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Studi Pendahuluan Polimorfisme Genetik Gen CYP1A2*1F pada Pasien Asma dan Nonasma di Indonesia Doddy de Queljoe; Mariana Wahjudi; Muhammad Erdiansyah; Rivan V. Suryadinata; Amelia Lorensia
Indonesian Journal of Clinical Pharmacy Vol 4, No 1 (2015)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.297 KB) | DOI: 10.15416/ijcp.2015.4.1.8

Abstract

Polimorfisme genetik CYP1A2 berkaitan dengan metabolisme teofilin sehingga dapat memengaruhi kadar obat dalam darah serta berpengaruh terhadap kejadian adverse drug reaction (ADR) dan outcome klinis terapi asma. Frekuensi polimorfisme CYP1A2 diketahui bervariasi antar etnis. Diduga populasi Indonesia memiliki frekuensi varian gen CYP1A2*1F yang tinggi. Penelitian ini bertujuan untuk mengetahui profil polimorfisme gen CYP1A2*1F pada sampel nonasma dan asma di Indonesia dengan populasi lain berdasarkan literatur. Pengambilan data dilakukan pada Januari–Juni 2014. Sampel darah diperoleh dari 29 orang nonasma dan 16 pasien asma. Setelah dilakukan ekstraksi DNA genomik kemudian ditentukan polimorfisme gen CYP1A2*1F dengan metode PCR-RFLP. Hasil penelitian ini menunjukkan bahwa polimorfisme gen CYP1A2*1F pada sampel nonasma adalah 10,35% (3/29) untuk C/C, 37,93% (11/29) untuk C/A dan 51,72% (15/29) untuk A/A. Pada penderita asma frekuensi distribusi genotip C/A sebesar 81,25% (13/16) dan A/A sebesar 18,75% (3/16). Tidak terdapat perbedaan signifikan (p=0,276) frekuensi alel antara sampel nonasma dan pasien asma. Frekuensi gen CYP1A2*1F pada populasi  Indonesia lebih besar dibandingkan dengan populasi Mesir, Jepang, dan Inggris akan tetapi lebih rendah dibandingkan dengan Malaysia. Oleh karena itu, dapat disimpulkan tidak terdapat perbedaan frekuensi.Kata kunci: Asma, CYP1A2*1F, polimorfisme genetikPilot Study on Genetic Polymorphisms CYP1A2*1F on Asthma Patients and Nonasthma in IndonesiaGenetic polymorphisms of CYP1A2 is related to the theophylline metabolism that may affect drug levels in the blood, which can also affect incidence of adverse drug reaction (ADR) and clinical outcomes of asthma therapy. The frequency of CYP1A2 polymorphism is known to vary among ethnic. Allegedly the Indonesian population has high frequency of gene variants of CYP1A2*1F. This study aims to determine the profile of CYP1A2*1F gene polymorphism in a sample of nonasthma and asthma in Indonesia with other populations based on the literature. Data were taken on January–June 2014. Blood samples were obtained from 29 nonasthma samples and 16 patients with asthma. After extraction of genomic DNA, CYP1A2*1F gene polymorphisms determined by PCR-RFLP. The results of this study indicate that the CYP1A2*1F gene polymorphism in nonasthma samples was 10.35% (3/29) for C/C, 37.93% (11/29) for the C/A, and 51.72% (15/29) for A/A. The asthmatics genotype have a frequency distribution of C/A genotype of 81.25% (13/16) and A/A of 18.75% (3/16). There was no significant difference (p=0.276) allele frequencies between samples of nonasthma and asthma patients. The frequency of CYP1A2*1F gene in Indonesian population is higher than the population of Egypt, Japan, and UK, but lower compared to Malaysia. It can be concluded that there is no difference in frequency.Keywords: Asthma, CYP1A2*1F, genetic polymorphisms
Efektivitas dan Risiko Toksisitas Aminofilin Intravena pada Pengobatan Awal Serangan Asma Amelia Lorensia; Zullies Ikawati; Tri M. Andayani; Rivan V. Suryadinata; Khaula A. A. Hantoro; Lisma D. Firanita
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.49 KB) | DOI: 10.15416/ijcp.2018.7.2.78

Abstract

Asma merupakan penyakit inflamasi kronis pada saluran pernafasan yang mempunyai prevalensi global yang cukup besar. Perburukan penyakit asma berupa serangan asma yang menyebabkan peningkatan gejala asma dan penurunan fungsi paru secara progresif. Salah satu obat asma yang masih sering digunakan di Indonesia adalah aminofilin intravena. Aminofilin merupakan obat dengan rentang terapi sempit yang berisiko menyebabkan toksisitas obat, namun data perbandingan keuntungan efektivitas dan keamanan obat tersebut belum memadai. Penelitian ini bertujuan untuk mengetahui efektivitas aminofilin intravena pada pengobatan awal serangan asma berupa perbaikan gejala asma dan kejadian toksisitas terkait gejala yang muncul dan kadar teofilin dalam darah di suatu rumah sakit di Surabaya, Indonesia. Penelitian ini menggunakan metode pra-eksperimental yang dilaksanakan sejak 2014 hingga 2016. Sebanyak 27 pasien terlibat dalam penelitian ini. Terapi yang diberikan adalah aminofilin intravena selama satu jam. Metode sampling yang digunakan adalah consecutive sampling dengan teknik analisis deskriptif dan jum. Semua subjek penelitian menunjukkan perbaikan gejala serangan asma dengan terapi aminofilin intravena selama satu jam, dan tidak ada yang mengalami toksisitas karena kadar teofilin dalam darah di bawah rentang terapi. Aminofilin masih efektif dalam mengurangi gejala pada serangan asma dan tidak menunjukkan risiko toksisitas.Kata kunci: Aminofilin, efektivitas, serangan asma, toksisitas Effectiveness and Toxicity Risk of Intravenous Aminophylline in Exacerbation Asthma TreatmentAbstractAsthma is a chronic inflammatory disease in the respiratory tract that has a considerable global prevalence. The worsening of asthma is an asthma attack that causes asthma symptoms to increase and decreased lung function progressively. One of the most commonly used asthma medications in Indonesia is intravenous aminophylline. Aminophylline is a drug with a narrow range of therapies that is at risk of causing drug toxicity, but the comparative data on the efficacy and safety benefits of the drug are inadequate. This study aimed to determine the effectiveness of aminophylline intravenously in the early treatment of asthma attacks in the form of improvements in asthma symptoms and toxicity events related to the symptoms that appear and blood theophylline levels in a hospital in Surabaya, Indonesia. This study used a pre-experimental method which was carried out from 2014 to 2016. A total of twenty seven patients were involved in the study. The therapy given was aminophylline intravenously for one hour. The sampling method used was consecutive sampling with descriptive analysis technique. All subjects showed improved symptoms of asthma attacks with intravenous aminophylline therapy for one hour, and none had toxicity due to theophylline levels in the blood below the therapeutic range. Aminophylline is still effective in reducing symptoms in asthma attacks and does not indicate the risk of toxicity.Keywords: Aminophylline, asthma attack, effectiveness, toxicity
Hubungan Persepsi Penyakit (Illness Perception) dengan Kontrol Gejala Asma pada Pasien Rawat Jalan Amelia Lorensia; Rika Yulia; Ika Sari Wahyuningtyas
MPI (Media Pharmaceutica Indonesiana) Vol. 1 No. 2 (2016): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.981 KB) | DOI: 10.24123/mpi.v1i2.191

Abstract

Prevalensi asma cukup tinggi di Indonesia. Terapi asma memerlukan self-managementyang baik dari pasien yang meliputi persepsi dan pemahaman terhadap penyakit. Persepsi penyakit(illness perception) dapat mempengaruhi kepatuhan pasien dalam pengobatan yang dapat menyebabkantujuan terapi tidak tercapai. Penelitian ini bertujuan mengetahui seberapa besar hubunganpersepsi penyakit dengan hasil outcome klinis berupa kontrol gejala asma. Oleh karena itu, dilakukanpenelitian hubungan persepsi sakit (illness perception) dan kontrol asma. Penelitian ini merupakannon eksperimental melalui pengisian kuesioner oleh responden. Responden dalam penelitianini adalah pasien asma yang menjalani rawat jalan di suatu apotek swasta di Surabaya. Kuesioneryang digunakan dalam penelitian ini adalah Asthma Control Test (ACT) dan Illness PerceptionQuestionnaire (IPQ). Besar sampel penelitian adalah 20 orang yang seluruhnya memiliki controlasma yang baik. Hasil penelitian ini menunjukkan bahwa 65% responden asmanya terkontrol denganbaik; 40% responden merasa asmanya tidak berpengaruh terhadap aktifitas; 50% respondenmerasa obat-obatan yang digunakan membantu serangan asma. Ada hubungan antara kontrol asmadan persepsi penyakit dalam aspek personal control dan identity. Tetapi, tidak terdapat hubunganantara kontrol asma dan persepsi penyakit dalam aspek consequences, timeline, treatment control,concern, dan emotional response.
Cost-Effectiveness Analysis Kloramfenikol Dan Seftriakson Untuk Pengobatan Demam Tifoid Pada Pasien Dewasa Di Rumah Sakit Sanglah Denpasar Amelia Lorensia; Doddy de Queljoe; Made Dwike Swari Santi
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (518.615 KB) | DOI: 10.24123/mpi.v2i2.1391

Abstract

The number of typhoid fever patient in Indonesia is still high. Typhoid fever can be treated by antibiotic therapy such as chloramphenicol and ceftriaxone. The purpose of this study was to compare the cost-effectiveness of chloramphenicol and ceftriaxone which was given to adult patients who were diagnosed with typhoid fever in Sanglah Denpasar Hospital. A comparative study between two alternatives was conducted using the hospital perspective. Retrospective method was used to collect data from patient medical records, who was diagnosed and hospitalized in Sanglah Denpasar Hospital during January 2017 until July 2018. The cost analysis was perform using cost-effectiveness grid and cost-effectiveness ratio (ACER) methods. Cost-effectiveness grid showed that dominant of ceftriaxone for patient with typhoid fever. ACER analysis for ceftriaxone was IDR 2,097,170.88 with effectivenes (length of stay) 4.27 days, and was IDR 2,097,170.88 with effectiveness (the time of reaching normal temperature) 2.42 days. ACER analysis for chloramphenicol was IDR 2,555,464.22 with effectivenes (length of stay) 10.22 days, and was IDR 2,555,464.22 with effectiveness (the time of reaching normal temperature) 3.44 days. ACER analysis showed lower degree of ceftriaxone and higher effectiveness based on length of stay and the time of reaching normal temperature. The conclusion of this study is that ceftriaxone is more cost-effective than chloramphenicol.
Drug-related problems and clinical risk factors relationship in hepatic cirrhosis patients Amelia Lorensia; Widyati .; Aziz Hubeis; Hary Bagijo
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (190.249 KB) | DOI: 10.14499/indonesianjpharm0iss0pp223-228

Abstract

Diffusion  processes  in  hepatic  cirrhosis  is  characterized  with  fibrosis  and structural changed. Patients with cirrhosis are at risk to get problems because of the  effects  of  the  drugs  used  have  drug-related  problems  (DRPs),  due  to changes  in  heart  function  that  affects  many  aspects of  drug  pharmacokinetics. Therefore,  treatment  of  patient  with  hepatic  cirrhosis  should  consider  the  drug and  dose  adjustment  so  that  subsequent  problems  could  be  avoided.  The research  method  was  prospective  and  descriptive,  with  a  purposive  sampling technique.  Patients’s  treatment  were  monitoring  and analyzed.  Significance  of 0000  means  that  p  (0000)  <0.05,  then  the  Pearson  correlation  test  results  are H1a, ie there was a relationship between the numberof DRPs events by the total number of clinical risk factors of DRPs in patientswith cirrhosis. Therefore from this relationship could be expected to know the possible risk of DRPs in patients. The  increasing  number  of  clinical  risk  factors  DRPs in  patients  with  cirrhosis, indicate  thatthe  patient  should  receive  a  more  stringent  monitoring  of  the provision of therapy because the risk of experiencing DRPs more.Key words: cirrhosis, drug related problems (DRPs), clinical risk factors of DRPs
GAMBARAN PERSEPSI PENYAKIT TERHADAP KESEHATAN FUNGSI PARU PADA PASIEN ASMA DI SURABAYA Amelia Lorensia; Rivan Virlando Suryadinata; Richa Ratnasari
The Indonesian Journal of Public Health Vol. 14 No. 2 (2019): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.952 KB) | DOI: 10.20473/ijph.v14i2.2019.263-271

Abstract

Asthma could affect quality of life and decrease productivity. The worsening of asthma symptoms also affected lung function. Symptoms of asthma could be control by self-management. The patient's behavior in self-management influenced by his perception of asthma.  This research aims to determine  effect of perception of disease on health function of parents in asma patients in surabaya. Research using observational methods with cross sectional design. Research Subjects were outpatient asthma patients aged 17-25 years. Data collection was conducted from June 2015 to January 2016 in Surabaya, to 27 people.  Assessment of asthma perception use Illness Perception Questionnaire (IPQ) and health condition of lung function with peak flow meter to assess PEF (peak expiratory flow). The results of this study indicate that both groups have a PEF value <50% of the estimated PEF value. The data showed no significant difference (p (0.766)> 0.05) between disease perceptions based on the number of asthma-related symptoms with lung function (PEF), with the greatest answer as the cause of asthma that is genetic. Therefore, the perception of asthma does not affect lung function (PEF) in adult asthma patients in Surabaya.
PROFIL VITAMIN D PADA PASIEN ASMA DAN NON-ASMA DEWASA DI SURABAYA Rivan Virlando Suryadinata; Amelia Lorensia; Anugrah Putri Aprilia
The Indonesian Journal of Public Health Vol. 12 No. 1 (2017): The Indonesian Journal Of Public Health
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (295.274 KB) | DOI: 10.20473/ijph.v12i1.2017.106-117

Abstract

Asthma is a chronic inflammatory disease on respiratory tract, where airflow are retricted dan chronic inflammation result in bronchial epithelium damage. Pathogenesis mechanism of asthma is influenced by vitamin D as an immunomodulator. The low vitamin D levels can trigger asthmaexacerbations. The study aimed to determine the levels of vitamin D from blood sample in astmatic young adult in compared to non astmatics, to identify the risk of vitamin D deficiency, that can aggravate asthma symptoms. The study used an observational analytic cross sectional design. Subjects were chosenthrough a purposive sampling method. Population was young adults in Surabaya. Subjects were 26 asthmatic patientsdan 26 non-asthmatic young adult in South Surabaya that fulfilled inclusion dan exclusion criteria. The study was conducted in May 2015 to July 2016. The results showed vitamin Dlevels in the asthma group 24.5 ± 2.95 while in the non-asthma group 20.52 ± 2.47. All respondents in both groups had vitamin D levels > 30 ng/mL (normal value), dan there was significant difference between levels of vitamin D in asthma dan non-asthma patients (p < 0.05). Therefore, increasing knowledge about the importance of vitamin D should be done, because it can change behavior through lifestyle, diet dan physical activity in the community.Keywords: asthma, vitamin D
PROFIL ASUPAN MAKRONUTRIEN PADA PENGEMUDI OJEK ONLINE DI SURABAYA Rivan Virlando Suryadinata; Amelia Lorensia; Vanny Sutjipto
Journal of Industrial Hygiene and Occupational Health Vol 6, No 1 (2021): Industrial Hygiene and Occupational Health
Publisher : Universitas Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/jihoh.v6i1.4861

Abstract

Pekerjaan menjadi pengemudi ojek online memiliki tantangan tersendiri. Penghasilan dan waktu mendapatkan penumpang yang tidak menentu menjadi salah satu faktor pengemudi ojek memiliki pola makan yang tidak teratur. Sebagian besar pengemudi ojek online lebih cenderung untuk menggunakan waktu luangnya dengan camilan atau merokok. Hal tersebut akan berdampak pada kebutuhan asupan makronutrien setiap hari seperti karbohidrat, protein dan lemak. Gangguan asupan makronutrien akan memicu terjadinya gangguan metabolisme tubuh. Penelitian ini bertujuan untuk mengetahui asupan makronutrien secara semikuantitatif pada pengemudi ojek online yang merokok dengan menggunakan Food Frequency Questionnaires (FFQ). Metode penelitian ini berjenis observasional dengan pendekatan secara cross sectional. Responden penelitian merupakan pengemudi ojek online di Surabaya yang berjumlah 49 orang dan dipilih secara purposive sampling. Instrumen yang digunakan adalah Food Frequency Questionnaires. Hasil penelitian ini memperlihatkan sebagian besar kebutuhan makronutrien pada pengemudi ojek online dapat dikategorikan cukup terutama pada asupan karbohidrat (95,92%), sedangkan protein (67,35%) dan lemak (65,31%). Kesimpulan kebutuhan asupan makronutrien sebagian besar terpenuhi pada pengemudi ojek online di Surabaya.Kata Kunci: asupan; makronutrien; pengemudi ojek
Cost-Effectiveness Analysis of Pharmacotherapy for Hematemesis-Melena Treatment in Hospitalized Patients with Hepatic Cirrhosis Doddy de Queljoe; Amelia Lorensia; Liana Widharta; Sugiarto Widjaja
The Indonesian Biomedical Journal Vol 5, No 1 (2013)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v5i1.50

Abstract

BACKGROUND: Acute variceal haemorrhage is a complication of cirrhosis that can be life threatening. It is a pharmacist’s duty to ensure therapeutic and pharmaceutical care which is not only safe and effective for the patient but also is cost-effective in order to attain improvement of the patient’s quality of life. Therefore, pharmacoeconomic evaluation especially cost-effectiveness analysis (CEA), which compares costs and consequences of drug therapy, is needed. This study was aimed to evaluate the therapeutic cost-effectiveness of hematemesis-melena treatment in hepatic cirrhotic patients.METHODS: A total of 42 patients receiving vitamin K and vitamin K-transamin were studied retrospectively from patients’ medical records in 2 years and analyzed with cost-effectiveness grid and average cost-effectiveness ratio (ACER) based on Child-Turcotte-Pugh (CTP) Score.RESULTS: Cost-effectiveness grid was dominant for vitamin K in patients with CTP Score A. ACER analysis showed a lower score for vitamin K in all patients included CTP Score classification. There was no significant difference in duration of cessation of bleeding treatment in patients with vitamin K compared with vitamin K-transamin in patients with CTP Score A and B, while significant difference was found in patients with CTP Score C.CONCLUSION: Vitamin K appeared to be more cost effective as compared with vitamin K-transamin in all patients. The use of vitamin K had greater benefit than the combination with transamin in all patients and CTP Score classification, and thus should be considered as a primary therapy. Therefore, transamin addition as an alternative therapy for hepatic cirrhosis patients with hematemesis-melena should be considered.KEYWORDS: CEA, cost-effectiveness analysis, child-turcotte-pugh score, hepatic cirrhosis, hematemesismelena, vitamin K, transamin
CYP1A2 Gene Polymorphism and Theophylline Level in Asthma Amelia Lorensia; Zullies Ikawati; Tri Murti Andayani; Daniel Maranatha; Mariana Wahyudi
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.475

Abstract

BACKGROUND: Aminophylline (theophylline) is one of the most frequent asthma therapies in Indonesia, although it remains as a narrow therapy. The effects of drugs are individualized and strongly influenced by genetic, one of which is CYP1A2 gene polymorphisms. This study aimed to determine the profile of CYP1A2 polymorphism and theophylline level in asthma exacerbation patients receiving intravenous aminophylline therapy.METHODS: This cross sectional study was conducted in the emergency room (ER), to adults asthma exacerbation patients without complication (n=27), visiting the ER. The gene polymorphism data were compared with theophylline levels in the blood using chi-square test.RESULTS: In the CYP1A2 gene polymorphism profile, the most common heterozygous alleles are T/G genotype of CYP1A2*1E and C/A genotype of CYP1A2*1F. Most homozygote alleles exist in CYP1A2*1D and CYP1A2*1F. There was significant difference between CYP1A2*1D (p<0.005), CYP1A2*1E (p<0.023) and CYP1A2*1F (p<0.000) polymorphisms and theophylline level.CONCLUSION: CYP1A2*1D, CYP1A2*1E and CYP1A2*1F gene polymorphisms had an effect on theophylline levels. However, no one experienced an overdose theophylline, and no correlation between theophylline levels with CYP1A2 gene polymorphism.KEYWORDS: exacerbation asthma, intravenous aminophylline, CYP1A2 polymorphism gene, theophylline
Co-Authors Abdul Rahem Abdul Rahem Abdul Rahem, Abdul Adi Suroso Agus Aan Adriansyah Aguslina Kirtishanti Aguslina Kirtishanti Akbar, Muhammad Reza Aprililo Amalia, Ratna Ayu Amilia, Eva Amir, Adilah Fatin Amir, Gabriella Ayuni Anak Agung Pradnya Paramitha Vidiani Ananda Yudiarso Ananta Yudiarso Ananta Yudiarso Ananta Yudiarso Andayani, Tri M. Andryanto, M. Hasan Anggara Martha Pratama Anggara Martha Pratama Anindita Dyah Pratiwi Anizzalati, Fida Shafi Anugrah Putri Aprilia Aprianti , Pande Made Ayu Arisandi, Jeffri asri dewayani Asti Indah Purwati AYU LESTARI Aziz Hubeis Benny Canggih Budhi Setianto Budipramana, Krisyanti Canggih, Beny Canggih, Beny Damayanti, Melly Dea Amelia Aditya Winata Devitya A. Sukarno Dhiba, Zahwa Diah Fatmala Dian Natasya Raharjo Dian Natasya Raharjo Dian Natasya Raharjo Diana Syarifah Diputra, I Nyoman Yoga Doddy de Queljoe Doddy de Queljoe Doddy de Queljoe Doddy de Queljoe, Doddy de Dwi Octamy Sari Dwi Wahyuningtyas Ema Arifatul Masruroh Emiliana Lamur Endang Wahjuningsih Endang Wahjuningsih Erdiansyah, Muhammad Erlin Oktavia Ferdias Kurnia Bahari Findry Rafsanjani Herwansyah Firanita, Lisma D. Fitrianingsih, Nurul Gebriella Ayuni Amir Gitaputri, Putu Aprilya Gora Dirga Kusuma Hantoro, Khaula A. A. Hary Bagijo Haryoko, Sugeng Hayati, Siti Nur Heru, Astri I Gede Agus Sindhu Aditama I Nyoman Yoga Diputra Ika Sari Wahyuningtyas Indraswari, Putu Ika Indah Jalmav, Marthy Meliana Jalmav, Marthy Meliana Ariyanti Juwariya, Firdayatul Kadek Yeni Dian Rismawati Karina, Bella Lony Kezia Sefania Khaula A. A. Hantoro Lalita Tirsa Leonardo Immanuel Lestiono Lestiono Liana Widharta Lidia Junita Lidia Junita Linggani Linggani Linggani Linggani Lisa Aditama, Lisa Lisiska, Natalia Lisma D. Firanita M Budi Indra Sudaryatmono Made Dwike Swari Santi Mahfidz, Ikhwan Khairul Mahmudah, Rifaatul Laila Maranatha, Daniel Mariana Wahjudi Mariana Wahjudi Mariana Wahjudi, Mariana Mariana Wahyudi Marthy Meliana Ariyanti Jalmav Masruroh, Ema Arifatul Matina Naim Muhammad Erdiansyah Natalia Lisiska Nathania, Jessica Nathania, Jessica Navaul Setiya Ningrum Nevyta Fitriandasari Ni Luh Mitha Rini Chandra Ni Wayan Deviani Susanti Ningrum, Navaul Setiya Noer Lailatul Istiqomah Novelia Gandawari Nuning Farida Nur Annisa Yuliana NURUL FITRIANINGSIH Nurul Safina Nyoman Yoga Diputra Pambagyanik, Apridita Anggun Pande Made Ayu Aprianti Pandu Laksono, Pandu Pratama, Anggara Martha Putu Melista Putri Raharjo, Dian Natasya Richa Ratnasari Richa Ratnasari Rifaatul L. Mahmudah Rifaatul Laila Mahmudah Rifaatul laila Mahmudah Rifaatul Laila Mahmudah Rika K. Sari Rika Yulia Rivan V. Suryadinata Rivan V. Suryadinata Rivan V. Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rivan Virlando Suryadinata Rizka I Wijaya Rizki Amalia Rizki, Rahmat Rizkia Arrahmah Salsabila, Unik Hanifah Santosa, Kristian Abram Saputra, I Nyoman Dodi Saputra, Rifaldi Saputra, Rifaldi Sari, Nina Purnama Sari, Nina Purnama Sari, Rika K. Saswita, Nuke Savitri, Kadek Yuli Dwi Selvia Agustina Selvia Agustina Septinellya, Cinthya Farah Sigar, Tiara Regina Beatriks Silitonga, Esteria Siska Fatkhul Hidayati Siska Rian Pratiwi Siti Saharah Abdullah Soedarsono Soedarsono Sri Rahayu Sugiarto Widjaja Supriadi Supriadi Suryadinata, Rivan V. Suryadinata, Rivan Virlando Suud Suud, Suud Suyanto Suyanto Suyanto Syahrani, Achmad Tangkilisan, Elisabeth Carolina Tinaka, Adela Juana Tri M. Andayani Tri Murti Andayani Tri Murti Andayani Try Suryandi Umi Fatmawati Vanny Sutjipto Wahjuningsih, Endang Wardani, Mariani Ika Wati, Angela Nofvianti Cahyo Widyati . Wijaya, Rizka Indra Wijaya, Rizka Indra Wijono, Heru Yessica Christina Wijaya Tandjung Yorasaki, Yosy Athaya Zullies Ikawati