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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Nexus Kedokteran Klinik Nexus Biomedika Majalah Obstetri dan Ginekologi Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Medicine Journal of Maternal and Child Health Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdidas GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Plexus Medical Journal Indonesian Basic and Experimental Health Sciences
Eriana Melinawati
Departemen Ilmu Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Sebelas Maret/RSUD Dr. Moewardi, Surakarta, Indonesia
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Journal : Universa Medicina

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Mucin-1 expression in endometrium is higher in polycystic ovary syndrome than in normal women Budihastuti, Uki Retno; Sulistyowati, Sri; Melinawati, Eriana; Marbun, Yohan Pamuji
Universa Medicina Vol 39, No 2 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.805 KB) | DOI: 10.18051/UnivMed.2020.v39.74-80

Abstract

BackgroundThe polycystic ovary syndrome (PCOS) is caused by endocrine system dysfunction in women. MUCIN-1 (MUC-1) expression is found in endometrial tissues, which leads to implantation process dysfunction because of imbalance of trophoblast adhesion process. This study was conducted to compare endometrial MUC-1 expression between PCOS and normal women considering all existing external variables.MethodsThis cross-sectional study was conducted in General Hospital Dr. Moewardi Surakarta. Endometrial samples were obtained from 30 infertile PCOS women based on Rotterdam criteria, and 30 normal women. Life style and reproductive data such as age, menstrual problems, menstrual cycle, age at menarche, and BMI were collected. Subjects underwent endometrial biopsy in luteinizing hormone (LH) secretion phase LH + 5 days to LH + 10 days for immunohistochemistry (IHC) of MUC-1 expression. An independent-t and multiple linear regression test were used to analyze the data at significance level of p<0.05. ResultsMean MUC-1 expression in the PCOS endometrium (49.66 ± 47.79) was significantly higher than in normal women (7.66 ± 14.55) (p=0.03). Multivariate linear regression model of life style and reproductive variables with MUC-1 showed that PCOS (b=29.54; 95% CI 9.57-49.49; p=0.004) and BMI (b= 29.99; 95% CI 5.91-54.07; p=0.001) significantly increase MUC-1 expression. PCOS (Beta=0.37) was more important than BMI (Beta=0.30) in increasing the MUC-1 expression. ConclusionExpression of MUC-1 levels in the PCOS endometrium was higher than in normal women. This suggests that MUC-1 contributes to the unexplained reproductive failure in PCOS.
Co-Authors ., Darto Abd. Rasyid Syamsuri Abdurahman Laqif Abdurahman Laqif Abida Zuhra Jatiningtyas Agung Sari Wijayanti Alfi Marita Tristiarti Alfi Marita Tristiarti Alfi Marita Tristiarti Alifa, Rosita Amira Masiah Syahvira Andreas Peter Sitorus Andreas Peter Sitorus Angelia Ratnasari, Affi Anggraeni, Asih Annang Giri Moelyo Asih Anggraeni Besar, Dwi Sakti Berlian Cahyono Hadi Darto Darto Darto - Darto - Darto . Darto . Darto Darto Dewi Kartika DJ Anwar Dwi Septiadi Badri Dyah Ratna Budiani Ediningtyas, Atifa Nadira Elita Rahmi Eric Edwin Yuliantara Fahsan, Fatmiyanti Farras Wahdan, Arib Hadi, Cahyono Hafiizha, Attahira Amalia Hanifah Karim Hapsari Nur Primastuti Hapsari Nur Primastuti Hermawan Udiyanto Heru Priyanto Heru Priyanto Ida Nurwati Jatiningtyas, Abida Zuhra Kartika Pertiwi Laqif, Abdurahman Lukman Aryoseto Lukman Aryoseto Lunardhi Susanto Marbun, Yohan Pamuji Mashuri, Yusuf Ari Metanolia Sukmawati Mufidah, Amatullah Mulyoto Pangestu Ngudi Insan Ksyatria, Yudhistira Nutria Widya Purna Anggraini Octavia, Dhamayanti Eka Prastyoningsih, Aris Prisasanti, Dympna Prameilita Raden Rara Pandhan Budi Larasati Rakano Kautsar Dwiyana Rantasari, Affi Angelia Ratnasari, Affi Angelia Regita, Immanuela Maria Saputra, Ricky Bernadi Sari, Arum Dessy Rahma Septiana, Yesika Cahya Sri Sulistyowati Sri Sulistyowati Supriyadi Hari Respati Supriyadi Hari Respati Tanti Arianti Teguh Prakosa, Teguh Tri Nugraha Susilawati Uki Retno Budihastuti Vicky Eko N.H Vicky Eko N.H Wasyanto, Trisulo Wesliaprilius, Todung Antony Wijayanti, Agung Sari WISNU PRABOWO Yulyanti, Yulyanti Zacky Arda, Mohammad