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All Journal Jurnal Bios Logos JURNAL BIOMEDIK Jurnal Pendidikan Biologi Undiksha JSME MIPA UNIMA Jurnal Sains dan Teknologi Jurnal Pendidikan IPA Indonesia Abdimas Jurnal Bioedukatika Jurnal Biologi Tropis Dinamisia: Jurnal Pengabdian Kepada Masyarakat JURNAL PENDIDIKAN TAMBUSAI Molekul: Jurnal Ilmiah Kimia Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Pembelajaran dan Biologi Nukleus SOSCIED Jurnal Aplikasi dan Inovasi Iptek (JASINTEK) Jurnal Dedikasi Bioscientist : Jurnal Ilmiah Biologi Majalah Info Sains Seminar Nasional Pengabdian Kepada Masyarakat Indonesian Biodiversity Journal Innovative: Journal Of Social Science Research Molekul: Jurnal Ilmiah Kimia Indonesian Biodiversity Journal Servitium Smart Journal Jurnal Pendidikan Progresif
Mokosuli Yermia Samuel
Universitas Negeri Manado
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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PENGEMBANGAN E-BOOK DAN PRAKTIKUM BERBASIS ANALISIS DNA LALAT BUAH ISOLAT LOKAL PADA MATERI GENETIKA DI SMA Djaila, Friscila Avianti; Semuel, Mokosuli Yermia; Wurarah, Masje
Jurnal Review Pendidikan dan Pengajaran Vol. 8 No. 1 (2025): Volume 8 No. 1 Tahun 2025
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jrpp.v8i1.41423

Abstract

Penelitian ini bertujuan untuk mengembangkan dan menghasilkan media pembelajaran e-book dan praktikum berbasis analisis DNA lalat buah isolat lokal pada materi genetika di SMA yang layak digunakan. Penelitian ini merupakan penelitian pengembangan (Research and Development) dengan model ADDIE yang terdiri 5 tahapan, yaitu Analysis, Design, Development, Implementation, dan Evaluation. Instrumen tes pada penelitian ini adalah angket, wawancara dan dokumentasi. Lembar angket penilaian diberikan kepada subjek penelitian yaitu ahli materi, ahli media, guru mata pelajaran biologi dan siswa kelas XII di SMA Negeri 1 Pagimana. Hasil penelitian ahli materi dengan persentase 93% kriteria sangat valid, ahli media dengan persentase 96% kriteria sangat valid, guru biologi dengan persentase 97% kriteria sangat valid dan respons siswa dengan persentase 88% kriteria sangat baik. Dapat disimpulkan bahwa media e-book dan praktikum berbasis analisis DNA lalat buah isolat lokal pada materi genetika di SMA produk yang dihasilkan sangat layak untuk digunakan sebagai media pembelajaran.
Anticancer Activity Of Apis Dorsata Binghami Nest Extract From West Uluway, Tana Toraja District Patandean, Selvrining; Mokosuli, Yermia Semuel; Ogi, Nova LIM; Djarang, Rievo H; Manampiring, Nonny; Moko, Emma Mauren
Indonesian Biodiversity Journal Vol. 6 No. 1 (2025): April 2025
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v6i1.12750

Abstract

Cancer is the leading cause of death in the world, with a high prevalence in Indonesia, especially breast cancer. Conventional therapies such as chemotherapy and radiotherapy have various limitations, including severe side effects and cancer cell resistance. This study aims to explore the anticancer potential of the ethanol extract of Apis dorsata Binghami nests originating from Uluway Barat Village, Tana Toraja Regency. Extraction was carried out using the maceration method with 96% ethanol solvent, with a yield of 51.42%, and bioactive compounds were identified through GC-MS analysis. Anticancer activity tests were carried out in vitro on MCF-7 breast cancer cells using the resazurin assay method . The results showed that the extract contained various bioactive compounds such as flavonoids, furanones, and aromatic aldehydes which are known to have antioxidant and anticancer activities. The IC50 value obtained was 434.30 µg/mL, indicating weak cytotoxic activity. Nevertheless, this extract showed significant ability to kill cancer cells at certain concentrations, especially 15.63 µg/mL which reduced cell viability by 44.39%. These results indicate that A. dorsata Binghami nests contain compounds that have the potential as natural anticancer agents, but require further research for fractionation and identification of more specific active compounds and further testing in vivo
Anticancer Activity Of Apis Dorsata Binghami Nest Extract From West Uluway, Tana Toraja District Patandean, Selvrining; Mokosuli, Yermia Semuel; Ogi, Nova LIM; Djarang, Rievo H; Manampiring, Nonny; Moko, Emma Mauren
Indonesian Biodiversity Journal Vol. 6 No. 1 (2025): April 2025
Publisher : Universitas Negeri Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53682/ibj.v6i1.12750

Abstract

Cancer is the leading cause of death in the world, with a high prevalence in Indonesia, especially breast cancer. Conventional therapies such as chemotherapy and radiotherapy have various limitations, including severe side effects and cancer cell resistance. This study aims to explore the anticancer potential of the ethanol extract of Apis dorsata Binghami nests originating from Uluway Barat Village, Tana Toraja Regency. Extraction was carried out using the maceration method with 96% ethanol solvent, with a yield of 51.42%, and bioactive compounds were identified through GC-MS analysis. Anticancer activity tests were carried out in vitro on MCF-7 breast cancer cells using the resazurin assay method . The results showed that the extract contained various bioactive compounds such as flavonoids, furanones, and aromatic aldehydes which are known to have antioxidant and anticancer activities. The IC50 value obtained was 434.30 µg/mL, indicating weak cytotoxic activity. Nevertheless, this extract showed significant ability to kill cancer cells at certain concentrations, especially 15.63 µg/mL which reduced cell viability by 44.39%. These results indicate that A. dorsata Binghami nests contain compounds that have the potential as natural anticancer agents, but require further research for fractionation and identification of more specific active compounds and further testing in vivo
Co-Authors Alfonds Andrew Maramis Anice I. Tuda Anita Costanci Christine Tengker Arrijani - Budiarto Buyang, Dalle Carolin Manuahe Decky D. W. Kamagi Dewa Nyoman Oka Dina Munawaroh Dina Rombot Djaila, Friscila Avianti Djarang, Rievo H Edieli Zebua Edyson Maneasa Emma M Moko Esibrena Br Kemit Eurika, Uwuh Jessie Fadly Steven Jefry Rumondor Fanny Nella Nanlohy Febiola Gabriela Tular Febiola Najoan Ferencia Esananda Rattu Ferni Margo Tumbel Ferny Margo Tumbel Feydina Tewu Friska Mery Montolalu Futwembun, Fransiska Gedoan, Sukmarayu Piter Grace Jenny Soputan H. M. Sumampouw Hariyadi Hariyadi Helen Joan Lawalata Hendra Pratama Maliangkay Hermanus, Britney Putri Herry Maurits Sumampouw Ilham Saputra Butar-butar IRIANI SETYAWATI Iriani Setyawati Jacklin Stella Manopo Jantje Ngangi Jantje Pelealu Jeane Mantiri Jimmy Langi Jonathan Polandos julduz ruland paus Kamagi, Decky D. W. Kandowangko, Sandy Kaunang, Eva S. N. Maidangkay, Vonny Mamuaya, Tripena Manampiring, Noni Manampiring, Nonny Mansyur, Djailani Masje Wurarah Masje Wurarah Masye Wurarah Max Tulung Meike Paat Meisa Tabita Rogahang Meity Nelltje Tanor Melita Irene Gracia Kaligis Meyer Worang Matey Migau, Natalina Mongdong, Priskila Indah Theresya Motulo, Serlin J Mulder, Keysia Stephanie Tesalonica Mundaeng, Camel Gantonio Nerni Potolangi Nonny Manampiring Nova L.I.M Ogi Ogi, Nova LIM Orbanus Naharia Orbanus Naharia Patandean, Selvrining Pomalingo, Moh Fikri Pratasik, Stralen Pratasik, Veronika Pua, Devis Christian Rahardiyan, Dino Revolson Mege Rolef Rumondor Rudi Alexander Repi Rymond Jusuf Rumampuk Sibala, Henike Simbolon, Kristina Br Sinyo Herry Sumampouw Suddin Simandjuntak Sukmarayu Gedoan Sukmarayu P. Gedoan Sumampouw, Harry Maurits Taariwuan, Marlin Bernadet Thesia Megi Kurniawati Rettob Timbuleng, Nobel Tjiakra, Rosalina A. Tuegeh, Reinny Silvana Tumanduk, Yahya Y.R. Turambi, James S. Utari Satiman Verawati I Y Roring Verawati Ida Yani Roring Verra E. J. Mawitjere Wisda Nurjannah Abdullah Worang, Rina L. Wuwungan, Axel Yessie K. Kelly