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Sonlimar mangunsong
Poltekkes Kemenkes Palembang
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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Spectroscopic analysis and cytotoxic activity of quas-sinoid isolated from the seeds of Brucea javanicaon Hela cell Sonlimar Mangunsong; Dwiprahasto I; Mustofa .; Jumina .
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.981 KB) | DOI: 10.14499/indonesianjpharm0iss0pp137-143

Abstract

The  quassinoids  from  Brucea  javanica exhibit  biological  activities  as antimalarial,  antitumor,  antiviral  and  antiamoebic  activities.  These  quassinoids having  a  promising  antitumor  activity.This  research was  aimed  to  isolated quassinoid  (bruceine  A,  MW  522  g/mol)   compound  from  B.  javanica and  to investigate  the  cytotoxicity  of  bruceine  A  under  invitro conditions  in  Hela  cells. The  cytotoxicity  assays   using   MTT  assay.  The  bruceine   showed  a  good cytotoxic  activity  in  Hela cells  at  24  hours  with  doxorubicine  as  a  positive control.  Structural  elucidation  of   bruceine   is  done  by   using  UV  and  FT-IR spectra,  NMR  spectra   recorded  on  Tesla  av600,  (400 MHz) 1HNMR  in  pyridine (D5),  some  in  Gyro  (300  MHz) 1HNMR  in  acetone-(d6),  DMSO-(d6)  and  CdCl3 ,13CNMR,  75  MHz,  mass  spectra  on  biospectrometry  LC-MS.  Analytical  HPLC retention time,tRwas 4.617 minutes (Met/H20) 60:40. Its Molecular formula was determined  to  be  (  C26 H34  O11)  by  the  [M+H]+ ion  peak  at  m/z  523 and  m/z 1045 confirmed by High Resolution mass spectra Orbitrap (HRESIMS). From the results demonstrated that could be bruceine A compound refers to our spectral data.  Its  has   activity  in  IC50 value  191,5  µM  on  Hela  Cells  under  invitro conditions.Key words: Quassinoid, B. javanica,Brusein A, Spectroscopic, Anticancer 
Co-Authors ., Listrianah Ade Agustianingsih Afifah Rahmah, Afifah Aguscik, Aguscik Agustianingsih, Ade Akbar, Widyan Muchzadi Anayani Dalilah ANITA OKTARIANI APRILLINA, PERMATA Athiutama, Ari Athur Bayunata Bayunata, Athur Bianggo NauE, Dian Adhe Cica Meliza Dahliyah Hayati Dahliyah Hayati Dalilah, Anayani Dewi Marlina Dian Adhe Bianggo Naue Dwiprahasto I Eka Puspa Sari Elvi Sunarsih Fadly Fadly Fadly Fadly FADLY FADLY Fransiska Angelina Hartati, Yuli Hayati, Dahliyah Helda Mirani Jumina . KURNIANTO, TEGUH Lega Aryanti Lia Marsela Lia Puspitasari LILIS MARYANTI Listrianah . M. Nizar M. Nizar Manurung, Monika Septiana Mas'ud, Beri Meli Fitriyani Minda Warnis Mirani, Helda Mohammad Achmad Amin Soetomo Mona Rachmi Rulianti Mona Rahmi Mona Rahmi Rulianti Mona Rahmi Rulianti MONA RAHMI RULIANTI Monika Septiana Manurung Muhamad Taswin Muhammad Totong Kamaluddin Muhammad Totong Kamaluddin Muhammad Totong Kamaluddin Muntaha, Amar Mustofa . Oktari, Vivi OKTARIANI, ANITA Pastari, Marta Pastati, Taufik Meidiansyah Pebriani, Indra PERMATA APRILLINA Podojoyo, Podojoyo Pratiwi, Tiara Mayang Priscila Natalia Marpaung Purnama, Fajriah Rahma Arum Sari Rahmi Rulianti, Mona Ramadhiani, Aninditha Rachmah Ramadhiani, Aninditha Rachmah Resi Sukma Melati Rifqi Assiddiqy Rika Saputri Rulianti, Mona Rahmi Samarlina Simamora Sari, Alfitria Sarmadi Sarmadi Sarmalina Sarmalina Sarmalina Simamora Sarmalina Simamora Sarmalina Simamora Sefriadi, Ilham SIMAMORA, SAMARLINA Siregar, Estelita O.N. Soetomo, Mohammad Achmad Amin Sri Martini Sumastri, Heni Taswin, Muhamad TEGUH KURNIANTO Theodorus Theodorus Theodorus Theodorus Theodorus Theodorus Tiara Mayang Pratiwi Trisna Yuniarti Trisna Yuniarti VERA ASTUTI Vera Astuti, Vera Warnis, Minda Yani, Tiara Yunida Yunida Yunida Yunida