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All Journal HAYATI Journal of Biosciences Khizanah al-Hikmah : Jurnal Ilmu Perpustakaan, Informasi, dan Kearsipan Nursing News : Jurnal Ilmiah Keperawatan An-Nuha : Jurnal Kajian Islam, Pendidikan, Budaya Dan Sosial MIX : Jurnal Ilmiah Manajemen AFEBI Economic and Finance Review Journal of Midwifery and Nursing FITOFARMAKA: Jurnal Ilmiah Farmasi MANAGERIA: Jurnal Manajemen Pendidikan Islam Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming JIMF (JURNAL ILMIAH MANAJEMEN FORKAMMA) Proceedings of International Conference on Da'wa and Communication International Journal of Economics Development Research (IJEDR) HERBAPHARMA : Journal of Herb Farmacological Jurnal Aksioma Al-Musaqoh ABDI MOESTOPO: Jurnal Pengabdian pada Masyarakat Mejuajua International Journal of Science and Society (IJSOC) Journal of Islamic Management International Journal of Tourism and Hospitality in Asia Pasific Abdimas Indonesian Journal Journal of Islamic Economics Lariba Innovative: Journal Of Social Science Research Warta LPM International Journal of Islamicate Social Studies Al-Urwatul Wutsqo: Jurnal Ilmu Keislaman Dan Pendidikan Jurnal Siber Transportasi dan Logistik Society
Imas Maesaroh
IAIN Syekh Nurjati Cirebon
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Journal : HAYATI Journal of Biosciences

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Anticancer Activities and Metabolite Profiling of UHPLC-HRMS Method from Chrysanthemum x morifolium (Ramat.) Hemsl Leaves Maesaroh, Imas; Barliana, Melisa Intan; Abdulah, Rizky; Muhaimin, Muhaimin
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.167-180

Abstract

The Chrysanthemum morifolium Ramat, traditionally used for cancer treatment, including breast cancer, possesses anticancer properties. The aim of this study is metabolite profiling using ultra-high-performance liquid chromatography in conjunction with the high-resolution mass spectrometry (UHPLC-HRMS) technique and its correlation with the cytotoxic activity of the extract and ethyl acetate fraction of Chrysanthemum x morifolium (Ramat.) Hemsl leaves on cancer cells. The ethyl acetate fraction from the hydrolyzed ethanol extract of (Chrysanthemum x morifolium (Ramat.) Hemsl) leaves has anticancer activity against the MCF-7 breast cancer cells. Metabolite profiling was used to understand the presence of metabolites that have anticancer activity. UHPLC-HRMS was used to profile their metabolites. Compound Discoverer 3.3 software finished data processing and metabolite annotation. Anticancer activity was performed using the 2-[2-methoxy-4-nitrophenyl]-3[4-nitrophenyl]-5[2,4-disulfophenyl]-2H-tetrazolium (WST-8) assay. As many as 57 secondary metabolites were identified by UHPLC-HRMS analysis. Secondary metabolites that have the potential as anti-breast cancer are glycitein, diosmetin, kaempferol, esculetin, scopoletin, dihydroartemisinin, and Chrysin, with successive percentages of 31.39%, 19.91%, 5.61%, 2.63%, 0.82%, 0.14%, and 0.05%. Ethyl acetate fraction showed stronger cytotoxic activity than ethanol extract against MCF-7 cells with IC50 values of 66.31 ppm at 24 hours incubation and 40.35 ppm at 48 hours. Further research can be conducted on the isolation of flavonoids from the ethyl acetate fraction, as well as the analysis of cell cycle apoptosis stimulation and gene expression mechanisms.
Co-Authors ABDUL MUJIB Adhitama, Tias Satria Ahmad Fadili, Dadan Albert Gamot Malau Ami Pujiwati Andriyansah . Anggraeni, Silvi Annisa, Hanun Nur Aprilia, Ilma Astuti, Luvhy Dwi Bambang Aditya Nugraha Basir, Mohammad Cucu Suhartini Devi Ayuni Diputra, Angga Anugra Eha Saleha Ema Arum Rukmasari Faizal Madya Fatkhurrohmah, Nurindah Firmansyah Firmansyah Fu'adi, Ahmad Najib Ginta Ginting, Ginta H, Angga Sucitra Hadiwidjaja, Rini Dwiyani Hadiyana Sukandar, Hadiyana Hana Handayani Hanny Hafiar Hasna, Lathifah Hastuti, Hediati Hendrayanaama, Angga Sucitra Hidayah, Zainur Ike Janita Dewi Ilmi, Muhammad Nasrulloh Irmawaty Irmawaty, Irmawaty Janita, Ike Kartikawati, Rr. Lisa Karwati, Karwati Kholis, Nur Komar Priatna, Deden Ledy Yolanda Lestari Pujiastuti, Sri Lilis Mamuroh marsigid, didik Mawaddah, Isdiadatul Meiliani Meiliani Melisa Intan Barliana Minrohayati . Muhaimin Muhaimin Muhammad Naufal, Ilham Muhrodi, Odi Nareswara, Anastu Regita Nasoha, Mohamad Nenah Sunarsih Nenden Nur Asriyani Maryam Ngarbingan, Hubertina Karolina Nopiana, Medi Nur Kholis Nursolihah, Siti Pradypta, Putu Gyzca Praningtyas, Elisabeth Ria Viana Pratiwi, Adinda Syani Prawesthi, Endang Prihananto, Prihananto Puji, Sri Lestari Purnama, Siska Putri Utami, Putri R, Radis Diding Rakhmini Juwita Ria Viana Praningtya, Elisabeth Riana, Kurnia Endah Ridwan, Ridwan Rima Yulia Senja, Rima Yulia Rini Subekti Riski Maulana, Riski Rizky Abdulah Rustina, Ina Salsabila, Dania Saputra, Sherly Annisa Siti Aisyah Siti Nurasiah, Siti Sri Lestari Pujiastuti, Sri Lestari Sukmawati Sukmawati Sylvana, Andi Tarsilah, Tarsilah Thaibd, Dina Wardaya, Ahmad Wildan Wisnu Widiya Avianti Wijayanti, Silvia Wiryani, Ani Siti