Cantika SC Lina, Rifda Naufa Mahardian Rahmadi Megawati, Selvi Mohammad Hasan Machfoed Muhamad Nasir Muhamad Nasir, Muhamad Muhammad Taher Naufalina, Rifda Niken Indriyanti Niken Indriyanti Novrynda Eko Satriawan Nurlaili Susanti Paulus Sugianto Prasetya, I Made Slamet Putra Rifda Naufa Lina Rifda Naufalina Rochmanti, Maftuchah Rochmanti Roihatul Muti’ah Samirah Samirah Samirah Samirah, Samirah Sarah Puspita Atmaja Sari, Dewi Perwito Satriawan, Novrynda Eko Sauma, Anis Khoirun Shah Faisal Siti Maimunah Siti Syamsiah Sjamsiah, Siti Sjamsiah, Siti Suharjono, Suharjono, Suharjono Sukardiman Sulistyanaengci Winarto Sumarno Sumarno SZ, Bambang SZ, Bambang Tsutomu Suzuki, Tsutomu Tuhfatul Ulya Utomo, Febriansyah Nur Wibisono, Cahyo Winda Fatma Sari Wirasasmita, Yuyun Yulistian, . Yulistian, . Yulistiani Yulistiani Yulistiani, . Yurika Sastyarina Yurika Sastyarina Yurika Sastyarina Yusuf Alif Pratama Zaidan, A. H. Zainul Amiruddin Zakaria