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All Journal Alchemy : Journal of Chemistry Medical Journal of Indonesia Jurnal Farmasi Klinik Indonesia INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Health Notions JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Majalah Kedokteran Neurosains Jurnal Layanan Masyarakat (Journal of Public Service) Pharmaceutical Sciences and Research (PSR) Riset Informasi Kesehatan Neurona Journal of Fisheries & Marine Journal of Tropical Pharmacy and Chemistry Folia Medica Indonesiana
Junaidi Khotib
Department Of Pharmacy Practice, Faculty Of Pharmacy, Universitas Airlangga, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Science and Technology Indonesia

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Phytochemical, Metabolite Compound, and Antioxidant Activity of Clinacanthus nutans Leaf Extract from Indonesia Nurlaili Susanti; Arifa Mustika; Junaidi Khotib; Roihatul Muti’ah; Maftuchah Rochmanti
Science and Technology Indonesia Vol. 8 No. 1 (2023): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.1.38-44

Abstract

The antioxidant properties from medicinal plants have protective effects against oxidative stress-linked diseases. Their antioxidant capacities are related to phenolic compounds, including phenols and flavonoids. Clinacanthus nutans, a native to Asia, including Malaysia, Thailand, and Indonesia, are used for treating diabetes and other diseases, but the exploration of the plant in Indonesia is still limited. Therefore, this study aimed to reveal the phytochemical constituents, metabolic compounds, and antioxidant activity of C. nutans extracts. Dried leaf powder was extracted with 70% ethanol and aqueous, each extract was subjected to qualitative phytochemical screening. Subsequently, total phenolic and flavonoid content was calculated using Folin-Ciocalteu and AlCl3 colorimetric assay. The antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The profiles of phenolic and flavonoid compounds of 70% ethanolic extract were investigated by LC MS/MS. Phytochemical screening showed that the extracts contain phenolic, flavonoid, tannin, and saponin. The total phenolic content of the 70% ethanol and aqueous extract was 4.14±1.9% mgGAE/g and 3.89±3.2% mgGAE/g, respectively. Meanwhile, the total flavonoid content obtained was 0.19±1.0% mgQE/g and 0.03±0.5% mgQE/g for 70% ethanol and aqueous extracts, respectively. Both extracts showed high antioxidant activity, with DPPH IC50 30.57 ????g/mL for 70% ethanol and 37.24 ????g/mL for aqueous extract. LC-MS/MS analysis of 70% ethanol extract revealed 5 phenolic and 3 flavonoid compounds, where DL-glutamic monohydrate and Boesenbergin B were the most dominant based on the percentage of area under the curve. C. nutans originating from Indonesia can be a good source of natural antioxidants because 70% ethanol and aqueous extract show high phytochemical content and antioxidant activity.
Co-Authors A. H. Zaidan Agus, Adhe Septa Ryant Aniek S Budiatin Aondohemba Samuel Nege Ardianto, Chrisnawan Arifa Mustika Arifianti, Lusiana Baiq Risky Wahyu Lisnasari Bambang Sidharta Bambang Subakti Zulkarnain Budi Suprapti Budiatin, Aniek S Budiatin, Aniek Setiya Cantika SC Lasandara Cantika Suci Adlina Lasandara Chrismawan Ardianto Chrismawan Ardianto Dewi Wara Shinta Diana Holidah Didik Hasmono Dwi Ningsih Eddy Rahardjo Elida Zairina Endang Dewi Masithah Fajrin, Fifteen A. Fifteen A. Fajrin Fifteen Aprila Fajrin Fransiska Maria Christianty Hamidah, Khusnul Fitri Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Honey Dzikri Marhaeny Ignasius Agyo Palmado Ika Ayu Mentari Imam Susilo Indriyanti, Niken Joewono Soeroso Joewono Soeroso JOEWONO SOEROSO Kuntoro Kuntoro Lasandara, Cantika SC Lina, Rifda Naufa Mahardian Rahmadi Megawati, Selvi Mohammad Hasan Machfoed Muhamad Nasir Muhamad Nasir, Muhamad Muhammad Taher Naufalina, Rifda Niken Indriyanti Niken Indriyanti Novrynda Eko Satriawan Nurlaili Susanti Paulus Sugianto Prasetya, I Made Slamet Putra Rifda Naufa Lina Rifda Naufalina Rochmanti, Maftuchah Rochmanti Roihatul Muti’ah Samirah Samirah Samirah Samirah, Samirah Sarah Puspita Atmaja Sari, Dewi Perwito Satriawan, Novrynda Eko Sauma, Anis Khoirun Shah Faisal Siti Maimunah Siti Syamsiah Sjamsiah, Siti Sjamsiah, Siti Suharjono, Suharjono, Suharjono Sukardiman Sulistyanaengci Winarto Sumarno Sumarno SZ, Bambang SZ, Bambang Tsutomu Suzuki, Tsutomu Tuhfatul Ulya Utomo, Febriansyah Nur Wibisono, Cahyo Winda Fatma Sari Wirasasmita, Yuyun Yulistian, . Yulistian, . Yulistiani Yulistiani Yulistiani, . Yurika Sastyarina Yurika Sastyarina Yurika Sastyarina Yusuf Alif Pratama Zaidan, A. H. Zainul Amiruddin Zakaria