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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Kesehatan Masyarakat Indonesia CALYPTRA : Jurnal Ilmiah Mahasiswa Universitas Surabaya Jurnal Kesehatan Masyarakat Indonesian Journal of Human Nutrition Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY The Indonesian Journal of Public Health Journal of Industrial Hygiene and Occupational Health (JIHOH) The Indonesian Biomedical Journal Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Syntax Literate: Jurnal Ilmiah Indonesia Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Ilmu Kesehatan Amerta Nutrition JFIOnline Medical Technology and Public Health Journal Surya Medika: Jurnal Ilmiah Ilmu Keperawatan dan Ilmu Kesehatan Masyarakat ANIMA Indonesian Psychological Journal Heart Science Journal Keluwih: Jurnal Kesehatan dan Kedokteran Budapest International Research in Exact Sciences (BirEx Journal) Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Kesehatan Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Amelia Lorensia

Fakultas Farmasi Universitas Surabaya

Author-ID : 308806

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Pilot Study of Lung Function Improvement in Peak Expiratory Flow (PEF) Value Using Fish Oil Containing Omega-3 Therapy in Asthma Amelia Lorensia; Rivan Virlando Suryadinata; Richa Ratnasari
Global Medical & Health Communication (GMHC) Vol 8, No 3 (2020)
Publisher : Universitas Islam Bandung

Fish oil contains omega-3 as an anti-inflammatory effect that can inhibit the production of arachidonic acid 5-lipoxygenase (ALOX5), an enzyme that aggravates the inflammation of the lungs that cause asthma. This study aims to determine the effect of omega-3 from fish oil on improving lung function with peak expiratory flow (PEF) value in patients with outpatient asthma in Surabaya. The research design used in this research is pre-post test design and lung function examination by using a peak flow meter. Then follow up every week for four weeks during the use of fish oil, and the results of his research were analyzed by t test. The study was conducted from April 2017 until January 2018 in Surabaya. The sample of the study was 27 adult asthma patients. The results showed that most of the study subjects had an increase in PEF value every week. Besides, there was a significant increase of PEF values gradually at T0 (before intervention) to T4 (intervention for four weeks), indicating an improved effect after the use of fish oil in a four-week study sample. In conclusion, fish oil containing omega-3 is effective in improving lung function in outpatient asthma patients. PILOT STUDI PERBAIKAN FUNGSI PARU MENURUT NILAI PEAK EXPIRATORY FLOW (PEF) MENGGUNAKAN TERAPI MINYAK IKAN MENGANDUNG OMEGA-3 PADA ASMAMinyak ikan mengandung omega-3 sebagai efek antiinflamasi yang dapat menghambat produksi asam arakidonat 5-lipoksigenase (ALOX5) merupakan enzim yang memperburuk peradangan paru yang menyebabkan asma. Penelitian ini bertujuan mengetahui pengaruh omega-3 dari minyak ikan terhadap perbaikan fungsi paru dengan nilai peak expiratory flow (PEF) pada pasien asma dewasa rawat jalan di Surabaya. Desain penelitian yang digunakan dalam penelitian ini adalah pre-post test dan pemeriksaan fungsi paru menggunakan peak flow meter. Kemudian dilakukan follow up setiap minggu selama empat minggu selama penggunaan minyak ikan dan hasilnya dianalisis dengan uji t. Penelitian dilakukan pada April 2017 hingga Januari 2018 di Surabaya. Sampel penelitian sebanyak 27 pasien asma dewasa. Hasil penelitian menunjukkan bahwa sebagian besar subjek penelitian mengalami peningkatan nilai PEF setiap minggunya. Selain itu, terdapat peningkatan signifikan nilai PEF secara bertahap pada T0 (sebelum intervensi) sampai T4 (intervensi selama empat minggu) yang menunjukkan efek membaik setelah penggunaan minyak ikan pada sampel penelitian selama empat minggu. Simpulan, minyak ikan yang mengandung omega-3 terbukti efektif dalam perbaikan fungsi paru pada pasien asma rawat jalan.

Effectiviness of Lime Peel Extract (Citrus aurantifolia Swingle) against C-Reactive Protein Levels in Alloxan-Induced Wistar Rats Rivan Virlando Suryadinata; Amelia Lorensia; Kezia Sefania
Global Medical & Health Communication (GMHC) Vol 9, No 1 (2021)
Publisher : Universitas Islam Bandung

Hyperglycemia is a metabolic disease that is most often found and continuously increasing. Various complications due to hyperglycemia in the blood can cause tissue damage. It will increase free radicals that can trigger an inflammatory response characterized by an increased C-reactive protein in the blood. Prevention can be done by administering flavonoid antioxidant and lime peel containing high flavonoid. This study aims to analyze the efficacy of lime peel extract against C-reactive protein level with hyperglycemia through alloxan-induced Wistar rats (140 mg/kgBW). It is an experimental study using a post-test control group design that was carried out at the Pharmacology Laboratory of the Universitas Surabaya for the period July–August 2020. Experimental Wistar rats were divided into a negative control group, a positive control group, and three groups with different doses of lime peel extract (2.35 mg, 4.7 mg, and 9.4 mg). Treatment was carried out for 30 days before measuring the C-reactive protein levels in the blood using ELISA. The results showed a difference in C-reactive protein level between groups (Man-Whitney, p=0.004). The increase in the dose of lime peel extract (9.4 mg) showed the lowest C-reactive protein level. Therefore, it can be concluded that the administration of lime peel extract in hyperglycemia conditions can reduce the inflammatory process in the body. EFEK EKSTRAK KULIT JERUK NIPIS (CITRUS AURANTIFOLIA SWINGLE) TERHADAP KADAR C-REACTIVE PROTEIN PADA TIKUS WISTAR YANG DIINDUKSI ALOKSANHiperglikemia merupakan penyakit metabolik yang paling sering dijumpai dan terus mengalami peningkatan dari tahun ke tahun. Berbagai komplikasi akibat hiperglikemia dalam darah dapat menyebabkan kerusakan jaringan. Hal ini dikarenakan hiperglikemia akan meningkatkan radikal bebas sehingga memicu respons inflamasi yang ditandai dengan peningkatan C-reactive protein dalam darah. Pencegahan dapat dilakukan dengan pemberian asupan antioksidan flavonoid. Kulit jeruk nipis memiliki kandungan flavonoid yang tinggi. Penelitian ini bertujuan menganalisis efikasi ekstrak kulit jeruk nipis terhadap kadar C-reactive protein pada tikus Wistar dengan kondisi hiperglikemia melalui induksi aloksan (140 mg/kgBB). Metode pada penelitian ini adalah eksperimental dengan menggunakan post-test control group yang dilaksanakan di Laboratorium Farmakologi Universitas Surabaya periode Juli–Agustus 2020. Hewan coba tikus Wistar dibagi menjadi kelompok kontrol negatif, kelompok kontrol positif, dan tiga kelompok perlakuan dengan pemberian dosis ekstrak jeruk nipis yang berbeda (2,35 mg; 4,7 mg; dan 9,4 mg). Pemberian perlakuan dilakukan selama 30 hari, selanjutnya akan dilakukan pengukuran kadar C-reactive protein dalam darah dengan menggunakan ELISA. Hasil penelitian memperlihatkan perbedaan kadar C-reactive protein antarkelompok (Mann-Whitney, p=0,004). Peningkatan pemberian dosis ekstrak kulit jeruk nipis (9,4 mg) menunjukkan penurunan kadar C-reactive protein paling rendah. Oleh karena itu, dapat disimpulkan bahwa pemberian ekstrak kulit jeruk nipis pada kondisi hiperglikemia dapat menurunkan proses inflamasi dalam tubuh.

Relation between Vitamin D Level and Knowledge and Attitude Towards Sunlight Exposure among Asthma Outpatients in Surabaya Amelia Lorensia; Rivan Virlando Suryadinata; Gebriella Ayuni Amir
Global Medical & Health Communication (GMHC) Vol 7, No 3 (2019)
Publisher : Universitas Islam Bandung

Asthma has become one of the health problems in the world. Asthma is characterized by chronic inflammation of the respiratory tract which leads to breathlessness, wheezing, and airflow limitation. Inflammatory reaction in asthma is related to inadequate vitamin D level. Vitamin D is a vitamin produced naturally by the body when exposed to sunlight that has immunomodulatory properties can reduce inflammation. Knowledge and positive attitude to sun exposure are necessary to prevent severe asthma attacks. This was a cross-sectional study involving 26 subjects in a private university in east Surabaya during January–June 2017 that was aimed to determine the relation between vitamin D and knowledge and attitude towards sunlight exposure. Data were collected by measuring the vitamin D level in blood serum and through the use of a questionnaire that consisted of two aspects, level of knowledge and attitude to sun exposure. Chi-square test was used to analyze the relationship between vitamin D level, knowledge, and attitude. No relationship was found between blood vitamin D level of asthma respondents and level of knowledge of sun exposure related to vitamin D (p=0.444, p>0.05). The same was also true for the relationship between blood vitamin D level of asthma respondents and attitude to sun exposure related to vitamin D (p=0.768, p>0.05). The closeness of the relationship between knolwedge and attitude was also relatively low (0.093). In conclusion, there is no correlation between vitamin D level, knowledge, and attitude. In addition, there is also no correlation between knowledge and attitude with low relationship between the two variables. HUBUNGAN KADAR VITAMIN D DENGAN PENGETAHUAN DAN SIKAP TENTANG PAPARAN SINAR MATAHARI PADA PASIEN ASMA RAWAT JALAN DI SURABAYAAsma telah menjadi masalah kesehatan di dunia. Asma ditandai oleh peradangan kronis pada saluran pernapasan yang menyebabkan sesak napas, mengi, dan keterbatasan aliran udara. Reaksi peradangan pada asma terkait dengan kadar vitamin D yang tidak memadai. Vitamin D merupakan vitamin yang diproduksi secara alami oleh tubuh ketika terkena sinar matahari yang memiliki sifat imunomodulator dapat mengurangi peradangan. Pengetahuan dan sikap positif terhadap paparan sinar matahari diperlukan untuk mencegah risiko keparahan asma. Penelitian ini menggunakan metode cross-sectional yang melibatkan 26 subjek di sebuah universitas swasta di Surabaya Timur pada Januari–Juni 2017 yang bertujuan menentukan hubungan vitamin D dengan pengetahuan dan sikap terhadap paparan sinar matahari. Data dikumpulkan dengan mengukur kadar vitamin D dalam serum darah dan melalui penggunaan kuesioner yang terdiri atas dua aspek, tingkat pengetahuan dan sikap terhadap paparan sinar matahari. Uji chi-square digunakan untuk menganalisis hubungan antara kadar vitamin D, pengetahuan, dan sikap. Tidak ada hubungan yang ditemukan antara kadar vitamin D darah responden asma dan tingkat pengetahuan paparan sinar matahari yang terkait dengan vitamin D (p=0,444; p>0,05). Hal yang sama juga berlaku untuk hubungan antara kadar vitamin D darah responden asma dan sikap terhadap paparan sinar matahari yang terkait dengan vitamin D (p=0,768; p>0,05). Kedekatan hubungan antara pengetahuan dan sikap juga relatif rendah (0,093). Simpulan, tidak ada hubungan antara kadar vitamin D, pengetahuan, dan sikap. Selain itu, juga tidak ada hubungan yang rendah antara pengetahuan dan sikap.

Identification of Health Knowledge of Lung Function in Predicting Respiratory Disorders in Smokers Amelia Lorensia; Rivan Virlando Suryadinata; Lalita Tirsa
Global Medical & Health Communication (GMHC) Vol 9, No 2 (2021)
Publisher : Universitas Islam Bandung

Chronic obstructive pulmonary disease (COPD) is a high risk for active smokers. Early assessment of the condition of lung function is needed to prevent a decrease in lung function. Knowledge of self-management that determines lung health. The purpose of this study was to determine the knowledge of lung function health in predicting respiratory disorders. The study design was a case-control from August 2018 to January 2019. Data was collected through a questionnaire, namely a lung health knowledge questionnaire consisting of categories: risk factors, symptoms, and therapy for respiratory disorders. The research sample was adult men who work in the transportation sector in Surabaya city using purposive sampling. Data analysis using chi-square. The data obtained were 300 people, consisting of 126 people without lung function disorders and 174 people with pulmonary function disorders. The risk factor knowledge category showed a significant difference (p=0.000) between the group, with the most disorders at the low knowledge level (42.0%). The symptom knowledge category showed a significant difference (p=0.000) between groups, and most of the groups with disorders were at a low knowledge level (55.8%). The category of knowledge of respiratory symptoms showed a significant difference (p=0.000) between groups, with the knowledge level in both of them mostly at a sufficient level. Therefore, low lung function health knowledge reflects low lung function conditions. IDENTIFIKASI PENGETAHUAN KESEHATAN FUNGSI PARU DALAM MEMPREDIKSI GANGGUAN PERNAPASAN PADA PEROKOKPenyakit paru obstruktif kronik (PPOK) berisiko tinggi dialami oleh perokok aktif. Pengkajian dini terhadap kondisi fungsi paru diperlukan untuk mencegah penurunan fungsi paru. Pengetahuan tentang manajemen diri yang menentukan kesehatan paru. Tujuan penelitian ini adalah mengetahui pengetahuan kesehatan fungsi paru dalam memprediksi gangguan pernapasan. Desain penelitian adalah case-control dari Agustus 2018 hingga Januari 2019. Pengumpulan data dilakukan melalui kuesioner, yaitu kuesioner pengetahuan kesehatan paru yang terdiri atas kategori: faktor risiko, gejala, dan terapi gangguan pernapasan. Sampel penelitian adalah laki-laki dewasa yang bekerja di sektor transportasi di Kota Surabaya dengan menggunakan purposive sampling. Analisis data menggunakan chi-square. Data yang diperoleh sebanyak 300 orang, terdiri atas 126 orang tanpa gangguan fungsi paru dan 174 orang dengan gangguan fungsi paru. Kategori pengetahuan faktor risiko menunjukkan perbedaan yang bermakna (p=0,000) antarkelompok dengan gangguan terbanyak pada pengetahuan tingkat rendah (42,0%). Kategori pengetahuan gejala menunjukkan perbedaan yang bermakna (p=0,000) antarkelompok dan sebagian besar kelompok dengan gangguan berada pada pengetahuan tingkat rendah (55,8%). Kategori pengetahuan gejala pernapasan menunjukkan perbedaan yang bermakna (p=0,000) antarkelompok dengan tingkat pengetahuan keduanya sebagian besar pada tingkat cukup. Oleh karena itu, pengetahuan kesehatan fungsi paru yang rendah mencerminkan kondisi fungsi paru yang rendah.

EVALUASI YIELD PRODUK TERHADAP FIX COST DAN VARIABLE COST PADA CAIRAN INFUS RINGER LACTATE Adi Suroso; Amelia Lorensia; Abdul Rahem
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 2 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

The need for quality drugs can affect the price of drugs, because there were many requirement in the manufacturing process as stated in the GMP standard. On the other hand, the price of the COGS (before production) standard and COGS varian (after production) can be different due to changes in the values of factory over head (fixed cost and variable cost). So that it requires an analysis of COGS standard and variant. This study aims to analyze the differences in the COGS variant of Ringer Lactate infusion products to COGS standard. COGS variant value was calculated based on the yield of 30 batches. Descriptive analysis was performed for (1) Value (%) of COGS standard (2) Differences in value of variable cost and fixed cost of COGS variant to COGS standard, (3) COGS standard and variant. The results showed (1) COGS standard consist of raw materials (6.70%), packaging materials (49.58%), factory over head with variable costs (25.80%) and Fixed costs (18.00%); (2) The average yield of 30 batches was 94.947% and this causes in differences in variable cost of COGS variant - standard 4.422% and the differences in fixed cost of COGS variant ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ COGS standard 3,958% (3) There was 4,201 % differences in COGS variant to standard. Product yield influences the value of variable cost and fixed cost of COGS variants, causing a gap to the COGS standard. So that this gap should considered in setting the COGS standard.

PENGARUH PENGETAHUAN-SIKAP MENGENAI VITAMIN D TERKAIT OBESITAS PADA MAHASISWA Amelia Lorensia; Dian Natasya Raharjo; Novelia Gandawari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 1 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Indonesia as a tropical country has a tendency to experience vitamin D deficiency. Knowledge and attitudes towards sun exposure contribute to the risk of vitamin D deficiency. In the midst of urban life patterns, obesity also increases the risk of vitamin D deficiency. This study was conducted to determine the effect of the level of knowledge and attitudes regarding vitamin D related to obesity in adults, which was conducted in March 2018 to January 2019. The study used a cross sectional design, with a knowledge and attitude questionnaire regarding vitamin D. Respondents were adults and domiciled in Surabaya , as many as 74 people in each group of obesity and non-obese. The results showed that obese and non-obese respondents both had good knowledge (OR 1.138) but had a bad attitude (OR 1,000). There was no significant difference in knowledge and attitudes in the two groups, and had a weak correlation.

TINGKAT PENGETAHUAN APOTEKER KOMUNITAS MENGENAI PENGOBATAN ASMA Amelia Lorensia; Rifaatul Laila Mahmudah; Leonardo Immanuel
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 2 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Optimal asthma therapy requires collaboration between patients and pharmacists as health workers. Through pharmacy services, pharmacists have the role of providing education and monitoring asthma therapy. But the level of pharmacist's knowledge will be important in its implementation. This study studies the level of medical knowledge from the community in the city of East Surabaya. The research design used in this study was cross sectional and data collection was carried out through questionnaires from previous studies. The level of knowledge includes 6 domains, namely the domain of pharmacological therapy, etiology and pathophysiology, risk factors, resolution, symptoms, and non-pharmacological therapy. The subject is a pharmacist who practices at a pharmacy in East Surabaya. Data is collected by visiting pharmacies one by one to invite pharmacists from each pharmacy. Interviews were conducted directly with research subjects. In this study descriptive data analysis was performed. The study was conducted from April to June 2019 with 108 people. The results of the study concluded: Most subjects had moderate / standard asthma knowledge (37.96%) and only a small proportion had a high level of knowledge (27.77%). From the questionnaire questions, the lowest domain was in non-pharmacological therapy (94.00) and the lowest value was in the question domain (43.00). Therefore, pharmacists need to increase their knowledge in order to help asthma patients achieve optimal treatment. Keywords: asthma, pharmacist, pharmacy, knowledge

METODE INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS (IPA): PERSEPSI TENAGA KESEHATAN DAN PASIEN TERHADAP PENGOBATAN ASMA Marthy Meliana Ariyanti Jalmav; Amelia Lorensia; Ananta Yudiarso; Daniel Maranatha
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Pharmaceutical care by pharmacists in the management have an important role of treatment monitoring. Optimal asthma treatment for patients requires cooperation between patients, healthcares, involving doctors, nurses, and pharmacists. Therefore the purpose of this study is to know the perception of healthcares and patients about asthma treatment and pharmaceutical cares on asthma mangement. The method of this study is based on phenomenological perspective with interpretative phenomenological analysis (IPA) on pulmonologist, outpatient asthma, pharmacist and nurse who directly correlated with asthma treatment at a hospital in Surabaya conducted for two years using purposive sampling. The results of this study indicate that asthma patients know how to manage asthma and use asthma drugs well. In addition it is known that asthma patients feel the role of doctors in the treatment of asthma is very dominating; pulmonologists and nurses perceive that the role of pharmacists is limited to drug delivery; and pharmacists assume that their role has been well done although not all patients get the same asthma treatment education. It is therefore necessary to evaluate the role of pharmacist in performing its role in the treatment of this asthma in order for a more harmonious collaboration.

Membandingkan Kejadian Gangguan Gastrointestinal Penggunaan Aminofilin dan Salbutamol pada Pasien Eksaserbasi Asma di Surabaya Amelia Lorensia; Zullies Ikawati; Tri Murti Andayani; Daniel Maranatha; Rizki Amalia
Keluwih: Jurnal Kesehatan dan Kedokteran Vol. 1 No. 1 (2019): Keluwih: Jurnal Kesehatan dan Kedokteran (December)
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Abstract—Asthma is a heterogeneous disease, which is characterized by inflammation of the respiratory tract with respiratory classification such as wheezing, shortness of breath, distress in the chest and coughing over time and intensity with variations in expiratory air flow. In Indonesia the prevalence of asthma is uncertain, it is not estimated that 2-5% of Indonesia's population has asthma. The main objective of this study is to study gastrointestinal-related cases of the use of aminophylline and salbutamol in asthma exacerbation patients in hospitals in Surabaya and also to discuss gastrointestinal problems related to ADRs (Bad Drug Reactions) using the use of aminophylline and salbutamol on Naranjo scale. In this study using the Quasi Experimental method. This research was conducted in October 2014 to February 2015. The results of the study of 7 samples obtained 14.29% using ADR from the use of aminophylline and from 13 patients in the use of salbutamol was not found ADR can be used in accordance with the existing salbutamol in patients with asthma exacerbations at hospitals in Surabaya. The general benefits of this study are useful in monitoring the treatment of acute asthma patients who need salbutamol and theophylline therapy so as to reduce the incidence of ADR. Abstrak—Asma merupakan penyakit heterogen, yang ditandai dengan peradangan saluran napas kronis dengan disertai riwayat gejala pernapasan seperti mengi, sesak napas, rasa tertekan di dada dan batuk dari waktu ke waktu dan intensitas dengan variasi keterbatasan aliran udara ekspirasi. Di Indonesia prevalensi asma belum diketahui secara pasti, namun diperkirakan 2-5 % penduduk Indonesia menderita asma. Tujuan utama penelitian ini adalah untuk mengetahui perbedaan kejadian gangguan gastrointestinal pada penggunaan aminofilin dan salbutamol pada pasien eksaserbasi asma di Rumah Sakit di Surabaya serta mengetahui kejadian gangguan gastrointestinal terkait ADRs (Adverse Drug Reaction) akibat penggunaan aminofilin dan salbutamol berdasarkan penilaian Naranjo scale. Pada penelitian ini menggunakan metode Quasi Eksperimental. Penelitian ini dilakukan pada bulan Oktober 2014 sampai Februari 2015. Hasil penelitian dari 7 sampel diperoleh 14,29% mengalami ADR dari penggunaan aminofilin dan dari 13 pasien pada pengguanaan salbutamol tidak ditemukan ADR sehingga dapat disimpulkan bahwa tidak ada perbedaan kejadian gangguan gastrointestinal pada penggunaan aminofilin dan salbutamol pada pasien eksaserbasi asma di Rumah Sakit di Surabaya. Manfaat umum dari penelitian ini adalah berguna dalam monitoring pengobatan pasien asma akut terutama yang mendapat terapi salbutamol dan teofilin sehingga dapat mengurangi angka kejadian ADR.

Study of Cost-Consequences Analysis Between Salbutamol With Aminophyllin For Exacerbation Asthma Amelia Lorensia
KELUWIH: Jurnal Kesehatan dan Kedokteran Vol. 1 No. 2 (2020): Keluwih: Jurnal Kesehatan dan Kedokteran (June)
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Abstract— Exacerbations asthma treatment can be done by giving medications therapy in the form of salbutamol and aminophyllin. This research conducted with a comparative study between two alternatives using a hospital perspective. Data were collected retrospectively based on the medical records of patients with mild-moderate exacerbations asthma who were admitted in emergency department Anwar Medika Sidoarjo Hospital during the period of January 2017 to Desember 2018. The data showing asthma exacerbations treatment effectiveness and costs were analyzed using ACER. Results of the data analysis using ACER based on total improvement of asthma sympthoms showed that in salbutamol group was Rp.2.403,75/%, and in aminophyllin group was Rp.1.688,31/%. Based on the result of study, cannot concluded which medications therapy were more cost-effective because total subject study of salbutamol and aminophyllin were different and too little. Results of the data analysis using ACER based on total improvement of asthma sympthoms showed that in salbutamol only group was Rp.2.073,18/%, and in salbutamol and corticosteroid group was Rp.1.688,31/%. Rp.2.573,40/%. Based on the result of ACER, salbutamol only group more cost-effective than salbutamol and corticosteroid group based on improvement of asthma sympthoms in mild-moderate exacerbations asthma patients in emergency department. Keywords: cost-effectiveness analysis, asthma exacerbations, salbutamol, aminophylline Abstrak— Pengobatan serangan asma dapat dilakukan dengan cara pemberian terapi pengobatan, yaitu salbutamol dan aminofilin. Penelitian ini merupakan penelitian yang dilakukan dengan studi perbandingan antara dua alternatif yang ada dengan menggunakan perspektif rumah sakit. Pengumpulan data dilakukan secara retrospektif berdasarkan basis data rekam medik pasien serangan asma mild moderate yang di IGD di Rumah Sakit Umum Anwar Medika Sidoarjo periode Januari 2017 sampai dengan Desember 2018. Data efektivitas dan biaya pengobatan serangan asma dianalisis dengan ACER. Dari hasil analisis data diperoleh nilai ACER berdasarkan total perbaikan gejala pada kelompok salbutamol sebesar Rp.2.403,75/%, dan kelompok aminofilin sebesar Rp.1.688,31/%. Berdasarkan hasil penelitian, tidak dapat disimpulkan terapi pengobatan yang lebih cost-effective karena jumlah subjek kelompok salbutamol dan kelompok aminofilin yang berbeda dan terlalu sedikit. Dari hasil analisis data diperoleh nilai ACER berdasarkan total perbaikan gejala pada penggunaan salbutamol tunggal sebesar Rp.2.073,18/%, pada kelompok salbutamol dan kortikosteroid sebesar Rp.2.573,40/%. Berdasarkan hasil nilai ACER tersebut, kelompok salbutamol tunggal lebih cost-effective dibandingkan kelompok salbutamol dan kortikosteroid berdasarkan perbaikan gejala pada pasien serangan asma mild moderate di IGD. Kata kunci: analisis efektivitas biaya, serangan asma, salbutamol, aminofilin

Co-Authors Abdul Rahem Abdul Rahem Abdul Rahem, Abdul Adi Suroso Agus Aan Adriansyah Aguslina Kirtishanti Aguslina Kirtishanti Akbar, Muhammad Reza Aprililo Amalia, Ratna Ayu Amilia, Eva Amir, Adilah Fatin Amir, Gabriella Ayuni Anak Agung Pradnya Paramitha Vidiani Ananda Yudiarso Ananta Yudiarso Ananta Yudiarso Ananta Yudiarso Andayani, Tri M. Andryanto, M. Hasan Anggara Martha Pratama Anggara Martha Pratama Anindita Dyah Pratiwi Anizzalati, Fida Shafi Anugrah Putri Aprilia Aprianti , Pande Made Ayu Arisandi, Jeffri asri dewayani Asti Indah Purwati AYU LESTARI Aziz Hubeis Benny Canggih Budhi Setianto Budipramana, Krisyanti Canggih, Beny Canggih, Beny Damayanti, Melly Dea Amelia Aditya Winata Devitya A. Sukarno Dhiba, Zahwa Diah Fatmala Dian Natasya Raharjo Dian Natasya Raharjo Dian Natasya Raharjo Diana Syarifah Diputra, I Nyoman Yoga Doddy de Queljoe Doddy de Queljoe Doddy de Queljoe Doddy de Queljoe, Doddy de Dwi Octamy Sari Dwi Wahyuningtyas Ema Arifatul Masruroh Emiliana Lamur Endang Wahjuningsih Endang Wahjuningsih Erdiansyah, Muhammad Erlin Oktavia Ferdias Kurnia Bahari Findry Rafsanjani Herwansyah Firanita, Lisma D. Fitrianingsih, Nurul Gebriella Ayuni Amir Gitaputri, Putu Aprilya Gora Dirga Kusuma Hantoro, Khaula A. A. Hary Bagijo Haryoko, Sugeng Hayati, Siti Nur Heru, Astri I Gede Agus Sindhu Aditama I Nyoman Yoga Diputra Ika Sari Wahyuningtyas Indraswari, Putu Ika Indah Jalmav, Marthy Meliana Jalmav, Marthy Meliana Ariyanti Juwariya, Firdayatul Kadek Yeni Dian Rismawati Karina, Bella Lony Kezia Sefania Khaula A. A. Hantoro Lalita Tirsa Leonardo Immanuel Lestiono Lestiono Liana Widharta Lidia Junita Lidia Junita Linggani Linggani Linggani Linggani Lisa Aditama, Lisa Lisiska, Natalia Lisma D. Firanita M Budi Indra Sudaryatmono Made Dwike Swari Santi Mahfidz, Ikhwan Khairul Mahmudah, Rifaatul Laila Maranatha, Daniel Mariana Wahjudi Mariana Wahjudi Mariana Wahjudi, Mariana Mariana Wahyudi Marthy Meliana Ariyanti Jalmav Masruroh, Ema Arifatul Matina Naim Muhammad Erdiansyah Natalia Lisiska Nathania, Jessica Nathania, Jessica Navaul Setiya Ningrum Nevyta Fitriandasari Ni Luh Mitha Rini Chandra Ni Wayan Deviani Susanti Ningrum, Navaul Setiya Noer Lailatul Istiqomah Novelia Gandawari Nuning Farida Nur Annisa Yuliana NURUL FITRIANINGSIH Nurul Safina Nyoman Yoga Diputra Pambagyanik, Apridita Anggun Pande Made Ayu Aprianti Pandu Laksono, Pandu Pratama, Anggara Martha Putu Melista Putri Raharjo, Dian Natasya Richa Ratnasari Richa Ratnasari Rifaatul L. Mahmudah Rifaatul Laila Mahmudah Rifaatul laila Mahmudah Rifaatul Laila Mahmudah Rika K. Sari Rika Yulia Rivan V. Suryadinata Rivan V. Suryadinata Rivan V. Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rizka I Wijaya Rizki Amalia Rizki, Rahmat Rizkia Arrahmah Salsabila, Unik Hanifah Santosa, Kristian Abram Saputra, I Nyoman Dodi Saputra, Rifaldi Saputra, Rifaldi Sari, Nina Purnama Sari, Nina Purnama Sari, Rika K. Saswita, Nuke Savitri, Kadek Yuli Dwi Selvia Agustina Selvia Agustina Septinellya, Cinthya Farah Sigar, Tiara Regina Beatriks Silitonga, Esteria Siska Fatkhul Hidayati Siska Rian Pratiwi Siti Saharah Abdullah Soedarsono Soedarsono Sri Rahayu Sugiarto Widjaja Supriadi Supriadi Suryadinata, Rivan V. Suryadinata, Rivan Virlando Suud Suud, Suud Suyanto Suyanto Suyanto Syahrani, Achmad Tangkilisan, Elisabeth Carolina Tinaka, Adela Juana Tri M. Andayani Tri Murti Andayani Tri Murti Andayani Try Suryandi Umi Fatmawati Vanny Sutjipto Wahjuningsih, Endang Wardani, Mariani Ika Wati, Angela Nofvianti Cahyo Widyati . Wijaya, Rizka Indra Wijaya, Rizka Indra Wijono, Heru Yessica Christina Wijaya Tandjung Yorasaki, Yosy Athaya Zullies Ikawati

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